Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0062 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0062 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0062 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0062 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0062 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0062 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0062 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0062 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0062 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0062 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0062 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0062 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0062 | 0.5 | 0.5 | |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0062 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0062 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0062 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0062 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0062 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0062 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0062 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0062 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0062 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0062 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0062 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0062 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0062 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0062 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0062 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0062 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0062 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0062 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0062 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0062 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0062 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0062 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0062 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Erythroid induction (functional) | = 27 % | Maximum level of percentage of benzidine-positive (hemoglobin-containing) K562 cells reached with in 9 days at 4 mM concentration | ChEMBL. | 10560743 |
Erythroid induction (functional) | = 27 % | Maximum level of percentage of benzidine-positive (hemoglobin-containing) K562 cells reached with in 9 days at 4 mM concentration | ChEMBL. | 10560743 |
IC50 (functional) | = 3.8 mM | Inhibition of cell growth against human myeloid leukemia K562(S) cells | ChEMBL. | 10560743 |
IC50 (functional) | = 3.8 mM | Inhibition of cell growth against human myeloid leukemia K562(S) cells | ChEMBL. | 10560743 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.