Detailed information for compound 1790375

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 331.368 | Formula: C20H17N3O2
  • H donors: 4 H acceptors: 2 LogP: 3.73 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)NC(c1c[nH]c2c1cccc2)c1c(O)ccc2c1cccc2
  • InChi: 1S/C20H17N3O2/c21-20(25)23-19(15-11-22-16-8-4-3-7-14(15)16)18-13-6-2-1-5-12(13)9-10-17(18)24/h1-11,19,22,24H,(H3,21,23,25)
  • InChiKey: UPEUMLVXHCJAEY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0098 0.0475 0.0475
Toxoplasma gondii exonuclease III APE 0.003 0.0052 0.2236
Loa Loa (eye worm) hypothetical protein 0.0048 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0938 0.5676 0.5676
Trypanosoma brucei glycerolphosphate mutase, putative 0.0028 0.0036 0.0002
Echinococcus granulosus neutral alpha glucosidase AB 0.0027 0.0035 0.0035
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.1608 0.9829 0.9828
Echinococcus granulosus geminin 0.0556 0.3309 0.3309
Schistosoma mansoni hypothetical protein 0.0556 0.3309 0.3309
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0101 0.0489 0.0489
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0036 0.0018
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0175 0.0175
Mycobacterium leprae probable isochorismate synthase EntC 0.0028 0.0036 0.5
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0031 0.0057 0.0022
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0104 0.0511 0.0511
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.0028 0.0036 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0124 0.0633 0.5979
Brugia malayi hypothetical protein 0.0159 0.0848 0.4619
Onchocerca volvulus 0.0071 0.0307 0.0307
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0028 0.0036 0.0018
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0028 0.0036 0.0002
Schistosoma mansoni hypothetical protein 0.0556 0.3309 0.3309
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.0511 0.0511
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.0028 0.0036 0.0036
Echinococcus multilocularis tumor protein p63 0.0328 0.1899 0.1899
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0189 0.1035 0.5639
Mycobacterium leprae PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) 0.0028 0.0036 0.5
Schistosoma mansoni ap endonuclease 0.003 0.0052 0.0052
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.003 0.0052 0.0017
Schistosoma mansoni hypothetical protein 0.0028 0.0036 0.0036
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0028 0.0036 0.0002
Brugia malayi exodeoxyribonuclease III family protein 0.003 0.0052 0.0283
Echinococcus multilocularis 0.0058 0.0227 0.0227
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1636 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.1035 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0175 0.0141
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.003 0.0052 0.0283
Trichomonas vaginalis glucosylceramidase, putative 0.0124 0.0633 0.5979
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.003 0.0052 0.2236
Trichomonas vaginalis set domain proteins, putative 0.0172 0.0934 0.8989
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0059 0.0232 0.0198
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0123 0.0628 0.0628
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0057 0.0216 0.0216
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1636 1 1
Echinococcus multilocularis phosphoglycerate mutase 0.0028 0.0036 0.0036
Trichomonas vaginalis glucosylceramidase, putative 0.0124 0.0633 0.5979
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0175 0.0141
Schistosoma mansoni tar DNA-binding protein 0.0098 0.0475 0.0475
Leishmania major fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein 0.0028 0.0036 0.0002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0101 0.0489 0.0489
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1262 0.7685 0.7685
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.003 0.0052 0.0052
Echinococcus multilocularis dual specificity protein kinase clk2 0.0059 0.0232 0.0232
Brugia malayi RNA binding protein 0.0098 0.0475 0.259
Echinococcus granulosus tar DNA binding protein 0.0098 0.0475 0.0475
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0175 0.0141
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0175 0.1402
