TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 430.502 | Formula: C24H26N6O2
H donors: 0 H acceptors: 5 LogP: 2.13 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N1CCN(CC1)CCc1ccc2c(c1)CCC2=O)Cc1ccc(cc1)n1cnnn1
InChi: 1S/C24H26N6O2/c31-23-8-4-20-15-19(3-7-22(20)23)9-10-28-11-13-29(14-12-28)24(32)16-18-1-5-21(6-2-18)30-17-25-26-27-30/h1-3,5-7,15,17H,4,8-14,16H2
InChiKey: VQPKBUFFFXCJLP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	potassium voltage-gated channel, subfamily H (eag-related), member 2	Starlite/ChEMBL	References
Homo sapiens	potassium inwardly-rectifying channel, subfamily J, member 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus granulosus	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	voltage and ligand gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	Potassium voltage-gated channel subfamily H member 2, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus multilocularis	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0092	0.0092	0.0093
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0092	0.0092	0.0093
Echinococcus granulosus	tyrosine protein kinase csk	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0266	0.0397	0.0404
Schistosoma mansoni	protein kinase	0.0092	0.0092	0.0092
Onchocerca volvulus		0.0092	0.0092	0.5
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0092	0.0092	0.0093
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0092	0.0092	0.1992
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0092	0.0092	0.8483
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0092	0.0092	0.1992
Loa Loa (eye worm)	TK/FER protein kinase	0.0092	0.0092	0.0093
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0092	0.0092	0.0093
Trichomonas vaginalis	conserved hypothetical protein	0.0092	0.0092	0.1992
Entamoeba histolytica	protein kinase, putative	0.0092	0.0092	0.1992
Entamoeba histolytica	tyrosine kinase, putative	0.0092	0.0092	0.1992
Entamoeba histolytica	protein kinase domain containing protein	0.0092	0.0092	0.1992
Brugia malayi	Raf kinase	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Echinococcus multilocularis	protein kinase	0.0092	0.0092	0.0093
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0092	0.0092	0.0093
Plasmodium falciparum	tyrosine kinase-like protein	0.0092	0.0092	1
Entamoeba histolytica	protein kinase domain containing protein	0.0092	0.0092	0.1992
Entamoeba histolytica	hypothetical protein	0.0092	0.0092	0.1992
Loa Loa (eye worm)	TK/FER protein kinase	0.0092	0.0092	0.0093
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0092	0.0092	0.0093
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Onchocerca volvulus		0.0092	0.0092	0.5
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0045	0.0009	0.0009
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0092	0.0092	0.0093
Schistosoma mansoni	protein kinase	0.0092	0.0092	0.0092
Entamoeba histolytica	tyrosin kinase, putative	0.0092	0.0092	0.1992
Trypanosoma brucei	Pseudokinase, putative	0.0092	0.0092	0.8483
Entamoeba histolytica	protein kinase domain containing protein	0.0092	0.0092	0.1992
Entamoeba histolytica	protein kinase domain containing protein	0.0092	0.0092	0.1992
Loa Loa (eye worm)	TK/FER protein kinase	0.0092	0.0092	0.0093
Echinococcus multilocularis	tyrosine protein kinase csk	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0092	0.0093
Echinococcus granulosus	activin receptor type	0.0092	0.0092	0.0093
Entamoeba histolytica	protein kinase, putative	0.0092	0.0092	0.1992
Entamoeba histolytica	tyrosine kinase, putative	0.0092	0.0092	0.1992
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0302	0.046	1
Echinococcus multilocularis	protein tyrosine kinase	0.0092	0.0092	0.0093
Brugia malayi	hypothetical protein	0.0092	0.0092	0.0093
Loa Loa (eye worm)	hypothetical protein	0.5651	0.9839	1
Echinococcus multilocularis	FL cytokine receptor	0.0092	0.0092	0.0093
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0101	0.0108	0.2348
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0092	0.0092	0.0093
Schistosoma mansoni	protein kinase	0.0092	0.0092	0.0092
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0092	0.0092	0.0093
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Echinococcus multilocularis	tyrosine protein kinase shark	0.0092	0.0092	0.0093
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0195	0.0274	0.0278
Echinococcus granulosus	insulin receptor	0.0092	0.0092	0.0093
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0092	0.0092	0.0093
Onchocerca volvulus		0.0092	0.0092	0.5
Schistosoma mansoni	hypothetical protein	0.0092	0.0092	0.0092
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Entamoeba histolytica	protein kinase domain containing protein	0.0092	0.0092	0.1992
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0092	0.0092	0.0093
Trichomonas vaginalis	conserved hypothetical protein	0.0092	0.0092	0.1992
