Detailed information for compound 1790362

Basic information

Technical information
  • TDR Targets ID: 1790362
  • Name: (E)-3-(4-methoxyphenyl)-1-(4-nitrophenyl)prop -2-en-1-one
  • MW: 283.279 | Formula: C16H13NO4
  • H donors: 0 H acceptors: 3 LogP: 3.49 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)/C=C/C(=O)c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C16H13NO4/c1-21-15-9-2-12(3-10-15)4-11-16(18)13-5-7-14(8-6-13)17(19)20/h2-11H,1H3/b11-4+
  • InChiKey: OEFOVQFJRDIUTL-NYYWCZLTSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(4-methoxyphenyl)-1-(4-nitrophenyl)prop-2-en-1-one
  • 6552-62-1
  • AIDS046025
  • BIM-0023759.P001
  • ZINC04582412
  • NSC75522
  • CBMicro_023682
  • (E)-3-(4-Methoxy-phenyl)-1-(4-nitro-phenyl)-propenone
  • NCIOpen2_004611
  • (2E)-3-(4-Methoxyphenyl)-1-(4-nitrophenyl)-2-propen-1-one
  • trans-4-Methoxy-4'-nitrochalcone
  • MixCom6_000706
  • DivK1c_005138
  • CDS1_004098
  • T5219164
  • AIDS-046025

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0018 0.0033 0.0016
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0085 0.0108
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0029
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0171 0.0319
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.1127 0.1111
Echinococcus granulosus 6 phosphofructo 2 kinase:fructose 2 0.1094 0.7876 0.7873
Onchocerca volvulus 0.074 0.5296 0.6724
Loa Loa (eye worm) hypothetical protein 0.1076 0.7742 0.9829
Trypanosoma cruzi phosphoglycerate mutase, putative 0.0018 0.0033 0.0042
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1094 0.7876 1
Mycobacterium tuberculosis Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) 0.0018 0.0033 0.2795
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0104 0.0132
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0104 0.0195
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0467 0.3303 0.4193
Plasmodium vivax casein kinase 1, putative 0.0749 0.5362 1
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0018 0.0033 0.0062
Trichomonas vaginalis CK1 family protein kinase 0.0749 0.5362 1
Leishmania major hypothetical protein, conserved 0.0018 0.0033 0.0042
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0085 0.0068
Onchocerca volvulus 0.0017 0.0023 0.0029
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0274 0.0512
Trypanosoma cruzi casein kinase, putative 0.0749 0.5362 0.6808
Onchocerca volvulus Protein UBASH3A homolog 0.0018 0.0033 0.0042
Schistosoma mansoni hypothetical protein 0.0018 0.0033 0.0016
Schistosoma mansoni hypothetical protein 0.0018 0.0033 0.0016
Brugia malayi phosphoglycerate mutase family protein 0.0018 0.0033 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0033 0.0062
Entamoeba histolytica casein kinase, putative 0.0749 0.5362 1
Mycobacterium ulcerans phosphoglycerate mutase 0.0018 0.0033 0.0015
Mycobacterium ulcerans lipoprotein LpqD 0.0018 0.0033 0.0015
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0646 0.4607 0.8591
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0069 0.0088
Brugia malayi plexin A 0.002 0.0045 0.0085
Mycobacterium ulcerans phosphoglycerate mutase 0.0018 0.0033 0.0015
Schistosoma mansoni hypothetical protein 0.0018 0.0033 0.0016
Plasmodium vivax phosphoglycerate mutase, putative 0.0018 0.0033 0.0013
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.2609 0.3313
Echinococcus granulosus lysosomal alpha glucosidase 0.0168 0.1127 0.1111
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0171 0.0319
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0749 0.5362 0.6808
Loa Loa (eye worm) hypothetical protein 0.0018 0.0033 0.0042
Trichomonas vaginalis CK1 family protein kinase 0.0749 0.5362 1
Mycobacterium tuberculosis PE-PGRS family protein PE_PGRS11 0.0018 0.0033 0.2795
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0827 0.5926 0.5919
Onchocerca volvulus Protein UBASH3A homolog 0.0018 0.0033 0.0042
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0152 0.0135
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0467 0.3303 0.4193
Mycobacterium tuberculosis Conserved protein 0.0018 0.0033 0.2795
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0085 0.0098
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0033
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0749 0.5362 0.6808
Echinococcus multilocularis phosphoglycerate mutase 0.0018 0.0033 0.0016
Echinococcus granulosus phosphoglycerate mutase 0.0018 0.0033 0.0016
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0069 0.0129
Schistosoma mansoni alpha glucosidase 0.0037 0.0171 0.0154
Leishmania major glycerolphosphate mutase, putative 0.0018 0.0033 0.0042
Echinococcus multilocularis phosphoglycerate mutase 0.0018 0.0033 0.0016
Plasmodium falciparum importin beta, putative 0.0035 0.0152 0.0237
Mycobacterium tuberculosis Conserved hypothetical protein 0.0018 0.0033 0.2795
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0104 0.0195
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0171 0.0154
