Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0188 | 0.014 | 0.014 |
Echinococcus granulosus | receptor type guanylyl cyclase | 0.0073 | 0.001 | 0.001 |
Echinococcus multilocularis | neutral amino acid transporter A | 0.0126 | 0.0069 | 0.0069 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0667 | 0.0683 | 0.0683 |
Brugia malayi | Cache domain containing protein | 0.0133 | 0.0078 | 0.0078 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.007 | 0.0005 | 0.0005 |
Schistosoma mansoni | jumonji domain containing protein | 0.0074 | 0.0011 | 0.0011 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.001 | 0.001 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0325 | 0.0295 | 0.0295 |
Loa Loa (eye worm) | glutamate receptor | 0.0398 | 0.0378 | 0.0378 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0188 | 0.014 | 0.014 |
Loa Loa (eye worm) | glutamate receptor | 0.0157 | 0.0105 | 0.0105 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.001 | 0.001 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.049 | 0.0483 | 0.0483 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.0301 | 0.0268 | 0.0268 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.007 | 0.0005 | 0.0005 |
Brugia malayi | Excitatory amino acid transporter | 0.0126 | 0.0069 | 0.0069 |
Brugia malayi | hypothetical protein | 0.0073 | 0.001 | 0.001 |
Brugia malayi | Dihydrofolate reductase | 0.8872 | 1 | 1 |
Echinococcus granulosus | sodium:dicarboxylate symporter | 0.0126 | 0.0069 | 0.0069 |
Echinococcus multilocularis | tyrosine kinase | 0.0073 | 0.001 | 0.001 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0138 | 0.0083 | 0.0083 |
Echinococcus multilocularis | atrial natriuretic peptide receptor | 0.0073 | 0.001 | 0.001 |
Schistosoma mansoni | solute carrier family 1 (glial high affinity glutamate transporter | 0.0126 | 0.0069 | 0.0069 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0188 | 0.014 | 0.014 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0188 | 0.014 | 0.014 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0188 | 0.014 | 0.014 |
Echinococcus multilocularis | excitatory amino acid transporter 2 | 0.0126 | 0.0069 | 0.0069 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0138 | 0.0083 | 0.0014 |
Schistosoma mansoni | hypothetical protein | 0.0155 | 0.0103 | 0.0103 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.1808 | 0.198 | 0.1913 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0261 | 0.0223 | 0.0223 |
Echinococcus multilocularis | receptor type guanylyl cyclase | 0.0073 | 0.001 | 0.001 |
Loa Loa (eye worm) | thymidylate synthase | 0.1808 | 0.198 | 0.198 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.0247 | 0.0848 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0073 | 0.001 | 0.001 |
Treponema pallidum | methyl-accepting chemotaxis protein (mcp2-1) | 0.0612 | 0.0622 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0417 | 0.04 | 0.04 |
Echinococcus granulosus | excitatory amino acid transporter 2 | 0.0126 | 0.0069 | 0.0069 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.8872 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0251 | 0.0211 | 0.0211 |
Echinococcus granulosus | excitatory amino acid transporter 3 | 0.0126 | 0.0069 | 0.0069 |
Brugia malayi | Pre-SET motif family protein | 0.0201 | 0.0155 | 0.0155 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0093 | 0.0032 | 0.0032 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.023 | 0.0188 | 0.0188 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.1098 | 0.1173 | 0.1112 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.0228 | 0.0185 | 0.0185 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0419 | 0.0402 | 0.0402 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0138 | 0.0083 | 0.0083 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0419 | 0.0402 | 0.0402 |
Schistosoma mansoni | serine-rich repeat protein | 0.0155 | 0.0103 | 0.0103 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0138 | 0.0083 | 0.0083 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.0247 | 0.0848 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0201 | 0.0155 | 0.0155 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0083 | 0.0083 |
Echinococcus granulosus | neutral amino acid transporter A | 0.0126 | 0.0069 | 0.0069 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0419 | 0.0402 | 0.0402 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.0247 | 0.0848 |
