Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | plasminogen activator, urokinase | Starlite/ChEMBL | References |
Homo sapiens | plasminogen | Starlite/ChEMBL | References |
Bos taurus | Trypsin II | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Drosophila melanogaster | CG9733 gene product from transcript CG9733-RB | Trypsin II | 247 aa | 262 aa | 31.3 % |
Echinococcus multilocularis | Mastin | Trypsin II | 247 aa | 306 aa | 25.5 % |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | Trypsin II | 247 aa | 287 aa | 27.2 % |
Schistosoma japonicum | Enteropeptidase, putative | Trypsin II | 247 aa | 267 aa | 26.2 % |
Echinococcus multilocularis | glycoprotein Antigen 5 | Trypsin II | 247 aa | 302 aa | 23.2 % |
Drosophila melanogaster | Jonah 66Ci | Trypsin II | 247 aa | 237 aa | 30.4 % |
Echinococcus granulosus | enteropeptidase | Trypsin II | 247 aa | 227 aa | 26.4 % |
Schistosoma japonicum | ko:K09637 transmembrane protease, serine 6, putative | Trypsin II | 247 aa | 242 aa | 29.8 % |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | Trypsin II | 247 aa | 247 aa | 34.0 % |
Drosophila melanogaster | CG33458 gene product from transcript CG33458-RA | Trypsin II | 247 aa | 255 aa | 29.4 % |
Drosophila melanogaster | CG31267 gene product from transcript CG31267-RA | Trypsin II | 247 aa | 263 aa | 32.7 % |
Schistosoma mansoni | cercarial elastase (S01 family) | Trypsin II | 247 aa | 239 aa | 22.2 % |
Echinococcus granulosus | Mastin | plasminogen activator, urokinase | 414 aa | 340 aa | 24.4 % |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | Trypsin II | 247 aa | 298 aa | 24.5 % |
Drosophila melanogaster | CG30083 gene product from transcript CG30083-RB | Trypsin II | 247 aa | 205 aa | 30.2 % |
Drosophila melanogaster | Jonah 65Aii | Trypsin II | 247 aa | 237 aa | 35.4 % |
Drosophila melanogaster | CG31220 gene product from transcript CG31220-RB | Trypsin II | 247 aa | 224 aa | 29.5 % |
Drosophila melanogaster | CG31326 gene product from transcript CG31326-RA | Trypsin II | 247 aa | 249 aa | 23.7 % |
Drosophila melanogaster | Spatzle-Processing Enzyme | Trypsin II | 247 aa | 269 aa | 27.5 % |
Echinococcus multilocularis | enteropeptidase | Trypsin II | 247 aa | 227 aa | 26.0 % |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | Trypsin II | 247 aa | 287 aa | 27.2 % |
Drosophila melanogaster | CG3505 gene product from transcript CG3505-RA | Trypsin II | 247 aa | 236 aa | 30.1 % |
Drosophila melanogaster | CG11313 gene product from transcript CG11313-RC | Trypsin II | 247 aa | 223 aa | 33.2 % |
Echinococcus granulosus | Mastin | Trypsin II | 247 aa | 306 aa | 25.2 % |
Echinococcus multilocularis | transmembrane protease serine 3 | Trypsin II | 247 aa | 233 aa | 34.8 % |
Echinococcus granulosus | glycoprotein Antigen 5 | Trypsin II | 247 aa | 301 aa | 22.3 % |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | Trypsin II | 247 aa | 302 aa | 25.5 % |
Onchocerca volvulus | Trypsin II | 247 aa | 258 aa | 22.9 % | |
Schistosoma mansoni | cercarial elastase (S01 family) | Trypsin II | 247 aa | 217 aa | 23.0 % |
Drosophila melanogaster | CG14990 gene product from transcript CG14990-RA | Trypsin II | 247 aa | 238 aa | 30.2 % |
Drosophila melanogaster | CG30287 gene product from transcript CG30287-RA | Trypsin II | 247 aa | 251 aa | 27.1 % |
Drosophila melanogaster | Jonah 65Aiii | Trypsin II | 247 aa | 238 aa | 32.8 % |
Drosophila melanogaster | CG30323 gene product from transcript CG30323-RB | Trypsin II | 247 aa | 212 aa | 23.6 % |
