Detailed information for compound 1791375

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 496.562 | Formula: C31H24N6O
  • H donors: 0 H acceptors: 3 LogP: 5.46 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)n1nc(c(c1)/C=N/n1c(nc2c(c1=O)cccc2)c1ccccc1C)c1ccncc1
  • InChi: 1S/C31H24N6O/c1-21-11-13-25(14-12-21)36-20-24(29(35-36)23-15-17-32-18-16-23)19-33-37-30(26-8-4-3-7-22(26)2)34-28-10-6-5-9-27(28)31(37)38/h3-20H,1-2H3/b33-19+
  • InChiKey: DHPWQTDUORDEGF-HNSNBQBZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi phosphoglycerate mutase family protein 0.004 0.0128 0.0987
Trichomonas vaginalis esterase, putative 0.0067 0.0244 0.2926
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0021 0.0049 0.047
Onchocerca volvulus 0.02 0.0804 0.0758
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0118 0.0458 0.0458
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0067 0.0244 0.1876
Mycobacterium leprae PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) 0.004 0.0128 0.4075
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0039 0.0018
Leishmania major GTP-binding protein, putative 0.0019 0.0041 0.0019
Leishmania major hypothetical protein, conserved 0.004 0.0128 0.0107
Brugia malayi Ets-domain containing protein 0.0067 0.0243 0.1871
Entamoeba histolytica hypothetical protein 0.0021 0.0049 0.0017
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0026 0.007 0.007
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.004 0.0128 0.0107
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.2375 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0067 0.0244 0.2926
Trypanosoma cruzi importin beta-1 subunit, putative 0.0021 0.0049 0.0028
Echinococcus granulosus dnaJ subfamily B 0.0373 0.1536 0.1536
Brugia malayi Importin beta-1 subunit 0.0026 0.007 0.0538
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0022 0.005 0.0039
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0021 0.0021
Entamoeba histolytica hypothetical protein 0.0135 0.0531 0.0841
Loa Loa (eye worm) hypothetical protein 0.0026 0.007 0.007
Echinococcus granulosus sodium:glucose cotransporter 2 0.0035 0.0107 0.0107
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0039 0.0018
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.0027
Plasmodium falciparum phosphoglucomutase-2 0.004 0.0128 1
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.004 0.0128 0.0128
Echinococcus multilocularis L aminoadipate semialdehyde 0.0076 0.0279 0.0279
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0021 0.0049 0.2583
Echinococcus multilocularis cpg binding protein 0.0058 0.0206 0.0206
Schistosoma mansoni hypothetical protein 0.004 0.0128 0.0128
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0012 0.0012
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0021 0.0049 0.072
Echinococcus granulosus phosphoglycerate mutase 0.004 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0035 0.0107 0.0107
Brugia malayi jmjC domain containing protein 0.0015 0.0021 0.0164
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0021 0.0021
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.004 0.0128 0.0128
Loa Loa (eye worm) intermediate filament protein 0.0026 0.007 0.007
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0134 0.0526 0.4047
Loa Loa (eye worm) hypothetical protein 0.0022 0.005 0.005
Brugia malayi jmjC domain containing protein 0.0059 0.0207 0.159
Leishmania major phosphoglycerate mutase family member 5, putative 0.004 0.0128 0.0107
Schistosoma mansoni ets-related 0.0204 0.0822 0.0822
Brugia malayi GH02984p 0.0317 0.1299 1
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.004 0.0128 0.0107
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0039 0.0347
Brugia malayi Ets-domain containing protein 0.0067 0.0243 0.1871
Schistosoma mansoni hypothetical protein 0.0029 0.008 0.008
Toxoplasma gondii HEAT repeat-containing protein 0.0026 0.007 0.1267
Mycobacterium tuberculosis Conserved protein 0.0067 0.0244 0.1255
Mycobacterium leprae Probable lipase LipE 0.0067 0.0244 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0019 0.0041 0.0312
Schistosoma mansoni jumonji domain containing protein 0.0055 0.0193 0.0193
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0035 0.0035
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.004 0.0128 0.0152
Trypanosoma cruzi phosphoglycerate mutase, putative 0.004 0.0128 0.0107
Entamoeba histolytica hypothetical protein 0.0135 0.0531 0.0841
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0012
Trypanosoma brucei glycerolphosphate mutase, putative 0.004 0.0128 0.0107
