Detailed information for compound 1790612

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 418.958 | Formula: C26H27ClN2O
  • H donors: 1 H acceptors: 1 LogP: 6.93 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCn1c2ccc(cc2c2c1cccc2)C(=O)NCCc1ccc(cc1)Cl
  • InChi: 1S/C26H27ClN2O/c1-2-3-6-17-29-24-8-5-4-7-22(24)23-18-20(11-14-25(23)29)26(30)28-16-15-19-9-12-21(27)13-10-19/h4-5,7-14,18H,2-3,6,15-17H2,1H3,(H,28,30)
  • InChiKey: ZHOSUVSORHKTJV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cannabinoid receptor 2 (macrophage) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.0159 0.0086
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0034 0.011 0.0082
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.1175 0.5877 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0026 0.0026
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0034 0.011 0.0082
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.004 0.004
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0528 0.2607 0.2607
Leishmania major trypanothione reductase 0.005 0.0193 0.0166
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0082 0.0353 0.0353
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0951 0.4749 0.4749
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.0034 0.011 0.0082
Schistosoma mansoni hypothetical protein 0.0038 0.013 0.013
Schistosoma mansoni hypothetical protein 0.0034 0.011 0.011
Schistosoma mansoni hypothetical protein 0.0038 0.013 0.013
Mycobacterium ulcerans hypothetical protein 0.1175 0.5877 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0004 0.0017
Loa Loa (eye worm) intermediate filament protein 0.0032 0.01 0.01
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0034 0.011 0.0082
Schistosoma mansoni hypothetical protein 0.0082 0.0353 0.0353
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.0159 0.0159
Mycobacterium tuberculosis Glucosyl-3-phosphoglycerate phosphatase GpgP 0.0034 0.011 0.1485
Toxoplasma gondii thioredoxin reductase 0.005 0.0193 0.3141
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0017 0.0017
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.0034 0.011 0.0082
Echinococcus multilocularis smad 0.0019 0.0038 0.0038
Toxoplasma gondii phosphoglycerate mutase family protein 0.0034 0.011 0.1563
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0159 1
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.1957 0.983 0.983
Toxoplasma gondii phosphoglycerate mutase family protein 0.0034 0.011 0.1563
Loa Loa (eye worm) hypothetical protein 0.0034 0.011 0.011
Trypanosoma cruzi glycerolphosphate mutase, putative 0.0034 0.011 0.0082
Plasmodium vivax phosphoglycerate mutase, putative 0.0034 0.011 0.4976
Brugia malayi Thioredoxin reductase 0.005 0.0193 0.074
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0043 0.0159 0.0159
Onchocerca volvulus Protein UBASH3A homolog 0.0034 0.011 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0159 1
Trypanosoma brucei trypanothione reductase 0.005 0.0193 0.0166
Echinococcus granulosus Smad4 0.0019 0.0038 0.0038
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.199 1 1
Leishmania major phosphoglycerate mutase protein, putative 0.0034 0.011 0.0082
Echinococcus multilocularis microtubule associated protein 2 0.154 0.7722 0.7722
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0114 0.0517 0.8837
Brugia malayi latrophilin 2 splice variant baaae 0.0081 0.0351 0.1347
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0038 0.013 0.013
Echinococcus granulosus TGF beta signal transducer SmadC 0.0019 0.0038 0.0038
Echinococcus multilocularis cpg binding protein 0.0068 0.0282 0.0282
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.1957 0.983 0.983
Leishmania major fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein 0.0034 0.011 0.0082
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.1175 0.5877 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0019 0.0038 0.0038
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0034 0.011 0.661
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0159 0.0159
Schistosoma mansoni hypothetical protein 0.0206 0.0979 0.0979
Schistosoma mansoni transcription factor LCR-F1 0.0082 0.0353 0.0353
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.0159 0.0159
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0159 0.0132
Mycobacterium tuberculosis Probable conserved lipoprotein LpqD 0.0034 0.011 0.1485
Mycobacterium tuberculosis Conserved protein 0.0034 0.011 0.1485
Leishmania major hypothetical protein, unknown function 0.0034 0.011 0.0082
Brugia malayi phosphoglycerate mutase family protein 0.0034 0.011 0.0422
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0019 0.0038 0.0038
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0849 0.4233 0.4217
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.03 0.518
Echinococcus granulosus phosphoglycerate mutase 0.0034 0.011 0.011
Onchocerca volvulus 0.0034 0.011 0.011
Echinococcus granulosus phosphoglycerate mutase 0.0034 0.011 0.011
Entamoeba histolytica hypothetical protein 0.0082 0.0353 0.0422
Echinococcus multilocularis phosphoglycerate mutase 0.0034 0.011 0.011
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0034 0.011 0.661
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0108 0.0484 0.1857
