Detailed information for compound 1790992

Basic information

Technical information
  • TDR Targets ID: 1790992
  • Name: 4-(2,5-dimethylphenyl)-1,3-thiazol-2-amine hy drochloride
  • MW: 240.752 | Formula: C11H13ClN2S
  • H donors: 1 H acceptors: 1 LogP: 3.8 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(c1)c1csc(n1)N)C.Cl
  • InChi: 1S/C11H12N2S.ClH/c1-7-3-4-8(2)9(5-7)10-6-14-11(12)13-10;/h3-6H,1-2H3,(H2,12,13);1H
  • InChiKey: QXIOSDBURWNOSL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(2,5-dimethylphenyl)thiazol-2-amine hydrochloride
  • 4-(2,5-dimethylphenyl)-2-thiazolamine hydrochloride
  • [4-(2,5-dimethylphenyl)thiazol-2-yl]amine hydrochloride

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.1085 1
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.1793 0.1743
Schistosoma mansoni tar DNA-binding protein 0.0065 0.351 0.351
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.351 0.6409
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.006 0.0546
Echinococcus multilocularis serine:threonine protein phosphatase PP1 beta 0.001 0.0223 0.0163
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.001 0.0223 0.0163
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0241 0.1329
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.1176 0.8221
Brugia malayi AMP-binding enzyme family protein 0.0024 0.1085 0.1981
Echinococcus granulosus serine:threonine protein phosphatase PP1 beta 0.001 0.0223 0.0163
Echinococcus multilocularis serine:threonine protein phosphatase PP1 isozyme 0.001 0.0223 0.0163
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0218 0.0218
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.1176 0.8221
Echinococcus multilocularis jumonji domain containing 1A 0.001 0.021 0.0151
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.006 0.0514
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0718 0.4846
Brugia malayi TAR-binding protein 0.0065 0.351 0.6409
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.1085 1
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0419 0.38
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0007 0.006 0.0557
Schistosoma mansoni hypothetical protein 0.0175 1 1
Leishmania major hypothetical protein, conserved 0.001 0.021 0.1787
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.021 0.0299
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0007 0.006 0.0514
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-beta catalytic subunit 0.001 0.0223 0.0317
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0419 0.3562
Schistosoma mansoni hypothetical protein 0.0175 1 1
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.1418 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.1085 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0241 0.0181
Leishmania major hypothetical protein, conserved 0.0026 0.1176 1
Echinococcus multilocularis geminin 0.0175 1 1
Schistosoma mansoni protein phosphatase-1 0.001 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0018 0.0718 0.1022
Mycobacterium ulcerans hypothetical protein 0.0024 0.1085 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.006 0.011
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0241 0.0181
Loa Loa (eye worm) hypothetical protein 0.0024 0.1085 0.1544
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.3317 0.4721
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.001 0.021 0.1787
Echinococcus multilocularis JmjC domain containing protein 4 0.001 0.021 0.0151
Schistosoma mansoni tar DNA-binding protein 0.0065 0.351 0.351
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0241 0.1329
Loa Loa (eye worm) hypothetical protein 0.001 0.021 0.0299
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.006 0.0546
Loa Loa (eye worm) hypothetical protein 0.0018 0.0718 0.1022
Schistosoma mansoni DNA helicase recq1 0.001 0.0241 0.0241
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0925 0.6367
Trypanosoma cruzi serine/threonine protein phosphatase catalytic subunit, putative 0.001 0.0223 0.1893
Loa Loa (eye worm) hypothetical protein 0.0007 0.006 0.0086
Toxoplasma gondii histone lysine demethylase JMJD6a 0.001 0.021 0.1104
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.006 0.0514
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0218 0.1849
Giardia lamblia PHD finger protein 15 0.003 0.1418 1
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0007 0.006 0.0514
Schistosoma mansoni protein phosphatase type 1 0.001 0.0223 0.0223
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.006 0.0514
Schistosoma mansoni hypothetical protein 0.001 0.0218 0.0218
Schistosoma mansoni protein phosphatase-1 0.001 0.0223 0.0223
Echinococcus multilocularis protein phosphatase 1 catalytic subunit 0.001 0.0223 0.0163
Echinococcus granulosus peregrin 0.003 0.1418 0.1366
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0241 0.0181
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.001 0.0218 0.1157
Brugia malayi Serine/threonine protein phosphatase PP1-beta catalytic subunit 0.001 0.0223 0.0407
Schistosoma mansoni tar DNA-binding protein 0.0065 0.351 0.351
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0718 0.6617
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.2433 0.2387
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.2433 0.2387
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.1085 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0616 0.4091
Echinococcus multilocularis bloom syndrome protein 0.0025 0.1103 0.1049
Echinococcus granulosus jumonji domain containing protein 0.0042 0.2116 0.2069
Echinococcus granulosus protein phosphatase 1, catalytic subunit, beta isozyme 0.001 0.0223 0.0163
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0241 0.0181
Brugia malayi jmjC domain containing protein 0.001 0.021 0.0384