Trypanosoma cruzi phosphoglycerate mutase, putative 0.0028 0.0036 0.0002
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0027 0.0035 0.1492
Plasmodium vivax phosphoglucomutase-2, putative 0.0028 0.0036 0.157
Mycobacterium tuberculosis Conserved hypothetical protein 0.0116 0.0583 1
Schistosoma mansoni alpha-glucosidase 0.0106 0.0522 0.0522
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1636 1 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0101 0.0489 0.0489
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.0511 0.0511
Trypanosoma brucei phosphoglycerate mutase protein, putative 0.0028 0.0036 0.0002
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein 0.0698 0.419 0.417
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0104 0.0511 0.0511
Brugia malayi hypoxia-induced factor 1 0.0146 0.0772 0.4204
Loa Loa (eye worm) hypothetical protein 0.1608 0.9829 0.9829
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0318 0.1835 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0175 0.0141
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0104 0.0511 0.0511
Schistosoma mansoni 6-phosphofructokinase 0.1636 1 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0175 0.0141
Brugia malayi Cytochrome P450 family protein 0.0029 0.0044 0.024
Brugia malayi Calcitonin receptor-like protein seb-1 0.0318 0.1835 1
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.0028 0.0036 0.0036
Leishmania major hypothetical protein, unknown function 0.0028 0.0036 0.0002
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0028 0.0036 0.0002
Brugia malayi latrophilin 2 splice variant baaae 0.0217 0.1212 0.6604
Brugia malayi phosphoglycerate mutase family protein 0.0028 0.0036 0.0199
Onchocerca volvulus 0.0028 0.0036 0.0036
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0028 0.0036 0.0018
Brugia malayi phosphoglycerate mutase family protein 0.0028 0.0036 0.0199
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0031 0.0057 0.0022
Echinococcus multilocularis phosphoglycerate mutase 0.0028 0.0036 0.0036
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0027 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0101 0.0489 0.0489
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.0028 0.0036 0.0002
Loa Loa (eye worm) TAR-binding protein 0.0098 0.0475 0.0475
Schistosoma mansoni hypothetical protein 0.0101 0.0489 0.0489
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0059 0.0232 0.0198
Entamoeba histolytica hypothetical protein 0.0057 0.0216 0.0313
Brugia malayi RNA recognition motif domain containing protein 0.0098 0.0475 0.259
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0036 0.5
Echinococcus multilocularis tar DNA binding protein 0.0098 0.0475 0.0475
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.003 0.0052 0.0052
Echinococcus multilocularis phosphoglycerate mutase 0.0028 0.0036 0.0036
Onchocerca volvulus 0.0048 0.0163 0.0163
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.003 0.0052 0.0017
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.1608 0.9829 0.9828
Brugia malayi TAR-binding protein 0.0098 0.0475 0.259
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0698 0.419 0.417
Echinococcus multilocularis lysosomal alpha glucosidase 0.0123 0.0628 0.0628
Schistosoma mansoni hypothetical protein 0.0101 0.0489 0.0489
Toxoplasma gondii phosphoglycerate mutase family protein 0.0028 0.0036 0.157
Echinococcus granulosus tumor protein p63 0.0328 0.1899 0.1899
Plasmodium vivax phosphoglycerate mutase, putative 0.0028 0.0036 0.157
Toxoplasma gondii phosphoglycerate mutase 0.0028 0.0036 0.157
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.003 0.0052 0.0789
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0044 0.0044
Mycobacterium ulcerans hypothetical protein 0.0965 0.5847 1
Schistosoma mansoni tar DNA-binding protein 0.0098 0.0475 0.0475
Trichomonas vaginalis glucosylceramidase, putative 0.0124 0.0633 0.5979
Echinococcus multilocularis phosphoglycerate mutase 0.0028 0.0036 0.0036
Chlamydia trachomatis 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 0.0028 0.0036 0.5
Giardia lamblia Hypothetical protein 0.0965 0.5847 1
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0232 0.1974
Onchocerca volvulus Protein UBASH3A homolog 0.0028 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0057 0.0216 0.0216
