TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 461.579 | Formula: C25H27N5O2S
H donors: 3 H acceptors: 4 LogP: 5.76 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc2c(c1)sc(n2)Nc1cc(Cc2ccccc2)nc(n1)N[C@@H]1CC[C@H](CC1)O
InChi: 1S/C25H27N5O2S/c1-32-20-11-12-21-22(15-20)33-25(28-21)30-23-14-18(13-16-5-3-2-4-6-16)27-24(29-23)26-17-7-9-19(31)10-8-17/h2-6,11-12,14-15,17,19,31H,7-10,13H2,1H3,(H2,26,27,28,29,30)/t17-,19-
InChiKey: GDOTWXUDXHZXHG-UAPYVXQJSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	IL2-inducible T-cell kinase	Starlite/ChEMBL	References
Homo sapiens	aurora kinase B	Starlite/ChEMBL	References
Homo sapiens	LCK proto-oncogene, Src family tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania braziliensis	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania donovani	Aurora I-related kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium berghei	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	tyrosine protein kinase Btk29A	Get druggable targets OG5_129320	All targets in OG5_129320
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium falciparum	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium hominis	protein kinase (EC 2.7.1.-) p46XlEg22	Get druggable targets OG5_127024	All targets in OG5_127024
Neospora caninum	hypothetical protein	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium vivax	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	ko:K08850 aurora kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	putative protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Toxoplasma gondii	aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium parvum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	Serine/threonine-protein kinase 12, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_129320	All targets in OG5_129320
Trypanosoma congolense	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Giardia lamblia	Aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine kinase 12	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium knowlesi	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei gambiense	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	tyrosine protein kinase Btk29A	Get druggable targets OG5_129320	All targets in OG5_129320
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania major	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	Tyrosine-protein kinase BTK, putative	Get druggable targets OG5_129320	All targets in OG5_129320
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania mexicana	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	ko:K07370 Bruton agammaglobulinemia tyrosine kinase, putative	Get druggable targets OG5_129320	All targets in OG5_129320
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine-protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma cruzi	aurora B kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	aurora kinase B	303 aa	299 aa	22.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0022	0.0055	0.0055
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0022	0.0055	0.0056
Schistosoma mansoni	protein kinase	0.0022	0.0055	0.0055
Echinococcus granulosus	protein kinase	0.0022	0.0055	0.0056
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0022	0.0055	0.0056
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0037	0.0179	0.0182
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0022	0.0055	0.0056
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0022	0.0055	0.0056
Loa Loa (eye worm)	TK/ACK protein kinase	0.0022	0.0055	0.0056
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0068	0.0438	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0055	0.0056
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0037	0.0179	0.0182
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0055	0.0056
Echinococcus multilocularis	tyrosine protein kinase csk	0.0022	0.0055	0.0056
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0438	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0022	0.0055	0.0056
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0055	0.0056
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0037	0.0179	0.0182
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0022	0.0055	0.0056
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0055	0.0056
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0037	0.0179	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0055	0.0056
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0022	0.0055	0.0056
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0029	0.0118	0.012
Loa Loa (eye worm)	TK/ALK protein kinase	0.0022	0.0055	0.0056
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0055	0.0056
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0022	0.0055	0.0056
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0022	0.0055	0.0056
Schistosoma mansoni	tyrosine kinase	0.0022	0.0055	0.0055
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0022	0.006	0.012
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0022	0.0055	0.0056
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0022	0.0055	0.0056
Loa Loa (eye worm)	TK protein kinase	0.0022	0.0055	0.0056
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0022	0.0055	0.0056
Brugia malayi	hypothetical protein	0.0029	0.0118	0.012
