Detailed information for compound 1790401

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 439.441 | Formula: C25H18FN5O2
  • H donors: 0 H acceptors: 4 LogP: 5.51 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)c1nn(cc1c1cc(nn1c1ccccc1)C)c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C25H18FN5O2/c1-17-15-24(30(27-17)21-5-3-2-4-6-21)23-16-29(20-11-13-22(14-12-20)31(32)33)28-25(23)18-7-9-19(26)10-8-18/h2-16H,1H3
  • InChiKey: LBQJZAUGKRBMQP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi TAR-binding protein 0.0058 0.0098 0.093
Trypanosoma brucei phosphoglycerate mutase protein, putative 0.0068 0.0124 0.0121
Echinococcus granulosus jumonji domain containing protein 0.0035 0.0041 0.0038
Loa Loa (eye worm) beta-lactamase 0.0141 0.0305 0.0302
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0124 0.1038
Trichomonas vaginalis set domain proteins, putative 0.0488 0.1169 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0109 0.0109
Brugia malayi phosphoglycerate mutase family protein 0.0068 0.0124 0.1188
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0082 0.2127
Toxoplasma gondii HEAT repeat-containing protein 0.0027 0.002 0.0577
Loa Loa (eye worm) hypothetical protein 0.0068 0.0124 0.0121
Schistosoma mansoni hypothetical protein 0.0046 0.007 0.007
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0165 0.0364 0.0361
Trypanosoma cruzi hypothetical protein, conserved 0.0141 0.0305 0.0302
Plasmodium vivax phosphoglucomutase-2, putative 0.0068 0.0124 0.401
Brugia malayi CXXC zinc finger family protein 0.0032 0.0034 0.0304
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0068 0.0124 0.0121
Trypanosoma brucei importin beta-1 subunit, putative 0.0027 0.002 0.0017
Toxoplasma gondii PHD-finger domain-containing protein 0.0025 0.0016 0.0442
Mycobacterium tuberculosis Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) 0.0068 0.0124 0.0201
Brugia malayi Probable ClpP-like protease 0.0078 0.0148 0.1428
Trypanosoma cruzi glycerolphosphate mutase, putative 0.0068 0.0124 0.0121
Schistosoma mansoni 6-phosphofructokinase 0.4039 1 1
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0068 0.0124 0.0121
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0022 0.0008 0.0042
Giardia lamblia Hypothetical protein 0.2384 0.5883 1
Leishmania major glycerolphosphate mutase, putative 0.0068 0.0124 0.0121
Mycobacterium tuberculosis Conserved hypothetical protein 0.0068 0.0124 0.0201
Trichomonas vaginalis D-aminoacylase, putative 0.0141 0.0305 0.2589
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0098 0.0098
Onchocerca volvulus 0.0068 0.0124 0.0108
Leishmania major phosphoglycerate mutase protein, putative 0.0068 0.0124 0.0121
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.3971 0.983 0.983
Echinococcus granulosus importin subunit beta 1 0.0027 0.002 0.0017
Brugia malayi phosphoglycerate mutase family protein 0.0068 0.0124 0.1188
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0068 0.0124 0.1038
Loa Loa (eye worm) hypothetical protein 0.0068 0.0124 0.0121
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0148 0.0145
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0148 0.4818
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0148 0.4818
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0109 0.0109
Toxoplasma gondii PHD-finger domain-containing protein 0.0025 0.0016 0.0442
Loa Loa (eye worm) hypothetical protein 0.0068 0.0124 0.0121
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0046 0.007 0.0067
Echinococcus multilocularis lysine specific demethylase 5A 0.003 0.0029 0.0026
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0141 0.0305 0.2963
Echinococcus granulosus phosphoglycerate mutase 0.0068 0.0124 0.0121
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0141 0.0305 0.0314
Echinococcus multilocularis phosphoglycerate mutase 0.0068 0.0124 0.0121
Mycobacterium tuberculosis Conserved protein 0.0068 0.0124 0.0201
Leishmania major fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein 0.0068 0.0124 0.0121
