Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | methionine synthase reductase | 0.0254 | 0.3812 | 0.3968 |
Brugia malayi | flavodoxin family protein | 0.0412 | 0.9606 | 0.9596 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0412 | 0.9606 | 0.9606 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0204 | 0.1975 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0208 | 0.209 | 0.2176 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0158 | 0.0253 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0412 | 0.9606 | 0.9596 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0423 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0412 | 0.9606 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0254 | 0.3812 | 0.3968 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0412 | 0.9606 | 0.9596 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0423 | 1 | 1 |
Echinococcus granulosus | methionine synthase reductase | 0.0254 | 0.3812 | 0.3968 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0412 | 0.9606 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0412 | 0.9606 | 0.9596 |
Trypanosoma cruzi | p450 reductase, putative | 0.0412 | 0.9606 | 0.9596 |
Loa Loa (eye worm) | hypothetical protein | 0.0216 | 0.2402 | 0.2402 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0365 | 0.7884 | 0.8159 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0412 | 0.9606 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0204 | 0.1975 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0254 | 0.3812 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0412 | 0.9606 | 0.9596 |
Brugia malayi | FAD binding domain containing protein | 0.0254 | 0.3812 | 0.3651 |
Leishmania major | p450 reductase, putative | 0.0412 | 0.9606 | 0.9596 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0158 | 0.0253 | 0.0253 |
Leishmania major | cytochrome P450 reductase, putative | 0.0365 | 0.7884 | 0.7829 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0158 | 0.0253 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0412 | 0.9606 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0365 | 0.7884 | 0.8159 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.9606 | 0.9606 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0158 | 0.0253 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0365 | 0.7884 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0412 | 0.9606 | 0.9596 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0412 | 0.9606 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0412 | 0.9606 | 0.9596 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0204 | 0.1975 | 0.2056 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0365 | 0.7884 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0412 | 0.9606 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0412 | 0.9606 | 0.9596 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0412 | 0.9606 | 0.9596 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0158 | 0.0253 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0412 | 0.9606 | 0.9596 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0254 | 0.3812 | 0.3812 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0423 | 1 | 1 |
Treponema pallidum | flavodoxin | 0.0158 | 0.0253 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0158 | 0.0253 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0412 | 0.9606 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0412 | 0.9606 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0412 | 0.9606 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.026 uM | Inhibition of rabbit small-intestinal Acyl coenzyme A:cholesterol acyltransferase 1 | ChEMBL. | 7636880 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.