TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 451.543 | Formula: C26H21N5OS
H donors: 1 H acceptors: 0 LogP: 4.33 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)N1C(=C(C2C1N=Cn1c2n[nH]c1=S)c1ccccc1)c1ccccc1
InChi: 1S/C26H21N5OS/c1-32-20-14-12-19(13-15-20)31-23(18-10-6-3-7-11-18)21(17-8-4-2-5-9-17)22-24(31)27-16-30-25(22)28-29-26(30)33/h2-16,22,24H,1H3,(H,29,33)
InChiKey: HKYJXXZAROCSCW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	intersectin 2	0.0091	0.011	0.011
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0123	0.0211	0.0211
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0939	0.2801	0.2801
Echinococcus granulosus	c src tyrosine kinase	0.0214	0.0501	0.0501
Loa Loa (eye worm)	TK/FER protein kinase	0.0123	0.0211	0.0211
Echinococcus granulosus	src region	0.0091	0.011	0.011
Echinococcus multilocularis	slit robo rho gtpase activating protein 1	0.0091	0.011	0.011
Onchocerca volvulus		0.0123	0.0211	0.0102
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0094	0.0118	0.0118
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.3209	1	1
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0094	0.0118	0.0118
Brugia malayi	SRC-1	0.0939	0.2801	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0848	0.2511	0.2511
Trichomonas vaginalis	conserved hypothetical protein	0.0091	0.011	0.5
Echinococcus granulosus	fch and double sh3 domains protein 2	0.0091	0.011	0.011
Schistosoma mansoni	tensin	0.0094	0.0118	0.0007
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0185	0.0407	0.03
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0094	0.0118	0.0118
Echinococcus granulosus	hematopoietic lineage cell specific protein	0.0091	0.011	0.011
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0094	0.0118	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0091	0.011	0.011
Schistosoma mansoni	vav2	0.0094	0.0118	0.0007
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0214	0.0501	0.0395
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0939	0.2801	0.2801
Brugia malayi	SH2 domain containing protein	0.0094	0.0118	0.0194
Trichomonas vaginalis	conserved hypothetical protein	0.0091	0.011	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0939	0.2801	0.2801
Brugia malayi	Variant SH3 domain containing protein	0.0094	0.0118	0.0194
Loa Loa (eye worm)	TK/FER protein kinase	0.0123	0.0211	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0211	0.0211
Loa Loa (eye worm)	TK/FER protein kinase	0.0123	0.0211	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0118	0.0118
Echinococcus granulosus	tensin	0.0094	0.0118	0.0118
Echinococcus granulosus	rho guanine nucleotide exchange factor 7	0.0091	0.011	0.011
Echinococcus granulosus	tyrosine protein kinase HCK	0.0755	0.2214	0.2214
Loa Loa (eye worm)	guanylate kinase	0.0091	0.011	0.011
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein	0.1369	0.4164	0.4099
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.3209	1	1
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0118	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0118	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0091	0.011	0.011
Echinococcus granulosus	tyrosine kinase	0.0848	0.2511	0.2511
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0094	0.0118	0.0118
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0091	0.011	0.011
Brugia malayi	SH2 domain containing protein	0.0094	0.0118	0.0194
Echinococcus multilocularis		0.0094	0.0118	0.0118
Schistosoma mansoni	tensin	0.0094	0.0118	0.0007
Giardia lamblia	Hypothetical protein	0.1894	0.5828	0.5
Brugia malayi	Protein kinase domain containing protein	0.0123	0.0211	0.0536
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0094	0.0118	0.0118
Loa Loa (eye worm)	STAT protein	0.0094	0.0118	0.0118
Onchocerca volvulus		0.0123	0.0211	0.0102
Echinococcus multilocularis	Spectrin alpha actinin	0.0091	0.011	0.011
Loa Loa (eye worm)	SH2 domain-containing protein	0.0094	0.0118	0.0118