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0021 0.0049 0.0037
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein 0.1013 0.4243 0.4231
Loa Loa (eye worm) hypothetical protein 0.2375 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.0027
Trichomonas vaginalis phosphoglycerate mutase, putative 0.004 0.0128 0.1471
Echinococcus granulosus importin subunit beta 1 0.0026 0.007 0.007
Echinococcus granulosus phosphoglycerate mutase 0.004 0.0128 0.0128
Schistosoma mansoni inositol transporter 0.0035 0.0107 0.0107
Brugia malayi hypothetical protein 0.0135 0.0531 0.4085
Onchocerca volvulus 0.0055 0.0192 0.0143
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.004 0.0128 0.0107
Brugia malayi AMP-binding enzyme family protein 0.0022 0.005 0.0386
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0022 0.005 0.0153
Echinococcus granulosus cpg binding protein 0.0058 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0062 0.0222 0.0222
Giardia lamblia Hypothetical protein 0.1402 0.5885 1
Echinococcus granulosus GA binding protein alpha chain 0.0067 0.0243 0.0243
Echinococcus multilocularis phosphoglycerate mutase 0.004 0.0128 0.0128
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0021 0.0021
Trichomonas vaginalis importin beta-1, putative 0.0021 0.0049 0.047
Onchocerca volvulus Protein UBASH3A homolog 0.004 0.0128 0.0078
Chlamydia trachomatis 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 0.004 0.0128 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0244 0.0244
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0039 0.0807
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.0027
Mycobacterium tuberculosis Glucosyl-3-phosphoglycerate phosphatase GpgP 0.004 0.0128 0.0598
Schistosoma mansoni hypothetical protein 0.004 0.0128 0.0128
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0026 0.007 0.1263
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0128 0.0598
Echinococcus granulosus microtubule associated protein 2 0.0674 0.2807 0.2807
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0022 0.005 0.0064
Entamoeba histolytica acyl-CoA synthetase, putative 0.0022 0.005 0.0019
Schistosoma mansoni hypothetical protein 0.004 0.0128 0.0128
Entamoeba histolytica hypothetical protein 0.0135 0.0531 0.0841
Trichomonas vaginalis phosphoglycerate mutase, putative 0.004 0.0128 0.1471
Brugia malayi jmjC domain containing protein 0.0015 0.0021 0.0164
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.007 0.007
Plasmodium falciparum phosphoglycerate mutase, putative 0.004 0.0128 1
Brugia malayi Pre-SET motif family protein 0.0176 0.0702 0.5407
Loa Loa (eye worm) hypothetical protein 0.0067 0.0244 0.0244
Schistosoma mansoni intermediate filament proteins 0.0026 0.007 0.007
Mycobacterium tuberculosis PE-PGRS family protein PE_PGRS11 0.004 0.0128 0.0598
Onchocerca volvulus 0.0067 0.0244 0.0194
Brugia malayi CXXC zinc finger family protein 0.0055 0.0192 0.1481
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0039 0.0091
Mycobacterium ulcerans phosphohistidine phosphatase SixA 0.004 0.0128 0.0173
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0019 0.0041 0.0502
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0134 0.0526 0.0526
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0021 0.0049 0.047
Echinococcus granulosus L aminoadipate semialdehyde 0.0076 0.0279 0.0279
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.2335 0.983 0.983
Mycobacterium ulcerans hypothetical protein 0.004 0.0128 0.0173
Schistosoma mansoni hypothetical protein 0.004 0.0128 0.0128
Mycobacterium leprae conserved hypothetical protein 0.004 0.0128 0.4075
Loa Loa (eye worm) hypothetical protein 0.0026 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.001
Leishmania major phosphopantetheinyl transferase-like protein 0.0021 0.0049 0.0028
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0431 0.1779 1
Brugia malayi UBASH3A protein homolog 0.004 0.0128 0.0987
Mycobacterium ulcerans phosphoglycerate mutase 0.004 0.0128 0.0173
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0021 0.0021
Echinococcus multilocularis phosphoglycerate mutase 0.004 0.0128 0.0128
Mycobacterium tuberculosis Probable esterase LipL 0.0067 0.0244 0.1255
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0021 0.0021
Echinococcus multilocularis high affinity choline transporter 1 0.0317 0.1299 0.1299
Loa Loa (eye worm) hypothetical protein 0.004 0.0128 0.0128
Schistosoma mansoni hypothetical protein 0.004 0.0128 0.0128
Echinococcus granulosus phd:f box containing protein 0.0015 0.0021 0.0021