Echinococcus multilocularis phosphoglycerate mutase 0.0028 0.0036 0.0036
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0104 0.051 0.0477
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0698 0.419 0.417
Schistosoma mansoni phosphoglycerate mutase 0.0028 0.0036 0.0036
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.003 0.0052 0.5
Onchocerca volvulus Protein UBASH3A homolog 0.0028 0.0036 0.0036
Leishmania major phosphoglycerate mutase family member 5, putative 0.0028 0.0036 0.0002
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0028 0.0036 0.0002
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.022 0.1228 0.1197
Leishmania major hypothetical protein, conserved 0.0028 0.0036 0.0002
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0175 0.1402
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0082 0.0082
Trichomonas vaginalis glucosylceramidase, putative 0.0131 0.0674 0.6392
Entamoeba histolytica exodeoxyribonuclease III, putative 0.003 0.0052 0.003
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0175 0.1402
Trichomonas vaginalis glucosylceramidase, putative 0.0124 0.0633 0.5979
Trypanosoma cruzi glycerolphosphate mutase, putative 0.0028 0.0036 0.0002
Echinococcus granulosus single minded 2 0.0035 0.0082 0.0082
Trypanosoma cruzi phosphoglycerate mutase, putative 0.0028 0.0036 0.0002
Onchocerca volvulus 0.0028 0.0036 0.0036
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.1608 0.9829 0.9828
Loa Loa (eye worm) hypothetical protein 0.0058 0.0227 0.0227
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0104 0.051 0.0477
Schistosoma mansoni phosphoglycerate mutase 0.0028 0.0036 0.0036
Mycobacterium ulcerans hypothetical protein 0.0116 0.0583 0.094
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0152 0.0804 0.0804
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.0965 0.5847 1
Loa Loa (eye worm) hypothetical protein 0.1636 1 1
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0028 0.0036 0.0002
Echinococcus granulosus phosphoglycerate mutase 0.0028 0.0036 0.0036
Plasmodium falciparum protein serine/threonine kinase-1 0.0059 0.0232 1
Plasmodium vivax serine/threonine kinase-1, putative 0.0059 0.0232 1
Schistosoma mansoni hypothetical protein 0.0217 0.1212 0.1212
Onchocerca volvulus Glucosylceramidase homolog 0.0124 0.0633 0.0633
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0082 0.0447
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0059 0.0232 0.0232
Echinococcus granulosus phosphoglycerate mutase 0.0028 0.0036 0.0036
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0698 0.419 0.417
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0036 0.5
Onchocerca volvulus 0.0028 0.0036 0.0036
Echinococcus multilocularis phosphoglycerate mutase 0.0028 0.0036 0.0036
Brugia malayi UBASH3A protein homolog 0.0028 0.0036 0.0199
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0175 0.0141
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0028 0.0036 0.0002
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0175 0.7533
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0232 0.0232
Giardia lamblia Kinase, CMGC CLK 0.0059 0.0232 0.0311
Brugia malayi Glycosyl hydrolases family 31 protein 0.0027 0.0035 0.0189
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0059 0.0232 0.0198
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0175 0.0212
Echinococcus granulosus phosphoglycerate mutase 0.0028 0.0036 0.0036
Entamoeba histolytica phosphoglycerate mutase family protein. putative 0.0028 0.0036 0.0003
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1608 0.9829 0.9828
Loa Loa (eye worm) RNA binding protein 0.0098 0.0475 0.0475
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.003 0.0052 0.0027
Schistosoma mansoni hypothetical protein 0.0028 0.0036 0.0036
Toxoplasma gondii phosphoglycerate mutase family protein 0.0028 0.0036 0.157
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0104 0.051 0.0477
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0028 0.0036 0.0002
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0175 0.0175
Brugia malayi Latrophilin receptor protein 2 0.0101 0.0489 0.2663
Toxoplasma gondii phosphoglycerate mutase PGMII 0.0028 0.0036 0.157
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0028 0.0036 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.1035 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.022 0.1228 0.1197
