Detailed information for compound 1791102

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 321.059 | Formula: C15H11BF3NO3
  • H donors: 2 H acceptors: 2 LogP: 2.65 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)C(F)(F)F)Nc1ccc2c(c1)B(O)OC2
  • InChi: 1S/C15H11BF3NO3/c17-15(18,19)11-4-1-9(2-5-11)14(21)20-12-6-3-10-8-23-16(22)13(10)7-12/h1-7,22H,8H2,(H,20,21)
  • InChiKey: DIYHHCDBZALXPB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear receptor NHR-67 0.0011 0.0006 0.0025
Mycobacterium ulcerans bifunctional RNase H/acid phosphatase 0.0033 0.0119 0.0114
Loa Loa (eye worm) hypothetical protein 0.1927 0.983 0.983
Brugia malayi hypothetical protein 0.0023 0.0067 0.028
Leishmania major hypothetical protein, conserved 0.0033 0.0119 0.0073
Mycobacterium tuberculosis Possible hydrolase MutT1 0.0033 0.0119 1
Mycobacterium tuberculosis Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) 0.0033 0.0119 1
Toxoplasma gondii phosphoglycerate mutase family protein 0.0033 0.0119 0.1298
Schistosoma mansoni phosphoglycerate mutase 0.0033 0.0119 0.0119
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0069 0.0286
Loa Loa (eye worm) hypothetical protein 0.0023 0.0069 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0047 0.0172
Onchocerca volvulus 0.0019 0.0047 0.0041
Loa Loa (eye worm) hypothetical protein 0.007 0.0309 0.0303
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0069 0.0069
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.007 0.0309 0.4702
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0069 0.0063
Echinococcus granulosus dnaJ subfamily B 0.0464 0.233 0.233
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0069 0.0286
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0047 0.0047
Mycobacterium leprae PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) 0.0033 0.0119 1
Brugia malayi conserved hypotetical protein 0.0011 0.0006 0.0025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0047 0.0172
Echinococcus multilocularis cpg binding protein 0.007 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0047
Brugia malayi Cathepsin L-like precursor 0.0019 0.0047 0.0196
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0011 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0069 0.0286
Echinococcus granulosus dna polymerase kappa 0.0022 0.0065 0.0065
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0053 0.4427
Leishmania major cathepsin L-like protease 0.0072 0.0321 0.0275
Echinococcus multilocularis phosphoglycerate mutase 0.0033 0.0119 0.0119
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0015 0.0015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0105 0.0489 0.0489
Mycobacterium tuberculosis Conserved protein 0.0033 0.0119 1
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0047 0.0041
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0065 0.0065
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0065 0.0065
Plasmodium vivax phosphoglycerate mutase, putative 0.0033 0.0119 0.3868
Brugia malayi Cathepsin L-like precursor 0.0019 0.0047 0.0196
Loa Loa (eye worm) hypothetical protein 0.0027 0.0088 0.0082
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0065 0.244
Schistosoma mansoni 6-phosphofructokinase 0.196 1 1
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.196 1 1
Leishmania major hypothetical protein, conserved 0.0033 0.0119 0.0073
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0088 0.5609
Leishmania major cathepsin L-like protease 0.0072 0.0321 0.0275
Echinococcus multilocularis phosphoglycerate mutase 0.0033 0.0119 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0026 0.0096
Leishmania major phosphoglycerate mutase protein, putative 0.0033 0.0119 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0047 0.0172
Loa Loa (eye worm) hypothetical protein 0.0023 0.0069 0.0063
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0105 0.0489 0.0489
Mycobacterium tuberculosis Conserved protein 0.0033 0.0119 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0069 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0026 0.0096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0069 0.0063
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0069 0.0063
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0119 1
Leishmania major phosphoglycerate mutase, putative 0.0033 0.0119 0.0073
Brugia malayi phosphoglycerate mutase family protein 0.0033 0.0119 0.0496
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0069 0.0063
Loa Loa (eye worm) hypothetical protein 0.0023 0.0067 0.0061
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0069 0.0063
Loa Loa (eye worm) hypothetical protein 0.0033 0.0119 0.0114
Mycobacterium tuberculosis Probable conserved lipoprotein LpqD 0.0033 0.0119 1
Echinococcus multilocularis cysteine protease 0.0019 0.0047 0.0047
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.0033 0.0119 0.0119
Brugia malayi Cathepsin L-like precursor 0.0019 0.0047 0.0196
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0047 0.0172
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0013 0.0013