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0034 0.011 0.0082
Mycobacterium ulcerans bifunctional RNase H/acid phosphatase 0.0034 0.011 0.0141
Mycobacterium tuberculosis PE-PGRS family protein PE_PGRS11 0.0034 0.011 0.1485
Loa Loa (eye worm) MH2 domain-containing protein 0.0285 0.138 0.138
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0034 0.011 0.0082
Brugia malayi Smad1 0.0019 0.0038 0.0147
Echinococcus granulosus survival motor neuron protein 1 0.0528 0.2607 0.2607
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0127 0.0581 1
Schistosoma mansoni phosphoglycerate mutase 0.0034 0.011 0.011
Schistosoma mansoni cpg binding protein 0.0068 0.0282 0.0282
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0849 0.4233 0.4217
Echinococcus granulosus intermediate filament protein 0.0032 0.01 0.01
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.004 0.004
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0081 0.0351 0.0351
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0159 0.0159
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0119 0.0541 0.0541
Leishmania major hypothetical protein, conserved 0.0034 0.011 0.0082
Schistosoma mansoni hypothetical protein 0.0108 0.0484 0.0484
Mycobacterium ulcerans lipoprotein LpqD 0.0034 0.011 0.0141
Trypanosoma cruzi phosphoglycerate mutase, putative 0.0034 0.011 0.0082
Toxoplasma gondii histone lysine methyltransferase SET1 0.0121 0.0554 1
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.199 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0038 0.013 0.013
Schistosoma mansoni hypothetical protein 0.0034 0.011 0.011
Echinococcus granulosus lamin 0.0032 0.01 0.01
Mycobacterium tuberculosis Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) 0.0034 0.011 0.1485
Toxoplasma gondii phosphoglycerate mutase 0.0034 0.011 0.1563
Brugia malayi hypothetical protein 0.0528 0.2607 1
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1957 0.983 0.983
Trypanosoma brucei glycerolphosphate mutase, putative 0.0034 0.011 0.0082
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0021 0.0021
Giardia lamblia Hypothetical protein 0.1175 0.5877 1
Echinococcus multilocularis phosphoglycerate mutase 0.0034 0.011 0.011
Plasmodium falciparum phosphoglycerate mutase, putative 0.0034 0.011 0.4976
Plasmodium falciparum glutathione reductase 0.005 0.0193 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0114 0.0517 0.8837
Schistosoma mansoni survival motor neuron protein 0.0108 0.0484 0.0484
Loa Loa (eye worm) hypothetical protein 0.0034 0.011 0.011
Echinococcus granulosus phosphoglycerate mutase 0.0034 0.011 0.011
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.03 0.03
Brugia malayi MH1 domain containing protein 0.0019 0.0038 0.0147
Onchocerca volvulus Protein UBASH3A homolog 0.0034 0.011 0.011
Echinococcus multilocularis mothers against decapentaplegic 5 0.0019 0.0038 0.0038
Loa Loa (eye worm) glutathione reductase 0.005 0.0193 0.0193
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0849 0.4233 0.4217
Toxoplasma gondii phosphoglycerate mutase family protein 0.0034 0.011 0.1563
Echinococcus multilocularis lamin dm0 0.0032 0.01 0.01
Schistosoma mansoni smad1 5 8 and 0.0019 0.0038 0.0038
Echinococcus granulosus dnaJ subfamily B 0.048 0.2366 0.2366
Mycobacterium ulcerans phosphohistidine phosphatase SixA 0.0034 0.011 0.0141
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.0034 0.011 0.0082
Schistosoma mansoni 6-phosphofructokinase 0.199 1 1
Echinococcus granulosus cpg binding protein 0.0068 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0034 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.1957 0.983 0.983
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.03 0.4923
Echinococcus multilocularis survival motor neuron protein 1 0.0528 0.2607 0.2607
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0114 0.0517 0.8837
Loa Loa (eye worm) hypothetical protein 0.1141 0.5707 0.5707
Schistosoma mansoni hypothetical protein 0.0034 0.011 0.011
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0021 0.0021
Trypanosoma brucei phosphoglycerate mutase, putative 0.0034 0.011 0.0082
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0028 0.0028
Echinococcus multilocularis geminin 0.0206 0.0979 0.0979
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.0159 0.0159
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0038 0.013 0.013
Schistosoma mansoni microtubule-associated protein tau 0.154 0.7722 0.7722
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0034 0.011 0.0082
Brugia malayi CXXC zinc finger family protein 0.0064 0.0264 0.1013
Echinococcus multilocularis musashi 0.0032 0.01 0.01
Plasmodium falciparum thioredoxin reductase 0.005 0.0193 1
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.0034 0.011 0.011
Entamoeba histolytica hypothetical protein 0.0082 0.0353 0.0422
Echinococcus multilocularis lamin 0.0032 0.01 0.01
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.199 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.011 0.011
Schistosoma mansoni cpg binding protein 0.0068 0.0282 0.0282
Onchocerca volvulus 0.0064 0.0264 0.0264
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.199 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.03 0.0466