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0152 0.0193
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0069 0.0094
Plasmodium vivax importin-beta 2, putative 0.0035 0.0152 0.0237
Onchocerca volvulus 0.0018 0.0033 0.0042
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0018 0.0033 0.0042
Mycobacterium ulcerans acid phosphatase 0.0018 0.0033 0.0015
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1076 0.7742 0.9829
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0152 0.0193
Onchocerca volvulus Protein UBASH3A homolog 0.0018 0.0033 0.0042
Trypanosoma cruzi casein kinase, putative 0.0749 0.5362 0.6808
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0018 0.0033 0.0062
Brugia malayi RNA, U transporter 1 0.0099 0.0621 0.1157
Echinococcus granulosus casein kinase I alpha 0.0749 0.5362 0.5354
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.1076 0.7742 0.9829
Trypanosoma cruzi casein kinase, delta isoform, putative 0.074 0.5296 0.6724
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0171 0.0319
Loa Loa (eye worm) hypothetical protein 0.0023 0.0069 0.0088
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0069 0.0094
Onchocerca volvulus 0.0018 0.0033 0.0042
Echinococcus granulosus casein kinase I alpha 0.0749 0.5362 0.5354
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.1094 0.7876 0.7873
Echinococcus multilocularis phosphoglycerate mutase 0.0018 0.0033 0.0016
Schistosoma mansoni hypothetical protein 0.0018 0.0033 0.0016
Schistosoma mansoni plexin 0.0017 0.0023 0.0005
Echinococcus granulosus casein kinase I alpha 0.0749 0.5362 0.5354
Echinococcus granulosus phosphoglycerate mutase 0.0018 0.0033 0.0016
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0069 0.0094
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein 0.0467 0.3303 0.4193
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0018 0.0033 0.0042
Schistosoma mansoni 6-phosphofructokinase 0.1094 0.7876 0.7873
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0018 0.0033 0.0062
Echinococcus granulosus plexin a4 0.002 0.0045 0.0028
Loa Loa (eye worm) hypothetical protein 0.0035 0.0152 0.0193
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0085 0.0108
Leishmania major fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein 0.0018 0.0033 0.0042
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.1076 0.7742 0.9829
Schistosoma mansoni importin beta-1 0.0035 0.0152 0.0135
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0171 0.0259
Trypanosoma brucei phosphoglycerate mutase, putative 0.0018 0.0033 0.0042
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0069 0.0094
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0022
Echinococcus granulosus importin subunit beta 1 0.0035 0.0152 0.0135
Leishmania major hypothetical protein, conserved 0.0018 0.0033 0.0042
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0168 0.1127 0.1431
Brugia malayi Glycosyl hydrolases family 31 protein 0.0168 0.1127 0.2102
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0171 0.0319
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0171 0.0319
Echinococcus multilocularis microtubule associated protein 2 0.1385 1 1
Brugia malayi Importin beta-1 subunit 0.0035 0.0152 0.0284
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0749 0.5362 0.6808
Loa Loa (eye worm) hypothetical protein 0.0018 0.0033 0.0042
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.0018 0.0033 0.0042
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0018 0.0033 0.0062
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0171 0.0319
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0016 0.0013 0.0016
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0018 0.0033 0.0042
Echinococcus multilocularis casein kinase I alpha 0.0749 0.5362 0.5354
Echinococcus granulosus casein kinase i 0.0749 0.5362 0.5354
Mycobacterium tuberculosis Probable conserved lipoprotein LpqD 0.0018 0.0033 0.2795
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0085 0.0108
Onchocerca volvulus Protein UBASH3A homolog 0.0018 0.0033 0.0042
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0018 0.0033 0.0062
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0018 0.0033 0.0042
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1094 0.7876 1
Plasmodium falciparum phosphoglycerate mutase, putative 0.0018 0.0033 0.0013
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0069 0.0129
Echinococcus multilocularis casein kinase I delta 0.0749 0.5362 0.5354
Loa Loa (eye worm) hypothetical protein 0.0627 0.4472 0.5678
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.1127 0.1111
Mycobacterium tuberculosis Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) 0.0018 0.0033 0.2795
Echinococcus multilocularis casein kinase I alpha 0.0749 0.5362 0.5354
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0152 0.0224
Mycobacterium ulcerans hypothetical protein 0.0018 0.0033 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0171 0.0217