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.0028 0.0036 0.0036
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0082 0.0079
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0036
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0104 0.0511 0.2783
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0028 0.0036 0.0018
Brugia malayi Glycosyl hydrolases family 31 protein 0.0123 0.0628 0.3423
Echinococcus multilocularis neutral alpha glucosidase AB 0.0027 0.0035 0.0035
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.1636 1 1
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0175 0.0175
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1636 1 1
Schistosoma mansoni tar DNA-binding protein 0.0098 0.0475 0.0475
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.0028 0.0036 0.0002
Loa Loa (eye worm) hypothetical protein 0.0159 0.0848 0.0848
Schistosoma mansoni hypothetical protein 0.0028 0.0036 0.0036
Onchocerca volvulus 0.1636 1 1
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.0028 0.0036 0.0002
Echinococcus multilocularis lysosomal alpha glucosidase 0.0123 0.0628 0.0628
Entamoeba histolytica hypothetical protein 0.0057 0.0216 0.0313
Onchocerca volvulus 0.0035 0.0082 0.0082
Echinococcus multilocularis GPCR, family 2 0.0101 0.0489 0.0489
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0175 0.1402
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0175 0.0175
Toxoplasma gondii phosphoglycerate mutase family protein 0.0028 0.0036 0.157
Treponema pallidum exodeoxyribonuclease (exoA) 0.003 0.0052 1
Leishmania major mitochondrial DNA polymerase beta 0.022 0.1228 0.1197
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.1035 1
Echinococcus granulosus dual specificity protein kinase clk2 0.0059 0.0232 0.0232
Toxoplasma gondii hypothetical protein 0.0035 0.0085 0.3665
Echinococcus granulosus lysosomal alpha glucosidase 0.0123 0.0628 0.0628
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0028 0.0036 0.0002
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.003 0.0052 0.0052
Leishmania major phosphoglycerate mutase, putative 0.0028 0.0036 0.0002
Schistosoma mansoni single-minded 0.0047 0.0158 0.0158
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0163 0.0163
Entamoeba histolytica hypothetical protein 0.0057 0.0216 0.0313
Mycobacterium leprae PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) 0.0028 0.0036 0.5
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0036 0.5
Schistosoma mansoni hypothetical protein 0.0028 0.0036 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0036 0.0018
Trypanosoma brucei mitochondrial DNA polymerase beta 0.022 0.1228 0.1197
Echinococcus granulosus phosphoglycerate mutase 0.0028 0.0036 0.0036
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.1035 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0101 0.0489 0.0489
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0175 0.0141
Trichomonas vaginalis glucosylceramidase, putative 0.0131 0.0674 0.6392
Mycobacterium leprae POSSIBLE HYDROLASE MUTT1 0.0028 0.0036 0.5
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0036
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0318 0.1835 0.1835
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0104 0.0511 0.0511
Brugia malayi MAP kinase sur-1 0.005 0.0175 0.0953
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0232 0.0232
Schistosoma mansoni transcription factor LCR-F1 0.0057 0.0216 0.0216
Trichomonas vaginalis ap endonuclease, putative 0.003 0.0052 0.0173
Loa Loa (eye worm) latrophilin receptor protein 2 0.0101 0.0489 0.0489
Schistosoma mansoni ap endonuclease 0.003 0.0052 0.0052
Onchocerca volvulus 0.0172 0.0934 0.0934
Leishmania major phosphoglycerate mutase protein, putative 0.0028 0.0036 0.0002
Mycobacterium leprae Possible phosphoglycerate mutase 0.0028 0.0036 0.5
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0028 0.0036 0.0003
Echinococcus granulosus hypothetical protein 0.0058 0.0227 0.0227
Entamoeba histolytica hypothetical protein 0.0057 0.0216 0.0313
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0028 0.0036 0.0002
Trypanosoma brucei Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative 0.0028 0.0036 0.0002
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0028 0.0036 0.0018