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0067 0.0244 0.1255
Schistosoma mansoni phosphoglycerate mutase 0.004 0.0128 0.0128
Schistosoma mansoni hypothetical protein 0.0029 0.008 0.008
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0021
Leishmania major hypothetical protein, conserved 0.0067 0.0244 0.0223
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0021 0.0049 0.0037
Loa Loa (eye worm) hypothetical protein 0.0091 0.0343 0.0343
Schistosoma mansoni sodium/solute symporter 0.0035 0.0107 0.0107
Brugia malayi AMP-binding enzyme family protein 0.0022 0.005 0.0386
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.0526 0.0526
Schistosoma mansoni high-affinity choline transporter 0.0317 0.1299 0.1299
Loa Loa (eye worm) hypothetical protein 0.0067 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.0027
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0018 0.0142
Onchocerca volvulus 0.0067 0.0244 0.0194
Trypanosoma brucei hypothetical protein, conserved 0.0067 0.0244 0.0223
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.004 0.0128 0.0128
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1013 0.4243 0.4231
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0021 0.0021
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0019 0.0041 0.0041
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0018 0.0018
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0021 0.0049 0.216
Schistosoma mansoni hypothetical protein 0.0029 0.008 0.008
Toxoplasma gondii phosphoglycerate mutase family protein 0.004 0.0128 0.2786
Toxoplasma gondii phosphoglycerate mutase family protein 0.004 0.0128 0.2786
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0035 0.0107 0.0107
Plasmodium vivax SET domain protein, putative 0.0026 0.007 0.2181
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0021 0.0021
Echinococcus granulosus sodium:myo inositol cotransporter 0.0035 0.0107 0.0107
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0067 0.0243 0.0243
Mycobacterium tuberculosis Probable lipase LipE 0.0067 0.0244 0.1255
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0026 0.007 0.007
Mycobacterium ulcerans hypothetical protein 0.004 0.0128 0.0173
Echinococcus granulosus sodium:glucose cotransporter 0.0035 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0021
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.004 0.0128 0.0107
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0207 0.0207
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0019 0.0041 0.0019
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.005 0.0153
Plasmodium falciparum importin beta, putative 0.0026 0.007 0.4547
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.004 0.0128 0.0107
Schistosoma mansoni hypothetical protein 0.004 0.0128 0.0128
Mycobacterium leprae POSSIBLE HYDROLASE MUTT1 0.004 0.0128 0.4075
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.2375 1 1
Brugia malayi beta-lactamase 0.0067 0.0244 0.1876
Trypanosoma brucei importin beta-1 subunit, putative 0.0026 0.007 0.0049
Toxoplasma gondii phosphoglycerate mutase family protein 0.004 0.0128 0.2786
Loa Loa (eye worm) hypothetical protein 0.1362 0.5715 0.5715
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0039 0.0018
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.004 0.0128 0.0107
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1013 0.4243 0.4231
Loa Loa (eye worm) hypothetical protein 0.004 0.0128 0.0128
Toxoplasma gondii exonuclease III APE 0.0019 0.0039 0.0467
Echinococcus multilocularis dnaJ subfamily B 0.0373 0.1536 0.1536
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.2335 0.983 0.983
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0021 0.0021
Echinococcus granulosus phosphoglycerate mutase 0.004 0.0128 0.0128
Echinococcus granulosus phosphoglycerate mutase 0.004 0.0128 0.0128
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0076 0.0279 0.215
Mycobacterium ulcerans phosphoglyceromutase 0.004 0.0128 0.0173
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.007 0.007
Schistosoma mansoni ran 0.0019 0.0041 0.0041
Echinococcus multilocularis lamin dm0 0.0026 0.007 0.007
Giardia lamblia Hypothetical protein 0.1402 0.5885 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0135 0.0531 0.0531
Mycobacterium tuberculosis Possible hydrolase MutT1 0.004 0.0128 0.0598
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.2375 1 1
Trypanosoma brucei Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative 0.004 0.0128 0.0107
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0091 0.0343 0.2642