Loa Loa (eye worm)	TK protein kinase	0.0022	0.0055	0.0056
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0022	0.0055	0.0056
Schistosoma mansoni	protein kinase	0.0022	0.0055	0.0055
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0037	0.0179	0.0182
Echinococcus granulosus	raf serine:threonine protein kinase	0.0022	0.0055	0.0056
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0037	0.0179	0.0182
Schistosoma mansoni	serine/threonine RGC	0.0022	0.0055	0.0055
Onchocerca volvulus		0.0029	0.0118	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0022	0.0055	0.0056
Schistosoma mansoni	serine/threonine protein kinase	0.0022	0.0055	0.0055
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0438	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.0022	0.0055	0.0056
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0037	0.0179	0.0182
Loa Loa (eye worm)	TK/Met protein kinase	0.0022	0.0055	0.0056
Loa Loa (eye worm)	TK/ABL protein kinase	0.0029	0.0118	0.012
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0022	0.0055	0.0056
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0055	0.0056
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0055	0.0056
Echinococcus granulosus	epidermal growth factor receptor	0.0022	0.0055	0.0056
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0055	0.0056
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0022	0.0055	0.0056
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0022	0.0055	0.0056
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0118	0.012
Brugia malayi	integrin-linked kinase	0.0022	0.0055	0.0056
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0022	0.0055	0.0056
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0055	0.0056
Onchocerca volvulus		0.0029	0.0118	1
Schistosoma mansoni	tyrosine kinase	0.0022	0.0055	0.0055
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0055	0.0056
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0118	0.012
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0118	0.012
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0022	0.0055	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0055	0.0056
Echinococcus multilocularis	heat shock protein 70	0.0022	0.0055	0.0056
Echinococcus granulosus	tyrosine protein kinase Srms	0.0029	0.0118	0.012
Echinococcus granulosus	tyrosine protein kinase csk	0.0022	0.0055	0.0056
Schistosoma mansoni	tyrosine kinase	0.0022	0.0055	0.0055
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0055	0.0056
Schistosoma mansoni	serine/threonine protein kinase	0.0068	0.0438	0.0438
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0055	0.0056
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0022	0.0055	0.0055
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0438	1
Schistosoma mansoni	tyrosine kinase	0.0037	0.0179	0.0179
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0118	0.012
Schistosoma mansoni	protein kinase	0.0022	0.0055	0.0055
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0022	0.0055	0.0056
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0037	0.0179	0.0179
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0022	0.0055	0.0056
Loa Loa (eye worm)	SRC-1	0.0037	0.0179	0.0182
Schistosoma mansoni	tyrosine kinase	0.0022	0.0055	0.0055
Schistosoma mansoni	protein kinase	0.0022	0.006	0.006
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0055	0.0056
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0055	0.0056
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0022	0.0055	0.0056
Brugia malayi	Protein kinase domain containing protein	0.0029	0.0118	0.012
Schistosoma mansoni	tyrosine kinase	0.0037	0.0179	0.0179
Schistosoma mansoni	protein kinase	0.0022	0.006	0.006
Echinococcus multilocularis	FL cytokine receptor	0.0022	0.0055	0.0056
Loa Loa (eye worm)	hypothetical protein	0.1208	0.9821	0.9995
Loa Loa (eye worm)	hypothetical protein	0.1208	0.9821	0.9995
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0055	0.0056
Schistosoma mansoni	tyrosine protein kinase	0.0022	0.0055	0.0055
Schistosoma mansoni	tyrosine kinase	0.0022	0.0055	0.0055
Brugia malayi	Protein kinase domain containing protein	0.0029	0.0118	0.012
Echinococcus multilocularis	activated cdc42 kinase 1	0.0022	0.0055	0.0056
Echinococcus granulosus	tyrosine kinase	0.0029	0.0118	0.012
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0055	0.0056
Echinococcus multilocularis	protein kinase	0.0022	0.0055	0.0056
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0022	0.0055	0.0056
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0022	0.0055	0.0056
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0022	0.0055	0.0056
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0037	0.0179	0.0182
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0438	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0055	0.0056
Loa Loa (eye worm)	TK protein kinase	0.0022	0.0055	0.0056
Brugia malayi	Protein kinase domain containing protein	0.0029	0.0118	0.012
Brugia malayi	Guanylyl cyclase protein 23	0.0022	0.0055	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0055	0.0056
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0022	0.0055	0.0056
Brugia malayi	ephrin receptor 1 precursor	0.0022	0.0055	0.0056
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0022	0.0055	0.0056
