Detailed information for compound 1790437

Basic information

Technical information
  • TDR Targets ID: 1790437
  • Name: (2R,3S,5R)-2-[(Z)-2-bromo-1-chloroethenyl]-5- (2-bromo-1-chloropropan-2-yl)-2-methyloxolan- 3-ol
  • MW: 396.931 | Formula: C10H14Br2Cl2O2
  • H donors: 1 H acceptors: 1 LogP: 2.89 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Br/C=C(/[C@]1(C)O[C@H](C[C@@H]1O)C(CCl)(Br)C)\Cl
  • InChi: 1S/C10H14Br2Cl2O2/c1-9(12,5-13)8-3-7(15)10(2,16-8)6(14)4-11/h4,7-8,15H,3,5H2,1-2H3/b6-4-/t7-,8+,9?,10-/m0/s1
  • InChiKey: KUMNGEFTSKDDEM-VKLHAYQKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R,3S,5R)-5-(1-bromo-2-chloro-1-methyl-ethyl)-2-[(Z)-2-bromo-1-chloro-vinyl]-2-methyl-tetrahydrofuran-3-ol
  • (2R,3S,5R)-5-(1-bromo-2-chloro-1-methylethyl)-2-[(Z)-2-bromo-1-chlorovinyl]-2-methyl-3-tetrahydrofuranol
  • (2R,3S,5R)-2-[(Z)-2-bromo-1-chloro-ethenyl]-5-(2-bromo-1-chloro-propan-2-yl)-2-methyl-oxolan-3-ol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 0.222 0.4749
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0159 0.222 0.5981
Schistosoma mansoni biogenic amine receptor 0.0159 0.222 0.4749
Echinococcus multilocularis g protein coupled receptor 0.0159 0.222 0.5981
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0533 0.114
Brugia malayi Dopamine receptor 0.0159 0.222 0.222
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Brugia malayi hypothetical protein 0.0159 0.222 0.222
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0216 0.0463
Schistosoma mansoni neuropeptide receptor 0.0159 0.222 0.4749
Echinococcus granulosus biogenic amine 5HT receptor 0.0159 0.222 0.5981
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0216 0.0583
Brugia malayi GnHR receptor homolog 0.0159 0.222 0.222
Onchocerca volvulus 0.0052 0.0542 0.1509
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0159 0.222 0.5981
Loa Loa (eye worm) hypothetical protein 0.0031 0.0216 0.0216
Schistosoma mansoni neuropeptide f receptor 76f 0.0159 0.222 0.4749
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.0141 0.1946 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.3122 0.3122
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Brugia malayi Pre-SET motif family protein 0.0031 0.0216 0.0216
Brugia malayi Tachykinin-like peptides receptor 99D 0.0159 0.222 0.222
Brugia malayi AKH receptor 0.0159 0.222 0.222
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0036 0.0098
Brugia malayi hypothetical protein 0.0159 0.222 0.222
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0542 0.0542
Onchocerca volvulus 0.0159 0.222 0.6183
Onchocerca volvulus 0.0159 0.222 0.6183
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.05 0.05
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.0235 0.3422 0.9816
Echinococcus granulosus rhodopsin orphan GPCR 0.0159 0.222 0.5981
Onchocerca volvulus 0.0159 0.222 0.6183
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0159 0.222 0.4749
Echinococcus granulosus allatostatin A receptor 0.0159 0.222 0.5981
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Echinococcus granulosus rhodopsin orphan GPCR 0.0159 0.222 0.5981
Giardia lamblia Hypothetical protein 0.0141 0.1946 1
Echinococcus multilocularis fmrfamide receptor 0.0159 0.222 0.5981
Echinococcus granulosus G protein coupled receptor 139 0.0159 0.222 0.5981
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.024 0.3485 1
Brugia malayi hypothetical protein 0.0159 0.222 0.222
Echinococcus granulosus rhodopsin orphan GPCR 0.0159 0.222 0.5981
Schistosoma mansoni ap endonuclease 0.002 0.0036 0.0078
Brugia malayi hypothetical protein 0.0254 0.3712 0.3712
Brugia malayi G-protein coupled receptor 0.0159 0.222 0.222
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.024 0.3485 0.9388
Loa Loa (eye worm) TYRA-2 protein 0.0159 0.222 0.222
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0116 0.1552 0.4182
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 0.222 0.5981
Echinococcus multilocularis g protein coupled receptor 0.0159 0.222 0.5981
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Onchocerca volvulus 0.0159 0.222 0.6183
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0159 0.222 0.5981
Echinococcus multilocularis neuropeptide receptor A26 0.0159 0.222 0.5981
Echinococcus granulosus 6 phosphofructo 2 kinase:fructose 2 0.024 0.3485 0.9388
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 0.222 0.4749
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Echinococcus granulosus lamin dm0 0.0029 0.0184 0.0495
Brugia malayi hypothetical protein 0.0159 0.222 0.222
Schistosoma mansoni amine GPCR 0.0159 0.222 0.4749
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0036 0.0098
