Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.1934 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.1901 | 0.9828 | 0.9828 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1934 | 1 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.004 | 0.0007 | 0.0007 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.1934 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.1141 | 0.5819 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1934 | 1 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0107 | 0.0363 | 0.0356 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1901 | 0.9828 | 0.9706 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.0093 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0094 | 0.0094 |
Schistosoma mansoni | jumonji domain containing protein | 0.0085 | 0.0247 | 0.0247 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.0093 | 0.2569 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.004 | 0.0007 | 0.0007 |
Giardia lamblia | Hypothetical protein | 0.1141 | 0.5819 | 0.5 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.1141 | 0.5819 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1934 | 1 | 1 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0045 | 0.0038 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0093 | 0.0093 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.0093 | 0.2569 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0107 | 0.0363 | 0.0356 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0067 | 0.0154 | 0.0154 |
Brugia malayi | jmjC domain containing protein | 0.004 | 0.0007 | 0.0197 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1901 | 0.9828 | 0.9706 |
Giardia lamblia | Hypothetical protein | 0.1141 | 0.5819 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.1934 | 1 | 1 |
Echinococcus granulosus | jumonji domain containing protein | 0.0045 | 0.0038 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.1109 | 0.5647 | 0.5647 |
Loa Loa (eye worm) | hypothetical protein | 0.1934 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1901 | 0.9828 | 0.9706 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1934 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.1901 | 0.9828 | 0.9706 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.004 | 0.0007 | 0.0007 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.1141 | 0.5819 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0107 | 0.0363 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.