Echinococcus multilocularis	fch and double sh3 domains protein 2	0.0091	0.011	0.011
Loa Loa (eye worm)	SRC-1	0.0939	0.2801	0.2801
Onchocerca volvulus		0.0094	0.0118	0.0007
Loa Loa (eye worm)	TK protein kinase	0.0848	0.2511	0.2511
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0094	0.0118	0.0118
Echinococcus granulosus	endophilin A3	0.0091	0.011	0.011
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0848	0.2511	0.2511
Brugia malayi	Protein kinase domain containing protein	0.0123	0.0211	0.0536
Trichomonas vaginalis	conserved hypothetical protein	0.0091	0.011	0.5
Echinococcus granulosus	tyrosine kinase	0.0123	0.0211	0.0211
Echinococcus multilocularis	tensin	0.0094	0.0118	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0118	0.0118
Brugia malayi	Tyrosine-protein kinase abl-1	0.0214	0.0501	0.1595
Echinococcus multilocularis	NCK adaptor protein	0.0185	0.0407	0.0407
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.3155	0.9828	0.9826
Echinococcus granulosus	SH2 domain containing protein 7	0.0094	0.0118	0.0118
Onchocerca volvulus		0.0094	0.0118	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0091	0.011	0.011
Schistosoma mansoni	tyrosine kinase	0.0939	0.2801	0.272
Schistosoma mansoni	tensin-related	0.0094	0.0118	0.0007
Echinococcus granulosus	epidermal growth factor receptor kinase	0.0091	0.011	0.011
Echinococcus granulosus	hypothetical protein	0.0094	0.0118	0.0118
Brugia malayi	hypothetical protein	0.0123	0.0211	0.0536
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0939	0.2801	0.2801
Schistosoma mansoni	tensin	0.0094	0.0118	0.0007
Brugia malayi	Variant SH3 domain containing protein	0.0091	0.011	0.0167
Schistosoma mansoni	tyrosine kinase	0.0123	0.0211	0.0102
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0094	0.0118	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0118	0.0118
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0185	0.0407	0.0407
Schistosoma mansoni	tyrosine kinase	0.0214	0.0501	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0118	0.0118
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0939	0.2801	0.2801
Loa Loa (eye worm)	TK/FER protein kinase	0.0123	0.0211	0.0211
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0123	0.0211	0.0211
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1369	0.4164	0.4099
Echinococcus granulosus	SH2 motif	0.0094	0.0118	0.0118
Echinococcus multilocularis	endophilin A3	0.0091	0.011	0.011
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0094	0.0118	0.0007
Loa Loa (eye worm)	p53BP2	0.0091	0.011	0.011
Loa Loa (eye worm)	protein-tyrosine kinase	0.0091	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0118	0.0118
Brugia malayi	Protein kinase domain containing protein	0.0123	0.0211	0.0536
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0094	0.0118	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0091	0.011	0.5
Echinococcus multilocularis	tensin	0.0094	0.0118	0.0118
Brugia malayi	Peripheral plasma membrane protein CASK	0.0091	0.011	0.0167
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0123	0.0211	0.0211
Entamoeba histolytica	protein kinase, putative	0.0094	0.0118	0.0013
Schistosoma mansoni	6-phosphofructokinase	0.3209	1	1
Echinococcus granulosus	nostrin	0.0091	0.011	0.011
Trichomonas vaginalis	conserved hypothetical protein	0.0091	0.011	0.5
Loa Loa (eye worm)	hypothetical protein	0.184	0.5657	0.5657
Echinococcus multilocularis	SH2 motif	0.0094	0.0118	0.0118
Echinococcus multilocularis	hematopoietic lineage cell specific protein	0.0091	0.011	0.011
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1369	0.4164	0.4099
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0939	0.2801	0.2801
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.3155	0.9828	0.9826
Echinococcus multilocularis	N chimaerin	0.0094	0.0118	0.0118
Echinococcus granulosus	expressed conserved protein	0.0094	0.0118	0.0118