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0198 0.0535
Loa Loa (eye worm) hypothetical protein 0.0051 0.0533 0.0533
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0644 0.1735
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Brugia malayi putative neuropeptide receptor 0.0159 0.222 0.222
Entamoeba histolytica hypothetical protein 0.0116 0.1552 0.7938
Schistosoma mansoni amine GPCR 0.0159 0.222 0.4749
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0159 0.222 0.5981
Brugia malayi hypothetical protein 0.0159 0.222 0.222
Brugia malayi RE15519p 0.0159 0.222 0.222
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.05 0.1347
Echinococcus granulosus neuropeptide FF receptor 2 0.0159 0.222 0.5981
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0184 0.0184
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0533 0.1436
Brugia malayi neuropeptide F receptor 0.0159 0.222 0.222
Loa Loa (eye worm) neuropeptide F receptor 0.0159 0.222 0.222
Schistosoma mansoni myosin xvIII 0.0159 0.222 0.4749
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0159 0.222 0.5981
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0644 0.1378
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0235 0.3422 0.9816
Schistosoma mansoni hypothetical protein 0.0159 0.222 0.4749
Echinococcus granulosus rhodopsin orphan GPCR 0.0159 0.222 0.5981
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0533 0.1484
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0102 0.1332 0.3757
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Onchocerca volvulus 0.0159 0.222 0.6183
Echinococcus granulosus orexin receptor type 2 0.0159 0.222 0.5981
Brugia malayi Pre-SET motif family protein 0.0216 0.3122 0.3122
Echinococcus multilocularis serotonin receptor 0.0159 0.222 0.5981
Brugia malayi G protein-coupled receptor F59B2.13 0.0159 0.222 0.222
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.024 0.3485 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0752 0.2027
Brugia malayi hypothetical protein 0.0159 0.222 0.222
Echinococcus granulosus serotonin receptor 0.0159 0.222 0.5981
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0644 0.1735
Schistosoma mansoni lamin 0.0029 0.0184 0.0393
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0141 0.1946 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0159 0.222 0.5981
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0159 0.222 0.5981
Echinococcus granulosus rhodopsin orphan GPCR 0.0159 0.222 0.5981
Echinococcus granulosus neuropeptide Y receptor 0.0159 0.222 0.5981
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.05 0.1347
Schistosoma mansoni hypothetical protein 0.0315 0.4675 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0216 0.2514
Echinococcus granulosus hypothetical protein 0.0159 0.222 0.5981
Echinococcus granulosus peptide allatostatin:somatostatin 0.0159 0.222 0.5981
Echinococcus granulosus rhodopsin orphan GPCR 0.0159 0.222 0.5981
Trichomonas vaginalis set domain proteins, putative 0.0246 0.3591 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 0.222 0.4749
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0159 0.222 0.222
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0644 0.1735
Echinococcus granulosus lamin 0.0029 0.0184 0.0495
Echinococcus multilocularis G-protein coupled receptor, putative 0.0159 0.222 0.5981
Onchocerca volvulus 0.0159 0.222 0.6183
Schistosoma mansoni survival motor neuron protein 0.0052 0.0542 0.1159
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0159 0.222 0.4749
Onchocerca volvulus 0.024 0.3485 0.9705
Echinococcus granulosus alpha 1A adrenergic receptor 0.0159 0.222 0.5981
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0159 0.222 0.4749
Echinococcus multilocularis g-protein coupled receptor 0.0159 0.222 0.5981
Echinococcus multilocularis neuropeptide Y receptor 0.0159 0.222 0.5981
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0533 0.1436
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0102 0.1332 0.3757
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0533 0.114
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0752 0.1609
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0533 0.1436
Echinococcus granulosus g protein coupled receptor 0.0159 0.222 0.5981
Onchocerca volvulus 0.0031 0.0216 0.0602
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0216 0.0463
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0159 0.222 0.222
Echinococcus multilocularis neuropeptide receptor 0.0159 0.222 0.5981
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0644 0.0644
Loa Loa (eye worm) hypothetical protein 0.024 0.3485 0.3485
Brugia malayi neuropeptide F receptor 0.0159 0.222 0.222