Drosophila melanogaster | CG30288 gene product from transcript CG30288-RC | Trypsin II | 247 aa | 248 aa | 28.6 % |
Drosophila melanogaster | Jonah 99Ci | Trypsin II | 247 aa | 268 aa | 32.5 % |
Drosophila melanogaster | CG9673 gene product from transcript CG9673-RB | Trypsin II | 247 aa | 258 aa | 26.4 % |
Drosophila melanogaster | CG13744 gene product from transcript CG13744-RA | Trypsin II | 247 aa | 250 aa | 31.6 % |
Drosophila melanogaster | CG18420 gene product from transcript CG18420-RA | Trypsin II | 247 aa | 233 aa | 28.3 % |
Schistosoma japonicum | Transmembrane protease, serine 9, putative | Trypsin II | 247 aa | 246 aa | 24.8 % |
Drosophila melanogaster | CG17239 gene product from transcript CG17239-RB | Trypsin II | 247 aa | 224 aa | 34.4 % |
Drosophila melanogaster | CG18180 gene product from transcript CG18180-RA | Trypsin II | 247 aa | 234 aa | 31.2 % |
Drosophila melanogaster | CG4815 gene product from transcript CG4815-RA | Trypsin II | 247 aa | 208 aa | 27.4 % |
Drosophila melanogaster | CG34436 gene product from transcript CG34436-RA | Trypsin II | 247 aa | 213 aa | 24.9 % |
Drosophila melanogaster | CG5909 gene product from transcript CG5909-RA | Trypsin II | 247 aa | 257 aa | 28.8 % |
Schistosoma mansoni | cercarial elastase (S01 family) | Trypsin II | 247 aa | 217 aa | 23.0 % |
Schistosoma japonicum | ko:K01346 pancreatic elastase II [EC3.4.21.71], putative | Trypsin II | 247 aa | 303 aa | 24.8 % |
Drosophila melanogaster | CG10405 gene product from transcript CG10405-RB | Trypsin II | 247 aa | 254 aa | 33.1 % |
Onchocerca volvulus | Trypsin II | 247 aa | 257 aa | 26.5 % | |
Drosophila melanogaster | CG33465 gene product from transcript CG33465-RC | Trypsin II | 247 aa | 203 aa | 20.7 % |
Echinococcus granulosus | transmembrane protease serine 3 | Trypsin II | 247 aa | 233 aa | 34.3 % |
Drosophila melanogaster | CG3916 gene product from transcript CG3916-RA | Trypsin II | 247 aa | 257 aa | 33.5 % |
Drosophila melanogaster | CG4914 gene product from transcript CG4914-RA | Trypsin II | 247 aa | 244 aa | 37.3 % |
Drosophila melanogaster | CG32277 gene product from transcript CG32277-RA | Trypsin II | 247 aa | 240 aa | 32.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | 0.2208 | 1 | 0.5 | |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.2208 | 1 | 1 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.2208 | 1 | 0.5 |
Toxoplasma gondii | fructose-bisphospatase II | 0.2208 | 1 | 1 |
Onchocerca volvulus | 0.0122 | 0.0076 | 1 | |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.2208 | 1 | 0.5 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.2208 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.2208 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.2208 | 1 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.2208 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.36 uM | Tested for inhibition of trypsin | ChEMBL. | 10560742 |
Ki (binding) | = 0.36 uM | Tested for inhibition of trypsin | ChEMBL. | 10560742 |
Ki (binding) | = 2.5 uM | Tested for inhibition of plasmin | ChEMBL. | 10560742 |
Ki (binding) | = 2.5 uM | Tested for inhibition of plasmin | ChEMBL. | 10560742 |
Ki (binding) | = 4.8 uM | Tested for inhibition of plasminogen activator urokinase (microPa) | ChEMBL. | 10560742 |
Ki (binding) | = 4.8 uM | Tested for inhibition of plasminogen activator urokinase (microPa) | ChEMBL. | 10560742 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.