TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 584.708 | Formula: C33H40N6O4
H donors: 1 H acceptors: 4 LogP: 6.22 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: COc1ccc(cc1OCCCCOc1ccc(cc1)c1n[nH]nn1)C1=NN(C2CCCCCC2)C(=O)[C@@H]2[C@H]1CC=CC2
InChi: 1S/C33H40N6O4/c1-41-29-19-16-24(31-27-12-6-7-13-28(27)33(40)39(36-31)25-10-4-2-3-5-11-25)22-30(29)43-21-9-8-20-42-26-17-14-23(15-18-26)32-34-37-38-35-32/h6-7,14-19,22,25,27-28H,2-5,8-13,20-21H2,1H3,(H,34,35,37,38)/t27-,28+/m1/s1
InChiKey: DNDNLFXKQSTINI-IZLXSDGUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphodiesterase 4C, cAMP-specific		References
Homo sapiens	phosphodiesterase 4D, cAMP-specific	Starlite/ChEMBL	References
Homo sapiens	phosphodiesterase 4B, cAMP-specific		References
Trypanosoma brucei	cAMP-specific phosphodiesterase	Starlite/ChEMBL	References
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative		References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	Get druggable targets OG5_128242	All targets in OG5_128242
Neospora caninum	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Cryptosporidium parvum	membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania donovani	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Importin beta-1 subunit	0.0149	0.0333	0.0339
Schistosoma mansoni	tar DNA-binding protein	0.0135	0.0278	0.0278
Leishmania major	hypothetical protein, conserved	0.0151	0.034	0.1631
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0314	0.1	0.5361
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0151	0.034	0.034
Loa Loa (eye worm)	hypothetical protein	0.0151	0.034	0.0346
Entamoeba histolytica	hypothetical protein	0.0121	0.0219	0.3023
Echinococcus multilocularis	Niemann Pick C1 protein	0.02	0.0538	0.0547
Mycobacterium tuberculosis	Probable dehydrogenase	0.0201	0.0544	0.1292
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0179	0.0454	0.1902
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.04	0.1348	0.137
Brugia malayi	Thioredoxin reductase	0.0088	0.0087	0.0089
Trichomonas vaginalis	conserved hypothetical protein	0.0525	0.1852	1
Toxoplasma gondii	hypothetical protein	0.0135	0.0276	0.0995
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0478	0.1666	0.8985
Loa Loa (eye worm)	beta-lactamase	0.0151	0.034	0.0346
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0478	0.1666	0.8985
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0179	0.0454	0.2388
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0201	0.0544	0.1292
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.031	0.0984	0.1001
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0179	0.0454	0.0454
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0248	0.0735	0.0747
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0478	0.1666	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0523	0.1847	0.1878
Loa Loa (eye worm)	hypothetical protein	0.0151	0.034	0.0346
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0151	0.034	0.0346
Leishmania major	trypanothione reductase	0.0088	0.0087	0.0035
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0525	0.1852	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0151	0.034	0.0715
Toxoplasma gondii	ABC1 family protein	0.0151	0.034	0.1319
Echinococcus granulosus	thioredoxin glutathione reductase	0.0089	0.0089	0.0091
Echinococcus multilocularis	geminin	0.0735	0.2705	0.275
Loa Loa (eye worm)	hypothetical protein	0.0149	0.0333	0.0339
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0211	0.0582	0.0592
Echinococcus multilocularis	tar DNA binding protein	0.0135	0.0278	0.0283
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0478	0.1666	0.8985
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0121	0.0219	0.111
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0478	0.1666	0.8985
Loa Loa (eye worm)	glutathione reductase	0.0088	0.0087	0.0089
Schistosoma mansoni	hypothetical protein	0.0083	0.0064	0.0064
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0224	0.0635	0.1548
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0392	0.1317	0.1339
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0314	0.1	0.5361
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.02	0.0538	1
Loa Loa (eye worm)	hypothetical protein	0.0391	0.1314	0.1336
Trypanosoma cruzi	trypanothione reductase, putative	0.0088	0.0087	0.0035
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.04	0.1348	0.137
Trichomonas vaginalis	conserved hypothetical protein	0.0135	0.0276	0.1421
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0179	0.0454	0.4127
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0179	0.0454	0.1902
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0571	0.2041	1
Schistosoma mansoni	tar DNA-binding protein	0.0135	0.0278	0.0278
Echinococcus granulosus	geminin	0.0735	0.2705	0.275
Mycobacterium tuberculosis	Probable oxidoreductase	0.0224	0.0635	0.1548
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0248	0.0735	0.3336
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0478	0.1666	0.8985
Schistosoma mansoni	chromobox protein	0.007	0.0015	0.0015
Trypanosoma cruzi	hypothetical protein, conserved	0.0179	0.0454	0.2352