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.0235 0.3422 0.9816
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0159 0.222 0.222
Schistosoma mansoni biogenic amine (5HT) receptor 0.0159 0.222 0.4749
Echinococcus granulosus intermediate filament protein 0.0029 0.0184 0.0495
Giardia lamblia Hypothetical protein 0.0141 0.1946 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.05 0.107
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Brugia malayi Melatonin receptor type 1A 0.0159 0.222 0.222
Echinococcus multilocularis survival motor neuron protein 1 0.0254 0.3712 1
Brugia malayi G protein-coupled receptor 0.0159 0.222 0.222
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 0.222 0.4749
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Loa Loa (eye worm) hypothetical protein 0.0137 0.1883 0.1883
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 0.222 0.5981
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 0.222 0.4749
Echinococcus multilocularis neuropeptide Y receptor 0.0159 0.222 0.5981
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0206 0.2957 0.7966
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.05 0.107
Echinococcus granulosus tm gpcr rhodopsin 0.0159 0.222 0.5981
Onchocerca volvulus 0.0029 0.0184 0.0512
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0216 0.0583
Loa Loa (eye worm) hypothetical protein 0.0235 0.3422 0.3422
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0159 0.222 0.4749
Schistosoma mansoni alpha-1 adrenergic receptor 0.0159 0.222 0.4749
Onchocerca volvulus 0.0159 0.222 0.6183
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Schistosoma mansoni 6-phosphofructokinase 0.024 0.3485 0.7455
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0752 0.2076
Brugia malayi Dopamine receptor protein 2 0.0159 0.222 0.222
Onchocerca volvulus 0.0246 0.3591 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0159 0.222 0.5981
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0159 0.222 0.4749
Brugia malayi hypothetical protein 0.0159 0.222 0.222
Schistosoma mansoni neuropeptide receptor 0.0159 0.222 0.4749
Schistosoma mansoni biogenic amine receptor 0.0159 0.222 0.4749
Echinococcus granulosus tm gpcr rhodopsin 0.0159 0.222 0.5981
Schistosoma mansoni lamin 0.0029 0.0184 0.0393
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Onchocerca volvulus 0.0159 0.222 0.6183
Schistosoma mansoni hypothetical protein 0.0159 0.222 0.4749
Echinococcus granulosus neuropeptide receptor 0.0159 0.222 0.5981
Echinococcus multilocularis g protein coupled receptor 0.0159 0.222 0.5981
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0533 0.0533
Brugia malayi putative neuropeptide receptor NPR1 0.0159 0.222 0.222
Loa Loa (eye worm) neuropeptide F receptor 0.0159 0.222 0.222
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.05 0.107
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 0.222 0.4749
Schistosoma mansoni opsin-like receptor 0.0159 0.222 0.4749
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.05 0.1347
Onchocerca volvulus 0.0159 0.222 0.6183
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0159 0.222 0.4749
Entamoeba histolytica hypothetical protein 0.0116 0.1552 0.7938
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Echinococcus granulosus g-protein coupled receptor 0.0159 0.222 0.5981
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0036 0.5
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Entamoeba histolytica hypothetical protein 0.0116 0.1552 0.7938
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0206 0.2957 0.7966
Onchocerca volvulus 0.0029 0.0184 0.0512
Echinococcus granulosus somatostatin receptor 0.0159 0.222 0.5981
Onchocerca volvulus 0.0159 0.222 0.6183
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.0235 0.3422 0.9816
Onchocerca volvulus 0.0159 0.222 0.6183
Plasmodium vivax SET domain protein, putative 0.0031 0.0216 1
Schistosoma mansoni neuropeptide receptor 0.0159 0.222 0.4749
Onchocerca volvulus 0.0159 0.222 0.6183
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0036 0.0036
Loa Loa (eye worm) melatonin receptor type 1A 0.0159 0.222 0.222
Echinococcus granulosus neuropeptides capa receptor 0.0159 0.222 0.5981
Brugia malayi ORL1-like opioid receptor 0.0159 0.222 0.222
Brugia malayi intermediate filament protein 0.0029 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0159 0.222 0.5981
Schistosoma mansoni intermediate filament proteins 0.0029 0.0184 0.0393
Brugia malayi hypothetical protein 0.0159 0.222 0.222
Echinococcus multilocularis lamin 0.0029 0.0184 0.0495
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0159 0.222 0.4749
Loa Loa (eye worm) MBCTL1 0.0058 0.0644 0.0644