Mycobacterium tuberculosis Probable conserved lipoprotein LpqD 0.0068 0.0124 0.0201
Echinococcus granulosus phosphoglycerate mutase 0.0068 0.0124 0.0121
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1723 0.4241 0.4239
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0076 0.0073
Toxoplasma gondii phosphoglycerate mutase 0.0068 0.0124 0.401
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.4039 1 1
Mycobacterium ulcerans beta-lactamase 0.0141 0.0305 0.0314
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0148 0.4484
Mycobacterium tuberculosis Possible penicillin-binding protein 0.09 0.2193 1
Loa Loa (eye worm) hypothetical protein 0.3971 0.983 0.983
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0068 0.0124 0.0121
Plasmodium falciparum phosphoglucomutase-2 0.0068 0.0124 0.8323
Onchocerca volvulus 0.0068 0.0124 0.0108
Mycobacterium tuberculosis Conserved protein 0.0068 0.0124 0.0201
Treponema pallidum phosphoglyceromutase 0.0068 0.0124 0.8082
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0148 0.0148
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0016 0.0013
Schistosoma mansoni hypothetical protein 0.0033 0.0037 0.0037
Mycobacterium tuberculosis Probable hydrolase 0.0141 0.0305 0.1057
Echinococcus multilocularis phosphoglycerate mutase 0.0068 0.0124 0.0121
Echinococcus granulosus PHD finger protein rhinoceros 0.0025 0.0016 0.0013
Onchocerca volvulus 0.0141 0.0305 0.0289
Loa Loa (eye worm) hypothetical protein 0.0141 0.0305 0.0302
Giardia lamblia Hypothetical protein 0.2384 0.5883 1
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.3971 0.983 0.983
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0082 0.0079
Echinococcus multilocularis PHD finger protein rhinoceros 0.0025 0.0016 0.0013
Loa Loa (eye worm) hypothetical protein 0.4039 1 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0148 1
Trypanosoma cruzi hypothetical protein, conserved 0.0141 0.0305 0.0302
Toxoplasma gondii phosphoglycerate mutase family protein 0.0068 0.0124 0.401
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.0068 0.0124 0.0121
Toxoplasma gondii phosphoglycerate mutase family protein 0.0068 0.0124 0.401
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0141 0.0305 0.1057
Schistosoma mansoni hypothetical protein 0.0046 0.007 0.007
Onchocerca volvulus 0.0062 0.0109 0.0093
Entamoeba histolytica hypothetical protein 0.0022 0.0008 0.0008
Brugia malayi RNA binding protein 0.0058 0.0098 0.093
Leishmania major hypothetical protein, conserved 0.0068 0.0124 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0124 0.1038
Echinococcus multilocularis GPCR, family 2 0.0046 0.007 0.0067
Echinococcus multilocularis cpg binding protein 0.0034 0.0038 0.0035
Echinococcus multilocularis importin subunit beta 1 0.0027 0.002 0.0017
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0141 0.0305 0.0305
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein 0.1723 0.4241 0.4239
Schistosoma mansoni phosphoglycerate mutase 0.0068 0.0124 0.0124
Brugia malayi jmjC domain containing protein 0.0081 0.0157 0.1513
Trypanosoma brucei importin beta-1 subunit, putative 0.0027 0.002 0.0017
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0146 0.0318 0.0316
Trypanosoma brucei hypothetical protein, conserved 0.0141 0.0305 0.0302
Echinococcus multilocularis snurportin 1 0.0283 0.0659 0.0656
Schistosoma mansoni phosphoglycerate mutase 0.0068 0.0124 0.0124
Leishmania major hypothetical protein, conserved 0.0068 0.0124 0.0121
Loa Loa (eye worm) latrophilin receptor protein 2 0.0046 0.007 0.0067
Brugia malayi beta-lactamase 0.0141 0.0305 0.2963
Mycobacterium leprae PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) 0.0068 0.0124 0.3624
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0146 0.0318 0.3098
Plasmodium vivax importin-beta 2, putative 0.0027 0.002 0.0577
Toxoplasma gondii ABC1 family protein 0.0141 0.0305 1
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0068 0.0124 0.0206