Schistosoma mansoni hypothetical protein 0.0081 0.0351 0.0351
Loa Loa (eye worm) histone methyltransferase 0.002 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0014
Brugia malayi MH2 domain containing protein 0.0019 0.0038 0.0147
Mycobacterium ulcerans acid phosphatase 0.0034 0.011 0.0141
Loa Loa (eye worm) phosphoglycerate mutase 0.0034 0.011 0.011
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.0159 0.0225
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0028 0.0976
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.03 0.03
Toxoplasma gondii phosphoglycerate mutase family protein 0.0034 0.011 0.1563
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.011 0.661
Schistosoma mansoni cpg binding protein 0.0064 0.0264 0.0264
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.0159 0.0611
Onchocerca volvulus 0.0034 0.011 0.011
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0193 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0064 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.0031 0.0097 0.0097
Schistosoma mansoni smad1 5 8 and 0.0019 0.0038 0.0038
Echinococcus multilocularis GPCR, family 2 0.0038 0.013 0.013
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0114 0.0517 0.8634
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0119 0.0541 0.0541
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.03 0.03
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0136 0.0627 0.0627
Mycobacterium tuberculosis Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) 0.0034 0.011 0.1485
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0034 0.011 0.0082
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0004 0.0017
Echinococcus granulosus microtubule associated protein 2 0.154 0.7722 0.7722
Schistosoma mansoni hypothetical protein 0.048 0.2366 0.2366
Schistosoma mansoni lamin 0.0032 0.01 0.01
Onchocerca volvulus 0.0032 0.01 0.01
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0119 0.0541 0.2077
Leishmania major phosphoglycerate mutase family member 5, putative 0.0034 0.011 0.0082
Plasmodium vivax glutathione reductase, putative 0.005 0.0193 1
Echinococcus granulosus GPCR family 2 0.0038 0.013 0.013
Trypanosoma cruzi glycerolphosphate mutase, putative 0.0034 0.011 0.0082
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0159 0.0159
Mycobacterium ulcerans phosphoglycerate mutase 0.0034 0.011 0.0141
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.03 0.0466
Echinococcus multilocularis dnaJ subfamily B 0.048 0.2366 0.2366
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0028 0.5
Plasmodium falciparum phosphoglucomutase-2 0.0034 0.011 0.4976
Mycobacterium tuberculosis Probable reductase 0.0114 0.0517 0.8837
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0193 0.0193
Schistosoma mansoni phosphoglycerate mutase 0.0034 0.011 0.011
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0028 0.0976
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0034 0.011 0.0082
Onchocerca volvulus Protein UBASH3A homolog 0.0034 0.011 0.011
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0038 0.013 0.013
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0028 0.5
Echinococcus granulosus smad 0.0019 0.0038 0.0038
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.0034 0.011 0.011
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0038 0.013 0.05
Schistosoma mansoni smad1 5 8 and 0.0019 0.0038 0.0038
Brugia malayi intermediate filament protein 0.0032 0.01 0.0384
Mycobacterium ulcerans hypothetical protein 0.0034 0.011 0.0141
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0034 0.011 0.0082
Brugia malayi UBASH3A protein homolog 0.0034 0.011 0.0422
Trypanosoma cruzi phosphoglycerate mutase, putative 0.0034 0.011 0.0082
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0193 0.0193
Echinococcus granulosus lamin dm0 0.0032 0.01 0.01
Schistosoma mansoni hypothetical protein 0.0034 0.011 0.011
Plasmodium vivax phosphoglucomutase-2, putative 0.0034 0.011 0.4976
Echinococcus granulosus geminin 0.0206 0.0979 0.0979
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.03 0.0273
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.011 0.661
Treponema pallidum phosphoglyceromutase 0.0034 0.011 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0019 0.0038 0.0038
Mycobacterium tuberculosis Possible hydrolase MutT1 0.0034 0.011 0.1485
Loa Loa (eye worm) latrophilin receptor protein 2 0.0038 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0014
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0127 0.0581 1
Mycobacterium ulcerans hypothetical protein 0.0034 0.011 0.0141
Schistosoma mansoni hypothetical protein 0.0038 0.013 0.013
Loa Loa (eye worm) Smad1 0.0019 0.0038 0.0038
Brugia malayi phosphoglycerate mutase family protein 0.0034 0.011 0.0422
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.0159 0.0159
Mycobacterium tuberculosis Probable dehydrogenase 0.0114 0.0517 0.8837
Onchocerca volvulus 0.0108 0.0484 0.0484
Leishmania major glycerolphosphate mutase, putative 0.0034 0.011 0.0082
Mycobacterium ulcerans phosphoglyceromutase 0.0034 0.011 0.0141
Trypanosoma brucei Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative 0.0034 0.011 0.0082
Brugia malayi MH2 domain containing protein 0.0019 0.0038 0.0147
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein 0.0849 0.4233 0.4217