Loa Loa (eye worm) RecQ helicase 0.0025 0.1103 0.157
Loa Loa (eye worm) hypothetical protein 0.003 0.1418 0.2018
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.006 0.0546
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.006 0.0546
Schistosoma mansoni tar DNA-binding protein 0.0065 0.351 0.351
Loa Loa (eye worm) RNA binding protein 0.0065 0.351 0.4995
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.1103 0.2015
Schistosoma mansoni phd/f-box containing protein 0.001 0.021 0.021
Schistosoma mansoni DNA helicase recq5 0.001 0.0241 0.0241
Echinococcus multilocularis phd:f box containing protein 0.001 0.021 0.0151
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0241 0.0151
Loa Loa (eye worm) hypothetical protein 0.0024 0.1085 0.1544
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.1176 0.8221
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.001 0.0218 0.1157
Brugia malayi RNA binding protein 0.0065 0.351 0.6409
Brugia malayi jmjC domain containing protein 0.001 0.021 0.0384
Brugia malayi AMP-binding enzyme family protein 0.0007 0.006 0.011
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.001 0.0223 0.0163
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0718 0.6421
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.1085 1
Brugia malayi hypothetical protein 0.0017 0.063 0.1151
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.1085 1
Brugia malayi jmjC domain containing protein 0.001 0.021 0.0384
Trichomonas vaginalis bsu-protein phosphatase, putative 0.001 0.0223 0.2019
Plasmodium falciparum JmjC domain-containing protein, putative 0.001 0.021 0.1104
Plasmodium vivax serine/threonine protein phosphatase PP1, putative 0.001 0.0223 0.1196
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.1085 1
Brugia malayi jmjC domain containing protein 0.0036 0.1793 0.3275
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.006 0.0514
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.1176 0.8221
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0218 0.1849
Leishmania major serine/threonine protein phosphatase catalytic subunit, putative 0.001 0.0223 0.1893
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.1085 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.2433 0.2387
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.006 0.0086
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.001 0.021 0.0151
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.5476 0.5448
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.001 0.021 0.1787
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.006 0.0514
Schistosoma mansoni phosphatidylserine receptor 0.001 0.021 0.021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0659 0.6071
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.006 0.006
Brugia malayi jmjC domain containing protein 0.001 0.021 0.0384
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.351 0.4995
Brugia malayi AMP-binding enzyme family protein 0.0024 0.1085 0.1981
Loa Loa (eye worm) hypothetical protein 0.0007 0.006 0.0086
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.1418 0.1366
Brugia malayi AMP-binding enzyme family protein 0.0007 0.006 0.011
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0007 0.006 0.0514
Echinococcus multilocularis peregrin 0.003 0.1418 0.1366
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0419 0.3562
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0659 0.6071
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0659 0.6071
Brugia malayi Bromodomain containing protein 0.003 0.1418 0.259
Loa Loa (eye worm) hypothetical protein 0.001 0.0218 0.031
Brugia malayi AMP-binding enzyme family protein 0.0024 0.1085 0.1981
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0628 0.4177
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0241 0.0343
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.1793 0.1743
Toxoplasma gondii serine/threonine phosophatase PP1 0.001 0.0223 0.1196
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0419 0.3562
Brugia malayi AMP-binding enzyme family protein 0.0007 0.006 0.011
Brugia malayi PHD-finger family protein 0.003 0.1418 0.259
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0218 0.0397
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.006 0.0546
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.006 0.0546
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.1085 1
Schistosoma mansoni protein phosphatase 2C 0.001 0.021 0.021
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.5476 0.5448
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.006 0.0546
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.006 0.0546
Schistosoma mansoni jumonji domain containing protein 0.001 0.021 0.021
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.021 0.0299
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.006 0.0086
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.1085 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0241 0.044
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.1103 1
Plasmodium vivax hypothetical protein, conserved 0.001 0.0218 0.1157
Schistosoma mansoni protein phosphatase type 1 0.001 0.0223 0.0223
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0326 0.0267
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.2433 0.4443
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.2433 0.2433
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.006 0.011
Plasmodium vivax hypothetical protein, conserved 0.003 0.1418 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.1085 0.1544
Brugia malayi jmjC domain containing protein 0.0098 0.5476 1
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.001 0.0223 0.2019
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.1793 0.1793