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Entamoeba histolytica	protein kinase domain containing protein	0.0092	0.0092	0.1992
Entamoeba histolytica	hypothetical protein	0.0092	0.0092	0.1992
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0195	0.0274	0.0278
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0092	0.0092	0.0093
Loa Loa (eye worm)	serine/threonine protein kinase	0.0092	0.0092	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0092	0.0093
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Entamoeba histolytica	hypothetical protein	0.0092	0.0092	0.1992
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0092	0.0093
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0092	0.0092	0.0093
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0092	0.0092	0.0093
Echinococcus granulosus	raf serine:threonine protein kinase	0.0092	0.0092	0.0093
Entamoeba histolytica	hypothetical protein	0.0092	0.0092	0.1992
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0092	0.0092	0.0093
Echinococcus multilocularis	tyrosine protein kinase csk	0.0092	0.0092	0.0093
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0092	0.0092	0.0093
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0092	0.0092	0.8483
Entamoeba histolytica	protein kinase, putative	0.0092	0.0092	0.1992
Echinococcus granulosus	kinase suppressor of Ras 1	0.0092	0.0092	0.0093
Entamoeba histolytica	tyrosine kinase, putative	0.0092	0.0092	0.1992
Brugia malayi	SH2 domain containing protein	0.0092	0.0092	0.0093
Onchocerca volvulus		0.0092	0.0092	0.5
Entamoeba histolytica	protein kinase, putative	0.0092	0.0092	0.1992
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0146	0.0186	1
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0092	0.0093
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0092	0.0092	0.0093
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0092	0.0092	0.0092
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0092	0.0092	0.0093
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0092	0.0092	0.0093
Entamoeba histolytica	protein kinase domain containing protein	0.0092	0.0092	0.1992
Schistosoma mansoni	tyrosine protein kinase	0.0092	0.0092	0.0092
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Echinococcus granulosus	natriuretic peptide receptor 1	0.0092	0.0092	0.0093
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Entamoeba histolytica	tyrosine kinase, putative	0.0092	0.0092	0.1992
Loa Loa (eye worm)	TK/FER protein kinase	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Loa Loa (eye worm)	hypothetical protein	0.0102	0.011	0.0112
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Onchocerca volvulus		0.0092	0.0092	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0092	0.0092	0.0093
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0092	0.0092	0.0092
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0092	0.0092	0.0093
Loa Loa (eye worm)	TK protein kinase	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Loa Loa (eye worm)	TK/FER protein kinase	0.0092	0.0092	0.0093
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0004	0.0088
Brugia malayi	Protein kinase domain containing protein	0.5651	0.9839	1
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0092	0.0092	0.0093
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Loa Loa (eye worm)	TK/FER protein kinase	0.0092	0.0092	0.0093
Loa Loa (eye worm)	TK/FAK protein kinase	0.0092	0.0092	0.0093
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0092	0.0092	0.0093
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Entamoeba histolytica	serine/threonine kinase, putative	0.0092	0.0092	0.1992
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0092	0.0092	0.0093
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0092	0.0092	0.0093
Echinococcus multilocularis	activin receptor type	0.0092	0.0092	0.0093
Echinococcus granulosus	tyrosine kinase	0.0092	0.0092	0.0093
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0016	0.0016
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Entamoeba histolytica	protein kinase domain containing protein	0.0092	0.0092	0.1992
Entamoeba histolytica	hypothetical protein	0.0092	0.0092	0.1992
Echinococcus multilocularis	c src tyrosine kinase	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0092	0.0092	0.1992
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Leishmania major	hypothetical protein, conserved	0.0092	0.0092	1
Entamoeba histolytica	hypothetical protein	0.0092	0.0092	0.1992
Onchocerca volvulus		0.0092	0.0092	0.5
Echinococcus multilocularis	integrin linked protein kinase	0.0092	0.0092	0.0093
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0092	0.1992
Echinococcus granulosus	receptor type guanylyl cyclase	0.0092	0.0092	0.0093
Loa Loa (eye worm)	TK protein kinase	0.0092	0.0092	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0092	0.0093
Entamoeba histolytica	protein kinase, putative	0.0092	0.0092	0.1992