Onchocerca volvulus 0.0159 0.222 0.6183
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0159 0.222 0.5981
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.05 0.05
Echinococcus multilocularis neuropeptide receptor 0.0159 0.222 0.5981
Schistosoma mansoni hypothetical protein 0.0116 0.1552 0.3321
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 0.222 0.4749
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 0.222 0.5981
Echinococcus granulosus neuropeptide receptor 0.0159 0.222 0.5981
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0159 0.222 0.222
Echinococcus granulosus tachykinin peptides receptor 99D 0.0159 0.222 0.5981
Schistosoma mansoni hypothetical protein 0.0159 0.222 0.4749
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0159 0.222 0.5981
Brugia malayi hypothetical protein 0.0159 0.222 0.222
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 0.222 0.4749
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0036 0.5
Brugia malayi Serotonin receptor 0.0159 0.222 0.222
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 0.222 0.5981
Schistosoma mansoni hypothetical protein 0.0052 0.0542 0.1159
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0036 0.5
Echinococcus multilocularis neuropeptide s receptor 0.0159 0.222 0.5981
Echinococcus granulosus neuropeptides capa receptor 0.0159 0.222 0.5981
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0159 0.222 0.4749
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Echinococcus granulosus g protein coupled receptor 0.0159 0.222 0.5981
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0102 0.1332 0.3757
Schistosoma mansoni amine GPCR 0.0159 0.222 0.4749
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 0.222 0.5981
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0752 0.2027
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0159 0.222 0.4749
Echinococcus granulosus 7tm_1 domain containing protein 0.0159 0.222 0.5981
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 0.222 0.5981
Onchocerca volvulus 0.0051 0.0533 0.1484
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 0.222 0.5981
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0116 0.1552 0.4182
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0159 0.222 0.5981
Echinococcus granulosus g protein coupled receptor 0.0159 0.222 0.5981
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Schistosoma mansoni biogenic amine receptor 0.0159 0.222 0.4749
Schistosoma mansoni biogenic amine (5HT) receptor 0.0159 0.222 0.4749
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0159 0.222 0.5981
Onchocerca volvulus Neuropeptide F receptor homolog 0.0159 0.222 0.6183
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0159 0.222 0.6183
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Brugia malayi G-protein coupled receptor 0.0159 0.222 0.222
Brugia malayi larval opioid receptor 0.0159 0.222 0.222
Brugia malayi mbt repeat family protein 0.0051 0.0533 0.0533
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.024 0.3485 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0644 0.1735
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0159 0.222 0.4749
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Schistosoma mansoni amine GPCR 0.0159 0.222 0.4749
Echinococcus granulosus tm gpcr rhodopsin 0.0159 0.222 0.5981
Onchocerca volvulus 0.0159 0.222 0.6183
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0159 0.222 0.4749
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0752 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0159 0.222 0.222
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0216 0.0463
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0533 0.114
Echinococcus granulosus rhodopsin orphan GPCR 0.0159 0.222 0.5981
Onchocerca volvulus 0.0159 0.222 0.6183
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Echinococcus multilocularis orexin receptor type 2 0.0159 0.222 0.5981
Echinococcus granulosus neuropeptide receptor A26 0.0159 0.222 0.5981
Brugia malayi mbt repeat family protein 0.0051 0.0533 0.0533
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein 0.0102 0.1332 0.3757
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0159 0.222 0.4749
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0159 0.222 0.4749
Schistosoma mansoni neuropeptide receptor 0.0159 0.222 0.4749
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0159 0.222 0.5981
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0752 0.3749
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Echinococcus multilocularis rhodopsin orphan GPCR 0.0159 0.222 0.5981
Loa Loa (eye worm) hypothetical protein 0.0028 0.0176 0.0176