Brugia malayi nuclear hormone receptor 0.0023 0.0069 0.0286
Brugia malayi Doublecortin family protein 0.0023 0.0067 0.028
Mycobacterium leprae conserved hypothetical protein 0.0033 0.0119 1
Mycobacterium leprae Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) 0.0033 0.0119 1
Onchocerca volvulus 0.0019 0.0047 0.0041
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0069 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0069 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0069 0.0286
Brugia malayi cathepsin L-like precursor 0.0013 0.0015 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0026 0.0096
Schistosoma mansoni lipoxygenase 0.0023 0.0067 0.0067
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0088 0.006
Brugia malayi ecdysone receptor 0.0011 0.0006 0.0025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0047 0.0172
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0067 0.0067
Onchocerca volvulus 0.007 0.0309 0.0303
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.0033 0.0119 0.0119
Loa Loa (eye worm) phosphoglycerate mutase 0.0033 0.0119 0.0114
Mycobacterium tuberculosis Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) 0.0033 0.0119 1
Schistosoma mansoni cpg binding protein 0.0066 0.0288 0.0288
Loa Loa (eye worm) fibroinase 0.0019 0.0047 0.0041
Loa Loa (eye worm) hypothetical protein 0.0033 0.0119 0.0114
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0064 0.0279 0.0279
Brugia malayi hypothetical protein 0.0012 0.0013 0.0053
Loa Loa (eye worm) cysteine protease 0.0019 0.0047 0.0041
Onchocerca volvulus 0.0027 0.0088 0.0082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0321 0.0321
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0033 0.0119 0.0119
Onchocerca volvulus 0.0019 0.0047 0.0041
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.1157 0.5881 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0321 0.0321
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0105 0.0489 0.0489
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0047 0.0047
Onchocerca volvulus 0.0023 0.0067 0.0061
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0033 0.0119 0.0203
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0065 0.0269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0047 0.0172
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0013 0.0013
Brugia malayi hypothetical protein 0.0011 0.0006 0.0025
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.0011 0.0011
Brugia malayi hypothetical protein 0.0139 0.0663 0.2751
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0069 0.0069
Brugia malayi Cathepsin L-like precursor 0.0019 0.0047 0.0196
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.0033 0.0119 0.0119
Brugia malayi nuclear receptor RXR 0.0011 0.0006 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0026 0.0096
Brugia malayi steroid hormone receptor 0.0023 0.0069 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0069 0.0286
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0069 0.0069
Echinococcus multilocularis phosphoglycerate mutase 0.0033 0.0119 0.0119
Plasmodium vivax vivapain-2 0.0019 0.0047 0.1529
Mycobacterium leprae conserved hypothetical protein 0.0033 0.0119 1
Brugia malayi tailless protein 0.0011 0.0006 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0007
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0047 0.0041
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0088 0.0041
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0033 0.0119 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0069 0.0286
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0006 0.0025
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0033 0.0119 0.0435
Onchocerca volvulus 0.0023 0.0067 0.0061
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0088 0.0364
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein 0.0836 0.4238 0.4211
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0047 0.0047
Echinococcus granulosus phosphoglycerate mutase 0.0033 0.0119 0.0119
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0047 0.0047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0105 0.0489 0.0489
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.007 0.0309 0.0309
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0065 0.0065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0321 0.0321
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0105 0.0489 0.2029
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0069 0.0069
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0088 0.0364
Loa Loa (eye worm) hypothetical protein 0.0013 0.0015 0.0009
Schistosoma mansoni hypothetical protein 0.0033 0.0119 0.0119
Onchocerca volvulus Protein UBASH3A homolog 0.0033 0.0119 0.0114
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0011 0.0006 0.0006
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0069 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0029 0.0029
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0069 0.0069
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0023 0.0069 0.0063
