Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | 0.0225 | 0.0757 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1051 | 0.4169 | 0.4169 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.005 | 0.0034 | 0.0034 |
Treponema pallidum | phosphoglyceromutase | 0.0042 | 0 | 0.5 |
Brugia malayi | hypoxia-induced factor 1 | 0.0146 | 0.0432 | 0.5707 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0225 | 0.0757 | 0.0757 |
Chlamydia trachomatis | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase | 0.0042 | 0 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.005 | 0.0034 | 0.0034 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.0034 | 0.4745 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2464 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0059 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.2464 | 1 | 1 |
Mycobacterium tuberculosis | Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) | 0.0042 | 0 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.1051 | 0.4169 | 0.4169 |
Echinococcus granulosus | hypothetical protein | 0.0058 | 0.0069 | 0.0069 |
Mycobacterium leprae | POSSIBLE HYDROLASE MUTT1 | 0.0042 | 0 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.2422 | 0.9828 | 0.9828 |
Plasmodium vivax | serine/threonine kinase-1, putative | 0.0059 | 0.0073 | 1 |
Giardia lamblia | Hypothetical protein | 0.1454 | 0.5831 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0328 | 0.1183 | 0.1183 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.0483 | 0.0483 |
Trypanosoma brucei | kinetoplastid kinetochore protein 19 | 0.0059 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.1413 | 0.566 | 0.566 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.005 | 0.0034 | 0.0034 |
Mycobacterium tuberculosis | Conserved protein | 0.0042 | 0 | 0.5 |
Brugia malayi | PAS domain containing protein | 0.0047 | 0.0023 | 0.0308 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.005 | 0.0034 | 0.0034 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.0034 | 0.4745 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0059 | 0.0073 | 0.0073 |
Toxoplasma gondii | cell-cycle-associated protein kinase CLK, putative | 0.0059 | 0.0073 | 1 |
Mycobacterium leprae | PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) | 0.0042 | 0 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1051 | 0.4169 | 0.4169 |
Mycobacterium leprae | PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2422 | 0.9828 | 0.9828 |
Mycobacterium ulcerans | hypothetical protein | 0.1454 | 0.5831 | 1 |
Plasmodium falciparum | protein serine/threonine kinase-1 | 0.0059 | 0.0073 | 1 |
Mycobacterium tuberculosis | Glucosyl-3-phosphoglycerate phosphatase GpgP | 0.0042 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC CLK | 0.0059 | 0.0073 | 0.0066 |
Mycobacterium tuberculosis | Possible hydrolase MutT1 | 0.0042 | 0 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 0.0034 | 0.0034 |
Mycobacterium leprae | probable isochorismate synthase EntC | 0.0042 | 0 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.005 | 0.0034 | 0.0034 |
Mycobacterium tuberculosis | Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) | 0.0042 | 0 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2464 | 1 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.2464 | 1 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0042 | 0 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2464 | 1 | 1 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.1454 | 0.5831 | 1 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0146 | 0.0432 | 0.0432 |
Mycobacterium leprae | Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) | 0.0042 | 0 | 0.5 |
Leishmania major | protein kinase, putative | 0.0059 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.005 | 0.0034 | 0.0034 |
Echinococcus granulosus | dual specificity protein kinase clk2 | 0.0059 | 0.0073 | 0.0073 |
Schistosoma mansoni | single-minded | 0.0047 | 0.0023 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0069 | 0.0069 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqD | 0.0042 | 0 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.2422 | 0.9828 | 0.9828 |
Echinococcus multilocularis | tumor protein p63 | 0.0328 | 0.1183 | 0.1183 |
Mycobacterium leprae | conserved hypothetical protein | 0.0042 | 0 | 0.5 |
Echinococcus multilocularis | 0.0058 | 0.0069 | 0.0069 | |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0059 | 0.0073 | 0.0073 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.005 | 0.0034 | 0.0034 |
Brugia malayi | Protein kinase domain containing protein | 0.0059 | 0.0073 | 0.0959 |
Loa Loa (eye worm) | CMGC/CLK protein kinase | 0.0059 | 0.0073 | 0.0073 |
Mycobacterium tuberculosis | PE-PGRS family protein PE_PGRS11 | 0.0042 | 0 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2464 | 1 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0042 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0042 | 0 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.005 | 0.0034 | 0.0034 |
Brugia malayi | hypothetical protein | 0.0159 | 0.0483 | 0.6377 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.2422 | 0.9828 | 0.9828 |
Echinococcus multilocularis | dual specificity protein kinase clk2 | 0.0059 | 0.0073 | 0.0073 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.005 | 0.0034 | 0.4745 |
Schistosoma mansoni | serine/threonine protein kinase | 0.005 | 0.0034 | 0.0034 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.1454 | 0.5831 | 1 |
Leishmania major | protein kinase, putative | 0.0059 | 0.0073 | 0.0073 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0059 | 0.0073 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.005 | 0.0034 | 0.0034 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.2422 | 0.9828 | 0.9828 |
Mycobacterium leprae | Possible phosphoglycerate mutase | 0.0042 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0059 | 0.0073 | 0.0073 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0059 | 0.0073 | 0.0073 |
Brugia malayi | MAP kinase sur-1 | 0.005 | 0.0034 | 0.0455 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.0034 | 0.4745 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 0.0034 | 0.0034 |
Trypanosoma brucei | kinetoplastid kinetochore protein 10 | 0.0059 | 0.0073 | 0.0073 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0047 | 0.0023 | 0.0023 |
Trypanosoma brucei | protein kinase, putative | 0.005 | 0.0034 | 0.0034 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0059 | 0.0073 | 0.0073 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.005 | 0.0034 | 0.0034 |
Mycobacterium tuberculosis | Conserved protein | 0.0042 | 0 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1051 | 0.4169 | 0.4169 |
Giardia lamblia | Hypothetical protein | 0.1454 | 0.5831 | 1 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.2464 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.0034 | 0.4745 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0048 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0027 | 0.0027 |
Onchocerca volvulus | 0.0048 | 0.0027 | 0.0027 | |
Onchocerca volvulus | 0.2464 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 42 % | Inhibition of human ROMK channel-mediated 86Rb+ flux expressed in CHO cells at 30 uM after 35 mins by scintillation counting analysis relative to control | ChEMBL. | 24075732 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.