Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | oxidoreductase | 0.0157 | 0.542 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0157 | 0.542 | 0.542 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0157 | 0.542 | 0.542 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0157 | 0.542 | 0.542 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0195 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0157 | 0.542 | 0.542 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0157 | 0.542 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0157 | 0.542 | 0.542 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0157 | 0.542 | 0.542 |
Echinococcus multilocularis | aldo keto reductase | 0.0157 | 0.542 | 0.542 |
Trypanosoma brucei | protein kinase, putative | 0.0195 | 1 | 1 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0195 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0157 | 0.542 | 0.542 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0157 | 0.542 | 0.542 |
Echinococcus multilocularis | aldo keto reductase | 0.0157 | 0.542 | 0.542 |
Echinococcus granulosus | aldo keto reductase | 0.0157 | 0.542 | 0.542 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0195 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0157 | 0.542 | 0.542 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0195 | 1 | 1 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0195 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0157 | 0.542 | 0.542 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0195 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0157 | 0.542 | 0.542 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0157 | 0.542 | 0.542 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0157 | 0.542 | 0.542 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0157 | 0.542 | 0.542 |
Echinococcus multilocularis | aldo keto reductase | 0.0157 | 0.542 | 0.542 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0195 | 1 | 1 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0195 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0157 | 0.542 | 0.542 |
Echinococcus granulosus | protein kinase shaggy | 0.0195 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0195 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0157 | 0.542 | 0.542 |
Echinococcus multilocularis | protein kinase shaggy | 0.0195 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0157 | 0.542 | 0.542 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0195 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0157 | 0.542 | 0.542 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0157 | 0.542 | 0.542 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0157 | 0.542 | 0.542 |
Onchocerca volvulus | 0.0195 | 1 | 1 | |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0157 | 0.542 | 1 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0195 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0157 | 0.542 | 0.542 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0157 | 0.542 | 0.542 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0195 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0195 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0195 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0157 | 0.542 | 0.542 |
Giardia lamblia | Kinase, CMGC GSK | 0.0195 | 1 | 1 |
Giardia lamblia | Kinase, CMGC GSK | 0.0195 | 1 | 1 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0195 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0157 | 0.542 | 0.542 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 404.25 uM | Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay | ChEMBL. | 24125880 |
IC50 (functional) | = 147 uM | Antipromastigote activity against Leishmania braziliensis MCAN/BR/98/R619 after 24 hrs by MTT assay | ChEMBL. | 24125880 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.