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Entamoeba histolytica	protein kinase, putative	0.0092	0.0092	0.1992
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0092	0.0092	0.1992
Plasmodium falciparum	protein kinase, putative	0.0092	0.0092	1
Entamoeba histolytica	tyrosine kinase, putative	0.0092	0.0092	0.1992
Loa Loa (eye worm)	TK protein kinase	0.0092	0.0092	0.0093
Entamoeba histolytica	tyrosine kinase, putative	0.0092	0.0092	0.1992
Loa Loa (eye worm)	TK/FER protein kinase	0.0092	0.0092	0.0093
Loa Loa (eye worm)	TK/ROR protein kinase	0.0092	0.0092	0.0093
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0092	0.0092	0.8335
Brugia malayi	integrin-linked kinase	0.0092	0.0092	0.0093
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0092	0.0092	0.1992
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0092	0.0092	0.1992
Loa Loa (eye worm)	TK/FER protein kinase	0.0092	0.0092	0.0093
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0092	0.0092	0.1992
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Loa Loa (eye worm)	TK/INSR protein kinase	0.0092	0.0092	0.0093
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0101	0.0108	0.2348
Giardia lamblia	Kinase	0.0092	0.0092	0.2802
Entamoeba histolytica	tyrosine kinase, putative	0.0092	0.0092	0.1992
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Loa Loa (eye worm)	TK protein kinase	0.0092	0.0092	0.0093
Loa Loa (eye worm)	TK/FER protein kinase	0.0092	0.0092	0.0093
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0293	0.0444	0.966
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0092	0.0092	0.0093
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Echinococcus multilocularis	tyrosine kinase	0.0092	0.0092	0.0093
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0092	0.0092	0.0093
Entamoeba histolytica	hypothetical protein	0.0092	0.0092	0.1992
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0092	0.0092	0.0093
Entamoeba histolytica	protein kinase, putative	0.0092	0.0092	0.1992
Entamoeba histolytica	protein kinase domain containing protein	0.0092	0.0092	0.1992
Entamoeba histolytica	serine/threonine kinase, putative	0.0092	0.0092	0.1992
Entamoeba histolytica	protein kinase domain containing protein	0.0092	0.0092	0.1992
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Brugia malayi	Furin-like cysteine rich region family protein	0.0092	0.0092	0.0093
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0092	0.0092	0.0093
Trichomonas vaginalis	conserved hypothetical protein	0.0092	0.0092	0.1992
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0092	0.0093
Brugia malayi	hypothetical protein	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Entamoeba histolytica	protein kinase domain containing protein	0.0092	0.0092	0.1992
Entamoeba histolytica	protein kinase, putative	0.0092	0.0092	0.1992
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0092	0.0092	0.0093
Loa Loa (eye worm)	inward rectifying k channel family protein 1	0.0102	0.011	0.0112
Loa Loa (eye worm)	TK protein kinase	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Schistosoma mansoni	serine/threonine protein kinase	0.0092	0.0092	0.0092
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0092	0.0092	0.0093
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Echinococcus granulosus	tyrosine protein kinase Srms	0.0092	0.0092	0.0093
Entamoeba histolytica	tyrosine kinase, putative	0.0092	0.0092	0.1992
Brugia malayi	protein-tyrosine kinase	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0092	0.0092	0.0093
Brugia malayi	SH2 domain containing protein	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Entamoeba histolytica	serine/threonine kinase, putative	0.0092	0.0092	0.1992
Entamoeba histolytica	protein kinase domain containing protein	0.0092	0.0092	0.1992
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Echinococcus multilocularis	tyrosine protein kinase csk	0.0092	0.0092	0.0093
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0302	0.046	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0092	0.0092	0.0093
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0092	0.0092	0.0093
Plasmodium falciparum	protein kinase, putative	0.0092	0.0092	1
Brugia malayi	SRC-1	0.0092	0.0092	0.0093
Loa Loa (eye worm)	TK/RYK protein kinase	0.0092	0.0092	0.0093
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0092	0.0092	0.0092
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Loa Loa (eye worm)	TK/FER protein kinase	0.0092	0.0092	0.0093
Entamoeba histolytica	protein kinase, putative	0.0092	0.0092	0.1992
Loa Loa (eye worm)	TK protein kinase	0.0092	0.0092	0.0093
Giardia lamblia	Kinase, NEK	0.0092	0.0092	0.2802
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0101	0.0108	0.2348
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0092	0.0093
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0092	0.0092	0.0093
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0092	0.0092	0.0093
Entamoeba histolytica	protein kinase domain containing protein	0.0092	0.0092	0.1992
