Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | expressed protein | 0.0361 | 0.8069 | 0.8069 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0201 | 0.0201 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0201 | 0.0201 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0019 | 0.0201 | 0.0829 |
Loa Loa (eye worm) | PXA domain-containing protein | 0.0019 | 0.0201 | 0.0201 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0445 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.019 | 0.4138 | 0.4016 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.019 | 0.4138 | 0.4016 |
Echinococcus granulosus | geminin | 0.0164 | 0.3541 | 0.3541 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0437 | 0.9827 | 0.9824 |
Echinococcus granulosus | axis inhibition protein axin | 0.0019 | 0.0201 | 0.0201 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0204 | 0.0204 |
Brugia malayi | MH2 domain containing protein | 0.0115 | 0.2428 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 0.0204 | 0.0134 |
Echinococcus granulosus | A kinase anchor protein 10 mitochondrial | 0.0019 | 0.0201 | 0.0201 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0204 | 0.0134 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0204 | 0.0841 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0204 | 0.0204 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0201 | 0.0829 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0019 | 0.0201 | 0.0201 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0201 | 0.0201 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0204 | 0.0204 |
Schistosoma mansoni | DNA polymerase eta | 0.0019 | 0.0204 | 0.0204 |
Echinococcus multilocularis | geminin | 0.0164 | 0.3541 | 0.3541 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0019 | 0.0201 | 0.0201 |
Giardia lamblia | Hypothetical protein | 0.0262 | 0.581 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0445 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0575 | 0.0666 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.9827 | 0.9827 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0019 | 0.0201 | 0.0201 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.0204 | 0.0204 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0575 | 0.0575 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0201 | 0.0829 |
Schistosoma mansoni | regulator of G protein signaling | 0.0019 | 0.0201 | 0.0201 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0204 | 0.0134 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0201 | 0.0201 |
Echinococcus multilocularis | regulator of G protein signaling | 0.0019 | 0.0201 | 0.0201 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0445 | 1 | 1 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0019 | 0.0201 | 0.0201 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0575 | 0.0666 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0262 | 0.581 | 1 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0019 | 0.0201 | 0.0201 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0575 | 0.0575 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0019 | 0.0201 | 0.0201 |
Brugia malayi | regulator of G-protein signaling rgs-7 | 0.0019 | 0.0201 | 0.0829 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.3541 | 0.3541 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0204 | 0.0134 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0019 | 0.0201 | 0.0201 |
Echinococcus multilocularis | A kinase anchor protein 10, mitochondrial | 0.0019 | 0.0201 | 0.0201 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0019 | 0.0201 | 0.0201 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0019 | 0.0201 | 0.0201 |
Schistosoma mansoni | regulator of G protein signaling | 0.0019 | 0.0201 | 0.0201 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0115 | 0.2428 | 0.2428 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0575 | 0.0666 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0019 | 0.0201 | 0.0201 |
Echinococcus granulosus | dna polymerase eta | 0.0019 | 0.0204 | 0.0204 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0262 | 0.581 | 1 |
Onchocerca volvulus | 0.0445 | 1 | 1 | |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0019 | 0.0201 | 0.0201 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0019 | 0.0201 | 0.0201 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0575 | 0.2367 |
Mycobacterium ulcerans | hypothetical protein | 0.0262 | 0.581 | 1 |
Schistosoma mansoni | regulator of G protein signaling | 0.0019 | 0.0201 | 0.0201 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.0204 | 0.0204 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0204 | 0.0134 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0019 | 0.0201 | 0.0201 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0019 | 0.0201 | 0.0201 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0445 | 1 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.0204 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.0204 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0201 | 0.0201 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.5637 | 0.5637 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0262 | 0.581 | 1 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.0019 | 0.0201 | 0.0829 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0204 | 0.0134 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.0204 | 0.0005 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0019 | 0.0201 | 0.0201 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0204 | 0.0134 |
Echinococcus granulosus | expressed protein | 0.0361 | 0.8069 | 0.8069 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.0204 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0204 | 0.0134 |
Schistosoma mansoni | regulator of G protein signaling | 0.0019 | 0.0201 | 0.0201 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.019 | 0.4138 | 0.4016 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.3541 | 0.3541 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.0204 | 0.0204 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0575 | 0.0575 |
Echinococcus multilocularis | dna polymerase eta | 0.0019 | 0.0204 | 0.0204 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0019 | 0.0201 | 0.0201 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0437 | 0.9827 | 0.9824 |
Echinococcus granulosus | Regulator of G protein signaling 20 | 0.0019 | 0.0201 | 0.0201 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.019 | 0.4138 | 0.4096 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0019 | 0.0201 | 0.0201 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0204 | 0.0841 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0437 | 0.9827 | 0.9826 |
Brugia malayi | A-kinase anchor protein 10, precursor | 0.0019 | 0.0201 | 0.0829 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0437 | 0.9827 | 0.9824 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.0204 | 0.0134 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0445 | 1 | 1 |
Echinococcus multilocularis | Regulator of G protein signaling 20 | 0.0019 | 0.0201 | 0.0201 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0201 | 0.0201 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0204 | 0.0134 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0019 | 0.0201 | 0.0829 |
Echinococcus granulosus | axis inhibition protein axin | 0.0019 | 0.0201 | 0.0201 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0019 | 0.0201 | 0.0201 |
Loa Loa (eye worm) | RGS-3 protein | 0.0019 | 0.0201 | 0.0201 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0204 | 0.0134 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0019 | 0.0201 | 0.0201 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0115 | 0.2428 | 0.2428 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0204 | 0.0134 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0445 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.0204 | 1 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0019 | 0.0201 | 0.0201 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0019 | 0.0201 | 0.0829 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.0204 | 0.0204 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.0204 | 0.0204 |
Schistosoma mansoni | regulator of G protein signaling | 0.0019 | 0.0201 | 0.0201 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0204 | 0.0134 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0204 | 0.0134 |
Brugia malayi | PXA domain containing protein | 0.0019 | 0.0201 | 0.0829 |
Schistosoma mansoni | axis inhibition protein axin | 0.0019 | 0.0201 | 0.0201 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0019 | 0.0201 | 0.0201 |
Schistosoma mansoni | axis inhibition protein axin | 0.0019 | 0.0201 | 0.0201 |
Brugia malayi | PXA domain containing protein | 0.0019 | 0.0201 | 0.0829 |
Schistosoma mansoni | regulator of G protein signaling 3 rgs3 | 0.0019 | 0.0201 | 0.0201 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0575 | 0.0666 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0575 | 0.0575 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0204 | 0.0134 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 90 % | Inhibition of androgen receptor in human LNCAP cells assessed as decrease in TMPRSS2 mRNA expression at 5 uM by RT-PCR analysis relative to control | ChEMBL. | 24044500 |
Inhibition (binding) | = 90 % | Inhibition of androgen receptor in human LNCAP cells assessed as decrease in PSA mRNA expression at 5 uM by RT-PCR analysis relative to control | ChEMBL. | 24044500 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.