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0207 0.0207
Echinococcus multilocularis phosphoglycerate mutase 0.004 0.0128 0.0128
Echinococcus multilocularis lamin 0.0026 0.007 0.007
Trichomonas vaginalis penicillin-binding protein, putative 0.0067 0.0244 0.2926
Trichomonas vaginalis D-aminoacylase, putative 0.0067 0.0244 0.2926
Loa Loa (eye worm) hypothetical protein 0.0067 0.0244 0.0244
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0035 0.0035
Onchocerca volvulus 0.0035 0.0107 0.0057
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0021 0.0021
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0034 0.0262
Loa Loa (eye worm) CXXC zinc finger family protein 0.0055 0.0192 0.0192
Onchocerca volvulus Protein UBASH3A homolog 0.004 0.0128 0.0078
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0021 0.0021
Mycobacterium tuberculosis Conserved protein 0.004 0.0128 0.0598
Echinococcus multilocularis beta LACTamase domain containing family member 0.0067 0.0244 0.0244
Leishmania major fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein 0.004 0.0128 0.0107
Plasmodium vivax phosphoglucomutase-2, putative 0.004 0.0128 0.4811
Trichomonas vaginalis ran, putative 0.0019 0.0041 0.0364
Echinococcus granulosus snurportin 1 0.0281 0.1146 0.1146
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0067 0.0244 0.0244
Echinococcus granulosus high affinity choline transporter 1 0.0317 0.1299 0.1299
Mycobacterium leprae probable isochorismate synthase EntC 0.004 0.0128 0.4075
Echinococcus granulosus lamin dm0 0.0026 0.007 0.007
Schistosoma mansoni lamin 0.0026 0.007 0.007
Brugia malayi RNA, U transporter 1 0.0075 0.0275 0.2116
Loa Loa (eye worm) hypothetical protein 0.0067 0.0244 0.0244
Trypanosoma brucei phosphoglycerate mutase protein, putative 0.004 0.0128 0.0107
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0134 0.0526 0.0526
Trichomonas vaginalis D-aminoacylase, putative 0.0067 0.0244 0.2926
Mycobacterium ulcerans esterase/lipase LipP 0.0067 0.0244 0.037
Mycobacterium tuberculosis Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) 0.004 0.0128 0.0598
Brugia malayi beta-lactamase family protein 0.0067 0.0244 0.1876
Mycobacterium ulcerans hypothetical protein 0.0067 0.0244 0.037
Echinococcus granulosus intermediate filament protein 0.0026 0.007 0.007
Brugia malayi Latrophilin receptor protein 2 0.0029 0.008 0.0619
Schistosoma mansoni hypothetical protein 0.0373 0.1536 0.1536
Mycobacterium ulcerans phosphoglycerate mutase 0.004 0.0128 0.0173
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0019 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.004 0.0128 0.0128
Onchocerca volvulus 0.004 0.0128 0.0078
Echinococcus granulosus solute carrier family 5 0.0035 0.0107 0.0107
Echinococcus multilocularis phosphoglycerate mutase 0.004 0.0128 0.0128
Brugia malayi jmjC domain containing protein 0.0015 0.0021 0.0164
Mycobacterium tuberculosis Conserved protein 0.0067 0.0244 0.1255
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0021 0.0021
Schistosoma mansoni ran 0.0019 0.0041 0.0041
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.007 0.0539
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.2375 1 1
Onchocerca volvulus 0.0067 0.0244 0.0194
Echinococcus granulosus phosphoglycerate mutase 0.004 0.0128 0.0128
Brugia malayi MH2 domain containing protein 0.0117 0.0452 0.3476
Loa Loa (eye worm) hypothetical protein 0.004 0.0128 0.0128
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0022 0.005 0.0064
Onchocerca volvulus Protein UBASH3A homolog 0.004 0.0128 0.0078
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0452 0.0452
Trichomonas vaginalis set domain proteins, putative 0.02 0.0804 1
Toxoplasma gondii phosphoglycerate mutase family protein 0.004 0.0128 0.2786
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.005 0.0039
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.005 0.0039
Plasmodium vivax hypothetical protein, conserved 0.0067 0.0244 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0076 0.0279 0.0279
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.004 0.0128 0.0107
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0021 0.0049 0.0146
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.004 0.0128 0.0107
Mycobacterium tuberculosis Conserved protein 0.004 0.0128 0.0598
Echinococcus granulosus GTP binding nuclear protein Ran 0.0019 0.0041 0.0041
Mycobacterium leprae Possible phosphoglycerate mutase 0.004 0.0128 0.4075
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.2335 0.983 0.983
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0176 0.0702 0.0702
