Detailed information for compound 1791179

Basic information

Technical information
  • TDR Targets ID: 1791179
  • Name: 7-morpholin-4-yl-2-oxochromene-3-carboxylic a cid
  • MW: 275.257 | Formula: C14H13NO5
  • H donors: 1 H acceptors: 3 LogP: 1.95 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1cc2ccc(cc2oc1=O)N1CCOCC1
  • InChi: 1S/C14H13NO5/c16-13(17)11-7-9-1-2-10(8-12(9)20-14(11)18)15-3-5-19-6-4-15/h1-2,7-8H,3-6H2,(H,16,17)
  • InChiKey: KCTFUVGCNPZNQR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-morpholino-2-oxo-chromene-3-carboxylic acid
  • 7-morpholino-2-oxo-3-chromenecarboxylic acid
  • 2-keto-7-morpholino-chromene-3-carboxylic acid
  • 7-morpholin-4-yl-2-oxo-chromene-3-carboxylic acid
  • Oprea1_426676

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 16 (monocarboxylate transporter), member 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Major Facilitator Superfamily protein solute carrier family 16 (monocarboxylate transporter), member 3 465 aa 438 aa 24.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Schistosoma mansoni protein tyrosine kinase 0.0026 0.0038 0.0002
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002
Schistosoma mansoni protein kinase 0.0027 0.004 0.0004
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0027 0.004 0.0004
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0026 0.0038 0.0002
Echinococcus multilocularis transfer RNA-Thr 0.0026 0.0038 0.0002
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0026 0.0038 0.0002
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0026 0.0038 0.0002
Echinococcus granulosus nervana 2 0.0032 0.0075 0.004
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002
Trypanosoma brucei rac serine-threonine kinase, putative 0.0052 0.0199 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0026 0.0038 0.0002
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0033 0.0078 0.0042
Schistosoma mansoni protein kinase 0.0026 0.0038 0.0002
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0038 0.0002
Echinococcus multilocularis tyrosine protein kinase Blk 0.0026 0.0038 0.0002
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0026 0.0038 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0038 0.1897
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0038 0.0002
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Echinococcus multilocularis tyrosine protein kinase csk 0.0026 0.0038 0.0002
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0026 0.0038 0.0002
Schistosoma mansoni protein kinase 0.0026 0.0038 0.0002
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0026 0.0038 0.0002
Echinococcus granulosus tyrosine protein kinase shark 0.0026 0.0038 0.0002
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0026 0.0038 0.0113
Onchocerca volvulus 0.0026 0.0038 1
Echinococcus granulosus epidermal growth factor receptor 0.0026 0.0038 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0038 0.1897
Echinococcus multilocularis protein KINase family member (kin 25) 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Entamoeba histolytica protein kinase domain containing protein 0.0027 0.004 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0038 0.1897
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0033 0.0078 0.6665
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002
Loa Loa (eye worm) TK/CSK protein kinase 0.0026 0.0038 0.0002
Echinococcus multilocularis FL cytokine receptor 0.0026 0.0038 0.0002
Echinococcus multilocularis tyrosine protein kinase Srms 0.0026 0.0038 0.0002
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.004 0.0375
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Echinococcus multilocularis Glutaredoxin protein 5 0.0032 0.0075 0.004
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0026 0.0038 0.0002
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0026 0.0038 0.0002
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0026 0.0038 0.0002
Loa Loa (eye worm) TK protein kinase 0.0026 0.0038 0.0002
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Onchocerca volvulus 0.0026 0.0038 1
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Toxoplasma gondii protein kinase domain-containing protein 0.0026 0.0038 0.0113
Schistosoma mansoni protein kinase 0.0026 0.0038 0.0002
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002
Echinococcus granulosus tyrosine protein kinase Fyn 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0026 0.0038 0.0002
Echinococcus granulosus tyrosine kinase 0.0026 0.0038 0.0002
Onchocerca volvulus 0.0026 0.0038 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0026 0.0038 0.0002
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Onchocerca volvulus 0.0026 0.0038 1
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Echinococcus granulosus c src tyrosine kinase 0.0026 0.0038 0.0002
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.004 0.0375
