Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Cannabinoid CB1 receptor | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.2828 | 0.4946 | 0.321 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.3914 | 0.9706 | 0.9706 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.235 | 0.2852 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.235 | 0.2852 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2828 | 0.4946 | 0.321 |
Loa Loa (eye worm) | TKL/MLK/LZK protein kinase | 0.2828 | 0.4946 | 0.321 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.3914 | 0.9706 | 0.9706 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3914 | 0.9706 | 0.9706 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.3981 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3981 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.235 | 0.2852 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3914 | 0.9706 | 0.9604 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.3914 | 0.9706 | 0.9706 |
Brugia malayi | Protein kinase domain containing protein | 0.2828 | 0.4946 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3981 | 1 | 1 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.235 | 0.2852 | 0.5 |
Onchocerca volvulus | 0.3981 | 1 | 0.5 | |
Mycobacterium ulcerans | hypothetical protein | 0.235 | 0.2852 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3981 | 1 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.3981 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3981 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3981 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 43.9 % | Induction of human CB2 receptor internalization expressed in HEK293 cells at 10 uM relative to CP55940 | ChEMBL. | 24125850 |
Activity (binding) | = 84.7 % | Induction of human CB1 receptor internalization expressed in HEK293 cells at 10 uM relative to CP55940 | ChEMBL. | 24125850 |
Ki (binding) | = 35.4 nM | Displacement of [3H]-CP55940 from human CB2 receptor expressed in HEK293 cells after 1.5 hrs by microbeta liquid scintillation counting analysis | ChEMBL. | 24125850 |
Ki (binding) | = 123 nM | Displacement of [3H]-CP55940 from CB1 receptor in rat brain homogenate after 1.5 hrs by microbeta liquid scintillation counting analysis | ChEMBL. | 24125850 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.