Plasmodium falciparum phosphoglucomutase-2 0.0018 0.0033 0.0013
Onchocerca volvulus 0.0749 0.5362 0.6808
Loa Loa (eye worm) hypothetical protein 0.1094 0.7876 1
Trypanosoma cruzi casein kinase, putative 0.0749 0.5362 0.6808
Brugia malayi UBASH3A protein homolog 0.0018 0.0033 0.0062
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0018 0.0033 0.0042
Trypanosoma cruzi casein kinase, putative 0.0749 0.5362 0.6808
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0171 0.0319
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0017 0.0032
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0274 0.0512
Plasmodium vivax phosphoglucomutase-2, putative 0.0018 0.0033 0.0013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0033
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0069 0.0088
Schistosoma mansoni serine/threonine protein kinase 0.0749 0.5362 0.5354
Giardia lamblia Hypothetical protein 0.0646 0.4607 0.8568
Mycobacterium ulcerans bifunctional RNase H/acid phosphatase 0.0018 0.0033 0.0015
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0171 0.0217
Trypanosoma brucei phosphoglycerate mutase protein, putative 0.0018 0.0033 0.0042
Leishmania major phosphoglycerate mutase protein, putative 0.0018 0.0033 0.0042
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0069 0.0129
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0085 0.0159
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.0018 0.0033 0.0042
Chlamydia trachomatis 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 0.0018 0.0033 1
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.0018 0.0033 0.0042
Mycobacterium ulcerans hypothetical protein 0.0018 0.0033 0.0015
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0069 1
Schistosoma mansoni alpha-glucosidase 0.0145 0.0956 0.094
Leishmania major hypothetical protein, unknown function 0.0018 0.0033 0.0042
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0018 0.0033 0.0042
Entamoeba histolytica phosphoglycerate mutase family protein. putative 0.0018 0.0033 0.0062
Toxoplasma gondii casein kinase I 0.0749 0.5362 1
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.0018 0.0033 0.0016
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0085 0.0111
Trypanosoma brucei Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative 0.0018 0.0033 0.0042
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0069 1
Echinococcus granulosus casein kinase I delta 0.0749 0.5362 0.5354
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0085 0.0111
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0749 0.5362 0.6808
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0467 0.3303 0.4193
Entamoeba histolytica Ran family GTPase 0.0026 0.0085 0.0159
Entamoeba histolytica hypothetical protein 0.0028 0.0104 0.0195
Echinococcus multilocularis phosphoglycerate mutase 0.0018 0.0033 0.0016
Trypanosoma cruzi casein kinase, putative 0.0749 0.5362 0.6808
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0017 0.0032
Mycobacterium tuberculosis Glucosyl-3-phosphoglycerate phosphatase GpgP 0.0018 0.0033 0.2795
Mycobacterium ulcerans hypothetical protein 0.0646 0.4607 1
Onchocerca volvulus 0.0023 0.0069 0.0088
Schistosoma mansoni phosphoglycerate mutase 0.0018 0.0033 0.0016
Giardia lamblia Hypothetical protein 0.0646 0.4607 0.8568
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0155 0.029
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0171 0.0154
Leishmania major GTP-binding protein, putative 0.0026 0.0085 0.0108
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0171 0.0319
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0171 0.0319
Loa Loa (eye worm) hypothetical protein 0.0023 0.0069 0.0088
Mycobacterium tuberculosis Possible hydrolase MutT1 0.0018 0.0033 0.2795
Mycobacterium ulcerans hydrolase MutT1 0.0018 0.0033 0.0015
Loa Loa (eye worm) hypothetical protein 0.0052 0.0274 0.0348
Schistosoma mansoni hypothetical protein 0.0018 0.0033 0.0016
Trypanosoma cruzi glycerolphosphate mutase, putative 0.0018 0.0033 0.0042
Entamoeba histolytica casein kinase 1, putative 0.0749 0.5362 1
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.1076 0.7742 0.9829
Trichomonas vaginalis CK1 family protein kinase 0.0749 0.5362 1
Schistosoma mansoni alpha-glucosidase 0.0145 0.0956 0.094
Brugia malayi phosphoglycerate mutase family protein 0.0018 0.0033 0.0062
Mycobacterium tuberculosis Conserved protein 0.0018 0.0033 0.2795
Echinococcus multilocularis casein kinase i 0.0749 0.5362 0.5354
Trypanosoma brucei casein kinase I, isoform 2 0.0749 0.5362 0.6808
Leishmania major phosphoglycerate mutase, putative 0.0018 0.0033 0.0042
Schistosoma mansoni ran 0.0026 0.0085 0.0068
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0033
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.0646 0.4607 1
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0018 0.0033 0.0062
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0069 0.0129
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0171 0.0217