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0184 0.0184
Schistosoma mansoni growth hormone secretagogue receptor 0.0159 0.222 0.4749
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0159 0.222 0.222
Echinococcus granulosus dro:myosuppressin receptor 0.0159 0.222 0.5981
Schistosoma mansoni neuropeptide F-like receptor 0.0159 0.222 0.4749
Echinococcus multilocularis allatostatin A receptor 0.0159 0.222 0.5981
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0254 0.3712 0.3712
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0216 0.0463
Echinococcus granulosus neuropeptide s receptor 0.0159 0.222 0.5981
Loa Loa (eye worm) hypothetical protein 0.0029 0.0184 0.0184
Loa Loa (eye worm) G-protein coupled receptor 0.0159 0.222 0.222
Brugia malayi Dopamine receptor protein 1 0.0159 0.222 0.222
Echinococcus multilocularis neuropeptides capa receptor 0.0159 0.222 0.5981
Echinococcus granulosus survival motor neuron protein 1 0.0254 0.3712 1
Echinococcus multilocularis musashi 0.0029 0.0184 0.0495
Echinococcus multilocularis dro:myosuppressin receptor 0.0159 0.222 0.5981
Loa Loa (eye worm) G-protein coupled receptor 0.0159 0.222 0.222
Echinococcus granulosus neuropeptide Y receptor 0.0159 0.222 0.5981
Brugia malayi sulfakinin receptor protein 0.0159 0.222 0.222
Echinococcus multilocularis sex peptide receptor 0.0159 0.222 0.5981
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Schistosoma mansoni histamine h1 receptor 0.0159 0.222 0.4749
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Echinococcus granulosus 7TM GPCR rhodopsin 0.0159 0.222 0.5981
Schistosoma mansoni opsin-like receptor 0.0159 0.222 0.4749
Echinococcus multilocularis somatostatin receptor 0.0159 0.222 0.5981
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.05 0.1347
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0159 0.222 0.4749
Brugia malayi hypothetical protein 0.0159 0.222 0.222
Schistosoma mansoni neuropeptide F-like receptor 0.0159 0.222 0.4749
Echinococcus multilocularis lamin dm0 0.0029 0.0184 0.0495
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0752 0.1609
Schistosoma mansoni transcription factor LCR-F1 0.0116 0.1552 0.3321
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Echinococcus multilocularis fmrfamide receptor 0.0159 0.222 0.5981
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0216 0.0583
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0159 0.222 0.5981
Onchocerca volvulus 0.0159 0.222 0.6183
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0752 0.3749
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0159 0.222 0.5981
Echinococcus multilocularis serotonin receptor 0.0159 0.222 0.5981
Onchocerca volvulus 0.0159 0.222 0.6183
Brugia malayi Serotonin receptor 0.0159 0.222 0.222
Echinococcus multilocularis neuropeptide FF receptor 2 0.0159 0.222 0.5981
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.024 0.3485 1
Schistosoma mansoni hypothetical protein 0.0159 0.222 0.4749
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0159 0.222 0.5981
Schistosoma mansoni amine GPCR 0.0159 0.222 0.4749
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0752 0.3749
Echinococcus multilocularis neuropeptides capa receptor 0.0159 0.222 0.5981
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0159 0.222 0.222
Brugia malayi hypothetical protein 0.0116 0.1552 0.1552
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0159 0.222 0.5981
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0159 0.222 0.222
Mycobacterium ulcerans hypothetical protein 0.0141 0.1946 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0159 0.222 0.5981
Echinococcus multilocularis G protein coupled receptor 139 0.0159 0.222 0.5981
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0533 0.1436
Echinococcus granulosus sex peptide receptor 0.0159 0.222 0.5981
Loa Loa (eye worm) hypothetical protein 0.0058 0.0644 0.0644
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0655 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0159 0.222 0.5981
Echinococcus granulosus fmrfamide receptor 0.0159 0.222 0.5981
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0159 0.222 0.222
Schistosoma mansoni opsin-like receptor 0.0159 0.222 0.4749
Entamoeba histolytica hypothetical protein 0.0116 0.1552 0.7938
Schistosoma mansoni adenoreceptor 0.0159 0.222 0.4749
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0752 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0159 0.222 0.5981
Schistosoma mansoni ap endonuclease 0.002 0.0036 0.0078
Loa Loa (eye worm) hypothetical protein 0.0159 0.222 0.222

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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