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0016 0.0442
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0348 0.082 0.0818
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0068 0.0124 0.0206
Onchocerca volvulus Protein UBASH3A homolog 0.0068 0.0124 0.0108
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.3971 0.983 0.983
Schistosoma mansoni hypothetical protein 0.0068 0.0124 0.0124
Brugia malayi hypothetical protein 0.0033 0.0037 0.0331
Loa Loa (eye worm) phosphoglycerate mutase 0.0068 0.0124 0.0121
Loa Loa (eye worm) jmjC domain-containing protein 0.0032 0.0034 0.0031
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0348 0.082 0.0818
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.0068 0.0124 0.0121
Schistosoma mansoni hypothetical protein 0.0068 0.0124 0.0124
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0068 0.0124 0.0121
Trypanosoma cruzi phosphoglycerate mutase, putative 0.0068 0.0124 0.0121
Loa Loa (eye worm) hypothetical protein 0.0141 0.0305 0.0302
Echinococcus granulosus phosphoglycerate mutase 0.0068 0.0124 0.0121
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.4039 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0058 0.0098 0.0095
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0098 0.0098
Echinococcus multilocularis geminin 0.0863 0.2101 0.2099
Trichomonas vaginalis penicillin-binding protein, putative 0.0141 0.0305 0.2589
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0283 0.0659 0.0656
Mycobacterium tuberculosis Possible hydrolase MutT1 0.0068 0.0124 0.0201
Mycobacterium tuberculosis Probable lipase LipD 0.0141 0.0305 0.1057
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0129 0.0129
Mycobacterium leprae conserved hypothetical protein 0.0068 0.0124 0.3624
Schistosoma mansoni hypothetical protein 0.0863 0.2101 0.2101
Mycobacterium leprae probable isochorismate synthase EntC 0.0068 0.0124 0.3624
Entamoeba histolytica phosphoglycerate mutase family protein. putative 0.0068 0.0124 0.0206
Echinococcus multilocularis tar DNA binding protein 0.0058 0.0098 0.0095
Loa Loa (eye worm) hypothetical protein 0.0078 0.0148 0.0145
Trypanosoma cruzi phosphoglycerate mutase, putative 0.0068 0.0124 0.0121
Mycobacterium tuberculosis Conserved protein 0.0141 0.0305 0.1057
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0068 0.0124 0.1038
Mycobacterium ulcerans hypothetical protein 0.2384 0.5883 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0081 0.0157 0.0154
Schistosoma mansoni hypothetical protein 0.0068 0.0124 0.0124
Plasmodium falciparum phosphoglycerate mutase, putative 0.0068 0.0124 0.8323
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0141 0.0305 0.1057
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0109 0.0106
Mycobacterium leprae Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) 0.0068 0.0124 0.3624
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.0364 0.0361
Brugia malayi UBASH3A protein homolog 0.0068 0.0124 0.1188
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0013
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0148 0.0042
Schistosoma mansoni hypothetical protein 0.0068 0.0124 0.0124
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0148 0.4818
Loa Loa (eye worm) hypothetical protein 0.0141 0.0305 0.0302
Onchocerca volvulus Protein UBASH3A homolog 0.0068 0.0124 0.0108
Leishmania major hypothetical protein, conserved 0.0068 0.0124 0.0121
Giardia lamblia PHD finger protein 15 0.0025 0.0016 0.0023
Schistosoma mansoni jumonji domain containing protein 0.0065 0.0115 0.0115
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0021 0.1257
Mycobacterium leprae PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) 0.0068 0.0124 0.3624
Schistosoma mansoni transcription factor LCR-F1 0.0033 0.0037 0.0037
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0068 0.0124 0.1038
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0141 0.0305 0.1057
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.0068 0.0124 0.0121
Leishmania major mitochondrial DNA polymerase beta 0.0348 0.082 0.0818