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0047 0.0172
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0836 0.4238 0.4238
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0047 0.0172
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0047 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0119 0.0435
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0047 0.0172
Onchocerca volvulus 0.196 1 1
Onchocerca volvulus 0.0066 0.0288 0.0282
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0066 0.0289 0.0289
Brugia malayi Pre-SET motif family protein 0.007 0.0309 0.1282
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0065 0.0021
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0067 0.0067
Schistosoma mansoni hypothetical protein 0.0033 0.0119 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0119 0.0435
Loa Loa (eye worm) CXXC zinc finger family protein 0.0066 0.0288 0.0282
Trypanosoma brucei glycerolphosphate mutase, putative 0.0033 0.0119 0.0119
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0069 0.0069
Schistosoma mansoni nuclear receptor nhr-48 0.0011 0.0006 0.0006
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0069 0.0069
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0321 0.0321
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0047 0.0172
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0006 0.0006
Brugia malayi ecdysteroid receptor 0.0023 0.0069 0.0286
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0041
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0006 0.0006
Trypanosoma brucei unspecified product 0.0015 0.0029 0.0029
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0069 0.0069
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0069 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0047 0.0172
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0069 0.0286
Loa Loa (eye worm) histone methyltransferase 0.0023 0.0067 0.0061
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0088 0.0149
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0065 0.0065
Echinococcus multilocularis nuclear receptor nhr 48 0.0011 0.0006 0.0006
Leishmania major fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein 0.0033 0.0119 0.0073
Schistosoma mansoni hypothetical protein 0.0033 0.0119 0.0119
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0047 0.0172
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0069 0.0069
Schistosoma mansoni cpg binding protein 0.007 0.0307 0.0307
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0321 0.0321
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.048 0.2409 0.2405
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0088 0.0149
Trypanosoma brucei unspecified product 0.0015 0.0029 0.0029
Brugia malayi nuclear receptor RXR 0.0012 0.0013 0.0053
Trypanosoma brucei phosphoglycerate mutase protein, putative 0.0033 0.0119 0.0119
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0047 0.0041
Onchocerca volvulus Protein UBASH3A homolog 0.0033 0.0119 0.0114
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0033 0.0119 0.0119
Mycobacterium ulcerans hypothetical protein 0.0033 0.0119 0.0114
Toxoplasma gondii phosphoglycerate mutase family protein 0.0033 0.0119 0.1298
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0047 0.0047
Mycobacterium ulcerans lipoprotein LpqD 0.0033 0.0119 0.0114
Plasmodium vivax vivapain-2 0.0019 0.0047 0.1529
Mycobacterium ulcerans phosphoglycerate mutase 0.0033 0.0119 0.0114
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0088 0.006
Trypanosoma brucei phosphoglycerate mutase, putative 0.0033 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0047
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0066 0.0274
Echinococcus multilocularis phosphoglycerate mutase 0.0033 0.0119 0.0119
Brugia malayi nuclear receptor NHR-88 0.0011 0.0006 0.0025
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0033 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.1124 0.5712 0.5709
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0067 0.0067
Plasmodium falciparum phosphoglycerate mutase, putative 0.0033 0.0119 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0047
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0069 0.0069
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0065 0.0021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0047 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0047 0.0172
Schistosoma mansoni hypothetical protein 0.0033 0.0119 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0069 0.0286
Brugia malayi nuclear receptor NHR-88 0.0023 0.0069 0.0286
Trypanosoma cruzi major cysteine proteinase, putative 0.0057 0.0242 0.0242
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0047 0.0041
Onchocerca volvulus 0.0019 0.0047 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0321 0.0321
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0088 0.006
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0065 0.0065
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0088 0.0041
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0033 0.0119 0.0119