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0185	0.0407	0.0407
Schistosoma mansoni	tensin-related	0.0094	0.0118	0.0007
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.1894	0.5828	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.0848	0.2511	0.2511
Onchocerca volvulus		0.0094	0.0118	0.0007
Loa Loa (eye worm)	hypothetical protein	0.3209	1	1
Loa Loa (eye worm)	hypothetical protein	0.0185	0.0407	0.0407
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0094	0.0118	0.0194
Echinococcus granulosus	SHC transforming protein 3	0.0094	0.0118	0.0118
Loa Loa (eye worm)	SH2 domain-containing protein	0.0094	0.0118	0.0118
Loa Loa (eye worm)	TK/FER protein kinase	0.0123	0.0211	0.0211
Echinococcus granulosus	tyrosine protein kinase shark	0.0123	0.0211	0.0211
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0123	0.0211	0.0211
Loa Loa (eye worm)	protein kinase C and casein kinase substrate in neurons protein 2	0.0091	0.011	0.011
Brugia malayi	hypothetical protein	0.0094	0.0118	0.0194
Brugia malayi	SH2 domain containing protein	0.0094	0.0118	0.0194
Echinococcus granulosus	expressed protein	0.0091	0.011	0.011
Onchocerca volvulus		0.0094	0.0118	0.0007
Schistosoma mansoni	tyrosine kinase	0.0123	0.0211	0.0102
Echinococcus multilocularis	breast cancer anti estrogen resistance protein	0.0091	0.011	0.011
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0939	0.2801	0.2801
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0094	0.0118	0.0118
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0939	0.2801	0.2801
Echinococcus multilocularis	transfer RNA-Ala	0.0091	0.011	0.011
Schistosoma mansoni	growth factor receptor-bound protein	0.0185	0.0407	0.03
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0214	0.0501	0.0501
Brugia malayi	Variant SH3 domain containing protein	0.0091	0.011	0.0167
Brugia malayi	Variant SH3 domain containing protein	0.0185	0.0407	0.1252
Brugia malayi	Variant SH3 domain containing protein	0.0185	0.0407	0.1252
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0094	0.0118	0.0013
Brugia malayi	Variant SH3 domain containing protein	0.0091	0.011	0.0167
Echinococcus multilocularis	SH2 motif	0.0094	0.0118	0.0118
Schistosoma mansoni	serine/threonine protein kinase	0.0121	0.0204	0.0095
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0939	0.2801	0.2801
Schistosoma mansoni	signal transduction protein lnk-related	0.0094	0.0118	0.0007
Echinococcus granulosus	signal transduction protein lnk realted	0.0094	0.0118	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0091	0.011	0.011
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0094	0.0118	0.0007
Echinococcus multilocularis	SH2 domain containing protein 7	0.0094	0.0118	0.0118
Loa Loa (eye worm)	TK/ABL protein kinase	0.0123	0.0211	0.0211
Echinococcus multilocularis	SHC transforming protein 3	0.0094	0.0118	0.0118
Onchocerca volvulus		0.3209	1	1
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0094	0.0118	0.0118
Schistosoma mansoni	growth factor receptor-bound protein	0.0185	0.0407	0.03
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0094	0.0118	0.0007
Echinococcus granulosus	N chimaerin	0.0094	0.0118	0.0118
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0214	0.0501	0.0501
Echinococcus multilocularis	rho guanine nucleotide exchange factor 7	0.0091	0.011	0.011
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0939	0.2801	0.2801
Loa Loa (eye worm)	TK/FER protein kinase	0.0123	0.0211	0.0211
Echinococcus granulosus	growth factor receptor bound protein 2	0.0185	0.0407	0.0407
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0091	0.011	0.011
Trichomonas vaginalis	neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative	0.0091	0.011	0.5
Brugia malayi	Spectrin alpha chain	0.0091	0.011	0.0167
Loa Loa (eye worm)	thyroid receptor interactor	0.0091	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.3155	0.9828	0.9828
Brugia malayi	protein-tyrosine kinase	0.0848	0.2511	0.8942