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0026 0.0038 0.0002
Echinococcus granulosus activated cdc42 kinase 1 0.0026 0.0038 0.0002
Echinococcus multilocularis c src tyrosine kinase 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Echinococcus multilocularis epidermal growth factor receptor 0.0026 0.0038 0.0002
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0038 0.0002
Trypanosoma brucei protein kinase, putative 0.0027 0.004 0.0139
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0026 0.0038 0.0002
Echinococcus granulosus serine/threonine protein kinase 0.0036 0.0098 0.0063
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002
Onchocerca volvulus 0.0026 0.0038 1
Echinococcus granulosus fibroblast growth factor receptor 4 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0026 0.0038 0.1897
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0199 1
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Loa Loa (eye worm) TK protein kinase 0.0026 0.0038 0.0002
Brugia malayi C-terminal src kinase protein 1 0.0026 0.0038 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0038 0.1897
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0032 0.0075 0.004
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0026 0.0038 0.0002
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0026 0.0038 0.0002
Onchocerca volvulus Tyrosine kinase homolog 0.0026 0.0038 1
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Echinococcus granulosus kinase suppressor of Ras 1 0.0026 0.0038 0.0002
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0026 0.0038 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0038 0.1897
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0026 0.0038 0.0002
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0026 0.0038 0.0113
Echinococcus granulosus ephrin type A receptor 4 A 0.0026 0.0038 0.0002
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0038 0.0002
Brugia malayi Immunoglobulin I-set domain containing protein 0.0026 0.0038 0.0002
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.1616 0.9841 1
Loa Loa (eye worm) TK/DDR protein kinase 0.0026 0.0038 0.0002
Echinococcus multilocularis activated cdc42 kinase 1 0.0026 0.0038 0.0002
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0033 0.0078 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0026 0.0038 0.0002
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Onchocerca volvulus 0.0026 0.0038 1
Echinococcus granulosus tyrosine protein kinase Srms 0.0026 0.0038 0.0002
Echinococcus granulosus tyrosine protein kinase ABL1 0.0026 0.0038 0.0002
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0038 0.1897
Schistosoma mansoni protein kinase 0.0027 0.004 0.0004
Loa Loa (eye worm) RGC/RGC protein kinase 0.0026 0.0038 0.0002
Loa Loa (eye worm) protein kinase domain-containing protein 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0026 0.0038 0.0002
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0026 0.0038 0.0002
Loa Loa (eye worm) TK/ACK protein kinase 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Echinococcus granulosus retinal guanylyl cyclase 2 0.0026 0.0038 0.0002
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Echinococcus granulosus receptor type guanylyl cyclase 0.0026 0.0038 0.0002
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Echinococcus granulosus tyrosine protein kinase csk 0.0026 0.0038 0.0002
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0026 0.0038 0.0002
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0199 1
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002
Echinococcus multilocularis integrin linked protein kinase 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0026 0.0038 0.0002
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0026 0.0038 0.0002
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0026 0.0038 0.0002
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0026 0.0038 0.0002
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0002
Echinococcus granulosus tyrosine protein kinase Src42A 0.0026 0.0038 0.0002
Trichomonas vaginalis protein tyrosine kinase, putative 0.0026 0.0038 0.1897
Echinococcus multilocularis tyrosine protein kinase pr2 0.0026 0.0038 0.0002
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0026 0.0038 0.0002
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0026 0.0038 0.0002
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0032 0.0075 0.004
Schistosoma mansoni protein kinase 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Schistosoma mansoni serine/threonine RGC 0.0026 0.0038 0.0002
Giardia lamblia Kinase, AGC PKA 0.0033 0.0078 1
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0026 0.0038 0.0002
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002
Echinococcus granulosus tyrosine protein kinase HCK 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Echinococcus multilocularis kinase suppressor of Ras 1 0.0026 0.0038 0.0002