Onchocerca volvulus		0.0092	0.0092	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Schistosoma mansoni	protein kinase	0.0092	0.0092	0.0092
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0092	0.0092	0.0093
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0092	0.0092	0.1992
Schistosoma mansoni	serine/threonine protein kinase	0.0092	0.0092	0.0092
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Leishmania major	protein kinase, putative	0.0092	0.0092	1
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0101	0.0108	0.2348
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0092	0.0092	0.0093
Entamoeba histolytica	serine/threonine kinase, putative	0.0092	0.0092	0.1992
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Trypanosoma cruzi	protein kinase, putative	0.0092	0.0092	0.1992
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0092	0.0092	0.0093
Loa Loa (eye worm)	hypothetical protein	0.5651	0.9839	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.5651	0.9839	1
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Entamoeba histolytica	serine/threonine kinase, putative	0.0092	0.0092	0.1992
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Trichomonas vaginalis	conserved hypothetical protein	0.0092	0.0092	0.1992
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0092	0.0092	0.1992
Onchocerca volvulus		0.0092	0.0092	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0092	0.0092	0.0093
Toxoplasma gondii	protein kinase domain-containing protein	0.0092	0.0092	0.8335
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0207	0.0294	0.6399
Loa Loa (eye worm)	TK/FER protein kinase	0.0092	0.0092	0.0093
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0134	0.0166	0.3601
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0092	0.0092	0.8335
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0302	0.046	0.0468
Onchocerca volvulus		0.0092	0.0092	0.5
Onchocerca volvulus		0.0092	0.0092	0.5
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0092	0.0092	0.0093
Entamoeba histolytica	hypothetical protein	0.0092	0.0092	0.1992
Entamoeba histolytica	cysteine surface protein, putative	0.0092	0.0092	0.1992
Entamoeba histolytica	protein kinase, putative	0.0092	0.0092	0.1992
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Loa Loa (eye worm)	TK/EPH protein kinase	0.0092	0.0092	0.0093
Entamoeba histolytica	hypothetical protein	0.0092	0.0092	0.1992
Onchocerca volvulus		0.0092	0.0092	0.5
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0302	0.046	1
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0092	0.0092	0.0093
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0092	0.0092	0.5
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Loa Loa (eye worm)	TK/FER protein kinase	0.0092	0.0092	0.0093
Entamoeba histolytica	protein kinase domain containing protein	0.0092	0.0092	0.1992
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0092	0.0092	0.0093
Brugia malayi	ephrin receptor 1 precursor	0.0092	0.0092	0.0093
Toxoplasma gondii	protein kinase	0.0092	0.0092	0.8335
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Entamoeba histolytica	tyrosine kinase, putative	0.0092	0.0092	0.1992
Entamoeba histolytica	tyrosine kinase, putative	0.0092	0.0092	0.1992
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0092	0.0092	0.0093
Echinococcus granulosus	tyrosine kinase	0.0092	0.0092	0.0093
Entamoeba histolytica	receptor protein kinase, putative	0.0092	0.0092	0.1992
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0092	0.0092	0.0093
Entamoeba histolytica	protein kinase domain containing protein	0.0092	0.0092	0.1992
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0101	0.0108	1
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.024	0.0352	0.7652
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0092	0.0092	0.0093
Echinococcus multilocularis	tyrosine protein kinase csk	0.0092	0.0092	0.0093
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.0092	0.1992
Loa Loa (eye worm)	phosphatidylinositol 3	0.0506	0.0818	0.0831
Trichomonas vaginalis	conserved hypothetical protein	0.0092	0.0092	0.1992
Entamoeba histolytica	protein kinase domain containing protein	0.0092	0.0092	0.1992
Echinococcus multilocularis	tyrosine protein kinase	0.0092	0.0092	0.0093
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0092	0.0092	1
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0092	0.0092	0.0093
Entamoeba histolytica	protein kinase, putative	0.0092	0.0092	0.1992
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Echinococcus multilocularis	protein kinase	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Onchocerca volvulus	Tyrosine kinase homolog	0.0092	0.0092	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0092	0.0092	0.1992
Loa Loa (eye worm)	TK/FER protein kinase	0.0092	0.0092	0.0093
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0092	0.0092	0.1992
