Detailed information for compound 1789562

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 504.526 | Formula: C26H32O10
  • H donors: 1 H acceptors: 1 LogP: 2.28 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC[C@H]1Oc2cc(c(cc2O[C@H]1C)OC)[C@H]1OC[C@]2([C@@H]1CO[C@@H]2Oc1c(OC)cccc1OC)O
  • InChi: 1S/C26H32O10/c1-14-22(12-28-2)35-20-9-15(19(31-5)10-21(20)34-14)23-16-11-32-25(26(16,27)13-33-23)36-24-17(29-3)7-6-8-18(24)30-4/h6-10,14,16,22-23,25,27H,11-13H2,1-5H3/t14-,16+,22+,23+,25+,26+/m0/s1
  • InChiKey: FFWVWYBZKASJPL-BWNKRUECSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0109 0.0056 0.0056
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.1333 0.2713 0.5
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0085 0.0005 0.0005
Schistosoma mansoni tyrosine kinase 0.0109 0.0056 0.0057
Echinococcus multilocularis signal transduction protein lnk realted 0.0085 0.0005 0.0005
Echinococcus granulosus tyrosine protein kinase Src42A 0.0192 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0085 0.0005 0.0017
Echinococcus granulosus tyrosine protein kinase Fyn 0.0192 0.0237 0.0237
Brugia malayi Tensin 0.0085 0.0005 0.0017
Loa Loa (eye worm) hypothetical protein 0.0085 0.0005 0.0017
Brugia malayi SH2 domain containing protein 0.0085 0.0005 0.0017
Loa Loa (eye worm) TK/FER protein kinase 0.0109 0.0056 0.0208
Brugia malayi Protein kinase domain containing protein 0.0109 0.0056 0.0208
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0131 0.0105 0.0388
Brugia malayi Variant SH3 domain containing protein 0.0168 0.0185 0.0681
Brugia malayi SH2 domain containing protein 0.0085 0.0005 0.0017
Brugia malayi Tyrosine-protein kinase abl-1 0.0192 0.0237 0.0872
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0109 0.0056 0.0056
Loa Loa (eye worm) SRC-1 0.0192 0.0237 0.0872
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0085 0.0005 0.0005
Echinococcus multilocularis NCK adaptor protein 0.0168 0.0185 0.0185
Schistosoma mansoni serine/threonine protein kinase 0.1333 0.2713 0.2762
Echinococcus multilocularis SH2 motif 0.0085 0.0005 0.0005
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0192 0.0237 0.0237
Trichomonas vaginalis CMGC family protein kinase 0.1333 0.2713 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0109 0.0056 0.5606
Echinococcus granulosus tyrosine protein kinase ABL1 0.0109 0.0056 0.0056
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0085 0.0005 0.0005
Brugia malayi SRC-1 0.0192 0.0237 0.0872
Brugia malayi Variant SH3 domain containing protein 0.0131 0.0105 0.0388
Onchocerca volvulus 0.0109 0.0056 0.1756
Schistosoma mansoni tyrosine kinase 0.0192 0.0237 0.0241
Echinococcus granulosus tyrosine protein kinase Src42A 0.0085 0.0005 0.0005
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0085 0.0005 0.0143
Brugia malayi hypothetical protein 0.0109 0.0056 0.0208
Loa Loa (eye worm) TK/ABL protein kinase 0.0109 0.0056 0.0208
Echinococcus granulosus suppressor of cytokine signaling 7 0.0085 0.0005 0.0005
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0192 0.0237 0.0237
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0168 0.0185 0.0681
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0085 0.0005 0.0005
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0109 0.0056 0.0056
Schistosoma mansoni tensin-related 0.0085 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0085 0.0005 0.0017
Loa Loa (eye worm) TK/FER protein kinase 0.0109 0.0056 0.0208
Echinococcus multilocularis N chimaerin 0.0085 0.0005 0.0005
Onchocerca volvulus 0.0085 0.0005 0.0143
Loa Loa (eye worm) hypothetical protein 0.0131 0.0105 0.0388
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0085 0.0005 0.0005
Loa Loa (eye worm) TK/FER protein kinase 0.0109 0.0056 0.0208
Brugia malayi Protein kinase domain containing protein 0.0109 0.0056 0.0208
Echinococcus multilocularis SH2 motif 0.0085 0.0005 0.0005
Echinococcus granulosus NCK adaptor protein 0.0168 0.0185 0.0185
Onchocerca volvulus 0.0109 0.0056 0.1756