Onchocerca volvulus 0.0026 0.0038 1
Echinococcus granulosus integrin linked protein kinase 0.0026 0.0038 0.0002
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0038 0.0002
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0026 0.0038 0.0002
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Onchocerca volvulus 0.0026 0.0038 1
Echinococcus granulosus nervana 2 0.0032 0.0075 0.004
Schistosoma mansoni protein kinase 0.0026 0.0038 0.0002
Echinococcus granulosus serine threonine protein kinase nrc 0.0033 0.0078 0.0042
Schistosoma mansoni ephrin receptor 0.0026 0.0038 0.0002
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0026 0.0038 0.0002
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Echinococcus multilocularis tyrosine protein kinase 0.0026 0.0038 0.0002
Echinococcus granulosus tyrosine kinase 0.0026 0.0038 0.0002
Onchocerca volvulus 0.0026 0.0038 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0026 0.0038 0.0002
Loa Loa (eye worm) TK protein kinase 0.0026 0.0038 0.0002
Echinococcus granulosus tyrosine protein kinase Fyn 0.0026 0.0038 0.0002
Echinococcus granulosus retinal guanylyl cyclase 2 0.0026 0.0038 0.0002
Loa Loa (eye worm) TK/EPH protein kinase 0.0026 0.0038 0.0002
Echinococcus granulosus tyrosine protein kinase Src64B 0.0026 0.0038 0.0002
Brugia malayi Guanylyl cyclase protein 23 0.0026 0.0038 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0038 0.0002
Echinococcus granulosus tyrosine kinase 0.0026 0.0038 0.0002
Giardia lamblia Kinase, NEK 0.0026 0.0038 0.039
Giardia lamblia Protein 21.1 0.0026 0.0038 0.039
Brugia malayi Protein kinase domain containing protein 0.1616 0.9841 1
Loa Loa (eye worm) TKL/MLK/LZK protein kinase 0.1616 0.9841 1
Giardia lamblia Kinase, NEK 0.0026 0.0038 0.039
Echinococcus multilocularis raf serine:threonine protein kinase 0.0026 0.0038 0.0002
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0027 0.004 0.0004
Echinococcus multilocularis natriuretic peptide receptor 1 0.0026 0.0038 0.0002
Trichomonas vaginalis STE family protein kinase 0.0026 0.0038 0.1897
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0026 0.0038 0.0002
Brugia malayi protein-tyrosine kinase 0.0026 0.0038 0.0002
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0038 0.0002
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0026 0.0038 0.0002
Brugia malayi p70 ribosomal S6 kinase beta 0.0049 0.0179 0.0146
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Loa Loa (eye worm) TK/ABL protein kinase 0.0026 0.0038 0.0002
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Schistosoma mansoni hypothetical protein 0.0026 0.0038 0.0002
Schistosoma mansoni protein kinase 0.0026 0.0038 0.0002
Loa Loa (eye worm) TK/Met protein kinase 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Echinococcus granulosus tyrosine protein kinase csk 0.0026 0.0038 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0002
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Echinococcus granulosus protein kinase 0.0026 0.0038 0.0002
Loa Loa (eye worm) SRC-1 0.0026 0.0038 0.0002
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0199 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0026 0.0038 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0038 0.0002
Trypanosoma cruzi Protein kinase B 0.0036 0.0098 1
Toxoplasma gondii STE kinase 0.0026 0.0038 0.0113
Entamoeba histolytica PH domain containing protein kinase, putative 0.0036 0.0098 0.3704
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Loa Loa (eye worm) TK protein kinase 0.0026 0.0038 0.0002
Trichomonas vaginalis TK family protein kinase 0.0026 0.0038 0.1897
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0199 1
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0026 0.0038 0.0002
Echinococcus multilocularis tyrosine protein kinase HCK 0.0026 0.0038 0.0002
Echinococcus multilocularis insulin receptor 0.0026 0.0038 0.0002
Giardia lamblia Kinase 0.0026 0.0038 0.039
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Echinococcus multilocularis receptor type guanylyl cyclase 0.0026 0.0038 0.0002
Echinococcus granulosus epidermal growth factor receptor 0.0026 0.0038 0.0002
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0026 0.0038 0.1897
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Echinococcus granulosus retinal guanylyl cyclase 2 0.0026 0.0038 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0002
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0038 0.1897
Loa Loa (eye worm) TK protein kinase 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0026 0.0038 0.0002
Brugia malayi hypothetical protein 0.0026 0.0038 0.0002
Loa Loa (eye worm) serine/threonine protein kinase 0.0026 0.0038 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0038 0.1897
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0026 0.0038 1
Brugia malayi hypothetical protein 0.0026 0.0038 0.0002