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0101 0.0489 0.2663
Schistosoma mansoni hypothetical protein 0.0101 0.0489 0.0489
Loa Loa (eye worm) hypothetical protein 0.0101 0.0489 0.0489
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0057 0.0216 0.0216
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0059 0.0232 0.0198
Echinococcus granulosus GPCR family 2 0.0101 0.0489 0.0489
Brugia malayi PAS domain containing protein 0.0047 0.0158 0.0862
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.003 0.0052 0.0017
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0104 0.0511 0.0511
Mycobacterium leprae Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) 0.0028 0.0036 0.5
Schistosoma mansoni hypothetical protein 0.0028 0.0036 0.0036
Leishmania major glycerolphosphate mutase, putative 0.0028 0.0036 0.0002
Loa Loa (eye worm) hypothetical protein 0.0318 0.1835 0.1835
Giardia lamblia Hypothetical protein 0.0965 0.5847 1
Onchocerca volvulus Protein UBASH3A homolog 0.0028 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.0511 0.0511
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.1035 1
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.1035 1
Brugia malayi Pre-SET motif family protein 0.0152 0.0804 0.4381
Toxoplasma gondii phosphoglycerate mutase family protein 0.0028 0.0036 0.157
Echinococcus granulosus phosphoglycerate mutase 0.0028 0.0036 0.0036
Brugia malayi Protein kinase domain containing protein 0.0059 0.0232 0.1265
Schistosoma mansoni hypothetical protein 0.0028 0.0036 0.0036
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0028 0.0036 0.0002
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0036
Leishmania major protein kinase, putative 0.0059 0.0232 0.0198
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0175 0.0175
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0189 0.1035 0.1035
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0059 0.0232 0.0198
Schistosoma mansoni alpha glucosidase 0.0027 0.0035 0.0035
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0158 0.0158
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.003 0.0052 0.0017
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0059 0.0232 1
Leishmania major protein kinase, putative 0.0059 0.0232 0.0198
Trichomonas vaginalis glucosylceramidase, putative 0.0124 0.0633 0.5979
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0965 0.5847 1
Echinococcus multilocularis geminin 0.0556 0.3309 0.3309
Loa Loa (eye worm) phosphoglycerate mutase 0.0028 0.0036 0.0036
Leishmania major hypothetical protein, conserved 0.0028 0.0036 0.0002
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0175 0.0175
Trichomonas vaginalis glucosylceramidase, putative 0.0124 0.0633 0.5979
Leishmania major hypothetical protein, conserved 0.0028 0.0036 0.0002
Loa Loa (eye worm) hypoxia-induced factor 1 0.0146 0.0772 0.0772
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0098 0.0475 0.0475
Schistosoma mansoni tar DNA-binding protein 0.0098 0.0475 0.0475
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0031 0.0057 0.0022
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0031 0.0057 0.0022
Trypanosoma cruzi glycerolphosphate mutase, putative 0.0028 0.0036 0.0002
Brugia malayi hypothetical protein 0.0057 0.0216 0.1179
Trypanosoma brucei phosphoglycerate mutase, putative 0.0028 0.0036 0.0002
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.0028 0.0036 0.0036
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0059 0.0232 0.0198
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0028 0.0036 0.0003
Trypanosoma brucei protein kinase, putative 0.005 0.0175 0.0141
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0038 0.0099 0.0064
Schistosoma mansoni alpha-glucosidase 0.0106 0.0522 0.0522
Loa Loa (eye worm) hypothetical protein 0.0217 0.1212 0.1212
Trichomonas vaginalis ap endonuclease, putative 0.003 0.0052 0.0173
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0028 0.0036 0.0018
Onchocerca volvulus Protein UBASH3A homolog 0.0028 0.0036 0.0036

Activities

Activity type Activity value Assay description Source Reference
GI (functional) Antibacterial activity against Escherichia coli assessed as growth inhibition LITERATURE. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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