Echinococcus multilocularis lysine specific demethylase 5A 0.0055 0.0193 0.0193
Schistosoma mansoni cpg binding protein 0.0055 0.0192 0.0192
Echinococcus granulosus histone lysine methyltransferase setb 0.0026 0.007 0.007
Toxoplasma gondii ABC1 family protein 0.0067 0.0244 0.5792
Schistosoma mansoni 6-phosphofructokinase 0.2375 1 1
Brugia malayi Pre-SET motif family protein 0.0026 0.007 0.0537
Loa Loa (eye worm) hypothetical protein 0.0026 0.0068 0.0068
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0128 0.1471
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0035 0.0107 0.0107
Echinococcus multilocularis phosphoglycerate mutase 0.004 0.0128 0.0128
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0029 0.008 0.008
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0016 0.0027 0.0021
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0019 0.0041 0.0019
Schistosoma mansoni cpg binding protein 0.0058 0.0206 0.0206
Mycobacterium ulcerans bifunctional RNase H/acid phosphatase 0.004 0.0128 0.0173
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0035 0.0107 0.0107
Leishmania major glycerolphosphate mutase, putative 0.004 0.0128 0.0107
Mycobacterium tuberculosis Probable hydrolase 0.0067 0.0244 0.1255
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0021 0.0049 1
Mycobacterium ulcerans beta-lactamase 0.0067 0.0244 0.037
Onchocerca volvulus 0.0026 0.007 0.002
Mycobacterium tuberculosis Conserved protein 0.0067 0.0244 0.1255
Leishmania major hypothetical protein, unknown function 0.004 0.0128 0.0107
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0207 0.0207
Mycobacterium tuberculosis Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) 0.004 0.0128 0.0598
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0019 0.0041 0.0019
Echinococcus multilocularis GA binding protein alpha chain 0.0067 0.0243 0.0243
Mycobacterium leprae conserved hypothetical protein 0.0067 0.0244 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0022 0.005 0.0029
Brugia malayi Sodium:solute symporter family protein 0.0035 0.0107 0.082
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0035 0.0035
Schistosoma mansoni inositol transporter 0.0035 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0076 0.0279 0.0279
Plasmodium falciparum acyl-CoA synthetase 0.0016 0.0027 0.0539
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0244 0.0223
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0134 0.0526 0.0526
Onchocerca volvulus Protein UBASH3A homolog 0.004 0.0128 0.0078
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0019 0.0041 0.0002
Schistosoma mansoni transcription factor LCR-F1 0.0135 0.0531 0.0531
Brugia malayi AMP-binding enzyme family protein 0.0022 0.005 0.0386
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0039 0.1677
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.005 0.0039
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0021 0.0021
Brugia malayi jmjC domain containing protein 0.0015 0.0021 0.0164
Entamoeba histolytica Ran family GTPase 0.0019 0.0041 0.0002
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0035 0.0035
Trypanosoma brucei phosphoglycerate mutase, putative 0.004 0.0128 0.0107
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.0526 0.0526
Onchocerca volvulus 0.2375 1 1
Loa Loa (eye worm) beta-lactamase 0.0067 0.0244 0.0244
Trichomonas vaginalis phosphoglycerate mutase, putative 0.004 0.0128 0.1471
Mycobacterium ulcerans lipoprotein LpqD 0.004 0.0128 0.0173
Trichomonas vaginalis phosphoglycerate mutase, putative 0.004 0.0128 0.1471
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0207 0.0207
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0019 0.0041 0.1803
Schistosoma mansoni hypothetical protein 0.0135 0.0531 0.0531
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0452 0.0452
Leishmania major importin beta-1 subunit, putative 0.0021 0.0049 0.0028
Loa Loa (eye worm) hypothetical protein 0.0022 0.005 0.005
Mycobacterium ulcerans hypothetical protein 0.1402 0.5885 1
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.004 0.0128 0.0107
Leishmania major 4-coumarate:coa ligase-like protein 0.0022 0.005 0.0029
Onchocerca volvulus 0.0076 0.0279 0.023
Loa Loa (eye worm) hypothetical protein 0.0029 0.008 0.008
Schistosoma mansoni lamin 0.0026 0.007 0.007
Entamoeba histolytica hypothetical protein 0.0021 0.0049 0.0017
Schistosoma mansoni microtubule-associated protein tau 0.0674 0.2807 0.2807
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0039 0.0039
Entamoeba histolytica acyl-CoA synthetase, putative 0.0022 0.005 0.0019
