Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0262 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0044 | 0.0698 | 0.0698 |
Echinococcus granulosus | peroxidasin | 0.0036 | 0.033 | 0.033 |
Brugia malayi | Carboxylesterase family protein | 0.0044 | 0.0698 | 0.0698 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0044 | 0.0698 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0044 | 0.0698 | 0.0698 |
Echinococcus granulosus | neuroligin | 0.0044 | 0.0698 | 0.0698 |
Onchocerca volvulus | 0.0044 | 0.0698 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Echinococcus granulosus | carboxylesterase 5A | 0.0262 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.0164 | 0.0164 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0044 | 0.0698 | 0.0698 |
Schistosoma mansoni | peroxidasin | 0.0036 | 0.033 | 0.033 |
Brugia malayi | Carboxylesterase family protein | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | carboxylesterase | 0.0262 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Onchocerca volvulus | 0.0044 | 0.0698 | 1 | |
Echinococcus granulosus | acetylcholinesterase | 0.0262 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0044 | 0.0698 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0213 | 0.7911 | 0.7911 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0032 | 0.0164 | 0.0164 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.0164 | 0.0164 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0213 | 0.7911 | 0.7911 |
Schistosoma mansoni | peroxidasin | 0.0032 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | carboxylesterase | 0.0044 | 0.0698 | 0.0698 |
Brugia malayi | Peroxidasin | 0.0036 | 0.033 | 0.033 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0034 | 0.0275 | 0.0275 |
Echinococcus granulosus | hormone sensitive lipase | 0.0213 | 0.7911 | 0.7911 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.0164 | 0.0164 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0044 | 0.0698 | 0.0698 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0032 | 0.0167 | 0.0167 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0698 | 0.0698 |
Brugia malayi | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0167 | 0.0167 |
Brugia malayi | Carboxylesterase family protein | 0.0044 | 0.0698 | 0.0698 |
Onchocerca volvulus | 0.0044 | 0.0698 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0044 | 0.0698 | 0.0698 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0698 | 0.0698 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0044 | 0.0698 | 0.0698 |
Onchocerca volvulus | 0.0044 | 0.0698 | 1 | |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0044 | 0.0698 | 0.0698 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0213 | 0.7911 | 0.7911 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.0164 | 0.0164 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.0164 | 0.0164 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0044 | 0.0698 | 0.0698 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0262 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0262 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0262 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0262 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0044 | 0.0698 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0044 | 0.0698 | 0.5 |
Schistosoma mansoni | cell adhesion molecule | 0.0032 | 0.0167 | 0.0167 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.0164 | 0.0164 |
Brugia malayi | Carboxylesterase family protein | 0.0044 | 0.0698 | 0.0698 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0262 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0044 | 0.0698 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0036 | 0.033 | 0.033 |
Echinococcus granulosus | roundabout 2 | 0.0032 | 0.0167 | 0.0167 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Echinococcus multilocularis | roundabout 2 | 0.0032 | 0.0167 | 0.0167 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0167 | 0.0167 |
Echinococcus multilocularis | neuroligin | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0167 | 0.0167 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0044 | 0.0698 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0698 | 0.0698 |
Brugia malayi | hypothetical protein | 0.0044 | 0.0698 | 0.0698 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Brugia malayi | Blistered cuticle protein 3 | 0.0032 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0262 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.033 | 0.033 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.7911 | 0.7911 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0034 | 0.0275 | 0.0275 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0213 | 0.7911 | 0.7911 |
Loa Loa (eye worm) | carboxylesterase | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Onchocerca volvulus | 0.0044 | 0.0698 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0164 | 0.0164 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log IC50 (binding) | = 0.36 | Inhibitory activity against prostaglandin G/H synthase 2 (COX-2) | ChEMBL. | 12383010 |
IC50 (binding) | = 0.36 | Inhibitory activity against prostaglandin G/H synthase 2 (COX-2) | ChEMBL. | 12383010 |
IC50 (binding) | = 6.36 | Inhibition of human Prostaglandin G/H synthase 2 | ChEMBL. | 11563921 |
IC50 (binding) | = 0.44 uM | Inhibitory activity against human Prostaglandin G/H synthase 2 | ChEMBL. | 10956225 |
IC50 (binding) | = 0.44 uM | Inhibitory activity against human Prostaglandin G/H synthase 2 | ChEMBL. | 10956225 |
IC50 (binding) | > 1000 uM | Inhibitory activity against Prostaglandin G/H synthase 1 | ChEMBL. | 10956225 |
IC50 (binding) | > 1000 uM | Inhibitory activity against Prostaglandin G/H synthase 1 | ChEMBL. | 10956225 |
Inhibition (functional) | = 100 % | Inhibitory activity against prostaglandin production in rat air-pouch model at 2 mg/kg dose | ChEMBL. | 10956225 |
Log IC50 (binding) | = 6.36 | Inhibition of human Prostaglandin G/H synthase 2 | ChEMBL. | 11563921 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.