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0033 0.0037 0.0034
Mycobacterium leprae conserved hypothetical protein 0.0141 0.0305 1
Entamoeba histolytica hypothetical protein 0.0033 0.0037 0.0057
Leishmania major hypothetical protein, unknown function 0.0068 0.0124 0.0121
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0148 0.5
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0148 0.0042
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.3971 0.983 0.983
Trichomonas vaginalis D-aminoacylase, putative 0.0141 0.0305 0.2589
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0022 0.0008 0.0042
Loa Loa (eye worm) TAR-binding protein 0.0058 0.0098 0.0095
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0111 0.3568
Entamoeba histolytica hypothetical protein 0.0033 0.0037 0.0057
Brugia malayi Pre-SET motif family protein 0.0062 0.0109 0.1041
Leishmania major importin beta-1 subunit, putative 0.0022 0.0008 0.0005
Entamoeba histolytica hypothetical protein 0.0033 0.0037 0.0057
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0098 0.0098
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0076 0.0073
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0017
Brugia malayi beta-lactamase family protein 0.0141 0.0305 0.2963
Loa Loa (eye worm) hypothetical protein 0.0146 0.0318 0.0316
Loa Loa (eye worm) hypothetical protein 0.0141 0.0305 0.0302
Trichomonas vaginalis penicillin-binding protein, putative 0.0141 0.0305 0.2589
Brugia malayi Pre-SET motif family protein 0.0429 0.1022 1
Loa Loa (eye worm) hypothetical protein 0.0141 0.0305 0.0302
Mycobacterium ulcerans lipase LipD 0.0141 0.0305 0.0314
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0076 0.0073
Onchocerca volvulus Protein UBASH3A homolog 0.0068 0.0124 0.0108
Schistosoma mansoni cpg binding protein 0.0034 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0025 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0068 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0141 0.0305 0.0302
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0068 0.0124 0.0121
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.2384 0.5883 1
Toxoplasma gondii phosphoglycerate mutase family protein 0.0068 0.0124 0.401
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0109 0.0106
Onchocerca volvulus Protein UBASH3A homolog 0.0068 0.0124 0.0108
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1723 0.4241 0.4239
Brugia malayi Importin beta-1 subunit 0.0027 0.002 0.0171
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0081 0.0157 0.0154
Echinococcus multilocularis phosphoglycerate mutase 0.0068 0.0124 0.0121
Mycobacterium tuberculosis Conserved protein 0.0141 0.0305 0.1057
Schistosoma mansoni hypothetical protein 0.0046 0.007 0.007
Mycobacterium leprae Probable lipase LipE 0.0141 0.0305 1
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.0068 0.0124 0.0121
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.0103 0.01
Echinococcus multilocularis peregrin 0.0025 0.0016 0.0013
Echinococcus granulosus geminin 0.0863 0.2101 0.2099
Schistosoma mansoni cpg binding protein 0.0034 0.0038 0.0038
Mycobacterium ulcerans hypothetical protein 0.0183 0.041 0.0497
Echinococcus granulosus phosphoglycerate mutase 0.0068 0.0124 0.0121
Onchocerca volvulus 0.0068 0.0124 0.0108
Mycobacterium leprae conserved hypothetical protein 0.0068 0.0124 0.3624
Schistosoma mansoni cpg binding protein 0.0032 0.0034 0.0034
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0148 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0021 0.0606
Trypanosoma brucei Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative 0.0068 0.0124 0.0121
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0005 0.0016
Echinococcus multilocularis beta LACTamase domain containing family member 0.0141 0.0305 0.0302
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0068 0.0124 0.0121
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0068 0.0124 0.0121