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0478	0.1666	0.8985
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0248	0.0735	0.4124
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0478	0.1666	0.8985
Onchocerca volvulus		0.0151	0.034	0.5
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0179	0.0454	0.1902
Mycobacterium tuberculosis	Probable lipase LipE	0.0151	0.034	0.0715
Schistosoma mansoni	sodium/chloride dependent transporter	0.0169	0.0415	0.0415
Leishmania major	hypothetical protein, conserved	0.0179	0.0454	0.2352
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0523	0.1847	0.1847
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0179	0.0454	0.1902
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0224	0.0635	0.1548
Echinococcus granulosus	histone lysine N methyltransferase Ez	0.0097	0.0123	0.0125
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0086	0.0077	0.0078
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0211	0.0582	0.0592
Loa Loa (eye worm)	TAR-binding protein	0.0135	0.0278	0.0283
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0179	0.0454	0.2352
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0179	0.0454	0.1902
Trypanosoma brucei	importin beta-1 subunit, putative	0.0149	0.0333	0.159
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0179	0.0454	0.1902
Trypanosoma brucei	importin beta-1 subunit, putative	0.0149	0.0333	0.159
Brugia malayi	beta-lactamase	0.0151	0.034	0.0346
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0523	0.1847	0.1847
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0478	0.1666	0.8985
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0169	0.0415	0.0422
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0179	0.0454	0.0462
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0179	0.0454	0.1902
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.031	0.0984	0.1001
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0211	0.0582	0.0592
Trypanosoma brucei	trypanothione reductase	0.0088	0.0087	0.0035
Mycobacterium leprae	Probable lipase LipE	0.0151	0.034	0.1772
Plasmodium falciparum	importin beta, putative	0.0149	0.0333	0.279
Echinococcus granulosus	Niemann Pick C1 protein	0.02	0.0538	0.0547
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0248	0.0735	0.4124
Schistosoma mansoni	hypothetical protein	0.0083	0.0064	0.0064
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0179	0.0454	0.2388
Echinococcus multilocularis	protein dispatched 1	0.0098	0.0126	0.0128
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0225	0.0641	0.3403
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0179	0.0454	0.4127
Loa Loa (eye worm)	hypothetical protein	0.0211	0.0582	0.0592
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0179	0.0454	0.2388
Echinococcus multilocularis	Niemann Pick C1 protein	0.0285	0.0884	0.0899
Schistosoma mansoni	hypothetical protein	0.0144	0.0313	0.0313
Brugia malayi	latrophilin 2 splice variant baaae	0.0144	0.0313	0.0318
Echinococcus granulosus	snurportin 1	0.1591	0.6167	0.627
Mycobacterium leprae	conserved hypothetical protein	0.0151	0.034	0.1772
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0184	0.0188
Trichomonas vaginalis	conserved hypothetical protein	0.0179	0.0454	0.2388
Brugia malayi	beta-lactamase family protein	0.0151	0.034	0.0346
Mycobacterium tuberculosis	Conserved protein	0.0151	0.034	0.0715
Brugia malayi	RNA recognition motif domain containing protein	0.0135	0.0278	0.0283
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0169	0.0415	0.0422
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0478	0.1666	0.8985
Brugia malayi	RNA binding protein	0.0135	0.0278	0.0283
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0087	0.0082	0.0083
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.031	0.0984	0.0984
Trypanosoma brucei	hypothetical protein, conserved	0.0179	0.0454	0.2352
Trichomonas vaginalis	D-aminoacylase, putative	0.0151	0.034	0.1767
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0478	0.1666	0.1666
Loa Loa (eye worm)	hypothetical protein	0.2498	0.9836	1
Echinococcus multilocularis	histone lysine N methyltransferase E(z)	0.0097	0.0123	0.0125
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0418	0.1422	0.1445
Schistosoma mansoni	importin beta-1	0.0149	0.0333	0.0333
Trypanosoma cruzi	hypothetical protein, conserved	0.0179	0.0454	0.2352
Brugia malayi	TAR-binding protein	0.0135	0.0278	0.0283
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0525	0.1852	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0151	0.034	0.0346
Leishmania major	importin beta-1 subunit, putative	0.0121	0.0219	0.087
Mycobacterium tuberculosis	Conserved protein	0.0151	0.034	0.0715
Brugia malayi	RNA, U transporter 1	0.0424	0.1445	0.1469
Trichomonas vaginalis	conserved hypothetical protein	0.0179	0.0454	0.2388
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0121	0.0219	0.087
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0179	0.0454	0.2352
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0181	0.0463	0.1062
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.031	0.0984	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0179	0.0454	0.2352
Mycobacterium tuberculosis	Conserved protein	0.0151	0.034	0.0715