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0092	0.0092	0.0093
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0092	0.0092	0.0093
Onchocerca volvulus		0.0092	0.0092	0.5
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0092	0.0093
Brugia malayi	Tyrosine-protein kinase PR2	0.0092	0.0092	0.0093
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0568	0.0926	0.0941
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0016	0.0016
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Onchocerca volvulus		0.0092	0.0092	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0092	0.0092	0.0093
Entamoeba histolytica	protein kinase, putative	0.0092	0.0092	0.1992
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0092	0.0092	0.0093
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0092	0.0092	0.0092
Entamoeba histolytica	ankyrin repeat protein	0.0092	0.0092	0.1992
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0092	0.0092	0.0093
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0092	0.0092	0.0093
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Loa Loa (eye worm)	TK/FER protein kinase	0.0092	0.0092	0.0093
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Entamoeba histolytica	protein kinase, putative	0.0092	0.0092	0.1992
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0117	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0092	0.0093
Entamoeba histolytica	protein kinase, putative	0.0092	0.0092	0.1992
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0195	0.0274	0.0278
Loa Loa (eye worm)	TK/DDR protein kinase	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Schistosoma mansoni	ephrin receptor	0.0092	0.0092	0.0092
Schistosoma mansoni	protein kinase	0.0092	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0092	0.0093
Entamoeba histolytica	tyrosine kinase, putative	0.0092	0.0092	0.1992
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0092	0.0092	0.0092
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Entamoeba histolytica	protein kinase, putative	0.0092	0.0092	0.1992
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0045	0.0009	0.0009
Entamoeba histolytica	hypothetical protein	0.024	0.0352	0.7652
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Echinococcus granulosus	tyrosine protein kinase HCK	0.0092	0.0092	0.0093
Echinococcus granulosus	tyrosine protein kinase Blk	0.0092	0.0092	0.0093
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0092	0.0092	0.1992
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0568	0.0926	0.0941
Entamoeba histolytica	ankyrin repeat protein	0.0092	0.0092	0.1992
Entamoeba histolytica	hypothetical protein	0.0092	0.0092	0.1992
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0101	0.0108	0.2348
Plasmodium vivax	protein kinase, putative	0.0092	0.0092	1
Entamoeba histolytica	protein kinase, putative	0.0092	0.0092	0.1992
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0092	0.0092	0.0093
Toxoplasma gondii	STE kinase	0.0092	0.0092	0.8335
Entamoeba histolytica	receptor protein kinase, putative	0.0092	0.0092	0.1992
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Entamoeba histolytica	tyrosin kinase, putative	0.0092	0.0092	0.1992
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0207	0.0294	0.6399
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0092	0.0092	0.1992
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0302	0.046	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0092	0.0092	0.1992
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Schistosoma mansoni	protein kinase	0.0092	0.0092	0.0092
Toxoplasma gondii	hypothetical protein	0.0102	0.011	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.5651	0.9839	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0092	0.0092	0.1992
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0092	0.0092	0.0093
Echinococcus granulosus	epidermal growth factor receptor	0.0092	0.0092	0.0093
Echinococcus multilocularis	epidermal growth factor receptor	0.0092	0.0092	0.0093
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0092	0.0092	0.0093
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0092	0.0092	0.0093
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0092	0.0092	0.0093
Schistosoma mansoni	serine/threonine protein kinase	0.0092	0.0092	0.0092
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0092	0.0092	0.1992
Entamoeba histolytica	tyrosin kinase, putative	0.0092	0.0092	0.1992
Echinococcus granulosus	c src tyrosine kinase	0.0092	0.0092	0.0093
Trichomonas vaginalis	conserved hypothetical protein	0.0092	0.0092	0.1992
Echinococcus granulosus	tyrosine kinase	0.0092	0.0092	0.0093
Plasmodium falciparum	tyrosine kinase-like protein	0.0092	0.0092	1
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Schistosoma mansoni	protein kinase	0.0092	0.0092	0.0092
Schistosoma mansoni	protein kinase	0.0092	0.0092	0.0092
Brugia malayi	C-terminal src kinase protein 1	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Echinococcus granulosus	ephrin type A receptor 4 A	0.0092	0.0092	0.0093
