TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 337.824 | Formula: C15H16ClN3O2S
H donors: 0 H acceptors: 1 LogP: 1.95 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N1CCOCC1)Cn1c(=N)scc1c1ccc(cc1)Cl
InChi: 1S/C15H16ClN3O2S/c16-12-3-1-11(2-4-12)13-10-22-15(17)19(13)9-14(20)18-5-7-21-8-6-18/h1-4,10,17H,5-9H2
InChiKey: IHOGKRIRHORAHV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase 1	Starlite/ChEMBL	References
Homo sapiens	leukotriene A4 hydrolase	Starlite/ChEMBL	References
Homo sapiens	epidermal growth factor receptor	Starlite/ChEMBL	References
Homo sapiens	SRC proto-oncogene, non-receptor tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	vitamin D (1,25- dihydroxyvitamin D3) receptor	Starlite/ChEMBL	References
Homo sapiens	thymidylate synthetase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis		Get druggable targets OG5_128597	All targets in OG5_128597
Leishmania donovani	mitogen activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania mexicana	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	leukotriene A4 hydrolase/leucyl aminopeptidase	Get druggable targets OG5_129538	All targets in OG5_129538
Leishmania major	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Trypanosoma brucei	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Neospora caninum	Bifunctional dihydrofolate reductase-thymidylate synthase, related	Get druggable targets OG5_127385	All targets in OG5_127385
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	Furin-like cysteine rich region family protein	Get druggable targets OG5_128597	All targets in OG5_128597
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C)	Get druggable targets OG5_127385	All targets in OG5_127385
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Leishmania braziliensis	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Cryptosporidium parvum	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Leishmania donovani	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Schistosoma japonicum	ko:K04371 extracellular signal-regulated kinase 1/2, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	leukotriene A 4 hydrolase	Get druggable targets OG5_129538	All targets in OG5_129538
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Theileria parva	dihydrofolate reductase-thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750
Leishmania mexicana	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Cryptosporidium hominis	chain A, crystal structure of Dhfr	Get druggable targets OG5_127385	All targets in OG5_127385
Echinococcus granulosus	leukotriene A 4 hydrolase	Get druggable targets OG5_129538	All targets in OG5_129538
Leishmania braziliensis	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Cryptosporidium parvum	MAPK, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Trypanosoma brucei gambiense	protein kinase, putative,tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-4 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Plasmodium berghei	bifunctional dihydrofolate reductase-thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	Get druggable targets OG5_129538	All targets in OG5_129538
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Plasmodium knowlesi	bifunctional dihydrofolate reductase-thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Leishmania infantum	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127385	All targets in OG5_127385
Loa Loa (eye worm)	TK/EGFR protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Cryptosporidium hominis	MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-2 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase implicated in PKC1-controlled signalling pathway	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma congolense	tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Plasmodium yoelii	thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Schistosoma japonicum	ko:K00560 thymidylate synthase [EC2.1.1.45], putative	Get druggable targets OG5_127385	All targets in OG5_127385
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K01254 leukotriene-A4 hydrolase [EC3.3.2.6], putative	Get druggable targets OG5_129538	All targets in OG5_129538
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	Get druggable targets OG5_127385	All targets in OG5_127385
Loa Loa (eye worm)	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Candida albicans	Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C)	Get druggable targets OG5_127385	All targets in OG5_127385
Echinococcus granulosus	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	MAP kinase sur-1	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei gambiense	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Tyrosine-protein kinase transforming protein erbB, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Leishmania infantum	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Mycobacterium ulcerans	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania mexicana	mitogen-activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania braziliensis	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Trypanosoma brucei gambiense	mitogen-activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania donovani	mitogen-activated protein kinase 4	Get druggable targets OG5_126781	All targets in OG5_126781