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0065 0.0018
Onchocerca volvulus 0.0033 0.0119 0.0114
Leishmania major phosphoglycerate mutase family member 5, putative 0.0033 0.0119 0.0073
Onchocerca volvulus 0.0033 0.0119 0.0114
Loa Loa (eye worm) hypothetical protein 0.0139 0.0663 0.0657
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0027 0.0088 0.0082
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0047 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0065 0.0065
Echinococcus granulosus thyroid hormone receptor alpha 0.0011 0.0006 0.0006
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0943 0.4785 0.4785
Schistosoma mansoni hypothetical protein 0.0033 0.0119 0.0119
Onchocerca volvulus 0.0019 0.0047 0.0041
Mycobacterium leprae conserved hypothetical protein 0.0033 0.0119 1
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.0067 0.5639
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0088 0.5609
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.196 1 1
Echinococcus multilocularis dna polymerase eta 0.0022 0.0065 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0069 0.0286
Mycobacterium ulcerans hypothetical protein 0.1157 0.5881 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0026 0.0096
Brugia malayi Cathepsin L-like precursor 0.0013 0.0015 0.0062
Schistosoma mansoni nuclear receptor 0.0011 0.0006 0.0006
Mycobacterium tuberculosis PE-PGRS family protein PE_PGRS11 0.0033 0.0119 1
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0069 0.0286
Brugia malayi CXXC zinc finger family protein 0.0066 0.0288 0.1196
Mycobacterium ulcerans hypothetical protein 0.0027 0.0088 0.006
Schistosoma mansoni zinc finger protein 0.0011 0.0006 0.0006
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0069 0.0286
Mycobacterium ulcerans hydrolase MutT1 0.0033 0.0119 0.0114
Onchocerca volvulus 0.0023 0.0069 0.0063
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0065 0.0059
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0007
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0033 0.0119 0.0203
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0088 0.006
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0069 0.0286
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0069 0.0069
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0026 0.0096
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0013 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0069 0.0063
Echinococcus multilocularis cysteine protease 0.0019 0.0047 0.0047
Echinococcus granulosus mixed lineage leukemia protein mll 0.0019 0.0047 0.0047
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.196 1 1
Chlamydia trachomatis 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 0.0033 0.0119 1
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0047 0.0047
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0047 0.008
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0047 0.0047
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0069 0.0069
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0105 0.0489 0.0483
Schistosoma mansoni hypothetical protein 0.0033 0.0119 0.0119
Brugia malayi orphan nuclear receptor NR2E1 0.0011 0.0006 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0069 0.0063
Mycobacterium leprae POSSIBLE HYDROLASE MUTT1 0.0033 0.0119 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0069 0.0069
Brugia malayi nuclear hormone receptor family member odr-7 0.0011 0.0006 0.0025
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0047 0.0047
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0047 0.3954
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0069 0.0063
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0006 0.0025
Loa Loa (eye worm) hypothetical protein 0.0027 0.0088 0.0082
Schistosoma mansoni phosphoglycerate mutase 0.0033 0.0119 0.0119
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0047 0.0172
Loa Loa (eye worm) hypothetical protein 0.0139 0.0663 0.0657
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0033 0.0119 0.0435
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0069 0.0286
Mycobacterium ulcerans acid phosphatase 0.0033 0.0119 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0026 0.0096
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0033 0.0119 0.0119
Mycobacterium leprae probable isochorismate synthase EntC 0.0033 0.0119 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0321 0.0321
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0047 0.0172
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0047 0.0172
Brugia malayi nuclear hormone receptor family member nhr-6 0.0011 0.0006 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0065 0.0065
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0047 0.0047
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0067 0.0067
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0065 0.0065
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0065 0.0065
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0006 0.0006
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0065 0.0236