Plasmodium vivax phosphoglycerate mutase, putative 0.004 0.0128 0.4811
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0039 0.0021
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0039 0.0039
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.004 0.0128 0.0107
Brugia malayi phosphoglycerate mutase family protein 0.004 0.0128 0.0987
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0055 0.0193 0.0193
Leishmania major hypothetical protein, conserved 0.004 0.0128 0.0107
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.007 0.007
Echinococcus granulosus GPCR family 2 0.0029 0.008 0.008
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.004 0.0128 0.0107
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0067 0.0244 0.1255
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1013 0.4243 0.4231
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0021 0.0021
Echinococcus multilocularis solute carrier family 5 0.0035 0.0107 0.0107
Schistosoma mansoni gabp alpha 0.0067 0.0243 0.0243
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.2335 0.983 0.983
Entamoeba histolytica phosphoglycerate mutase family protein. putative 0.004 0.0128 0.0152
Schistosoma mansoni hypothetical protein 0.0062 0.0222 0.0222
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0039 0.0347
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0091 0.0343 0.0343
Onchocerca volvulus 0.0026 0.007 0.002
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0281 0.1146 0.1146
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0021 0.0021
Loa Loa (eye worm) latrophilin receptor protein 2 0.0029 0.008 0.008
Schistosoma mansoni hypothetical protein 0.0029 0.008 0.008
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0039 0.0302
Brugia malayi Calcitonin receptor-like protein seb-1 0.0091 0.0343 0.2642
Brugia malayi intermediate filament protein 0.0026 0.007 0.0539
Brugia malayi beta-lactamase family protein 0.0067 0.0244 0.1876
Trypanosoma brucei importin beta-1 subunit, putative 0.0026 0.007 0.0049
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0035 0.0107 0.0107
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0067 0.0244 0.1255
Leishmania major hypothetical protein, conserved 0.004 0.0128 0.0107
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0026 0.007 0.007
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0021 0.0021
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0022 0.005 0.0039
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0029 0.008 0.0619
Entamoeba histolytica acyl-coA synthetase, putative 0.0022 0.005 0.0019
Leishmania major phosphoglycerate mutase, putative 0.004 0.0128 0.0107
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0021 0.0049 0.072
Echinococcus multilocularis importin subunit beta 1 0.0026 0.007 0.007
Mycobacterium ulcerans lipase LipD 0.0067 0.0244 0.037
Loa Loa (eye worm) hypothetical protein 0.0057 0.0202 0.0202
Treponema pallidum phosphoglyceromutase 0.004 0.0128 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0021 0.0021
Brugia malayi latrophilin 2 splice variant baaae 0.0062 0.0222 0.1706
Plasmodium vivax acyl-CoA synthetase, putative 0.0016 0.0027 0.0259
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.004 0.0128 0.0107
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0021 0.0049 0.1242
Loa Loa (eye worm) hypothetical protein 0.0067 0.0244 0.0244
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0134 0.0526 0.0526
Trichomonas vaginalis phosphoglycerate mutase, putative 0.004 0.0128 0.1471
Mycobacterium ulcerans hydrolase MutT1 0.004 0.0128 0.0173
Echinococcus multilocularis phosphoglycerate mutase 0.004 0.0128 0.0128
Schistosoma mansoni hypothetical protein 0.0281 0.1146 0.1146
Leishmania major phosphoglycerate mutase protein, putative 0.004 0.0128 0.0107
Echinococcus multilocularis musashi 0.0026 0.007 0.007
Onchocerca volvulus 0.0026 0.007 0.002
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.004 0.0128 0.0107
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0012 0.0012
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0067 0.0244 0.0244
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0135 0.0531 0.0531
Toxoplasma gondii phosphoglycerate mutase PGMII 0.004 0.0128 0.2786
Trichomonas vaginalis D-aminoacylase, putative 0.0067 0.0244 0.2926
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0021 0.0049 0.1088
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.007 0.007
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0039 0.0018
Echinococcus multilocularis GPCR, family 2 0.0029 0.008 0.008
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0067 0.0244 0.037