Loa Loa (eye worm) hypothetical protein 0.2316 0.5714 0.5712
Brugia malayi Bromodomain containing protein 0.0025 0.0016 0.0131
Schistosoma mansoni ran 0.002 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0068 0.0124 0.0124
Schistosoma mansoni importin beta-1 0.0027 0.002 0.002
Trypanosoma cruzi glycerolphosphate mutase, putative 0.0068 0.0124 0.0121
Trypanosoma brucei glycerolphosphate mutase, putative 0.0068 0.0124 0.0121
Echinococcus multilocularis phosphoglycerate mutase 0.0068 0.0124 0.0121
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0033 0.0037 0.0034
Plasmodium vivax SET domain protein, putative 0.0062 0.0109 0.3512
Toxoplasma gondii phosphoglycerate mutase PGMII 0.0068 0.0124 0.401
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.0068 0.0124 0.0121
Loa Loa (eye worm) hypothetical protein 0.0068 0.0124 0.0121
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0141 0.0305 0.0302
Echinococcus granulosus snurportin 1 0.0283 0.0659 0.0656
Echinococcus granulosus GPCR family 2 0.0046 0.007 0.0067
Loa Loa (eye worm) hypothetical protein 0.0043 0.0061 0.0058
Echinococcus granulosus peregrin 0.0025 0.0016 0.0013
Trichomonas vaginalis D-aminoacylase, putative 0.0141 0.0305 0.2589
Schistosoma mansoni jumonji/arid domain-containing protein 0.0032 0.0034 0.0034
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0068 0.0124 0.0121
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0025 0.0016 0.0016
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0068 0.0124 0.1038
Entamoeba histolytica hypothetical protein 0.0033 0.0037 0.0057
Brugia malayi Latrophilin receptor protein 2 0.0046 0.007 0.0654
Onchocerca volvulus 0.4039 1 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0032 0.0034 0.0034
Brugia malayi RNA recognition motif domain containing protein 0.0058 0.0098 0.093
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0148 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0109 0.0106
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.3316 0.8202 0.8202
Leishmania major phosphoglycerate mutase family member 5, putative 0.0068 0.0124 0.0121
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0076 0.0073
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0034 0.0031
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.0068 0.0124 0.0121
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0148 0.0145
Toxoplasma gondii hypothetical protein 0.0056 0.0094 0.3018
Brugia malayi Calcitonin receptor-like protein seb-1 0.0146 0.0318 0.3098
Mycobacterium tuberculosis Conserved protein 0.0141 0.0305 0.1057
Leishmania major phosphoglycerate mutase, putative 0.0068 0.0124 0.0121
Loa Loa (eye worm) hypothetical protein 0.01 0.0203 0.02
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0068 0.0124 0.0121
Loa Loa (eye worm) hypothetical protein 0.0046 0.007 0.0067
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0098 0.0098
Brugia malayi latrophilin 2 splice variant baaae 0.01 0.0203 0.1967
Schistosoma mansoni hypothetical protein 0.0863 0.2101 0.2101
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0082 0.0079
Leishmania major hypothetical protein, conserved 0.0141 0.0305 0.0302
Echinococcus granulosus beta LACTamase domain containing family member 0.0141 0.0305 0.0302
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.0068 0.0124 0.0121
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0046 0.007 0.0067
Trichomonas vaginalis esterase, putative 0.0141 0.0305 0.2589
Mycobacterium leprae POSSIBLE HYDROLASE MUTT1 0.0068 0.0124 0.3624
Plasmodium vivax phosphoglycerate mutase, putative 0.0068 0.0124 0.401
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0046 0.007 0.0067
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.0364 0.0361
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0109 0.0109
Brugia malayi jmjC domain containing protein 0.0032 0.0034 0.0303
Trypanosoma brucei phosphoglycerate mutase, putative 0.0068 0.0124 0.0121
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0141 0.0305 0.0305
