TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 439.549 | Formula: C28H29N3O2
H donors: 2 H acceptors: 2 LogP: 5.55 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccc(cc1)c1nc(c([nH]1)c1ccccc1)c1ccc(cc1)OCCN1CCCCC1
InChi: 1S/C28H29N3O2/c32-24-13-9-23(10-14-24)28-29-26(21-7-3-1-4-8-21)27(30-28)22-11-15-25(16-12-22)33-20-19-31-17-5-2-6-18-31/h1,3-4,7-16,32H,2,5-6,17-20H2,(H,29,30)
InChiKey: BMKKXFAIQHKZLM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	importin beta, putative	0.0028	0.067	0.3608
Loa Loa (eye worm)	hypothetical protein	0.001	0.0056	0.0056
Schistosoma mansoni	hypothetical protein	0.0017	0.0277	0.0277
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0157	0.0157
Loa Loa (eye worm)	transcription factor SMAD2	0.0128	0.403	0.403
Loa Loa (eye worm)	inositol-1	0.0036	0.0941	0.0941
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0056	0.0056
Onchocerca volvulus		0.0028	0.0641	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.1362	0.1362
Echinococcus granulosus	GPCR family 2	0.0017	0.0277	0.0277
Plasmodium falciparum	T-complex protein 1 subunit beta	0.0024	0.0535	0.1694
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0056	0.0056
Toxoplasma gondii	t-complex protein beta subunit	0.0024	0.0535	0.1433
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0277	0.0558
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0487	0.1374
Leishmania major	T-complex protein 1, beta subunit, putative	0.0024	0.0535	0.2275
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0056	0.0113
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0056	0.0056
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0941	0.0941
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0941	0.6298
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0941	1
Loa Loa (eye worm)	cyclophilin Ovcyp-2	0.0023	0.0474	0.0474
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0056	0.0113
Entamoeba histolytica	hypothetical protein	0.0023	0.0487	0.1023
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0487	0.0866
Brugia malayi	RNA binding protein	0.0136	0.4324	0.8724
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0056	0.0113
Schistosoma mansoni	coup transcription factor	0.001	0.0056	0.0056
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0024	0.0535	0.0535
Echinococcus multilocularis	lamin dm0	0.0028	0.0641	0.0641
Trichomonas vaginalis	peptidyl-prolyl cis-trans isomerase A, ppia, putative	0.0023	0.0474	0.0704
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0487	0.1374
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.1511	0.3049
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0277	0.0277
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.1362	0.1362
Loa Loa (eye worm)	hypothetical protein	0.001	0.0056	0.0056
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0056	0.0056
Toxoplasma gondii	cyclophilin precursor	0.0023	0.0474	0.0704
Plasmodium vivax	T-complex protein 1 subunit beta, putative	0.0024	0.0535	0.1433
Loa Loa (eye worm)	hypothetical protein	0.001	0.0056	0.0056
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0046	0.1249	1
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.067	0.3051
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0013	0.014	0.014
Trichomonas vaginalis	chaperonin-60kD, ch60, putative	0.0024	0.0535	0.1433
Loa Loa (eye worm)	cyclophilin-type peptidyl-prolyl cis-trans isomerase-2	0.0023	0.0474	0.0474
Loa Loa (eye worm)	hypothetical protein	0.001	0.0056	0.0056
Schistosoma mansoni	eukaryotic translation initiation factor 4h	0.0136	0.4324	0.4324
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.1362	0.1362
Loa Loa (eye worm)	hypothetical protein	0.001	0.0056	0.0056
Brugia malayi	steroid hormone receptor	0.001	0.0056	0.0113
Trypanosoma brucei	T-complex protein 1, beta subunit, putative	0.0024	0.0535	0.2275
Echinococcus multilocularis	snurportin 1	0.0304	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0056	0.0113
Brugia malayi	ecdysteroid receptor	0.001	0.0056	0.0113
Brugia malayi	T-complex protein 1, beta subunit	0.0024	0.0535	0.1079
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0641	0.1294
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase	0.0023	0.0474	0.0833
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0056	0.0113
Brugia malayi	Inositol-1	0.0036	0.0941	0.1898
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0056	0.0113
Loa Loa (eye worm)	MH2 domain-containing protein	0.0128	0.403	0.403
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0155	0.4956	0.4956
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0129	0.4074	0.4074
Echinococcus granulosus	expressed protein	0.0023	0.0474	0.0474
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0056	0.0056
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0056	0.0056
Schistosoma mansoni	hypothetical protein	0.0129	0.4074	0.4074
Schistosoma mansoni	hypothetical protein	0.0166	0.5327	0.5327
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0941	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0056	0.0056
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0056	0.0056
Brugia malayi	Importin beta-1 subunit	0.0028	0.067	0.1351
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0056	0.0056
Trypanosoma cruzi	cyclophilin type peptidyl-prolyl cis-trans isomerase	0.0023	0.0474	0.1118
Entamoeba histolytica	acetyltransferase, GNAT family	0.0042	0.1121	1
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0056	0.0056
Entamoeba histolytica	hypothetical protein	0.0037	0.0954	0.7634
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0056	0.0056
Plasmodium vivax	cyclophilin, putative	0.0023	0.0474	0.0704