Schistosoma mansoni hypothetical protein 0.0085 0.0005 0.0005
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0192 0.0237 0.0237
Echinococcus multilocularis tensin 0.0085 0.0005 0.0005
Echinococcus multilocularis growth factor receptor bound protein 2 0.0168 0.0185 0.0185
Brugia malayi tRNA modification GTPase TrmE family protein 0.0085 0.0005 0.0017
Loa Loa (eye worm) STAT protein 0.0085 0.0005 0.0017
Echinococcus multilocularis 0.0085 0.0005 0.0005
Brugia malayi Protein kinase domain containing protein 0.0109 0.0056 0.0208
Schistosoma mansoni tensin 0.0085 0.0005 0.0005
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.1333 0.2713 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0085 0.0005 0.0017
Schistosoma mansoni tensin 0.0085 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0085 0.0005 0.0017
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.1333 0.2713 1
Onchocerca volvulus 0.0109 0.0056 0.1756
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0129 0.0101 0.0101
Echinococcus granulosus tyrosine protein kinase Src64B 0.0192 0.0237 0.0237
Trypanosoma brucei protein kinase, putative 0.1333 0.2713 1
Giardia lamblia Kinase, CMGC MAPK 0.1333 0.2713 0.5
Schistosoma mansoni tyrosine kinase 0.4607 0.982 1
Schistosoma mansoni adapter molecule crk 0.0168 0.0185 0.0188
Echinococcus granulosus SH2 domain containing adapter protein F 0.0085 0.0005 0.0005
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0085 0.0005 0.0017
Echinococcus granulosus c src tyrosine kinase 0.0192 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0085 0.0005 0.0017
Onchocerca volvulus 0.0109 0.0056 0.1756
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0085 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0085 0.0005 0.0017
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.1333 0.2713 1
Echinococcus multilocularis tyrosine protein kinase shark 0.0109 0.0056 0.0056
Echinococcus granulosus tyrosine kinase 0.0109 0.0056 0.0056
Echinococcus granulosus tyrosine protein kinase Srms 0.0109 0.0056 0.0056
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0085 0.0005 0.0017
Trichomonas vaginalis CMGC family protein kinase 0.1333 0.2713 1
Echinococcus multilocularis SHC transforming protein 3 0.0085 0.0005 0.0005
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0085 0.0005 0.0005
Schistosoma mansoni tyrosine kinase 0.0192 0.0237 0.0241
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0168 0.0185 0.0681
Schistosoma mansoni growth factor receptor-bound protein 0.0168 0.0185 0.0188
Loa Loa (eye worm) SH2 domain-containing protein 0.0085 0.0005 0.0017
Brugia malayi RhoGAP domain containing protein 0.0085 0.0005 0.0017
Schistosoma mansoni hypothetical protein 0.0165 0.0179 0.0182
Echinococcus granulosus mitogen activated protein kinase 3 0.1333 0.2713 0.2713
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0085 0.0005 0.0005
Echinococcus granulosus tyrosine protein kinase Lyn 0.0204 0.0263 0.0263
Loa Loa (eye worm) p53BP2 0.0083 0.000000002647 0.0000000097582
Onchocerca volvulus 0.0231 0.0321 1
Echinococcus multilocularis SH2 motif 0.0085 0.0005 0.0005
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0192 0.0237 0.0237
Echinococcus granulosus N chimaerin 0.0085 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0085 0.0005 0.0017
Loa Loa (eye worm) hypothetical protein 0.0085 0.0005 0.0017
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0192 0.0237 0.0237
Brugia malayi SH2 domain containing protein 0.0109 0.0056 0.0208
Loa Loa (eye worm) hypothetical protein 0.0085 0.0005 0.0017
Loa Loa (eye worm) TK/FER protein kinase 0.0109 0.0056 0.0208
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0083 0.000000002647 0.0000000097582
Schistosoma mansoni SH2A 0.0085 0.0005 0.0005
Schistosoma mansoni tensin-related 0.0085 0.0005 0.0005
Brugia malayi Protein kinase domain containing protein 0.0109 0.0056 0.0208
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0085 0.0005 0.0005