Brugia malayi	RhoGAP domain containing protein	0.0094	0.0118	0.0194
Onchocerca volvulus		0.0094	0.0118	0.0007
Onchocerca volvulus		0.0123	0.0211	0.0102
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.3209	1	1
Entamoeba histolytica	SH2 domain containing protein	0.0094	0.0118	0.0013
Echinococcus granulosus	SH2 motif	0.0094	0.0118	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0118	0.0118
Brugia malayi	Myosin tail family protein	0.0091	0.011	0.0167
Brugia malayi	SH2 domain containing protein	0.0094	0.0118	0.0194
Echinococcus multilocularis	SH2 motif	0.0094	0.0118	0.0118
Brugia malayi	SH2 domain containing protein	0.0123	0.0211	0.0536
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0094	0.0118	0.0118
Echinococcus multilocularis	tyrosine protein kinase shark	0.0123	0.0211	0.0211
Schistosoma mansoni	SH2A	0.0094	0.0118	0.0007
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0094	0.0118	0.0118
Trichomonas vaginalis	conserved hypothetical protein	0.0091	0.011	0.5
Echinococcus multilocularis	tyrosine kinase	0.0123	0.0211	0.0211
Loa Loa (eye worm)	TK/FER protein kinase	0.0123	0.0211	0.0211
Brugia malayi	Variant SH3 domain containing protein	0.0091	0.011	0.0167
Brugia malayi	Sex muscle abnormal protein 5	0.0185	0.0407	0.1252
Loa Loa (eye worm)	hypothetical protein	0.0091	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0118	0.0118
Entamoeba histolytica	protein kinase, putative	0.0755	0.2214	0.3679
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0094	0.0118	0.0118
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0819	0.2418	0.2418
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0094	0.0118	0.0118
Loa Loa (eye worm)	TK protein kinase	0.0755	0.2214	0.2214
Echinococcus multilocularis	6 phosphofructo 2 kinase:fructose 2	0.3209	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0123	0.0211	0.0211
Loa Loa (eye worm)	SH2 domain-containing protein	0.0094	0.0118	0.0118
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0094	0.0118	0.0007
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0094	0.0118	0.0194
Brugia malayi	SH2 domain containing protein	0.0094	0.0118	0.0194
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0848	0.2511	0.2511
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0214	0.0501	0.0501
Mycobacterium ulcerans	fructose-2,6-bisphosphatase GpmB	0.1894	0.5828	0.5
Brugia malayi	Src substrate cortactin	0.0091	0.011	0.0167
Schistosoma mansoni	nck2/grb4	0.0185	0.0407	0.03
Schistosoma mansoni	tyrosine kinase	0.0939	0.2801	0.272
Brugia malayi	protein-tyrosine kinase	0.0091	0.011	0.0167
Echinococcus granulosus	Spectrin alpha actinin	0.0091	0.011	0.011
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0094	0.0118	0.0118
Brugia malayi	Variant SH3 domain containing protein	0.0091	0.011	0.0167
Echinococcus multilocularis	epidermal growth factor receptor kinase	0.0091	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0118	0.0118
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0123	0.0211	0.0177
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1369	0.4164	0.4099
Onchocerca volvulus		0.0123	0.0211	0.0102
Schistosoma mansoni	suppressor of cytokine signaling	0.0094	0.0118	0.0007
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.3155	0.9828	0.9826
Brugia malayi	SH2 domain containing protein	0.0094	0.0118	0.0194
Echinococcus granulosus	NCK adaptor protein	0.0185	0.0407	0.0407
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0939	0.2801	0.2801
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0185	0.0407	0.0407
Loa Loa (eye worm)	TK/FER protein kinase	0.0123	0.0211	0.0211
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0077	0.0065	0.0065
Brugia malayi	Protein kinase domain containing protein	0.0123	0.0211	0.0536
Loa Loa (eye worm)	hypothetical protein	0.0091	0.011	0.011
Brugia malayi	Fes/CIP4 homology domain containing protein	0.0091	0.011	0.0167