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.2433 0.3462
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.1176 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0718 0.1022
Loa Loa (eye worm) oxidoreductase 0.0007 0.006 0.0086
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0718 0.4846
Loa Loa (eye worm) TAR-binding protein 0.0065 0.351 0.4995
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.001 0.021 0.1787
Loa Loa (eye worm) PHD-finger family protein 0.003 0.1418 0.2018
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.006 0.0548
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.1085 0.9221
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.1085 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.001 0.021 0.0151
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0241 0.044
Echinococcus granulosus JmjC domain containing protein 4 0.001 0.021 0.0151
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.2116 0.2069
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0241 0.1329
Loa Loa (eye worm) hypothetical protein 0.001 0.021 0.0299
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0419 0.3863
Echinococcus granulosus tar DNA binding protein 0.0065 0.351 0.347
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.1793 0.1793
Schistosoma mansoni tar DNA-binding protein 0.0065 0.351 0.351
Trichomonas vaginalis protein phosphatase-1, putative 0.001 0.0223 0.2019
Echinococcus granulosus lysine specific demethylase 6a 0.001 0.021 0.0151
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0718 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.0241 0.0343
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.001 0.021 0.1104
Loa Loa (eye worm) hypothetical protein 0.0026 0.1176 0.1674
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.1176 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.006 0.0546
Loa Loa (eye worm) hypothetical protein 0.001 0.0223 0.0317
Schistosoma mansoni hypothetical protein 0.003 0.1418 0.1418
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.1418 0.1366
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.006 0.0514
Echinococcus granulosus phd:f box containing protein 0.001 0.021 0.0151
Toxoplasma gondii PHD-finger domain-containing protein 0.001 0.0218 0.1157
Echinococcus granulosus bloom syndrome protein 0.0025 0.1103 0.1049
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.1085 0.9221
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.1085 1
Brugia malayi Serine/threonine protein phosphatase F56C9.1 in chromosomeIII 0.001 0.0223 0.0407
Loa Loa (eye worm) hypothetical protein 0.0125 0.7026 1
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.001 0.0223 0.0163
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.006 0.0548
Echinococcus granulosus protein phosphatase 1 catalytic subunit 0.001 0.0223 0.0163
Trichomonas vaginalis protein phosphatase, caeel, putative 0.001 0.0223 0.2019
Plasmodium vivax JmjC domain containing protein 0.001 0.021 0.1104
Brugia malayi PHD-finger family protein 0.001 0.0218 0.0397
Schistosoma mansoni jumonji domain containing protein 0.0078 0.4275 0.4275
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.1103 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.001 0.021 0.021
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.1793 0.2552
Loa Loa (eye worm) hypothetical protein 0.0052 0.2692 0.3831
Trichomonas vaginalis bsu-protein phosphatase, putative 0.001 0.0223 0.2019
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.1085 0.9221
Plasmodium falciparum serine/threonine protein phosphatase PP1 0.001 0.0223 0.1196
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.2433 0.2387
Echinococcus multilocularis lysine specific demethylase 6a 0.001 0.021 0.0151
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0659 0.6071
Onchocerca volvulus Alhambra homolog 0.003 0.1418 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.006 0.0546
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.001 0.0223 0.0163
Echinococcus granulosus jumonji domain containing 1A 0.001 0.021 0.0151
Echinococcus multilocularis tar DNA binding protein 0.0065 0.351 0.347
Brugia malayi AMP-binding enzyme family protein 0.0007 0.006 0.011
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.021 0.0299
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0326 0.0267
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.1085 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.1418 0.1418
Plasmodium falciparum phd finger protein, putative 0.003 0.1418 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.006 0.0546
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.2433 0.2433
Schistosoma mansoni hypothetical protein 0.0012 0.0326 0.0326
Loa Loa (eye worm) hypothetical protein 0.0018 0.0718 0.1022
Onchocerca volvulus 0.0024 0.1085 0.7546
Trichomonas vaginalis bsu-protein phosphatase, putative 0.001 0.0223 0.2019
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.1176 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.1085 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.2433 0.2433
Brugia malayi AF-10 protein 0.001 0.0218 0.0397
Loa Loa (eye worm) hypothetical protein 0.0018 0.0718 0.1022
Brugia malayi hypothetical protein 0.0026 0.1176 0.2149
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.1418 1
Trypanosoma brucei protein phosphatase 1, putative 0.001 0.0223 0.1893
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0794 0.0794

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 22.6 % Inhibition of human Arno Sec7 domain-mediated nucleotide exchange in delta17 Arf1 (17 to 181) at 2 mM by BODIPY-GTP based time resolved fluorescence assay relative to control ChEMBL. 24112024

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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