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0478	0.1666	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0523	0.1847	0.1847
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0523	0.1847	0.1878
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0201	0.0544	0.1292
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0179	0.0454	0.2352
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.2498	0.9836	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0151	0.034	0.0715
Schistosoma mansoni	hypothetical protein	0.0083	0.0064	0.0064
Trichomonas vaginalis	conserved hypothetical protein	0.03	0.0942	0.5046
Trypanosoma cruzi	hypothetical protein, conserved	0.0151	0.034	0.1631
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0478	0.1666	0.8985
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0179	0.0454	0.2352
Brugia malayi	Protein kinase domain containing protein	0.2498	0.9836	1
Echinococcus multilocularis	expressed conserved protein	0.0187	0.0489	0.0497
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0478	0.1666	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0151	0.034	0.0346
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.031	0.0984	0.4609
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0523	0.1847	0.1878
Trichomonas vaginalis	penicillin-binding protein, putative	0.0151	0.034	0.1767
Trichomonas vaginalis	D-aminoacylase, putative	0.0151	0.034	0.1767
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0525	0.1852	1
Trypanosoma brucei	hypothetical protein, conserved	0.0151	0.034	0.1631
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0179	0.0454	0.2352
Schistosoma mansoni	patched 1	0.0086	0.0077	0.0077
Leishmania major	hypothetical protein, conserved	0.0179	0.0454	0.2352
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0415	0.0422
Plasmodium falciparum	phosphodiesterase delta, putative	0.0179	0.0454	0.4127
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0184	0.0188
Echinococcus granulosus	tar DNA binding protein	0.0135	0.0278	0.0283
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0179	0.0454	0.1902
Mycobacterium tuberculosis	Probable reductase	0.0201	0.0544	0.1292
Plasmodium vivax	hypothetical protein, conserved	0.0135	0.0276	0.2983
Trichomonas vaginalis	conserved hypothetical protein	0.03	0.0942	0.5046
Brugia malayi	Niemann-Pick C1 protein precursor	0.02	0.0538	0.0547
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0291	0.0908	0.0908
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0248	0.0735	0.3336
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0344	0.112	0.6554
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.1179	0.45	0.4574
Loa Loa (eye worm)	hypothetical protein	0.0256	0.0768	0.0781
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0179	0.0454	0.5701
Schistosoma mansoni	sodium/chloride dependent transporter	0.0169	0.0415	0.0415
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0179	0.0454	0.2388
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0179	0.0454	0.1902
Toxoplasma gondii	thioredoxin reductase	0.0088	0.0087	0.0029
Echinococcus multilocularis	chromobox protein 1	0.007	0.0015	0.0016
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0344	0.112	0.6013
Loa Loa (eye worm)	SET domain-containing protein	0.0097	0.0123	0.0125
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0179	0.0454	0.1902
Toxoplasma gondii	hypothetical protein	0.0135	0.0276	0.0995
Echinococcus granulosus	sodium and chloride dependent glycine	0.0169	0.0415	0.0422
Loa Loa (eye worm)	hypothetical protein	0.0291	0.0908	0.0923
Mycobacterium ulcerans	lipase LipD	0.0151	0.034	0.3407
Echinococcus multilocularis	protein patched	0.0086	0.0077	0.0078
Echinococcus granulosus	sodium and chloride dependent glycine	0.0169	0.0415	0.0422
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0478	0.1666	0.8985
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0415	0.0422
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0087	0.0082	0.0083
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0201	0.0544	0.1292
Trypanosoma cruzi	hypothetical protein, conserved	0.0151	0.034	0.1631
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0203	0.055	0.055
Mycobacterium ulcerans	beta-lactamase	0.0151	0.034	0.3407
Schistosoma mansoni	enhancer of zeste ezh	0.0097	0.0123	0.0123
Schistosoma mansoni	hypothetical protein	0.0735	0.2705	0.2705
Echinococcus granulosus	importin subunit beta 1	0.0149	0.0333	0.0339
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0121	0.0219	0.111
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0571	0.2041	0.2075
Brugia malayi	glutathione reductase	0.0088	0.0087	0.0089
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0478	0.1666	0.1694
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0344	0.112	0.6013
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0571	0.2041	1
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0291	0.0908	0.0923
Schistosoma mansoni	hypothetical protein	0.0735	0.2705	0.2705
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0169	0.0415	0.0422
Trichomonas vaginalis	importin beta-1, putative	0.0121	0.0219	0.111
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0179	0.0454	0.0454