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0022	0.0055	0.0056
Schistosoma mansoni	tyrosine kinase	0.0022	0.0055	0.0055
Echinococcus granulosus	epidermal growth factor receptor	0.0022	0.0055	0.0056
Brugia malayi	Raf kinase	0.0022	0.0055	0.0056
Brugia malayi	serine/threonine kinase 12	0.0068	0.0438	0.0446
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0055	0.0056
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0029	0.0118	0.012
Trypanosoma brucei	protein kinase, putative	0.0022	0.006	0.012
Brugia malayi	Tyrosine-protein kinase abl-1	0.0037	0.0179	0.0182
Schistosoma mansoni	protein kinase	0.0022	0.0055	0.0055
Echinococcus multilocularis	epidermal growth factor receptor	0.0022	0.0055	0.0056
Schistosoma mansoni	tyrosine kinase	0.0022	0.0055	0.0055
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0022	0.0055	0.0056
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0055	0.0056
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0022	0.0055	0.0056
Echinococcus multilocularis	activin receptor type	0.0022	0.006	0.0061
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0022	0.0055	0.0056
Echinococcus multilocularis	transfer RNA-Thr	0.0022	0.0055	0.0056
Loa Loa (eye worm)	TK/RYK protein kinase	0.0022	0.0055	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0055	0.0056
Loa Loa (eye worm)	TK/CSK protein kinase	0.0022	0.0055	0.0056
Echinococcus multilocularis	tyrosine protein kinase	0.0022	0.0055	0.0056
Schistosoma mansoni	tyrosine kinase	0.0022	0.0055	0.0055
Echinococcus granulosus	receptor type guanylyl cyclase	0.0022	0.0055	0.0056
Schistosoma mansoni	serine/threonine protein kinase	0.0029	0.0116	0.0116
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0022	0.0055	0.0056
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0022	0.006	0.012
Echinococcus multilocularis	aurora kinase A	0.0068	0.0438	0.0446
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0022	0.0055	0.0056
Echinococcus granulosus	activated cdc42 kinase 1	0.0022	0.0055	0.0056
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0055	0.0056
Echinococcus multilocularis	tyrosine protein kinase shark	0.0029	0.0118	0.012
Schistosoma mansoni	protein kinase	0.0022	0.0055	0.0055
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0022	0.0055	0.0056
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0029	0.0118	0.012
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0022	0.0055	0.0056
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0022	0.0055	0.0056
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0037	0.0179	0.0182
Echinococcus granulosus	tyrosine protein kinase csk	0.0022	0.0055	0.0056
Echinococcus granulosus	protein tyrosine kinase	0.0022	0.0055	0.0056
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0022	0.0055	0.0056
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0438	1
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0055	0.0056
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0029	0.0118	0.012
Echinococcus granulosus	integrin linked protein kinase	0.0022	0.0055	0.0056
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.1208	0.9826	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0118	0.012
Brugia malayi	Receptor family ligand binding region containing protein	0.0022	0.0055	0.0056
Echinococcus granulosus	tyrosine protein kinase pr2	0.0022	0.0055	0.0056
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0118	0.012
Entamoeba histolytica	protein kinase , putative	0.0068	0.0438	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.0022	0.0055	0.0056
Schistosoma mansoni	tyrosine kinase	0.0022	0.0055	0.0055
Schistosoma mansoni	tyrosine kinase	0.0022	0.0055	0.0055
Schistosoma mansoni	tyrosine kinase	0.0022	0.0055	0.0055
Schistosoma mansoni	protein kinase	0.0022	0.0055	0.0055
Schistosoma mansoni	tyrosine kinase	0.0022	0.0055	0.0055
Schistosoma mansoni	tyrosine kinase	0.0022	0.0055	0.0055
Toxoplasma gondii	aurora kinase	0.0068	0.0438	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.0022	0.0055	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0055	0.0056
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0037	0.0179	0.0182
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0022	0.0055	0.0056
Echinococcus multilocularis	tyrosine protein kinase csk	0.0022	0.0055	0.0056
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0022	0.0055	0.0056
Schistosoma mansoni	protein tyrosine kinase	0.0022	0.0055	0.0055
Schistosoma mansoni	tyrosine kinase	0.0022	0.0055	0.0055
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0037	0.0179	0.0182
Schistosoma mansoni	tyrosine kinase	0.0022	0.0055	0.0055
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0022	0.0055	0.0055
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0118	0.012
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0022	0.0055	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0055	0.0056
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0029	0.0118	0.012
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0068	0.0438	1
Schistosoma mansoni	tyrosine kinase	0.0037	0.0179	0.0179
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0068	0.0438	1
Entamoeba histolytica	protein kinase domain containing protein	0.0022	0.006	0.012
Brugia malayi	Furin-like cysteine rich region family protein	0.0022	0.0055	0.0056