Echinococcus granulosus casein kinase I delta 0.0749 0.5362 0.5354
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0104 0.0195
Leishmania major casein kinase, putative 0.0749 0.5362 0.6808
Mycobacterium ulcerans hypothetical protein 0.0023 0.0069 0.0094
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0171 0.0319
Mycobacterium ulcerans phosphoglyceromutase 0.0018 0.0033 0.0015
Echinococcus multilocularis phosphoglycerate mutase 0.0018 0.0033 0.0016
Loa Loa (eye worm) phosphoglycerate mutase 0.0018 0.0033 0.0042
Schistosoma mansoni phosphoglycerate mutase 0.0018 0.0033 0.0016
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0069 0.0129
Schistosoma mansoni ran 0.0026 0.0085 0.0068
Trypanosoma brucei glucosidase, putative 0.0037 0.0171 0.0217
Treponema pallidum phosphoglyceromutase 0.0018 0.0033 0.5
Echinococcus granulosus phosphoglycerate mutase 0.0018 0.0033 0.0016
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0026 0.139
Echinococcus multilocularis phosphoglycerate mutase 0.0018 0.0033 0.0016
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0018 0.0033 0.0042
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0018 0.0033 0.0042
Loa Loa (eye worm) hypothetical protein 0.0023 0.0069 0.0088
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0017 0.0022
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0018 0.0033 0.0042
Schistosoma mansoni protein kinase 0.0749 0.5362 0.5354
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.0018 0.0033 0.0042
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0171 0.0319
Brugia malayi casein kinase 1, delta 0.0749 0.5362 1
Trypanosoma cruzi glycerolphosphate mutase, putative 0.0018 0.0033 0.0042
Echinococcus multilocularis plexin a4 0.002 0.0045 0.0028
Schistosoma mansoni hypothetical protein 0.0035 0.0155 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0033 0.0062
Echinococcus multilocularis casein kinase I alpha 0.0749 0.5362 0.5354
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0069 1
Onchocerca volvulus 0.1094 0.7876 1
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1094 0.7876 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0033 0.0042
Echinococcus granulosus phosphoglycerate mutase 0.0018 0.0033 0.0016
Echinococcus multilocularis snurportin 1 0.0372 0.2609 0.2596
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0069 0.0094
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0171 0.0319
Leishmania major phosphoglycerate mutase family member 5, putative 0.0018 0.0033 0.0042
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.0018 0.0033 0.0016
Loa Loa (eye worm) plexin A 0.002 0.0045 0.0058
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0069 0.0094
Brugia malayi casein kinase I 0.0749 0.5362 1
Giardia lamblia Kinase, CK1 Casein kinase 0.0749 0.5362 1
Trichomonas vaginalis ran, putative 0.0026 0.0085 0.0159
Loa Loa (eye worm) hypothetical protein 0.0018 0.0033 0.0042
Echinococcus granulosus snurportin 1 0.0372 0.2609 0.2596
Onchocerca volvulus 0.0018 0.0033 0.0042
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0018 0.0033 0.0042
Onchocerca volvulus 0.0097 0.0609 0.0773
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0171 0.0217
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0069 1
Echinococcus granulosus phosphoglycerate mutase 0.0018 0.0033 0.0016
Trypanosoma brucei glycerolphosphate mutase, putative 0.0018 0.0033 0.0042
Echinococcus multilocularis casein kinase I delta 0.0749 0.5362 0.5354
Brugia malayi Plexin repeat family protein 0.0017 0.0023 0.0042
Leishmania major hypothetical protein, conserved 0.0018 0.0033 0.0042
Plasmodium falciparum casein kinase 1 0.0749 0.5362 1
Trypanosoma cruzi phosphoglycerate mutase, putative 0.0018 0.0033 0.0042
Schistosoma mansoni hypothetical protein 0.0372 0.2609 0.2596
Schistosoma mansoni microtubule-associated protein tau 0.1385 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0274 0.0348
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0018 0.0033 0.0042
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.0018 0.0033 0.0016
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0018 0.0033 0.0062
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.0018 0.0033 0.0016
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0069 0.0129
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0069 0.0094
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0085 0.0068
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0085 0.0108
Leishmania major importin beta-1 subunit, putative 0.0028 0.0104 0.0132
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0069 0.0088
Loa Loa (eye worm) hypothetical protein 0.0035 0.0155 0.0197
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0033
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0033
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1094 0.7876 1
Mycobacterium ulcerans phosphohistidine phosphatase SixA 0.0018 0.0033 0.0015

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.