Echinococcus granulosus	tyrosine protein kinase pr2	0.0092	0.0092	0.0093
Entamoeba histolytica	protein kinase, putative	0.0092	0.0092	0.1992
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0568	0.0926	0.0926
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0092	0.0092	0.0093
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Echinococcus multilocularis	tyrosine kinase	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0092	0.0092	0.0093
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0302	0.046	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0045	0.0009	0.0009
Trypanosoma cruzi	protein kinase, putative	0.0092	0.0092	0.1992
Entamoeba histolytica	hypothetical protein	0.0092	0.0092	0.1992
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0092	0.0092	0.8335
Loa Loa (eye worm)	hypothetical protein	0.0102	0.011	0.0112
Loa Loa (eye worm)	TK/ACK protein kinase	0.0092	0.0092	0.0093
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0302	0.046	1
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Trichomonas vaginalis	protein kinase atn1, putative	0.0092	0.0092	0.1992
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0101	0.0108	0.0108
Loa Loa (eye worm)	TK/Met protein kinase	0.0092	0.0092	0.0093
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0092	0.0092	0.1992
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0092	0.0092	0.8483
Trichomonas vaginalis	STE family protein kinase	0.0092	0.0092	0.1992
Loa Loa (eye worm)	SRC-1	0.0092	0.0092	0.0093
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Echinococcus granulosus	epidermal growth factor receptor	0.0092	0.0092	0.0093
Loa Loa (eye worm)	TK/ALK protein kinase	0.0092	0.0092	0.0093
Entamoeba histolytica	protein kinase, putative	0.0092	0.0092	0.1992
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Brugia malayi	hypothetical protein	0.0092	0.0092	0.0093
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0092	0.0093
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Loa Loa (eye worm)	TK/FER protein kinase	0.0092	0.0092	0.0093
Brugia malayi	Receptor family ligand binding region containing protein	0.0092	0.0092	0.0093
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0092	0.0092	0.0093
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0092	0.0092	0.1992
Loa Loa (eye worm)	phosphatidylinositol 3	0.0092	0.0092	0.0094
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Trichomonas vaginalis	conserved hypothetical protein	0.0092	0.0092	0.1992
Entamoeba histolytica	protein kinase domain containing protein	0.0092	0.0092	0.1992
Loa Loa (eye worm)	hypothetical protein	0.0102	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Echinococcus granulosus	protein tyrosine kinase	0.0092	0.0092	0.0093
Giardia lamblia	Kinase, NEK	0.0092	0.0092	0.2802
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0092	0.0092	0.0093
Echinococcus multilocularis	epidermal growth factor receptor	0.0092	0.0092	0.0093
Brugia malayi	Tyrosine-protein kinase abl-1	0.0092	0.0092	0.0093
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0092	0.0092	0.0093
Leishmania major	protein kinase, putative	0.0092	0.0092	1
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Echinococcus granulosus	integrin linked protein kinase	0.0092	0.0092	0.0093
Echinococcus multilocularis	transfer RNA-Thr	0.0092	0.0092	0.0093
Loa Loa (eye worm)	TK/FER protein kinase	0.0092	0.0092	0.0093
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0092	0.0092	0.0093
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Echinococcus multilocularis	heat shock protein 70	0.0092	0.0092	0.0093
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0092	0.0092	0.0093
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Schistosoma mansoni	protein tyrosine kinase	0.0092	0.0092	0.0092
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Entamoeba histolytica	tyrosine kinase, putative	0.0092	0.0092	0.1992
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0004	0.0088
Schistosoma mansoni	ephrin receptor	0.0092	0.0092	0.0092
Entamoeba histolytica	tyrosine kinase, putative	0.0092	0.0092	0.1992
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0195	0.0274	0.0278
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0092	0.0092	0.0093
Loa Loa (eye worm)	TK protein kinase	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Trypanosoma brucei	protein kinase, putative	0.0092	0.0092	0.8483
Plasmodium falciparum	protein kinase, putative	0.0092	0.0092	1
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Entamoeba histolytica	protein kinase domain containing protein	0.0092	0.0092	0.1992
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0092	0.0092	0.0093
Schistosoma mansoni	protein kinase	0.0092	0.0092	0.0092
Onchocerca volvulus		0.0092	0.0092	0.5
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0092	0.0092	0.1992
Entamoeba histolytica	protein kinase domain containing protein	0.0092	0.0092	0.1992