Brugia malayi hypothetical protein 0.0082 0.0353 0.1355
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0159 1
Giardia lamblia Hypothetical protein 0.1175 0.5877 1
Brugia malayi Latrophilin receptor protein 2 0.0038 0.013 0.05
Leishmania major hypothetical protein, conserved 0.0034 0.011 0.0082
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.03 0.03
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0021 0.0021
Schistosoma mansoni intermediate filament proteins 0.0032 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0017
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.199 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0082 0.0353 0.0353
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0039 0.015
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.03 0.0466
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.0034 0.011 0.011
Brugia malayi MH1 domain containing protein 0.0019 0.0038 0.0147
Onchocerca volvulus 0.0032 0.01 0.01
Loa Loa (eye worm) transcription factor SMAD2 0.0285 0.138 0.138
Brugia malayi Calcitonin receptor-like protein seb-1 0.0119 0.0541 0.2077
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.0034 0.011 0.0082
Schistosoma mansoni smad 0.0019 0.0038 0.0038
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0193 0.0193
Onchocerca volvulus 0.0034 0.011 0.011
Schistosoma mansoni hypothetical protein 0.0034 0.011 0.011
Trypanosoma brucei phosphoglycerate mutase protein, putative 0.0034 0.011 0.0082
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0034 0.011 0.661
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0028 0.0106
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0034 0.011 0.0082
Schistosoma mansoni hypothetical protein 0.0034 0.011 0.011
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0021 0.0021
Toxoplasma gondii phosphoglycerate mutase PGMII 0.0034 0.011 0.1563
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0159 0.0132
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.1957 0.983 0.983
Schistosoma mansoni Smad4 0.0019 0.0038 0.0038
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.0038 0.0038
Mycobacterium ulcerans phosphoglycerate mutase 0.0034 0.011 0.0141
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.0159 0.0132
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0038 0.013 0.013
Echinococcus granulosus phosphoglycerate mutase 0.0034 0.011 0.011
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0159 0.0132
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0021 0.0021
Echinococcus multilocularis Smad4 0.0019 0.0038 0.0038
Mycobacterium ulcerans hydrolase MutT1 0.0034 0.011 0.0141
Echinococcus multilocularis phosphoglycerate mutase 0.0034 0.011 0.011
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0034 0.011 0.661
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0034 0.011 0.0082
Leishmania major hypothetical protein, conserved 0.0034 0.011 0.0082
Echinococcus multilocularis phosphoglycerate mutase 0.0034 0.011 0.011
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0193 0.0166
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0127 0.0581 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.01 0.01
Brugia malayi MH2 domain containing protein 0.0285 0.138 0.5295
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.01 0.0384
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.01 0.01
Onchocerca volvulus Protein UBASH3A homolog 0.0034 0.011 0.011
Entamoeba histolytica hypothetical protein 0.0082 0.0353 0.0422
Mycobacterium tuberculosis Conserved hypothetical protein 0.0034 0.011 0.1485
Loa Loa (eye worm) hypothetical protein 0.199 1 1
Schistosoma mansoni lamin 0.0032 0.01 0.01
Echinococcus granulosus phosphoglycerate mutase 0.0034 0.011 0.011
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0114 0.0517 0.8837
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0193 0.2985
Onchocerca volvulus 0.199 1 1
Chlamydia trachomatis 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 0.0034 0.011 1
Mycobacterium tuberculosis Conserved protein 0.0034 0.011 0.1485
Entamoeba histolytica hypothetical protein 0.0082 0.0353 0.0422
Schistosoma mansoni hypothetical protein 0.0038 0.013 0.013
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0034 0.011 0.661
Mycobacterium tuberculosis Probable oxidoreductase 0.0127 0.0581 1
Schistosoma mansoni hypothetical protein 0.0206 0.0979 0.0979
Leishmania major phosphoglycerate mutase, putative 0.0034 0.011 0.0082
Echinococcus multilocularis phosphoglycerate mutase 0.0034 0.011 0.011
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.0034 0.011 0.011
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0026 0.0099
Brugia malayi glutathione reductase 0.005 0.0193 0.074
Echinococcus multilocularis phosphoglycerate mutase 0.0034 0.011 0.011

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) Displacement of [3H]-CP55940 from CB1 receptor in rat brain homogenate after 1.5 hrs by microbeta liquid scintillation counting analysis ChEMBL. 24125850
Ki (binding) = 3594 nM Displacement of [3H]-CP55940 from human CB2 receptor expressed in HEK293 cells after 1.5 hrs by microbeta liquid scintillation counting analysis ChEMBL. 24125850

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.