Echinococcus granulosus	tyrosine protein kinase Srms	0.0123	0.0211	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0118	0.0118
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0094	0.0118	0.0118
Brugia malayi	Variant SH3 domain containing protein	0.0094	0.0118	0.0194
Brugia malayi	Variant SH3 domain containing protein	0.0091	0.011	0.0167
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0094	0.0118	0.0118
Schistosoma mansoni	tyrosine kinase	0.0214	0.0501	0.0395
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0094	0.0118	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0118	0.0118
Schistosoma mansoni	hypothetical protein	0.0094	0.0118	0.0007
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0939	0.2801	0.2801
Echinococcus multilocularis	intersectin 2	0.0091	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0091	0.011	0.011
Brugia malayi	SH2 domain containing protein	0.0123	0.0211	0.0536
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0848	0.2511	0.2511
Brugia malayi	Guanylate kinase family protein	0.0091	0.011	0.0167
Onchocerca volvulus		0.0123	0.0211	0.0102
Brugia malayi	Tensin	0.0094	0.0118	0.0194
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0939	0.2801	0.2801
Brugia malayi	SH3 domain containing protein	0.0091	0.011	0.0167
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0939	0.2801	0.2801
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0094	0.0118	0.0118
Onchocerca volvulus		0.0123	0.0211	0.0102
Echinococcus multilocularis	nostrin	0.0091	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0118	0.0118
Onchocerca volvulus		0.0094	0.0118	0.0007
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0819	0.2418	0.2418
Trichomonas vaginalis	p67phox protein, putative	0.0091	0.011	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0123	0.0211	0.0211
Echinococcus granulosus	breast cancer anti estrogen resistance protein	0.0091	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0091	0.011	0.011
Echinococcus granulosus	slit robo rho gtpase activating protein 1	0.0091	0.011	0.011
Schistosoma mansoni	hypothetical protein	0.0094	0.0118	0.0007
Schistosoma mansoni	GTPase activating protein	0.0094	0.0118	0.0007
Schistosoma mansoni	shc transforming protein	0.0094	0.0118	0.0007
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0939	0.2801	0.2801
Brugia malayi	SH2 domain containing protein	0.0094	0.0118	0.0194
Mycobacterium ulcerans	hypothetical protein	0.1894	0.5828	0.5
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.3209	1	1
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0118	0.0118
Schistosoma mansoni	suppressor of cytokine signaling	0.0094	0.0118	0.0007
Trypanosoma brucei	6-phosphofructo-2-kinase 2	0.3155	0.9828	0.9826
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0939	0.2801	0.2801
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0094	0.0118	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0091	0.011	0.011
Echinococcus multilocularis	c src tyrosine kinase	0.0214	0.0501	0.0501
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0094	0.0118	0.0118
Echinococcus multilocularis	signal transduction protein lnk realted	0.0094	0.0118	0.0118
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0939	0.2801	0.2801
Giardia lamblia	Hypothetical protein	0.1894	0.5828	0.5
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0094	0.0118	0.0007
Echinococcus multilocularis	expressed protein	0.0091	0.011	0.011
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0091	0.011	0.011
Brugia malayi	Protein kinase domain containing protein	0.0123	0.0211	0.0536
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0755	0.2214	0.2214
Schistosoma mansoni	adapter molecule crk	0.0185	0.0407	0.03
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0094	0.0118	0.0194
Trichomonas vaginalis	conserved hypothetical protein	0.0091	0.011	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2297792

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1791408