Onchocerca volvulus		Get druggable targets OG5_127385	All targets in OG5_127385
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Candida albicans	leukotriene A4 hydrolase/leucyl aminopeptidase	Get druggable targets OG5_129538	All targets in OG5_129538
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Babesia bovis	dihydrofolate reductase/thymidilate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Leishmania infantum	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Giardia lamblia	Kinase, CMGC MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	Get druggable targets OG5_127385	All targets in OG5_127385
Loa Loa (eye worm)	leukotriene A4 hydrolase	Get druggable targets OG5_129538	All targets in OG5_129538
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	ko:K05085 receptor tyrosine-protein kinase erbB-4, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	steroid hormone receptor	vitamin D (1,25- dihydroxyvitamin D3) receptor	427 aa	416 aa	24.5 %
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	leukotriene A4 hydrolase	611 aa	508 aa	22.8 %
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 1	360 aa	361 aa	33.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	aminopeptidase N	0.0015	0.0016	0.0019
Loa Loa (eye worm)	SRC-1	0.0055	0.0461	0.0809
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0149	0.0668
Echinococcus granulosus	tyrosine protein kinase Srms	0.0015	0.0023	0.003
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.01	0.0962	0.1686
Schistosoma mansoni	tyrosine kinase	0.019	0.1953	0.3336
Brugia malayi	hypothetical protein	0.0015	0.0023	0.0012
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.002	0.0072	0.0096
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0062	0.0533	0.0934
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0062	0.0533	0.2598
Schistosoma mansoni	serine/threonine protein kinase	0.054	0.5821	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0015	0.0016	0.0019
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0062	0.0533	0.2598
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0149	0.0668
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0051	0.0412	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0279	0.0489
Loa Loa (eye worm)	TK protein kinase	0.0051	0.0412	0.0723
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0027	0.0149	0.0448
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.0279	0.2936	0.5145
Schistosoma mansoni	hypothetical protein	0.0055	0.0456	0.0758
Plasmodium vivax	acyl-CoA synthetase, putative	0.002	0.0074	0.0291
Loa Loa (eye worm)	TK/FER protein kinase	0.0015	0.0023	0.004
Loa Loa (eye worm)	TK/FER protein kinase	0.0015	0.0023	0.004
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0149	0.0668
Loa Loa (eye worm)	TK/FER protein kinase	0.0015	0.0023	0.004
Echinococcus granulosus	tyrosine protein kinase shark	0.0015	0.0023	0.003
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0015	0.0016	0.0011
Brugia malayi	hypothetical protein	0.0128	0.127	0.2204
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.01	0.0962	0.163
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0015	0.0016	0.0011
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0055	0.0456	0.0773
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0149	0.0668
Echinococcus multilocularis	GPCR, family 2	0.0018	0.005	0.0044
Loa Loa (eye worm)	hypothetical protein	0.002	0.0074	0.013
Onchocerca volvulus		0.0015	0.0023	0.0033
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.0149	0.3843
Echinococcus granulosus	intermediate filament protein	0.0029	0.017	0.0288
Brugia malayi	Tyrosine-protein kinase abl-1	0.002	0.0072	0.0098
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0055	0.0461	0.0456
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0149	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0164	0.0288
Schistosoma mansoni	tyrosine kinase	0.002	0.0072	0.0096
Echinococcus multilocularis	epidermal growth factor receptor	0.0107	0.1032	0.1026
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.01	0.0962	0.0957
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.002	0.0074	0.0062
Echinococcus multilocularis	musashi	0.0029	0.017	0.0164
Giardia lamblia	Kinase, CMGC MAPK	0.0062	0.0533	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0015	0.0022	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0149	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0529	0.57	0.9989
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0055	0.0461	0.0456
Brugia malayi	SH2 domain containing protein	0.0015	0.0023	0.0012
Schistosoma mansoni	tyrosine kinase	0.0096	0.0911	0.1542