Brugia malayi Cathepsin L-like cysteine proteinase 0.0013 0.0015 0.0062
Brugia malayi Cathepsin L-like precursor 0.0013 0.0015 0.0062
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0143 0.068 0.068
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0069 0.0069
Echinococcus granulosus cathepsin l1 0.0019 0.0047 0.0047
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0006 0.0006
Trypanosoma cruzi phosphoglycerate mutase, putative 0.0033 0.0119 0.0119
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0047 0.0047
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0026 0.0096
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.0033 0.0119 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0065 0.0065
Brugia malayi nuclear hormone receptor 0.0011 0.0006 0.0025
Brugia malayi Cathepsin L-like precursor 0.0019 0.0047 0.0196
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0069 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0047 0.0172
Onchocerca volvulus Protein UBASH3A homolog 0.0033 0.0119 0.0114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0047 0.0172
Mycobacterium tuberculosis Glucosyl-3-phosphoglycerate phosphatase GpgP 0.0033 0.0119 1
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0033 0.0119 0.0435
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0011 0.0006 0.0006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0105 0.0489 0.0489
Schistosoma mansoni hypothetical protein 0.0464 0.233 0.233
Brugia malayi hypothetical protein 0.0012 0.0013 0.0053
Echinococcus granulosus cpg binding protein 0.007 0.0307 0.0307
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0033 0.0119 0.0119
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0088 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0321 0.0321
Loa Loa (eye worm) hypothetical protein 0.0033 0.0119 0.0114
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.0015 0.0026
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0069 0.0069
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0013 0.0007
Leishmania major DNA polymerase kappa, putative 0.0022 0.0065 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0069 0.0286
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0321 0.0321
Loa Loa (eye worm) ctsf protein 0.0019 0.0047 0.0041
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0105 0.0489 0.0489
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0088 0.0149
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.007 0.0309 0.0309
Toxoplasma gondii histone lysine methyltransferase SET1 0.0128 0.0604 1
Schistosoma mansoni coup transcription factor 0.0023 0.0069 0.0069
Giardia lamblia Hypothetical protein 0.1157 0.5881 1
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0067 0.0061
Echinococcus multilocularis dnaJ subfamily B 0.0464 0.233 0.233
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0069 0.0069
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.0069 0.0063
Toxoplasma gondii phosphoglycerate mutase family protein 0.0033 0.0119 0.1298
Schistosoma mansoni rab6-interacting 0.0023 0.0067 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0047 0.0172
Mycobacterium ulcerans phosphoglycerate mutase 0.0033 0.0119 0.0114
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0321 0.0321
Schistosoma mansoni DNA polymerase eta 0.0022 0.0065 0.0065
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0065 0.011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0069 0.0069
Echinococcus granulosus phosphoglycerate mutase 0.0033 0.0119 0.0119
Onchocerca volvulus 0.0019 0.0047 0.0041
Schistosoma mansoni rab6-interacting 0.0023 0.0067 0.0067
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0836 0.4238 0.4238
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0065 0.0065
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0065 0.0065
Echinococcus multilocularis phosphoglycerate mutase 0.0033 0.0119 0.0119
Mycobacterium leprae Possible phosphoglycerate mutase 0.0033 0.0119 1
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0069 0.0069
Plasmodium falciparum phosphoglucomutase-2 0.0033 0.0119 1
Onchocerca volvulus 0.0033 0.0119 0.0114
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.0033 0.0119 0.0119
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0065 0.244
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0015 0.0055
Echinococcus granulosus phosphoglycerate mutase 0.0033 0.0119 0.0119
Trypanosoma brucei unspecified product 0.0022 0.0065 0.0065
Brugia malayi hypothetical protein 0.0011 0.0006 0.0025
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0088 0.006
Mycobacterium ulcerans phosphohistidine phosphatase SixA 0.0033 0.0119 0.0114
Schistosoma mansoni cpg binding protein 0.007 0.0307 0.0307
Onchocerca volvulus 0.0019 0.0047 0.0041
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0033 0.0119 0.0119
Echinococcus granulosus dna polymerase eta 0.0022 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0023 0.0067 0.0067
Toxoplasma gondii phosphoglycerate mutase PGMII 0.0033 0.0119 0.1298
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0065 0.0065