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0092	0.0092	0.1992
Schistosoma mansoni	serine/threonine RGC	0.0092	0.0092	0.0092
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0092	0.0092	1
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0092	0.0092	0.0093
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0092	0.0092	0.0093
Onchocerca volvulus		0.0092	0.0092	0.5
Trichomonas vaginalis	TK family protein kinase	0.0092	0.0092	0.1992
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0092	0.0092	0.2008
Loa Loa (eye worm)	TK/ABL protein kinase	0.0092	0.0092	0.0093
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0092	0.0092	0.0093
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Entamoeba histolytica	serine/threonine kinase, putative	0.0092	0.0092	0.1992
Loa Loa (eye worm)	TKL/MLK/LZK protein kinase	0.5651	0.9839	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0092	0.0092	0.0093
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0092	0.0092	0.1992
Loa Loa (eye worm)	TK protein kinase	0.0092	0.0092	0.0093
Brugia malayi	Guanylyl cyclase protein 23	0.0092	0.0092	0.0093
Echinococcus granulosus	tyrosine protein kinase	0.0092	0.0092	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0092	0.0093
Entamoeba histolytica	tyrosin kinase, putative	0.0092	0.0092	0.1992
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0092	0.0092	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0092	0.0092	0.1992
Entamoeba histolytica	protein kinase domain containing protein	0.0092	0.0092	0.1992
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0092	0.0092	0.0092
Schistosoma mansoni	protein kinase	0.0092	0.0092	0.0092
Echinococcus granulosus	activated cdc42 kinase 1	0.0092	0.0092	0.0093
Entamoeba histolytica	hypothetical protein, conserved	0.0092	0.0092	0.1992
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0092	0.0092	0.0093
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0092	0.0092	0.0093
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0045	0.0009	0.0009
Entamoeba histolytica	tyrosine kinase, putative	0.0092	0.0092	0.1992
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0092	0.0092	0.1992
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0092	0.0092	0.0093
Loa Loa (eye worm)	TK protein kinase	0.0092	0.0092	0.0093
Echinococcus multilocularis	insulin receptor	0.0092	0.0092	0.0093
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0101	0.0108	0.011
Entamoeba histolytica	protein kinase domain containing protein	0.0092	0.0092	0.1992
Entamoeba histolytica	tyrosine kinase, putative	0.0092	0.0092	0.1992
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0092	0.0092	0.0092
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0092	0.0092	0.1992
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0092	0.0092	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0092	0.0092	0.1992
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0092	0.0092	0.0093
Echinococcus granulosus	protein kinase	0.0092	0.0092	0.0093
Entamoeba histolytica	protein kinase domain containing protein	0.0092	0.0092	0.1992
Loa Loa (eye worm)	TK protein kinase	0.0092	0.0092	0.0093
Giardia lamblia	Protein 21.1	0.0092	0.0092	0.2802
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0092	0.0092	0.0093
Entamoeba histolytica	protein kinase, putative	0.0092	0.0092	0.1992
Echinococcus multilocularis	activated cdc42 kinase 1	0.0092	0.0092	0.0093
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0092	0.0092	0.0093
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0101	0.0108	0.2348
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0092	0.0092	0.0093
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0092	0.0092	0.0093
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0092	0.0092	0.0093
Echinococcus granulosus	tyrosine protein kinase csk	0.0092	0.0092	0.0093
Schistosoma mansoni	protein kinase	0.0092	0.0092	0.0092
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Loa Loa (eye worm)	TK/CSK protein kinase	0.0092	0.0092	0.0093
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0092	0.0092	0.1992
Schistosoma mansoni	tyrosine kinase	0.0092	0.0092	0.0092
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0092	0.0092	0.0093
Echinococcus granulosus	tyrosine protein kinase shark	0.0092	0.0092	0.0093
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0092	0.0093
Entamoeba histolytica	tyrosine kinase, putative	0.0092	0.0092	0.1992
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0092	0.0092	0.0093

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.2 uM	Inhibition of human ROMK channel-mediated 86Rb+ flux expressed in CHO cells after 35 mins by scintillation counting analysis	ChEMBL.	24075732
IC50 (binding)	= 6.5 uM	Displacement of [35S]-MK499 from human ERG	ChEMBL.	24075732

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2441441

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1791541