Loa Loa (eye worm)	TKL/MLK/LZK protein kinase	0.1208	0.9826	1
Schistosoma mansoni	protein kinase	0.0022	0.0055	0.0055
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0022	0.0055	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0055	0.0056
Brugia malayi	SRC-1	0.0037	0.0179	0.0182
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0037	0.0179	0.0182
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0068	0.0438	1
Brugia malayi	C-terminal src kinase protein 1	0.0022	0.0055	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0055	0.0056
Loa Loa (eye worm)	TK protein kinase	0.0022	0.0055	0.0056
Onchocerca volvulus		0.0029	0.0118	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0022	0.0055	0.0056
Loa Loa (eye worm)	TK protein kinase	0.0022	0.0055	0.0056
Echinococcus granulosus	kinase suppressor of Ras 1	0.0022	0.0055	0.0056
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0055	0.0056
Schistosoma mansoni	tyrosine kinase	0.0022	0.0055	0.0055
Echinococcus granulosus	tyrosine protein kinase Blk	0.0029	0.0118	0.012
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0055	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0055	0.0056
Schistosoma mansoni	tyrosine kinase	0.0029	0.0118	0.0118
Brugia malayi	SH2 domain containing protein	0.0029	0.0118	0.012
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0022	0.0055	0.0056
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0022	0.0055	0.0056
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0118	0.012
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0055	0.0056
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0022	0.0055	0.0056
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0022	0.0055	0.0056
Brugia malayi	serine/threonine protein kinase 6	0.0068	0.0438	0.0446
Echinococcus multilocularis	tyrosine kinase	0.0022	0.0055	0.0056
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0055	0.0056
Brugia malayi	protein-tyrosine kinase	0.0029	0.0118	0.012
Brugia malayi	Protein kinase domain containing protein	0.0029	0.0118	0.012
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.0438	0.0446
Brugia malayi	Tyrosine-protein kinase PR2	0.0022	0.0055	0.0056
Leishmania major	protein kinase, putative	0.0068	0.0438	1
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0022	0.0055	0.0056
Schistosoma mansoni	tyrosine kinase	0.0022	0.0055	0.0055
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0022	0.0055	0.0055
Schistosoma mansoni	protein kinase	0.0068	0.0438	0.0438
Echinococcus granulosus	tyrosine kinase	0.0022	0.0055	0.0056
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0055	0.0056
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0029	0.0118	0.012
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0037	0.0179	0.0182
Schistosoma mansoni	tyrosine kinase	0.0022	0.0055	0.0055
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0022	0.006	0.012
Loa Loa (eye worm)	TK/FAK protein kinase	0.0022	0.0055	0.0056
Leishmania major	protein kinase, putative	0.0022	0.006	0.012
Entamoeba histolytica	protein kinase, putative	0.0068	0.0438	1
Echinococcus granulosus	activin receptor type	0.0022	0.006	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0055	0.0056
Schistosoma mansoni	protein kinase	0.0022	0.0055	0.0055
Loa Loa (eye worm)	TK/ROR protein kinase	0.0022	0.0055	0.0056
Schistosoma mansoni	tyrosine kinase	0.0022	0.0055	0.0055
Schistosoma mansoni	tyrosine kinase	0.0022	0.0055	0.0055
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0022	0.0055	0.0056
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0037	0.0179	0.0182
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0197	0.1498	0.1524
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0055	0.0056
Brugia malayi	hypothetical protein	0.0022	0.0055	0.0056
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0022	0.0055	0.0056
Brugia malayi	Protein kinase domain containing protein	0.0029	0.0118	0.012
Loa Loa (eye worm)	TK protein kinase	0.0022	0.0055	0.0056
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0022	0.0055	0.0055
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0068	0.0438	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.0022	0.0055	0.0056
Loa Loa (eye worm)	TK protein kinase	0.0029	0.0118	0.012
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0118	0.012
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0022	0.006	0.0061
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0022	0.0055	0.0056
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0022	0.0055	0.0056
Brugia malayi	SH2 domain containing protein	0.0029	0.0118	0.012
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0055	0.0056
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0022	0.0055	0.0056
Echinococcus granulosus	tyrosine kinase	0.0029	0.0118	0.012
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0118	0.012
Schistosoma mansoni	tyrosine kinase	0.0022	0.0055	0.0055
Onchocerca volvulus		0.0029	0.0118	1
Onchocerca volvulus		0.0029	0.0118	1
Brugia malayi	Protein kinase domain containing protein	0.1208	0.9826	1
Schistosoma mansoni	serine/threonine protein kinase	0.0022	0.0055	0.0055
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.0438	0.0446
Giardia lamblia	Aurora kinase	0.0068	0.0438	1
Trypanosoma cruzi	aurora B kinase, putative	0.0068	0.0438	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0022	0.0055	0.0055