Trypanosoma brucei Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative 0.0033 0.0119 0.0119
Leishmania major glycerolphosphate mutase, putative 0.0033 0.0119 0.0073
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0013 0.0013
Brugia malayi phosphoglycerate mutase family protein 0.0033 0.0119 0.0496
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0321 0.0321
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0069 0.0069
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0026 0.0096
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.0321 0.0321
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0065 0.0065
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0065 0.0065
Trypanosoma cruzi phosphoglycerate mutase, putative 0.0033 0.0119 0.0119
Plasmodium vivax SET domain protein, putative 0.007 0.0309 1
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0836 0.4238 0.4238
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0069 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0015 0.0055
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.1927 0.983 0.983
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0026 0.0096
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0007
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0053 0.078
Echinococcus granulosus neuropeptide s receptor 0.1063 0.5398 0.5398
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0026 0.0096
Mycobacterium leprae PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) 0.0033 0.0119 1
Trypanosoma cruzi glycerolphosphate mutase, putative 0.0033 0.0119 0.0119
Schistosoma mansoni nuclear receptor 0.0011 0.0006 0.0006
Mycobacterium ulcerans hypothetical protein 0.0033 0.0119 0.0114
Mycobacterium ulcerans phosphoglyceromutase 0.0033 0.0119 0.0114
Leishmania major hypothetical protein, conserved 0.0033 0.0119 0.0073
Echinococcus granulosus phosphoglycerate mutase 0.0033 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.196 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0047 0.0172
Loa Loa (eye worm) hypothetical protein 0.0023 0.0067 0.0061
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0033 0.0119 0.0119
Echinococcus granulosus phosphoglycerate mutase 0.0033 0.0119 0.0119
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0105 0.0489 0.0489
Onchocerca volvulus 0.0546 0.2748 0.2744
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0065 0.0236
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0066 0.0289 0.0289
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0013 0.0015 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0069 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0026 0.0096
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0007
Echinococcus granulosus RUN 0.0023 0.0067 0.0067
Leishmania major DNA polymerase eta, putative 0.0022 0.0065 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0065 0.0065
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0053 0.1712
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.007 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0007
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0069 0.0069
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0013 0.0053
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.0067 0.2181
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0006 0.0006
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.0033 0.0119 0.0119
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0026 0.0096
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0019 0.0047 0.0047
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0033 0.0119 0.0119
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.1157 0.5881 1
Entamoeba histolytica phosphoglycerate mutase family protein. putative 0.0033 0.0119 0.0203
Treponema pallidum phosphoglyceromutase 0.0033 0.0119 0.5
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0033 0.0119 0.0435
Loa Loa (eye worm) hypothetical protein 0.0023 0.0069 0.0063
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.196 1 1
Trichomonas vaginalis helicase, putative 0.0015 0.0026 0.0096
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0047 0.0172
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0006 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0065 0.0065
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0047 0.0172
Toxoplasma gondii phosphoglycerate mutase 0.0033 0.0119 0.1298
Schistosoma mansoni polycystin 1-related 0.0023 0.0067 0.0067
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0047 0.0196
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0065 0.0065
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0069 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0029 0.0029
Echinococcus granulosus nuclear receptor nhr 48 0.0011 0.0006 0.0006
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0013 0.0053
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0069 0.0069
Onchocerca volvulus Huntingtin homolog 0.0139 0.0663 0.0657
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0047 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0047 0.0172