Echinococcus granulosus | dihydrofolate reductase | 0.8872 | 1 | 1 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0188 | 0.014 | 0.014 |
Brugia malayi | Guanylyl cyclase protein 23 | 0.0073 | 0.001 | 0.001 |
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.0661 | 0.0677 | 0.0677 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0667 | 0.0683 | 0.0683 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0073 | 0.001 | 0.001 |
Schistosoma mansoni | glutamate receptor kainate | 0.0346 | 0.0319 | 0.0319 |
Echinococcus granulosus | Ribosomal protein S1 RNA binding domain | 0.007 | 0.0005 | 0.0005 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1808 | 0.198 | 0.1924 |
Echinococcus granulosus | tyrosine kinase | 0.0073 | 0.001 | 0.001 |
Echinococcus granulosus | neutral amino acid transporter | 0.0126 | 0.0069 | 0.0069 |
Schistosoma mansoni | tyrosine kinase | 0.0073 | 0.001 | 0.001 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.1098 | 0.1173 | 0.1099 |
Echinococcus multilocularis | Excitatory amino acid transporter | 0.0126 | 0.0069 | 0.0069 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0188 | 0.014 | 0.014 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.0661 | 0.0677 | 0.0677 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0333 | 0.0305 | 0.0305 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.0247 | 0.0848 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0093 | 0.0033 | 0.0033 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.0247 | 0.0848 |
Echinococcus granulosus | Excitatory amino acid transporter | 0.0126 | 0.0069 | 0.0069 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0188 | 0.014 | 0.014 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.001 | 0.001 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0093 | 0.0032 | 0.0032 |
Echinococcus multilocularis | neutral amino acid transporter excitatory amino acid transporter | 0.0126 | 0.0069 | 0.0069 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.5656 | 0.6349 | 0.5 |
Echinococcus multilocularis | NMDA receptor | 0.0228 | 0.0185 | 0.0185 |
Schistosoma mansoni | tyrosine kinase | 0.0073 | 0.001 | 0.001 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0188 | 0.014 | 0.014 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0073 | 0.001 | 0.001 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.0247 | 0.0848 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.5656 | 0.6349 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0261 | 0.0223 | 0.0223 |
Onchocerca volvulus | 0.0229 | 0.0186 | 0.0941 | |
Schistosoma mansoni | dihydropyridine-sensitive l-type calcium channel | 0.0145 | 0.0092 | 0.0092 |
Mycobacterium ulcerans | thymidylate synthase | 0.1808 | 0.198 | 0.1913 |
Onchocerca volvulus | Excitatory amino acid transporter homolog | 0.0126 | 0.0069 | 0.0348 |
Brugia malayi | jmjC domain containing protein | 0.0093 | 0.0033 | 0.0033 |
Echinococcus granulosus | neutral amino acid transporter A | 0.0126 | 0.0069 | 0.0069 |
Echinococcus granulosus | glutamate receptor 2 | 0.0261 | 0.0223 | 0.0223 |
Echinococcus multilocularis | neutral amino acid transporter A | 0.0126 | 0.0069 | 0.0069 |
Schistosoma mansoni | glutamate receptor kainate | 0.0188 | 0.014 | 0.014 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.8872 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.8872 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.8872 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.8872 | 1 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0093 | 0.0033 | 0.0033 |
Onchocerca volvulus | 0.1808 | 0.198 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.001 | 0.001 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.086 | 0.0903 | 0.141 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0282 | 0.0247 | 0.5 |
Loa Loa (eye worm) | metabotropic glutamate receptor 8 | 0.0073 | 0.001 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.001 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0078 | 0.0078 |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.0228 | 0.0185 | 0.0185 |
Wolbachia endosymbiont of Brugia malayi | Na+/H+-dicarboxylate symporter | 0.0126 | 0.0069 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.0247 | 0.0848 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.001 | 0.001 |
Onchocerca volvulus | 0.0073 | 0.001 | 0.0048 | |
Brugia malayi | thymidylate synthase | 0.1808 | 0.198 | 0.198 |