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0038 0.0002
Onchocerca volvulus 0.0026 0.0038 1
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0049 0.0179 0.0146
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0026 0.0038 0.0002
Echinococcus granulosus Glutaredoxin protein 5 0.0032 0.0075 0.004
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0026 0.0038 0.0002
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0026 0.0038 0.1897
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002
Loa Loa (eye worm) hypothetical protein 0.1615 0.9839 0.9998
Loa Loa (eye worm) TK/ALK protein kinase 0.0026 0.0038 0.0002
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0026 0.0038 0.0002
Entamoeba histolytica protein kinase, putative 0.0052 0.0199 1
Echinococcus multilocularis activin receptor type 0.0027 0.004 0.0004
Loa Loa (eye worm) AGC/AKT protein kinase 0.0052 0.0199 0.0166
Loa Loa (eye worm) RGC/RGC protein kinase 0.0026 0.0038 0.0002
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0026 0.0038 0.0002
Loa Loa (eye worm) TK/EGFR protein kinase 0.0026 0.0038 0.0002
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0026 0.0038 0.0002
Brugia malayi integrin-linked kinase 0.0026 0.0038 0.0002
Brugia malayi Immunoglobulin I-set domain containing protein 0.0026 0.0038 0.0002
Loa Loa (eye worm) TK protein kinase 0.0026 0.0038 0.0002
Onchocerca volvulus 0.0026 0.0038 1
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002
Echinococcus multilocularis epidermal growth factor receptor 0.0026 0.0038 0.0002
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0026 0.0038 0.0002
Leishmania major protein kinase, putative 0.0027 0.004 1
Onchocerca volvulus 0.0026 0.0038 1
Echinococcus multilocularis tyrosine protein kinase shark 0.0026 0.0038 0.0002
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0033 0.0078 1
Brugia malayi Tyrosine-protein kinase PR2 0.0026 0.0038 0.0002
Echinococcus multilocularis tyrosine protein kinase csk 0.0026 0.0038 0.0002
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0026 0.0038 0.0002
Brugia malayi Tyrosine-protein kinase abl-1 0.0026 0.0038 0.0002
Echinococcus multilocularis heat shock protein 70 0.0026 0.0038 0.0002
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0038 0.0002
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0026 0.0038 0.0002
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0026 0.0038 0.0002
Loa Loa (eye worm) TK/ROR protein kinase 0.0026 0.0038 0.0002
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002
Echinococcus multilocularis rac serine:threonine kinase 0.0036 0.0098 0.0063
Loa Loa (eye worm) TK protein kinase 0.0026 0.0038 0.0002
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Echinococcus granulosus tyrosine protein kinase Lyn 0.0027 0.004 0.0004
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Onchocerca volvulus 0.0026 0.0038 1
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0002
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.004 0.0139
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0027 0.004 0.027
Echinococcus multilocularis tyrosine kinase 0.0026 0.0038 0.0002
Loa Loa (eye worm) TK protein kinase 0.0026 0.0038 0.0002
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0026 0.0038 0.0002
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0199 1
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0038 0.0002
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0026 0.0038 0.0002
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Onchocerca volvulus 0.0026 0.0038 1
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0036 0.0098 1
Echinococcus multilocularis nervana 2 0.0032 0.0075 0.004
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0026 0.0038 1
Schistosoma mansoni protein kinase 0.0026 0.0038 0.0002
Loa Loa (eye worm) TK/INSR protein kinase 0.0026 0.0038 0.0002
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0026 0.0038 0.0002
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0026 0.0038 0.0002
Echinococcus multilocularis protein tyrosine kinase 0.0026 0.0038 0.0002
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0026 0.0038 0.0002
Echinococcus granulosus tyrosine protein kinase 0.0026 0.0038 0.0002
Schistosoma mansoni serine/threonine-protein kinase 0.0036 0.0098 0.0062
Echinococcus granulosus insulin receptor 0.0026 0.0038 0.0002
Brugia malayi SRC-1 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Schistosoma mansoni protein kinase 0.0027 0.004 0.0004
Brugia malayi Furin-like cysteine rich region family protein 0.0026 0.0038 0.0002
Plasmodium falciparum protein kinase, putative 0.0027 0.004 0.0562
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0026 0.0038 0.0002
Onchocerca volvulus 0.0026 0.0038 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0002
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0026 0.0038 0.1897
Entamoeba histolytica PH domain containing protein kinase, putative 0.0036 0.0098 0.3704