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0179	0.0454	0.2352
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0478	0.1666	0.8985
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0179	0.0454	0.2388
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0179	0.0454	0.1902
Loa Loa (eye worm)	hypothetical protein	0.0151	0.034	0.0346
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0087	0.0082	0.0083
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0523	0.1847	0.1878
Trypanosoma cruzi	hypothetical protein, conserved	0.0179	0.0454	0.2352
Echinococcus multilocularis	chromobox protein 1	0.007	0.0015	0.0016
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0151	0.034	0.034
Plasmodium falciparum	thioredoxin reductase	0.0088	0.0087	0.0062
Echinococcus granulosus	chromobox protein 1	0.007	0.0015	0.0016
Onchocerca volvulus		0.0151	0.034	0.5
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0478	0.1666	0.1694
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0179	0.0454	0.2388
Brugia malayi	Heterochromatin protein 1	0.007	0.0015	0.0016
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0179	0.0454	0.4127
Schistosoma mansoni	tar DNA-binding protein	0.0135	0.0278	0.0278
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0418	0.1422	0.1422
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0571	0.2041	0.2075
Mycobacterium tuberculosis	Probable hydrolase	0.0151	0.034	0.0715
Loa Loa (eye worm)	hypothetical protein	0.0151	0.034	0.0346
Echinococcus granulosus	chromobox protein 1	0.007	0.0015	0.0016
Mycobacterium tuberculosis	Probable esterase LipL	0.0151	0.034	0.0715
Plasmodium vivax	glutathione reductase, putative	0.0088	0.0087	0.0086
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0248	0.0735	1
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0248	0.0735	0.4124
Echinococcus multilocularis	sterol regulatory element binding protein	0.0086	0.0077	0.0078
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0633	0.2293	0.2331
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0313	0.0318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0225	0.0641	0.3403
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0179	0.0454	0.2388
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0523	0.1847	0.1878
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0478	0.1666	0.8985
Loa Loa (eye worm)	RNA binding protein	0.0135	0.0278	0.0283
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0392	0.1317	0.1339
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0201	0.0544	0.1292
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0478	0.1666	1
Schistosoma mansoni	hypothetical protein	0.1591	0.6167	0.6167
Trichomonas vaginalis	esterase, putative	0.0151	0.034	0.1767
Plasmodium falciparum	GAF domain-related protein, putative	0.0135	0.0276	0.2159
Loa Loa (eye worm)	hypothetical protein	0.2498	0.9836	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0151	0.034	0.0346
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0478	0.1666	0.8985
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0963	0.3625	1
Schistosoma mansoni	tar DNA-binding protein	0.0135	0.0278	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0418	0.1422	0.1445
Brugia malayi	beta-lactamase family protein	0.0151	0.034	0.0346
Trypanosoma cruzi	hypothetical protein, conserved	0.0179	0.0454	0.2352
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0179	0.0454	0.2388
Toxoplasma gondii	HEAT repeat-containing protein	0.0149	0.0333	0.1286
Loa Loa (eye worm)	hypothetical protein	0.0571	0.2041	0.2075
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0314	0.1	0.5361
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0478	0.1666	0.8985
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0478	0.1666	0.8985
Echinococcus granulosus	sterol regulatory element binding protein	0.0086	0.0077	0.0078
Brugia malayi	CHE-14 protein	0.0086	0.0077	0.0078
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0633	0.2293	0.2331
Trypanosoma cruzi	hypothetical protein, conserved	0.0179	0.0454	0.2352
Toxoplasma gondii	hypothetical protein	0.03	0.0942	0.4394
Giardia lamblia	hypothetical protein	0.0179	0.0454	0.1902
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0571	0.2041	0.2075
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.1591	0.6167	0.627
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0155	0.0157
Onchocerca volvulus		0.0151	0.034	0.5
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.1678	0.6517	0.6626
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0179	0.0454	0.0454
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0201	0.0544	0.7467
Plasmodium vivax	phosphodiesterase gamma, putative	0.0179	0.0454	0.5701
Plasmodium vivax	hypothetical protein, conserved	0.0151	0.034	0.3955
Loa Loa (eye worm)	hypothetical protein	0.0151	0.034	0.0346
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0478	0.1666	0.8985
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0179	0.0454	0.0454
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0248	0.0735	0.0747
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0478	0.1666	0.8985
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0478	0.1666	0.8985