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0037	0.0179	0.0182
Onchocerca volvulus		0.0029	0.0118	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0029	0.0118	0.012
Echinococcus multilocularis	insulin receptor	0.0022	0.0055	0.0056
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0022	0.0055	0.0056
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0022	0.0055	0.0056
Brugia malayi	serine/threonine-protein kinase 6	0.0068	0.0438	0.0446
Schistosoma mansoni	hypothetical protein	0.0022	0.0055	0.0055
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.1208	0.9826	1
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0055	0.0056
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0055	0.0056
Echinococcus granulosus	natriuretic peptide receptor 1	0.0022	0.0055	0.0056
Echinococcus granulosus	tyrosine protein kinase	0.0022	0.0055	0.0056
Echinococcus granulosus	ephrin type A receptor 4 A	0.0022	0.0055	0.0056
Echinococcus granulosus	aurora kinase A	0.0068	0.0438	0.0446
Schistosoma mansoni	tyrosine kinase	0.0022	0.0055	0.0055
Schistosoma mansoni	ephrin receptor	0.0022	0.0055	0.0055
Brugia malayi	hypothetical protein	0.0022	0.0055	0.0056
Schistosoma mansoni	protein kinase	0.0022	0.006	0.006
Echinococcus granulosus	activated cdc42 kinase 1	0.0022	0.0055	0.0056
Echinococcus multilocularis	integrin linked protein kinase	0.0022	0.0055	0.0056
Echinococcus multilocularis	tyrosine kinase	0.0029	0.0118	0.012
Echinococcus multilocularis	tyrosine protein kinase csk	0.0022	0.0055	0.0056
Entamoeba histolytica	protein kinase, putative	0.0068	0.0438	1
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0068	0.0438	0.0446
Schistosoma mansoni	tyrosine kinase	0.0189	0.1437	0.1437
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0022	0.0055	0.0056
Schistosoma mansoni	tyrosine kinase	0.0022	0.0055	0.0055
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0055	0.0056
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0068	0.0438	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0029	0.0118	0.1632
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0022	0.0055	0.0056
Loa Loa (eye worm)	TK/FER protein kinase	0.0029	0.0118	0.012
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0022	0.0055	0.0056
Schistosoma mansoni	tyrosine kinase	0.0022	0.0055	0.0055
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0022	0.0055	0.0056
Schistosoma mansoni	tyrosine kinase	0.0022	0.0055	0.0055
Schistosoma mansoni	tyrosine kinase	0.0037	0.0179	0.0179
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0022	0.0055	0.0056
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0037	0.0183	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0055	0.0056
Schistosoma mansoni	ephrin receptor	0.0022	0.0055	0.0055
Trypanosoma brucei	aurora B kinase	0.0068	0.0438	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0022	0.006	0.012
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0055	0.0056
Echinococcus granulosus	insulin receptor	0.0022	0.0055	0.0056
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0022	0.0055	0.0056
Echinococcus granulosus	tyrosine protein kinase shark	0.0029	0.0118	0.012
Echinococcus granulosus	tyrosine protein kinase csk	0.0022	0.0055	0.0056
Echinococcus multilocularis	protein tyrosine kinase	0.0022	0.0055	0.0056
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.0438	0.0446
Echinococcus multilocularis	c src tyrosine kinase	0.0037	0.0179	0.0182
Echinococcus multilocularis	tyrosine protein kinase csk	0.0022	0.0055	0.0056
Loa Loa (eye worm)	TK protein kinase	0.0022	0.0055	0.0056
Loa Loa (eye worm)	TK protein kinase	0.0022	0.0055	0.0056
Plasmodium falciparum	protein kinase, putative	0.0022	0.006	0.012
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0055	0.0056
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0197	0.1498	0.1524
Echinococcus multilocularis	protein kinase	0.0022	0.0055	0.0056
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0022	0.0055	0.0056
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0037	0.0179	0.0182
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0022	0.006	0.0061
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0037	0.0179	0.0182
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0029	0.0118	0.012
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0022	0.0055	0.0056
Echinococcus granulosus	c src tyrosine kinase	0.0037	0.0179	0.0182
Loa Loa (eye worm)	TK protein kinase	0.0022	0.0055	0.0056

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 7.6	Inhibition of cytostim-induced IFNgamma production in human PBMC treated 1 hr before cytostim stimulation measured after 18 hrs by MSD assay	ChEMBL.	24900590
Ki (binding)	= 6.3	Inhibition of Aurora-B (unknown origin) using 5FAM-PKAtide as substrate after 120 mins	ChEMBL.	24900590
Ki (binding)	= 6.9	Inhibition of LCK (unknown origin) using tamra-p34cdc-derived peptide as substrate after 30 mins	ChEMBL.	24900590
Ki (binding)	= 8.4	Inhibition of recombinant human FLAG-tagged ITK using biotinylated GST-SAM68 as substrate after 30 mins	ChEMBL.	24900590

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	24900590

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2441112

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1789764