Brugia malayi	SH2 domain containing protein	0.0015	0.0023	0.0012
Brugia malayi	Protein kinase domain containing protein	0.0529	0.5707	1
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0015	0.0016	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0029	0.017	0.0298
Echinococcus multilocularis	mitogen activated protein kinase	0.0062	0.0533	0.0528
Echinococcus granulosus	tyrosine kinase	0.0015	0.0023	0.003
Brugia malayi	Protein kinase domain containing protein	0.0015	0.0023	0.0012
Loa Loa (eye worm)	TK/EGFR protein kinase	0.019	0.1953	0.3422
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0195	0.2005	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0015	0.0023	0.004
Onchocerca volvulus		0.0015	0.0023	0.0033
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.01	0.0962	0.1678
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0062	0.0533	0.2598
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.01	0.0962	0.163
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0093	0.0876	0.4325
Echinococcus granulosus	tyrosine protein kinase Src42A	0.004	0.0292	0.0502
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0015	0.0023	0.0017
Echinococcus multilocularis		0.0056	0.0469	0.0463
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0055	0.0461	0.0456
Echinococcus multilocularis	lamin dm0	0.0029	0.017	0.0164
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0046	0.0362	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0476	0.0835
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.0149	0.3843
Schistosoma mansoni	hypothetical protein	0.0018	0.005	0.0058
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0533	0.6007
Loa Loa (eye worm)	TK/FER protein kinase	0.0015	0.0023	0.004
Echinococcus multilocularis	lamin	0.0029	0.017	0.0164
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.017	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0029
Loa Loa (eye worm)	aminopeptidase N	0.0015	0.0016	0.0029
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0055	0.0461	0.0799
Echinococcus multilocularis	insulin receptor	0.0067	0.0598	0.0592
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0015	0.0016	0.0011
Brugia malayi	Furin-like cysteine rich region family protein	0.019	0.1953	0.3403
Onchocerca volvulus		0.0027	0.0149	0.0668
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0533	0.6007
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0051	0.0412	0.0407
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0055	0.0461	0.0456
Onchocerca volvulus		0.0029	0.017	0.0773
Loa Loa (eye worm)	hypothetical protein	0.002	0.0074	0.013
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.005	0.0077
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.01	0.0962	0.1663
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0027	0.0149	0.0668
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.002	0.0074	0.0291
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.0533	0.2598
Schistosoma mansoni	tyrosine kinase	0.0107	0.1032	0.1749
Loa Loa (eye worm)	hypothetical protein	0.002	0.0074	0.013
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0029
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0015	0.0016	0.0019
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0055	0.0461	0.0456
Plasmodium falciparum	acyl-CoA synthetase	0.002	0.0074	0.0291
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0015	0.0016	0.0019
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.002	0.0072	0.0066
Echinococcus granulosus	lamin dm0	0.0029	0.017	0.0288
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0015	0.0016	0.0019
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0279	0.0462
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.005	0.0044
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0195	0.2005	1
Echinococcus granulosus	insulin receptor	0.0067	0.0598	0.1039
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.004	0.0292	0.0287
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0051	0.0412	0.0713
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0195	0.2005	1
Mycobacterium ulcerans	hypothetical protein	0.0027	0.0149	0.0668
Loa Loa (eye worm)	TK/ABL protein kinase	0.0015	0.0023	0.004
Schistosoma mansoni	tyrosine kinase	0.0015	0.0023	0.0011
Loa Loa (eye worm)	TK/INSR protein kinase	0.0067	0.0598	0.1048
Mycobacterium tuberculosis	Hypothetical protein	0.0093	0.0876	0.4192
Schistosoma mansoni	tyrosine kinase	0.0055	0.0461	0.0767
Onchocerca volvulus		0.0015	0.0023	0.0033
Schistosoma mansoni	hypothetical protein	0.0039	0.0279	0.0452
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.01	0.0962	0.0957
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0149	0.0262
Echinococcus granulosus	tyrosine protein kinase HCK	0.0046	0.0362	0.0625
Entamoeba histolytica	acyl-coA synthetase, putative	0.0027	0.0149	0.3843
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.005	0.0077
Loa Loa (eye worm)	TK/FER protein kinase	0.0015	0.0023	0.004
