Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2878 | 1 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2878 | 1 | 1 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.2878 | 1 | 1 |
Mycobacterium leprae | POSSIBLE HYDROLASE MUTT1 | 0.0049 | 0 | 0.5 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0049 | 0 | 0.5 |
Mycobacterium tuberculosis | PE-PGRS family protein PE_PGRS11 | 0.0049 | 0 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1228 | 0.4169 | 0.4169 |
Mycobacterium tuberculosis | Possible hydrolase MutT1 | 0.0049 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0049 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.1698 | 0.5831 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2829 | 0.9828 | 0.9828 |
Mycobacterium leprae | Possible phosphoglycerate mutase | 0.0049 | 0 | 0.5 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0049 | 0 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2829 | 0.9828 | 0.9828 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0089 | 0.0089 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0089 | 0.0089 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 0.0089 | 0.0089 |
Mycobacterium ulcerans | hypothetical protein | 0.1698 | 0.5831 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.165 | 0.566 | 0.566 |
Mycobacterium tuberculosis | Glucosyl-3-phosphoglycerate phosphatase GpgP | 0.0049 | 0 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.1228 | 0.4169 | 0.4169 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0089 | 0.0089 |
Plasmodium vivax | phosphoglucomutase-2, putative | 0.0049 | 0 | 0.5 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0049 | 0 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2878 | 1 | 1 |
Mycobacterium leprae | PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) | 0.0049 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0089 | 0.0089 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 0.0089 | 0.0089 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1228 | 0.4169 | 0.4169 |
Mycobacterium leprae | PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) | 0.0049 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) | 0.0049 | 0 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.2878 | 1 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0049 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0074 | 0.0089 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1228 | 0.4169 | 0.4169 |
Mycobacterium leprae | conserved hypothetical protein | 0.0049 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 0.0089 | 0.0089 |
Plasmodium falciparum | phosphoglucomutase-2 | 0.0049 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqD | 0.0049 | 0 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2878 | 1 | 1 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.1698 | 0.5831 | 1 |
Onchocerca volvulus | 0.2878 | 1 | 1 | |
Treponema pallidum | phosphoglyceromutase | 0.0049 | 0 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.2829 | 0.9828 | 0.9828 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0049 | 0 | 0.5 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.1698 | 0.5831 | 1 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0049 | 0 | 0.5 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0049 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 0.0089 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.2829 | 0.9828 | 0.9828 |
Toxoplasma gondii | phosphoglycerate mutase | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 0.0089 | 0.0089 |
Plasmodium vivax | phosphoglycerate mutase, putative | 0.0049 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0049 | 0 | 0.5 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0049 | 0 | 0.5 |
Chlamydia trachomatis | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase | 0.0049 | 0 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.2829 | 0.9828 | 0.9828 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0942 | 0.3159 | 0.3159 |
Mycobacterium leprae | conserved hypothetical protein | 0.0049 | 0 | 0.5 |
Mycobacterium leprae | Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) | 0.0049 | 0 | 0.5 |
Plasmodium falciparum | phosphoglycerate mutase, putative | 0.0049 | 0 | 0.5 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0049 | 0 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2878 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0049 | 0 | 0.5 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0049 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0089 | 0.0089 |
Toxoplasma gondii | phosphoglycerate mutase PGMII | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 0.0089 | 0.0089 |
Giardia lamblia | Hypothetical protein | 0.1698 | 0.5831 | 0.5 |
Mycobacterium leprae | probable isochorismate synthase EntC | 0.0049 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0074 | 0.0089 | 1 |
Mycobacterium tuberculosis | Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) | 0.0049 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Neuroprotective activity in differentiated human SH-SY5Y cells assessed as decrease in amyloid beta (1 to 42)-induced neurotoxicity incubated overnight prior to amyloid beta (1 to 42)-stimulation measured after 48 hrs by WST-1 assay | ChEMBL. | 24900591 | |
Inhibition (binding) | Inhibition of HSP90 in human BT474 cells expressing HER2 assessed as increase in HSP90 protein level at 0.5 to 5 uM after 24 hrs by chemiluminescence assay | ChEMBL. | 24900591 | |
Inhibition (binding) | Inhibition of HSP90 in human BT474 cells expressing HER2 assessed as HER2 protein degradation at 0.5 to 25 uM after 24 hrs by chemiluminescence assay | ChEMBL. | 24900591 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.