Echinococcus multilocularis snurportin 1 0.0281 0.1146 0.1146
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.004 0.0128 0.0107
Plasmodium vivax importin-beta 2, putative 0.0026 0.007 0.2187
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0022 0.005 0.0039
Echinococcus multilocularis microtubule associated protein 2 0.0674 0.2807 0.2807
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.004 0.0128 0.0152
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0022 0.005 0.005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0067 0.0244 0.0244
Trypanosoma cruzi glycerolphosphate mutase, putative 0.004 0.0128 0.0107
Loa Loa (eye worm) hypothetical protein 0.0026 0.007 0.007
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0029 0.008 0.008
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0055 0.0193 0.0193
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0024 0.0061 0.0061
Trypanosoma cruzi phosphoglycerate mutase, putative 0.004 0.0128 0.0107
Entamoeba histolytica hypothetical protein 0.0135 0.0531 0.0841
Echinococcus granulosus beta LACTamase domain containing family member 0.0067 0.0244 0.0244
Schistosoma mansoni ap endonuclease 0.0019 0.0039 0.0039
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.005 0.0039
Mycobacterium tuberculosis Probable conserved lipoprotein LpqD 0.004 0.0128 0.0598
Echinococcus granulosus lamin 0.0026 0.007 0.007
Mycobacterium leprae conserved hypothetical protein 0.004 0.0128 0.4075
Mycobacterium leprae Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) 0.004 0.0128 0.4075
Mycobacterium leprae PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) 0.004 0.0128 0.4075
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0021 0.0021
Onchocerca volvulus 0.004 0.0128 0.0078
Mycobacterium ulcerans acid phosphatase 0.004 0.0128 0.0173
Leishmania major 4-coumarate:coa ligase-like protein 0.0022 0.005 0.0029
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.004 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0317 0.1299 0.1299
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0128 0.1471
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.2375 1 1
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.1402 0.5885 1
Loa Loa (eye worm) phosphoglycerate mutase 0.004 0.0128 0.0128
Brugia malayi Fli-1 protein 0.0204 0.0822 0.6328
Loa Loa (eye worm) hypothetical protein 0.2335 0.983 0.983
Schistosoma mansoni phosphoglycerate mutase 0.004 0.0128 0.0128
Trypanosoma brucei hypothetical protein, conserved 0.0021 0.0049 0.0028
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.0027
Toxoplasma gondii phosphoglycerate mutase 0.004 0.0128 0.2786
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0029 0.008 0.008
Schistosoma mansoni importin beta-1 0.0026 0.007 0.007
Mycobacterium leprae conserved hypothetical protein 0.004 0.0128 0.4075
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0134 0.0526 0.0526
Schistosoma mansoni cpg binding protein 0.0058 0.0206 0.0206
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0244 0.0223
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0021 0.0021
Loa Loa (eye worm) fli-1 protein 0.0204 0.0822 0.0822
Schistosoma mansoni ap endonuclease 0.0019 0.0039 0.0039
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.1402 0.5885 1
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.004 0.0128 0.0107
Onchocerca volvulus 0.004 0.0128 0.0078
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0035 0.0107 0.2221
Mycobacterium tuberculosis Probable lipase LipD 0.0067 0.0244 0.1255
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0019 0.0041 0.0868
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.0526 0.0526
Mycobacterium ulcerans hypothetical protein 0.0022 0.005 0.0039
Toxoplasma gondii histone lysine methyltransferase SET1 0.0106 0.0405 1
Brugia malayi jmjC domain containing protein 0.0055 0.0193 0.1488
Trypanosoma cruzi glycerolphosphate mutase, putative 0.004 0.0128 0.0107
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0029 0.008 0.008

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 94 % Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition at <6.25 ug/ml by primary screen assay ChEMBL. No reference
MIC (functional) < 3.125 ug ml-1 Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition by secondary screen assay ChEMBL. No reference
MIC (functional) < 6.25 ug ml-1 Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition by primary screen assay ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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