Brugia malayi	Protein kinase domain containing protein	0.0015	0.0023	0.0012
Schistosoma mansoni	hypothetical protein	0.0018	0.005	0.0058
Echinococcus granulosus	lamin	0.0029	0.017	0.0288
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0529	0.5707	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0149	0.0262
Schistosoma mansoni	hypothetical protein	0.0018	0.005	0.0058
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.01	0.0962	0.163
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0067	0.0598	0.0592
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.005	0.0059
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0051	0.0412	0.0407
Schistosoma mansoni	tyrosine kinase	0.0096	0.0911	0.1542
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0062	0.0533	0.2598
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0055	0.0461	0.0456
Echinococcus multilocularis	aminopeptidase N	0.0015	0.0016	0.0011
Loa Loa (eye worm)	TK/FER protein kinase	0.0015	0.0023	0.004
Mycobacterium ulcerans	thymidylate synthase	0.0195	0.2005	1
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0533	0.6007
Loa Loa (eye worm)	TATA binding protein associated factor	0.0015	0.0016	0.0029
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.01	0.0962	0.1678
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0195	0.2005	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.005	0.0044
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0195	0.2005	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0055	0.0461	0.0799
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0027	0.0149	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0023	0.004
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.0533	0.2598
Schistosoma mansoni	tyrosine kinase	0.002	0.0072	0.0096
Schistosoma mansoni	tyrosine kinase	0.0067	0.0598	0.1002
Schistosoma mansoni	tyrosine kinase	0.0096	0.0911	0.1542
Schistosoma mansoni	survival motor neuron protein	0.0055	0.0456	0.0758
Echinococcus granulosus	GPCR family 2	0.0018	0.005	0.0077
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0149	0.0233
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0195	0.2005	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0029
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.0279	0.2936	0.2932
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0195	0.2005	1
Echinococcus granulosus	epidermal growth factor receptor	0.0107	0.1032	0.1799
Loa Loa (eye worm)	TK/FER protein kinase	0.0015	0.0023	0.004
Loa Loa (eye worm)	thymidylate synthase	0.0195	0.2005	0.3513
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0015	0.0023	0.003
Echinococcus granulosus	survival motor neuron protein 1	0.0268	0.2812	0.4922
Brugia malayi	hypothetical protein	0.0093	0.0876	0.1511
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0062	0.0533	0.2598
Echinococcus granulosus	epidermal growth factor receptor	0.019	0.1953	0.3416
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0149	0.0668
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0533	0.6007
Loa Loa (eye worm)	hypothetical protein	0.0529	0.57	0.9989
Loa Loa (eye worm)	hypothetical protein	0.0018	0.005	0.0088
Schistosoma mansoni	lamin	0.0029	0.017	0.0265
Echinococcus multilocularis	epidermal growth factor receptor	0.019	0.1953	0.1948
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0015	0.0023	0.0017
Brugia malayi	Protein kinase domain containing protein	0.0015	0.0023	0.0012
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0055	0.0461	0.0456
Schistosoma mansoni	lamin	0.0029	0.017	0.0265
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0149	0.0233
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0015	0.0023	0.003
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0062	0.0533	0.0528
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0062	0.0533	0.2598
Loa Loa (eye worm)	TKL/MLK/LZK protein kinase	0.0529	0.5707	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0056	0.0468	0.081
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0056	0.0476	0.0808
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.017	0.027
Loa Loa (eye worm)	TK/FER protein kinase	0.0015	0.0023	0.004
Echinococcus granulosus	leukotriene A 4 hydrolase	0.0279	0.2936	0.514
Brugia malayi	Protein kinase domain containing protein	0.0067	0.0598	0.1022
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0027	0.0149	0.0668
Brugia malayi	SRC-1	0.0055	0.0461	0.0782
Echinococcus multilocularis	tyrosine kinase	0.0015	0.0023	0.0017
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0056	0.0476	0.0835
Loa Loa (eye worm)	hypothetical protein	0.002	0.0074	0.013
Brugia malayi	hypothetical protein	0.0268	0.2812	0.4912
Loa Loa (eye worm)	TK protein kinase	0.0046	0.0362	0.0635
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0055	0.0461	0.0456
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0067	0.0598	0.1039
Loa Loa (eye worm)	TK/FER protein kinase	0.0015	0.0023	0.004
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0015	0.0016	0.0019