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0085 0.0005 0.0005
Loa Loa (eye worm) SH2 domain-containing protein 0.0085 0.0005 0.0017
Loa Loa (eye worm) hypothetical protein 0.0085 0.0005 0.0017
Echinococcus granulosus SH2 domain containing protein 7 0.0085 0.0005 0.0005
Echinococcus granulosus growth factor receptor bound protein 2 0.0168 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0168 0.0185 0.0681
Echinococcus multilocularis geminin 0.0165 0.0179 0.0179
Schistosoma mansoni hypothetical protein 0.0165 0.0179 0.0182
Echinococcus granulosus signal transduction protein lnk realted 0.0085 0.0005 0.0005
Brugia malayi SH2 domain containing protein 0.0109 0.0056 0.0208
Loa Loa (eye worm) TK/FER protein kinase 0.0109 0.0056 0.0208
Schistosoma mansoni apoptosis stimulating of P53 0.0083 0.000000002647 0.0000000026955
Echinococcus granulosus SH2 motif 0.0085 0.0005 0.0005
Brugia malayi SH2 domain containing protein 0.0085 0.0005 0.0017
Brugia malayi Pre-SET motif family protein 0.0203 0.026 0.096
Echinococcus multilocularis tyrosine kinase 0.0109 0.0056 0.0056
Echinococcus granulosus tyrosine protein kinase Fyn 0.0192 0.0237 0.0237
Schistosoma mansoni signal transduction protein lnk-related 0.0085 0.0005 0.0005
Brugia malayi protein-tyrosine kinase 0.0109 0.0056 0.0208
Echinococcus granulosus tyrosine protein kinase Fyn 0.0192 0.0237 0.0237
Brugia malayi SH2 domain containing protein 0.0085 0.0005 0.0017
Echinococcus granulosus tensin 0.0085 0.0005 0.0005
Onchocerca volvulus 0.0085 0.0005 0.0143
Echinococcus granulosus tyrosine kinase 0.0109 0.0056 0.0056
Echinococcus multilocularis SH2 domain containing protein 7 0.0085 0.0005 0.0005
Echinococcus granulosus tyrosine protein kinase Blk 0.0109 0.0056 0.0056
Onchocerca volvulus 0.0109 0.0056 0.1756
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.469 1 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0005 0.0017
Echinococcus multilocularis tyrosine protein kinase Srms 0.0109 0.0056 0.0056
Brugia malayi Variant SH3 domain containing protein 0.0083 0.000000002647 0.0000000097582
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.1333 0.2713 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0192 0.0237 0.0237
Echinococcus granulosus tyrosine protein kinase shark 0.0109 0.0056 0.0056
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0085 0.0005 0.0005
Loa Loa (eye worm) TK protein kinase 0.0109 0.0056 0.0208
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0085 0.0005 0.0005
Schistosoma mansoni tyrosine kinase 0.0192 0.0237 0.0241
Onchocerca volvulus 0.0095 0.0026 0.0814
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0085 0.0005 0.0005
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0192 0.0237 0.0237
Brugia malayi Variant SH3 domain containing protein 0.0085 0.0005 0.0017
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.1333 0.2713 1
Entamoeba histolytica SH2 domain containing protein 0.0085 0.0005 0.0455
Loa Loa (eye worm) TK/FER protein kinase 0.0109 0.0056 0.0208
Brugia malayi Protein kinase domain containing protein 0.0109 0.0056 0.0208
Onchocerca volvulus 0.0109 0.0056 0.1756
Schistosoma mansoni tensin 0.0085 0.0005 0.0005
Onchocerca volvulus 0.0085 0.0005 0.0143
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0085 0.0005 0.0143
Brugia malayi SH2 domain containing protein 0.0085 0.0005 0.0017
Brugia malayi hypothetical protein 0.0085 0.0005 0.0017
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0192 0.0237 0.0241
Loa Loa (eye worm) hypothetical protein 0.0085 0.0005 0.0017
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.1333 0.2713 1
Echinococcus granulosus suppressor of cytokine signaling 6 0.0085 0.0005 0.0005
Trichomonas vaginalis set domain proteins, putative 0.0231 0.0321 0.1185
Schistosoma mansoni suppressor of cytokine signaling 0.0085 0.0005 0.0005
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0085 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0109 0.0056 0.0208
