Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mbt domain containing 1 | Starlite/ChEMBL | References |
Homo sapiens | PHD finger protein 23 | Starlite/ChEMBL | References |
Homo sapiens | l(3)mbt-like 1 (Drosophila) | Starlite/ChEMBL | References |
Homo sapiens | lysine (K)-specific demethylase 5A | Starlite/ChEMBL | References |
Homo sapiens | l(3)mbt-like 4 (Drosophila) | Starlite/ChEMBL | References |
Homo sapiens | tumor protein p53 binding protein 1 | Starlite/ChEMBL | References |
Homo sapiens | ubiquitin-like with PHD and ring finger domains 1 | Starlite/ChEMBL | References |
Homo sapiens | l(3)mbt-like 3 (Drosophila) | Starlite/ChEMBL | References |
Homo sapiens | chromobox homolog 7 | Starlite/ChEMBL | References |
Homo sapiens | Scm-like with four mbt domains 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0624 | 0.5883 | 0.9274 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0318 | 0.2754 | 0.4342 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0658 | 0.6228 | 0.9706 |
Brugia malayi | jmjC domain containing protein | 0.0164 | 0.1178 | 0.1139 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0461 | 0.4212 | 0.4212 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0115 | 0.0674 | 0.1063 |
Schistosoma mansoni | chromobox protein | 0.0236 | 0.1914 | 0.1914 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0669 | 0.6343 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0669 | 0.6343 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0318 | 0.2754 | 0.2754 |
Brugia malayi | mbt repeat family protein | 0.0547 | 0.5098 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0093 | 0.045 | 0.071 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0669 | 0.6343 | 1 |
Echinococcus multilocularis | chromobox protein 2 | 0.0236 | 0.1914 | 0.3017 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0461 | 0.4212 | 0.6641 |
Mycobacterium ulcerans | hypothetical protein | 0.0395 | 0.3539 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0395 | 0.3539 | 0.5 |
Echinococcus granulosus | chromobox protein 2 | 0.0236 | 0.1914 | 0.3017 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.3424 | 0.485 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0164 | 0.1178 | 0.0889 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0331 | 0.2886 | 0.3902 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0658 | 0.6228 | 0.9706 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0318 | 0.2754 | 0.4342 |
Loa Loa (eye worm) | hypothetical protein | 0.0547 | 0.5098 | 0.7803 |
Echinococcus granulosus | 6 phosphofructo 2 kinase:fructose 2 | 0.0669 | 0.6343 | 1 |
Echinococcus multilocularis | tumor suppressor p53 binding protein 1 | 0.0392 | 0.3507 | 0.553 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0115 | 0.0674 | 0.1063 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0111 | 0.064 | 0.064 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0111 | 0.064 | 0.064 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0624 | 0.5883 | 0.9274 |
Echinococcus granulosus | tumor suppressor p53 binding protein 1 | 0.0392 | 0.3507 | 0.553 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0669 | 0.6343 | 1 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0115 | 0.0674 | 0.1063 |
Brugia malayi | mbt repeat family protein | 0.0331 | 0.2886 | 0.5001 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0547 | 0.5098 | 0.6044 |
Loa Loa (eye worm) | hypothetical protein | 0.0658 | 0.6228 | 0.9796 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0395 | 0.3539 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0392 | 0.3507 | 0.3507 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0137 | 0.0898 | 0.1416 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0669 | 0.6343 | 1 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0461 | 0.4212 | 0.6641 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0137 | 0.0898 | 0.1416 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0395 | 0.3539 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0395 | 0.3539 | 0.5 |
Toxoplasma gondii | PLU-1 family protein | 0.0053 | 0.0039 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0111 | 0.064 | 0.101 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0318 | 0.2754 | 0.2754 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0669 | 0.6343 | 1 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0115 | 0.0674 | 0.0674 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0658 | 0.6228 | 0.9706 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0115 | 0.0674 | 0.1063 |
Onchocerca volvulus | 0.0669 | 0.6343 | 1 | |
Schistosoma mansoni | 6-phosphofructokinase | 0.0669 | 0.6343 | 0.6343 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0658 | 0.6228 | 0.9706 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.043 uM | Inhibition of L3MBTL3 (unknown origin) using H4K20me2 as substrate after 30 mins by LNCE-TR-FRET assay | ChEMBL. | 24040942 |
IC50 (binding) | = 0.072 uM | Inhibition of L3MBTL3 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | = 3.1 uM | Inhibition of L3MBTL1 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | = 5.7 uM | Inhibition of MBTD1 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of L3MBTL4 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of JARID1A (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of PHF23 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of UHRF1 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of CBX7 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of SFMBT1 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | = 10.7 uM | Inhibition of 53BP1 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.