Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.1409 | 1 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0183 | 0.7857 | 0.7857 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.1409 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1409 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1409 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.1409 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0183 | 0.7857 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1409 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0183 | 0.7857 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0183 | 0.7857 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0183 | 0.7857 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0714 | 0.5064 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0183 | 0.7857 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0183 | 0.7857 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0183 | 0.7857 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1409 | 1 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.1409 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0714 | 0.5064 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.1409 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0183 | 0.7857 | 1 |
Brugia malayi | RNA binding protein | 0.0061 | 0.1409 | 1 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0714 | 0.5064 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1409 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.1409 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0714 | 0.5064 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.1409 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.