Toxoplasma gondii protein kinase 0.0026 0.0038 0.0113
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0026 0.0038 0.0002
Brugia malayi Raf kinase 0.0026 0.0038 0.0002
Echinococcus granulosus raf serine:threonine protein kinase 0.0026 0.0038 0.0002
Schistosoma mansoni serine/threonine-protein kinase 0.0036 0.0098 0.0062
Brugia malayi Protein kinase domain containing protein 0.0052 0.0199 0.0166
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Toxoplasma gondii AGC kinase 0.0049 0.0179 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0026 0.0038 0.0002
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0026 0.0038 0.0002
Echinococcus granulosus tyrosine protein kinase pr2 0.0026 0.0038 0.0002
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Brugia malayi SH2 domain containing protein 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0038 0.0002
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002
Brugia malayi Receptor family ligand binding region containing protein 0.0026 0.0038 0.0002
Echinococcus multilocularis nervana 2 0.0032 0.0075 0.004
Brugia malayi bone morphogenetic protein type 1 receptor 0.0026 0.0038 0.0002
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0026 0.0038 0.0002
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0026 0.0038 0.0002
Echinococcus granulosus natriuretic peptide receptor 1 0.0026 0.0038 0.0002
Schistosoma mansoni protein kinase 0.0026 0.0038 0.0002
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0026 0.0038 0.0002
Echinococcus multilocularis protein kinase 0.0026 0.0038 0.0002
Loa Loa (eye worm) TK protein kinase 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Loa Loa (eye worm) hypothetical protein 0.1615 0.9839 0.9998
Echinococcus granulosus activated cdc42 kinase 1 0.0026 0.0038 0.0002
Brugia malayi ephrin receptor 1 precursor 0.0026 0.0038 0.0002
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0033 0.0078 0.0042
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0038 0.0002
Echinococcus multilocularis tyrosine protein kinase csk 0.0026 0.0038 0.0002
Echinococcus multilocularis tyrosine kinase 0.0026 0.0038 0.0002
Schistosoma mansoni ephrin receptor 0.0026 0.0038 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0002
Entamoeba histolytica protein kinase, putative 0.0052 0.0199 1
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002
Entamoeba histolytica protein kinase 2, putative 0.0033 0.0078 0.2469
Echinococcus granulosus activin receptor type 0.0027 0.004 0.0004
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0026 0.0038 0.0002
Entamoeba histolytica protein kinase, putative 0.0049 0.0179 0.8765
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.1616 0.9841 1
Schistosoma mansoni tyrosine protein kinase 0.0026 0.0038 0.0002
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0026 0.0038 0.0002
Loa Loa (eye worm) TK/FAK protein kinase 0.0026 0.0038 0.0002
Brugia malayi SH2 domain containing protein 0.0026 0.0038 0.0002
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0038 0.0002
Loa Loa (eye worm) TK/RYK protein kinase 0.0026 0.0038 0.0002
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0026 0.0038 0.0002
Echinococcus multilocularis protein kinase 0.0026 0.0038 0.0002
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Echinococcus multilocularis tyrosine protein kinase Abl 0.0026 0.0038 0.0002
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0199 1
Trichomonas vaginalis CAMK family protein kinase 0.0026 0.0038 0.1897
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Brugia malayi hypothetical protein 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Echinococcus multilocularis ephrin type A receptor 4 A 0.0026 0.0038 0.0002
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Echinococcus granulosus tyrosine protein kinase csk 0.0026 0.0038 0.0002
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0199 1
Loa Loa (eye worm) TK protein kinase 0.0026 0.0038 0.0002
Echinococcus granulosus protein tyrosine kinase 0.0026 0.0038 0.0002
Trichomonas vaginalis TKL family protein kinase 0.0026 0.0038 0.1897
Trichomonas vaginalis protein kinase atn1, putative 0.0026 0.0038 0.1897
Schistosoma mansoni tyrosine kinase 0.0026 0.0038 0.0002
Brugia malayi Protein kinase domain containing protein 0.0026 0.0038 0.0002

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 17.5 uM Cytotoxicity against human SiHa cells in lactate-containing medium after 72 hrs by MTT assay ChEMBL. 24095010
IC50 (binding) = 7.9 uM Inhibition of MCT4-mediated [14C]-lactate uptake in human SiHa cells in lactate-containing medium assessed as remaining lactate concentration in culture medium after 24 hrs by liquid scintillation counting ChEMBL. 24095010

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 24095010

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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