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0179	0.0454	0.1902
Schistosoma mansoni	ran	0.0087	0.0082	0.0082
Giardia lamblia	Hypothetical protein	0.0179	0.0454	0.1902
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0478	0.1666	0.8985
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0571	0.2041	0.2041
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0151	0.034	0.3407
Plasmodium vivax	importin-beta 2, putative	0.0149	0.0333	0.3854
Schistosoma mansoni	ran	0.0087	0.0082	0.0082
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0248	0.0735	0.4124
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0077	0.0334
Toxoplasma gondii	GAF domain-containing protein	0.0135	0.0276	0.0995
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0179	0.0454	0.0454
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0478	0.1666	0.8985
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.057	0.2037	0.2071
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0151	0.034	0.0715
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.04	0.1348	0.1348
Echinococcus multilocularis	importin subunit beta 1	0.0149	0.0333	0.0339
Brugia malayi	SET domain containing protein	0.0097	0.0123	0.0125
Echinococcus granulosus	expressed conserved protein	0.0187	0.0489	0.0497
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0179	0.0454	0.1902
Schistosoma mansoni	tar DNA-binding protein	0.0135	0.0278	0.0278
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0291	0.0908	0.0923
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0077	0.0078
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0392	0.1317	0.1339
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.04	0.1348	0.137
Schistosoma mansoni	chromobox protein	0.007	0.0015	0.0015
Loa Loa (eye worm)	TKL/MLK/LZK protein kinase	0.2498	0.9836	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0478	0.1666	0.8985
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0478	0.1666	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0478	0.1666	0.8985
Trichomonas vaginalis	penicillin-binding protein, putative	0.0151	0.034	0.1767
Echinococcus multilocularis	snurportin 1	0.1591	0.6167	0.627
Plasmodium falciparum	glutathione reductase	0.0088	0.0087	0.0062
Loa Loa (eye worm)	hypothetical protein	0.02	0.0538	0.0547
Loa Loa (eye worm)	hypothetical protein	0.1	0.3776	0.3839
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0224	0.0635	1
Plasmodium vivax	thioredoxin reductase, putative	0.0088	0.0087	0.0086
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0179	0.0454	0.1902
Echinococcus granulosus	Niemann Pick C1 protein	0.0285	0.0884	0.0899
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0392	0.1317	0.1339
Mycobacterium ulcerans	hypothetical protein	0.0151	0.034	0.3407
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0179	0.0454	0.5701
Trichomonas vaginalis	conserved hypothetical protein	0.03	0.0942	0.5046
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0087	0.0082	0.0083
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0135	0.0278	0.0283
Trichomonas vaginalis	ran, putative	0.0087	0.0082	0.036
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0523	0.1847	0.1878
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0184	0.0188
Trichomonas vaginalis	D-aminoacylase, putative	0.0151	0.034	0.1767
Loa Loa (eye worm)	thioredoxin reductase	0.0088	0.0087	0.0089
Schistosoma mansoni	hypothetical protein	0.0083	0.0064	0.0064
Loa Loa (eye worm)	heterochromatin protein 1	0.007	0.0015	0.0016
Loa Loa (eye worm)	PDE1B protein	0.04	0.1348	0.137
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0179	0.0454	0.4127
Loa Loa (eye worm)	hypothetical protein	0.0151	0.034	0.0346
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0571	0.2041	0.2075
Loa Loa (eye worm)	hypothetical protein	0.1179	0.45	0.4574
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.057	0.2037	0.2071
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0478	0.1666	0.8985
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0478	0.1666	0.8985
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0089	0.0089	0.0091
Mycobacterium ulcerans	esterase/lipase LipP	0.0151	0.034	0.3407
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0151	0.034	0.0715
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0135	0.0276	0.0535
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0181	0.0463	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0169	0.0415	0.0422
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.057	0.2037	0.2071
Echinococcus granulosus	Protein patched homolog 1	0.0086	0.0077	0.0078
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.2498	0.9836	1

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 80 nM	Antitrypanosomal activity against Trypanosoma brucei brucei	ChEMBL.	24042005
IC50 (binding)	= 0.6 nM	Inhibition of human PDE4	ChEMBL.	24042005
IC50 (binding)	= 3.98 nM	Inhibition of Trypanosoma brucei PDEB1	ChEMBL.	24042005

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Trypanosoma brucei gambiense		24042005

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2436771

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1789155