Onchocerca volvulus		0.0195	0.2005	1
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.017	0.0298
Onchocerca volvulus		0.0029	0.017	0.0773
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0015	0.0023	0.0192
Onchocerca volvulus		0.0015	0.0023	0.0033
Echinococcus granulosus	thymidylate synthase	0.0195	0.2005	0.3507
Echinococcus granulosus	mitogen activated protein kinase	0.0062	0.0533	0.0925
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0055	0.0461	0.0799
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0195	0.2005	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0006	0.001
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.005	0.0088
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0195	0.2005	0.3426
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0015	0.0016	0.0011
Schistosoma mansoni	tyrosine kinase	0.0055	0.0461	0.0767
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0055	0.0461	0.0799
Brugia malayi	protein-tyrosine kinase	0.0051	0.0412	0.0696
Brugia malayi	intermediate filament protein	0.0029	0.017	0.027
Onchocerca volvulus		0.0055	0.0456	0.2212
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0055	0.0461	0.0799
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.002	0.0074	0.5
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0023	0.004
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0027	0.0149	0.0448
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.005	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0268	0.2812	0.4927
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0055	0.0461	0.0799
Echinococcus multilocularis	tyrosine protein kinase Abl	0.002	0.0072	0.0066
Onchocerca volvulus		0.0015	0.0023	0.0033
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0055	0.0461	0.0799
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0015	0.0016	0.0011
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0055	0.0461	0.0456
Echinococcus granulosus	tyrosine kinase	0.0051	0.0412	0.0713
Echinococcus granulosus	tyrosine protein kinase Blk	0.0051	0.0412	0.0713
Schistosoma mansoni	tyrosine kinase	0.0107	0.1032	0.1749
Brugia malayi	MAP kinase sur-1	0.0062	0.0533	0.0908
Entamoeba histolytica	protein kinase, putative	0.0046	0.0362	1
Echinococcus multilocularis	c src tyrosine kinase	0.002	0.0072	0.0066
Brugia malayi	thymidylate synthase	0.0195	0.2005	0.3494
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0015	0.0016	0.0019
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.0279	0.2936	0.503
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0056	0.0476	0.0808
Schistosoma mansoni	intermediate filament proteins	0.0029	0.017	0.0265
Echinococcus granulosus	mitogen activated protein kinase 3	0.0062	0.0533	0.0925
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0.0876	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0268	0.2812	0.2808
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0529	0.5707	0.5704
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0015	0.0016	0.0011
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0107	0.1032	0.1799
Brugia malayi	Protein kinase domain containing protein	0.0015	0.0023	0.0012
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0149	0.0668
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.002	0.0072	0.0116
Loa Loa (eye worm)	hypothetical protein	0.002	0.0074	0.013
Schistosoma mansoni	tyrosine kinase	0.0067	0.0598	0.1002
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0027	0.0149	0.0668
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0023	0.0011
Trypanosoma brucei	protein kinase, putative	0.0062	0.0533	0.2598
Echinococcus granulosus	c src tyrosine kinase	0.002	0.0072	0.0116
Onchocerca volvulus		0.0015	0.0023	0.0033
Schistosoma mansoni	serine/threonine protein kinase	0.0062	0.0533	0.089
Echinococcus multilocularis	thymidylate synthase	0.0195	0.2005	0.2
Schistosoma mansoni	hypothetical protein	0.0018	0.005	0.0058
Brugia malayi	Protein kinase domain containing protein	0.0015	0.0023	0.0012
Schistosoma mansoni	tyrosine kinase	0.0015	0.0023	0.0011
Echinococcus multilocularis	tyrosine protein kinase shark	0.0015	0.0023	0.0017

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 95.47 %	Growth inhibition of human MDA-MB-468 cells assessed as cell growth at 10'-5 M after 48 hrs by sulforhodamine B assay relative to control	ChEMBL.	24125851
Ki (binding)	= 1.06 uM	Inhibition of human leukotriene A-4 hydrolase	ChEMBL.	24125851
Ki (binding)	= 3.73 uM	Inhibition of human thymidylate synthase	ChEMBL.	24125851
Ki (binding)	= 4.13 uM	Inhibition of human vitamin D3 receptor	ChEMBL.	24125851
Ki (binding)	= 6.64 uM	Inhibition of human EGFR	ChEMBL.	24125851
Ki (binding)	= 9.18 uM	Inhibition of human MAPK1	ChEMBL.	24125851
Ki (binding)	= 16.69 uM	Inhibition of human SRC	ChEMBL.	24125851
Ki (binding)	= 44.9 uM	Inhibition of human cathepsin K	ChEMBL.	24125851

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2437302

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1789278