Echinococcus multilocularis | thymidylate synthase | 0.1808 | 0.198 | 0.198 |
Echinococcus multilocularis | Excitatory amino acid transporter | 0.0126 | 0.0069 | 0.0069 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.049 | 0.0483 | 0.0483 |
Echinococcus multilocularis | sodium:dicarboxylate symporter | 0.0126 | 0.0069 | 0.0069 |
Echinococcus multilocularis | excitatory amino acid transporter 2 | 0.0126 | 0.0069 | 0.0069 |
Loa Loa (eye worm) | excitatory amino acid transporter | 0.0126 | 0.0069 | 0.0069 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.5656 | 0.6349 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.5656 | 0.6349 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.1808 | 0.198 | 0.198 |
Onchocerca volvulus | 0.0073 | 0.001 | 0.0048 | |
Echinococcus granulosus | excitatory amino acid transporter 2 | 0.0126 | 0.0069 | 0.0069 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0282 | 0.0247 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.0247 | 0.0848 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0667 | 0.0683 | 0.0683 |
Echinococcus granulosus | glutamate receptor 2 | 0.0192 | 0.0144 | 0.0144 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0188 | 0.014 | 0.014 |
Mycobacterium tuberculosis | Hypothetical protein | 0.086 | 0.0903 | 0.084 |
Chlamydia trachomatis | dihydrofolate reductase | 0.8872 | 1 | 1 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0073 | 0.001 | 0.001 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.5656 | 0.6349 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0419 | 0.0402 | 0.0402 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0333 | 0.0305 | 0.0305 |
Echinococcus multilocularis | excitatory amino acid transporter 3 | 0.0126 | 0.0069 | 0.0069 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.8872 | 1 | 1 |
Echinococcus granulosus | atrial natriuretic peptide receptor | 0.0073 | 0.001 | 0.001 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0333 | 0.0305 | 0.0305 |
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.0301 | 0.0268 | 0.0268 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.049 | 0.0483 | 0.0483 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.5656 | 0.6349 | 0.5 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0073 | 0.001 | 0.001 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0188 | 0.014 | 0.014 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0073 | 0.001 | 0.001 |
Onchocerca volvulus | Atrial natriuretic peptide receptor 3 homolog | 0.0073 | 0.001 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.001 | 0.001 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0419 | 0.0402 | 0.0402 |
Echinococcus granulosus | Excitatory amino acid transporter | 0.0126 | 0.0069 | 0.0069 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.023 | 0.0188 | 0.0188 |
Schistosoma mansoni | glutamate receptor kainate | 0.0346 | 0.0319 | 0.0319 |
Schistosoma mansoni | protein kinase | 0.0073 | 0.001 | 0.001 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0261 | 0.0223 | 0.0223 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0192 | 0.0144 | 0.0144 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0398 | 0.0378 | 0.0378 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0261 | 0.0223 | 0.0223 |
Echinococcus multilocularis | neutral amino acid transporter A | 0.0126 | 0.0069 | 0.0069 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.0228 | 0.0185 | 0.0185 |
Schistosoma mansoni | dihydropyridine-sensitive l-type calcium channel | 0.0289 | 0.0254 | 0.0254 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1808 | 0.198 | 0.198 |
Brugia malayi | hypothetical protein | 0.086 | 0.0903 | 0.0903 |
Trichomonas vaginalis | conserved hypothetical protein | 0.086 | 0.0903 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0419 | 0.0402 | 0.0402 |
Echinococcus multilocularis | Ribosomal protein S1, RNA binding domain | 0.007 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0073 | 0.001 | 0.001 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0282 | 0.0247 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ka (ADMET) | = 73 min-1 | Binding constant of the compound was determined | ChEMBL. | 2002457 |
Ks (ADMET) | = 630 uM | Acylation rate constant of the compound | ChEMBL. | 2002457 |
Ratio (ADMET) | = 0.002 M-1 s-1 | Second order rate constant of the compound for acylation( ka/Ks) | ChEMBL. | 2002457 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.