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0011 0.0006 0.0025
Echinococcus multilocularis RUN 0.0023 0.0067 0.0067
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0047 0.3954
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.196 1 1
Brugia malayi Pre-SET motif family protein 0.048 0.2409 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0065 0.0065
Plasmodium vivax phosphoglucomutase-2, putative 0.0033 0.0119 0.3868
Echinococcus granulosus histone lysine methyltransferase setb 0.007 0.0309 0.0309
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.1927 0.983 0.983
Echinococcus multilocularis neuropeptide s receptor 0.1063 0.5398 0.5398
Loa Loa (eye worm) hypothetical protein 0.0033 0.0119 0.0114
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0011 0.0006 0.0006
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.1927 0.983 0.983
Loa Loa (eye worm) hypothetical protein 0.0022 0.0065 0.0059
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0065 0.0065
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.0033 0.0119 0.0119
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0047 0.3954
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0069 0.0069
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0064 0.0279 0.0279
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0011 0.0006 0.0006
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0026 0.0096
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.0033 0.0119 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0065 0.0065
Schistosoma mansoni loxhd1 0.0023 0.0067 0.0067
Entamoeba histolytica cysteine protease, putative 0.0019 0.0047 0.008
Schistosoma mansoni lipoxygenase 0.0064 0.0279 0.0279
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0067 0.0067
Onchocerca volvulus 0.0013 0.0015 0.0009
Toxoplasma gondii phosphoglycerate mutase family protein 0.0033 0.0119 0.1298
Loa Loa (eye worm) hypothetical protein 0.0023 0.0069 0.0063
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0023 0.0069 0.0063
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0033 0.0119 0.0435
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0026 0.0096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0321 0.0321
Loa Loa (eye worm) hypothetical protein 0.0013 0.0015 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0026 0.0096
Brugia malayi Cathepsin L-like precursor 0.0019 0.0047 0.0196
Leishmania major hypothetical protein, unknown function 0.0033 0.0119 0.0073
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0047 0.008
Brugia malayi UBASH3A protein homolog 0.0033 0.0119 0.0496
Giardia lamblia Hypothetical protein 0.1157 0.5881 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0067 0.0067
Trichomonas vaginalis set domain proteins, putative 0.0546 0.2748 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0069 0.0063
Echinococcus multilocularis neuropeptide receptor A26 0.1063 0.5398 0.5398
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.007 0.0309 0.0309
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0069 0.0069
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0026 0.0096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0321 0.0321
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0033 0.0119 0.0119
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0067 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0047 0.0172
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0088 0.0364
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0088 0.0041
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0069 0.0069
Echinococcus granulosus cathepsin l1 0.0013 0.0015 0.0015
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0065 0.0269
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0088 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0029 0.0029
Onchocerca volvulus Protein UBASH3A homolog 0.0033 0.0119 0.0114
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.007 0.0309 0.0309
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0069 0.0286
Trypanosoma cruzi glycerolphosphate mutase, putative 0.0033 0.0119 0.0119
Echinococcus granulosus neuropeptide receptor A26 0.1063 0.5398 0.5398
Brugia malayi hypothetical protein 0.0023 0.0067 0.028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0321 0.0321
Onchocerca volvulus Huntingtin homolog 0.0139 0.0663 0.0657
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0047
Echinococcus multilocularis phosphoglycerate mutase 0.0033 0.0119 0.0119
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0006 0.0006
Leishmania major cathepsin L-like protease 0.0072 0.0321 0.0275
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1927 0.983 0.983
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.007 0.0309 0.0309

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 100 uM Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced IL-6 release incubated for 15 mins prior to LPS-challenge measured after 24 hrs by HTRF assay ChEMBL. 24075731

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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