Brugia malayi STAT protein, DNA binding domain containing protein 0.0085 0.0005 0.0017
Schistosoma mansoni vav2 0.0131 0.0105 0.0107
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.026 0.096
Echinococcus granulosus mitogen activated protein kinase 0.1333 0.2713 0.2713
Onchocerca volvulus 0.0085 0.0005 0.0143
Brugia malayi MAP kinase sur-1 0.1333 0.2713 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0085 0.0005 0.0017
Echinococcus granulosus geminin 0.0165 0.0179 0.0179
Loa Loa (eye worm) TK/FER protein kinase 0.0109 0.0056 0.0208
Echinococcus granulosus hypothetical protein 0.0085 0.0005 0.0005
Trichomonas vaginalis CMGC family protein kinase 0.1333 0.2713 1
Onchocerca volvulus 0.0085 0.0005 0.0143
Brugia malayi cytokine inducible SH2-containing protein 5 0.0085 0.0005 0.0017
Echinococcus multilocularis c src tyrosine kinase 0.0192 0.0237 0.0237
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0085 0.0005 0.0005
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0085 0.0005 0.0017
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0192 0.0237 0.0237
Brugia malayi SH2 domain containing protein 0.0085 0.0005 0.0017
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0192 0.0237 0.0237
Echinococcus granulosus SHC transforming protein 3 0.0085 0.0005 0.0005
Brugia malayi SH2 domain containing protein 0.0085 0.0005 0.0017
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.1333 0.2713 1
Schistosoma mansoni hypothetical protein 0.0085 0.0005 0.0005
Schistosoma mansoni shc transforming protein 0.0085 0.0005 0.0005
Loa Loa (eye worm) TK/FER protein kinase 0.0109 0.0056 0.0208
Loa Loa (eye worm) TK/FER protein kinase 0.0109 0.0056 0.0208
Schistosoma mansoni growth factor receptor-bound protein 0.0168 0.0185 0.0188
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0085 0.0005 0.0005
Schistosoma mansoni GTPase activating protein 0.0085 0.0005 0.0005
Brugia malayi Variant SH3 domain containing protein 0.0168 0.0185 0.0681
Schistosoma mansoni suppressor of cytokine signaling 0.0085 0.0005 0.0005
Schistosoma mansoni nck2/grb4 0.0168 0.0185 0.0188
Echinococcus multilocularis mitogen activated protein kinase 3 0.1333 0.2713 0.2713
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0085 0.0005 0.0005
Entamoeba histolytica protein kinase, putative 0.0097 0.0031 0.3055
Trichomonas vaginalis CMGC family protein kinase 0.1333 0.2713 1
Schistosoma mansoni tyrosine kinase 0.0192 0.0237 0.0241
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.1333 0.2713 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0192 0.0237 0.0237
Echinococcus multilocularis mitogen activated protein kinase 0.1333 0.2713 0.2713
Onchocerca volvulus 0.0085 0.0005 0.0143
Echinococcus multilocularis tyrosine protein kinase Abl 0.0192 0.0237 0.0237
Echinococcus multilocularis tyrosine protein kinase Blk 0.0109 0.0056 0.0056
Echinococcus granulosus expressed conserved protein 0.0085 0.0005 0.0005
Loa Loa (eye worm) TK/FER protein kinase 0.0109 0.0056 0.0208
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0085 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0085 0.0005 0.0017
Entamoeba histolytica hypothetical protein 0.0129 0.0101 1
Echinococcus granulosus SH2 motif 0.0085 0.0005 0.0005
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0109 0.0056 0.0056
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0168 0.0185 0.0188
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0129 0.0101 0.0103
Brugia malayi Sex muscle abnormal protein 5 0.0168 0.0185 0.0681
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0129 0.0101 0.0101
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0192 0.0237 0.0237
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0097 0.0031 0.3055
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0109 0.0056 0.0056
Echinococcus multilocularis tensin 0.0085 0.0005 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.0052 0.0053

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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