Schistosoma mansoni hypothetical protein 0.0046 0.007 0.007
Schistosoma mansoni hypothetical protein 0.01 0.0203 0.0203
Mycobacterium leprae Possible phosphoglycerate mutase 0.0068 0.0124 0.3624
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1723 0.4241 0.4239
Trypanosoma cruzi importin beta-1 subunit, putative 0.0022 0.0008 0.0005
Brugia malayi beta-lactamase family protein 0.0141 0.0305 0.2963
Toxoplasma gondii phosphoglycerate mutase family protein 0.0068 0.0124 0.401
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0429 0.1022 0.1019
Plasmodium vivax hypothetical protein, conserved 0.0141 0.0305 1
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.0068 0.0124 0.0121
Toxoplasma gondii hypothetical protein 0.0027 0.0021 0.0606
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0068 0.0124 0.1038
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0068 0.0124 0.0121
Brugia malayi PHD-finger family protein 0.0025 0.0016 0.0131
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.4039 1 1
Onchocerca volvulus 0.0141 0.0305 0.0289
Mycobacterium tuberculosis Probable esterase LipL 0.0141 0.0305 0.1057
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0148 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0109 0.0109
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.4039 1 1
Mycobacterium tuberculosis Probable lipase LipE 0.0141 0.0305 0.1057
Mycobacterium tuberculosis Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) 0.0068 0.0124 0.0201
Onchocerca volvulus 0.0488 0.1169 0.1154
Plasmodium falciparum importin beta, putative 0.0027 0.002 0.1198
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0348 0.082 0.0818
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.2384 0.5883 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0046 0.007 0.0654
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0068 0.0124 0.0121
Onchocerca volvulus 0.0141 0.0305 0.0289
Onchocerca volvulus 0.0032 0.0034 0.0018
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0102 0.0099
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0046 0.007 0.0067
Plasmodium falciparum phd finger protein, putative 0.0025 0.0016 0.0917
Mycobacterium leprae conserved hypothetical protein 0.0068 0.0124 0.3624
Mycobacterium ulcerans esterase/lipase LipP 0.0141 0.0305 0.0314
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0109 0.0106
Mycobacterium tuberculosis Glucosyl-3-phosphoglycerate phosphatase GpgP 0.0068 0.0124 0.0201
Echinococcus granulosus lysine specific demethylase 5A 0.0032 0.0034 0.0031
Brugia malayi RNA, U transporter 1 0.0075 0.0142 0.1365
Schistosoma mansoni hypothetical protein 0.0283 0.0659 0.0659
Echinococcus granulosus cpg binding protein 0.0034 0.0038 0.0035
Mycobacterium tuberculosis Conserved hypothetical protein 0.0183 0.041 0.1558
Mycobacterium ulcerans hypothetical protein 0.0141 0.0305 0.0314
Echinococcus multilocularis phosphoglycerate mutase 0.0068 0.0124 0.0121
Echinococcus multilocularis phosphoglycerate mutase 0.0068 0.0124 0.0121
Schistosoma mansoni ran 0.002 0.0003 0.0003
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0109 0.3512
Echinococcus granulosus tar DNA binding protein 0.0058 0.0098 0.0095
Echinococcus multilocularis jumonji domain containing protein 0.0035 0.0041 0.0038
Loa Loa (eye worm) jmjC domain-containing protein 0.0051 0.0082 0.0079
Loa Loa (eye worm) RNA binding protein 0.0058 0.0098 0.0095
Mycobacterium tuberculosis PE-PGRS family protein PE_PGRS11 0.0068 0.0124 0.0201
Trichomonas vaginalis importin beta-1, putative 0.0022 0.0008 0.0042
Echinococcus granulosus phosphoglycerate mutase 0.0068 0.0124 0.0121
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0098 0.0098
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.4039 1 1

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antibacterial activity against Escherichia coli MTCC 1652 at 2 mg/ml after 24 hr by agar well diffusion method ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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