Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0038 | 0.0038 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0965 | 0.5831 | 1 |
Plasmodium vivax | importin-beta 2, putative | 0.0034 | 0.0038 | 1 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0028 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) | 0.0028 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqD | 0.0028 | 0 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0028 | 0 | 0.5 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0028 | 0 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.1608 | 0.9828 | 0.9828 |
Echinococcus granulosus | snurportin 1 | 0.0361 | 0.2071 | 0.2071 |
Mycobacterium leprae | conserved hypothetical protein | 0.0028 | 0 | 0.5 |
Brugia malayi | RNA, U transporter 1 | 0.0096 | 0.0426 | 1 |
Mycobacterium tuberculosis | Glucosyl-3-phosphoglycerate phosphatase GpgP | 0.0028 | 0 | 0.5 |
Mycobacterium leprae | POSSIBLE HYDROLASE MUTT1 | 0.0028 | 0 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1636 | 1 | 1 |
Mycobacterium tuberculosis | PE-PGRS family protein PE_PGRS11 | 0.0028 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0965 | 0.5831 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1608 | 0.9828 | 0.9828 |
Mycobacterium tuberculosis | Possible hydrolase MutT1 | 0.0028 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) | 0.0028 | 0 | 0.5 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0028 | 0 | 0.5 |
Mycobacterium leprae | Possible phosphoglycerate mutase | 0.0028 | 0 | 0.5 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0034 | 0.0038 | 0.0038 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0034 | 0.0038 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1608 | 0.9828 | 0.9828 |
Echinococcus granulosus | importin subunit beta 1 | 0.0034 | 0.0038 | 0.0038 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0698 | 0.4169 | 0.4169 |
Brugia malayi | Importin beta-1 subunit | 0.0034 | 0.0038 | 0.0902 |
Schistosoma mansoni | 6-phosphofructokinase | 0.1636 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1636 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0965 | 0.5831 | 0.5 |
Mycobacterium leprae | PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) | 0.0028 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0361 | 0.2071 | 0.2071 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0698 | 0.4169 | 0.4169 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.0698 | 0.4169 | 0.4169 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0028 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.1636 | 1 | 1 | |
Plasmodium falciparum | importin beta, putative | 0.0034 | 0.0038 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1636 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0361 | 0.2071 | 0.2071 |
Mycobacterium ulcerans | hypothetical protein | 0.0965 | 0.5831 | 1 |
Schistosoma mansoni | importin beta-1 | 0.0034 | 0.0038 | 0.0038 |
Echinococcus multilocularis | snurportin 1 | 0.0361 | 0.2071 | 0.2071 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0034 | 0.0038 | 0.0038 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1608 | 0.9828 | 0.9828 |
Mycobacterium tuberculosis | Conserved protein | 0.0028 | 0 | 0.5 |
Mycobacterium leprae | Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0938 | 0.566 | 0.566 |
Mycobacterium leprae | conserved hypothetical protein | 0.0028 | 0 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0698 | 0.4169 | 0.4169 |
Mycobacterium leprae | probable isochorismate synthase EntC | 0.0028 | 0 | 0.5 |
Chlamydia trachomatis | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase | 0.0028 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0028 | 0 | 0.5 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0028 | 0 | 0.5 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0965 | 0.5831 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1608 | 0.9828 | 0.9828 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0034 | 0.0038 | 0.0038 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0028 | 0 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1636 | 1 | 1 |
Treponema pallidum | phosphoglyceromutase | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1636 | 1 | 1 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.1636 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 50 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition after 24 hrs by agar microdilution method | ChEMBL. | 24900592 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.