Schistosoma mansoni	thyroid hormone receptor	0.0139	0.4425	0.4425
Loa Loa (eye worm)	hypothetical protein	0.001	0.0056	0.0056
Schistosoma mansoni	hypothetical protein	0.0017	0.0277	0.0277
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0641	0.0641
Brugia malayi	T-complex protein 1, beta subunit	0.0024	0.0535	0.1079
Echinococcus granulosus	lamin dm0	0.0028	0.0641	0.0641
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.1511	0.3049
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0415	0.0415
Trypanosoma cruzi	cyclophilin, putative	0.0023	0.0474	0.1118
Brugia malayi	nuclear receptor NHR-88	0.001	0.0056	0.0113
Loa Loa (eye worm)	hypothetical protein	0.001	0.0056	0.0056
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0941	1
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0056	0.0113
Echinococcus granulosus	Eukaryotic translation initiation factor 4H	0.0136	0.4324	0.4324
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.1362	0.1362
Schistosoma mansoni	hypothetical protein	0.0166	0.5327	0.5327
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1511	0.1511
Loa Loa (eye worm)	T-complex protein 1	0.0024	0.0535	0.0535
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0056	0.0056
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.1362	0.1362
Schistosoma mansoni	cyclophilin	0.0023	0.0474	0.0474
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0151	0.4809	0.4809
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0624	0.0624
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0056	0.0056
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0056	0.0113
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0056	0.0113
Brugia malayi	RNA, U transporter 1	0.0081	0.2448	0.4939
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0487	0.0866
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0024	0.0535	0.0535
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0023	0.0474	0.1118
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0487	0.0866
Brugia malayi	hypothetical protein	0.0037	0.0954	0.1925
Trichomonas vaginalis	chaperonin, putative	0.0024	0.0535	0.1433
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0033	0.0811	0.5
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0941	0.6298
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0033	0.0811	0.5
Schistosoma mansoni	hypothetical protein	0.0017	0.0277	0.0277
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0415	0.0837
Echinococcus multilocularis	Eukaryotic translation initiation factor 4H	0.0136	0.4324	0.4324
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0277	0.0277
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0277	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0013	0.014	0.014
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.1362	0.2749
Schistosoma mansoni	hypothetical protein	0.0036	0.094	0.094
Schistosoma mansoni	hypothetical protein	0.0017	0.0277	0.0277
Onchocerca volvulus		0.0023	0.0474	0.714
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0277	0.0277
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0056	0.0056
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0941	0.0941
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0304	1	1
Onchocerca volvulus		0.0023	0.0474	0.714
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0277	0.0277
Schistosoma mansoni	lamin	0.0028	0.0641	0.0641
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0641	0.0641
Entamoeba histolytica	hypothetical protein	0.0037	0.0954	0.7634
Schistosoma mansoni	lamin	0.0028	0.0641	0.0641
Loa Loa (eye worm)	hypothetical protein	0.001	0.0056	0.0056
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0046	0.1249	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0056	0.0056
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0941	0.0941
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0641	0.0641
Schistosoma mansoni	importin beta-1	0.0028	0.067	0.067
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.094	0.1896
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0046	0.1249	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0056	0.0056
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0941	0.6298
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0056	0.0056
Brugia malayi	acetyltransferase, GNAT family protein	0.0155	0.4956	1
Echinococcus multilocularis	geminin	0.0166	0.5327	0.5327
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0046	0.1249	0.1249
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0056	0.0113
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.067	0.4845
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0056	0.0056
Plasmodium falciparum	histone acetyltransferase GCN5	0.0042	0.1121	1
Onchocerca volvulus		0.0028	0.0641	1
Loa Loa (eye worm)	acetyltransferase	0.0155	0.4956	0.4956
Trypanosoma brucei	cyclophilin a	0.0023	0.0474	0.1118
Entamoeba histolytica	T-complex protein 1 beta subunit, putative	0.0024	0.0535	0.1694
Brugia malayi	cyclophilin-type peptidyl-prolyl cis-trans isomerase-3, Bmcyp-3	0.0023	0.0474	0.0956
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.1511	0.1511
Trypanosoma cruzi	rotamase, putative	0.0023	0.0474	0.1118
Brugia malayi	nuclear hormone receptor	0.001	0.0056	0.0113
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0207	0.0207
Toxoplasma gondii	cyclophilin 1, putative	0.0023	0.0474	0.0704
Leishmania major	cyclophilin 4, putative	0.0023	0.0474	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0036	0.094	0.094
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0028	0.067	0.067
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0277	0.0277
Giardia lamblia	TCP-1 chaperonin subunit beta	0.0024	0.0535	0.1694
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0056	0.0056
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.067	0.4845
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0941	0.7447
Echinococcus granulosus	lamin	0.0028	0.0641	0.0641
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0277	0.0277
Echinococcus granulosus	chaperonin containing TCP1 subunit 2 beta	0.0024	0.0535	0.0535
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0415	0.0415
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0056	0.0056
Echinococcus granulosus	intermediate filament protein	0.0028	0.0641	0.0641
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.1362	0.1362
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0056	0.0056
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.1362	0.1362
Trypanosoma cruzi	21 kDa cyclophilin, putative	0.0023	0.0474	0.1118
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0056	0.0056
Trypanosoma cruzi	T-complex protein 1, beta subunit, putative	0.0024	0.0535	0.2275
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.0941	0.5
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0056	0.0056
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0056	0.0056
Entamoeba histolytica	hypothetical protein	0.0037	0.0954	0.7634
Entamoeba histolytica	hypothetical protein	0.0037	0.0954	0.7634
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0277	0.0558
Leishmania major	cyclophilin a	0.0023	0.0474	0.1118
Echinococcus multilocularis	musashi	0.0028	0.0641	0.0641
Plasmodium vivax	importin-beta 2, putative	0.0028	0.067	0.3051
Loa Loa (eye worm)	hypothetical protein	0.0136	0.4324	0.4324
Echinococcus granulosus	geminin	0.0166	0.5327	0.5327
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0954	0.0954
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.067	0.067
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0056	0.0056
Giardia lamblia	Histone acetyltransferase GCN5	0.0042	0.1121	1
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0023	0.0474	0.1118
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0415	0.0415
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0056	0.0056
Schistosoma mansoni	hypothetical protein	0.0037	0.0954	0.0954
Schistosoma mansoni	hypothetical protein	0.0304	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0056	0.0113
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0139	0.4425	0.4425
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0207	0.0417
Brugia malayi	intermediate filament protein	0.0028	0.0641	0.1294
Plasmodium vivax	unspecified product	0.0023	0.0474	0.0704
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0046	0.1249	1
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0023	0.0474	0.1118
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0941	0.6298
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0157	0.0157
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0056	0.0113
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0056	0.0113
Brugia malayi	cyclophilin-type peptidyl-prolyl cis-trans isomerase-2, Bmcyp-2	0.0023	0.0474	0.0956
Echinococcus multilocularis	lamin	0.0028	0.0641	0.0641
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0941	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0056	0.0113
Schistosoma mansoni	ran	0.0021	0.0415	0.0415
Schistosoma mansoni	eukaryotic translation initiation factor 4h	0.0136	0.4324	0.4324
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0056	0.0056
Brugia malayi	MH2 domain containing protein	0.0128	0.403	0.8132
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0056	0.0056
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0129	0.4074	0.4074
Schistosoma mansoni	ran	0.0021	0.0415	0.0415
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0056	0.0056
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0046	0.1249	1
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0024	0.0535	0.0535
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0056	0.0113
Leishmania major	cyclophilin 11, putative	0.0023	0.0474	0.1118
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0954	0.0954
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0056	0.0113
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0056	0.0056
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0056	0.0056
Schistosoma mansoni	thyroid hormone receptor	0.0139	0.4425	0.4425
Echinococcus multilocularis	expressed protein	0.0023	0.0474	0.0474
Trypanosoma brucei	cyclophilin, putative	0.0023	0.0474	0.1118
Schistosoma mansoni	eukaryotic translation initiation factor 4h	0.0136	0.4324	0.4324
Echinococcus multilocularis	chaperonin containing TCP1, subunit 2 (beta)	0.0024	0.0535	0.0535
Echinococcus granulosus	importin subunit beta 1	0.0028	0.067	0.067
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0641	0.0641
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0157	0.0157
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0941	0.5
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0155	0.4956	0.4956
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.1362	0.1362
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0954	0.0954
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0941	0.0941
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0056	0.0056

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	< 0.1 uM	Cytotoxicity against Homo sapiens (human) MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hr by MTT assay	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2298731

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1791700