Detailed information for compound 1791761

Basic information

Technical information
  • TDR Targets ID: 1791761
  • Name: 4-[[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydrox ymethyl)oxolan-2-yl]purin-6-yl]amino]methyl]b enzonitrile
  • MW: 382.373 | Formula: C18H18N6O4
  • H donors: 4 H acceptors: 7 LogP: -0.03 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1ccc(cc1)C#N
  • InChi: 1S/C18H18N6O4/c19-5-10-1-3-11(4-2-10)6-20-16-13-17(22-8-21-16)24(9-23-13)18-15(27)14(26)12(7-25)28-18/h1-4,8-9,12,14-15,18,25-27H,6-7H2,(H,20,21,22)/t12-,14-,15-,18-/m1/s1
  • InChiKey: IREPDRNDMVFTIH-SCFUHWHPSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-[[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]purin-6-yl]amino]methyl]benzonitrile
  • 4-[[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-6-purinyl]amino]methyl]benzonitrile
  • 4-[[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]purin-6-yl]amino]methyl]benzonitrile
  • AIDS471975
  • 9H-Purin-6-amine, N-[(4-cyanophenyl)methyl]-9-b-D-ribofuranosyl-
  • AIDS-471975

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Toxoplasma gondii kinase, pfkB family protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum GG10762, related Get druggable targets OG5_128398 All targets in OG5_128398
Brugia malayi Adenosine kinase-like Get druggable targets OG5_128398 All targets in OG5_128398
Echinococcus granulosus adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania infantum adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Candida albicans putative adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma cruzi adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Schistosoma mansoni adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma brucei gambiense adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Cryptosporidium parvum adenosine kinase like ribokinase Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania mexicana adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma congolense adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma brucei adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania major adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma brucei adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma cruzi adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Echinococcus multilocularis adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Schistosoma mansoni adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Babesia bovis adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania donovani adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Candida albicans adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Toxoplasma gondii kinase, pfkB family protein Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma brucei gambiense adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania braziliensis adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Schistosoma japonicum ko:K00856 adenosine kinase [EC2.7.1.20], putative Get druggable targets OG5_128398 All targets in OG5_128398
Onchocerca volvulus Get druggable targets OG5_128398 All targets in OG5_128398
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128398 All targets in OG5_128398
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus adenosine kinase 0.0105 0.2209 0.2184
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Echinococcus multilocularis fmrfamide receptor 0.011 0.2361 0.2337
Schistosoma mansoni biogenic amine (dopamine) receptor 0.011 0.2361 0.4914
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011 0.2361 0.4914
Onchocerca volvulus Neuropeptide F receptor homolog 0.011 0.2361 1
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Onchocerca volvulus 0.011 0.2361 1
Schistosoma mansoni amine GPCR 0.011 0.2361 0.4914
Echinococcus multilocularis thyroid hormone receptor alpha 0.0151 0.3525 0.3505
Brugia malayi hypothetical protein 0.011 0.2361 1
Echinococcus multilocularis neuropeptide Y receptor 0.011 0.2361 0.2337
Plasmodium vivax glutathione reductase, putative 0.0053 0.0705 0.5
Schistosoma mansoni hypothetical protein 0.011 0.2361 0.4914
Echinococcus multilocularis rhodopsin orphan GPCR 0.011 0.2361 0.2337
Brugia malayi Intermediate filament tail domain containing protein 0.006 0.0921 0.3566
Echinococcus granulosus rhodopsin orphan GPCR 0.011 0.2361 0.2337
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.011 0.2361 0.2337
Echinococcus multilocularis neuropeptide s receptor 0.011 0.2361 0.2337
Echinococcus granulosus tachykinin peptides receptor 99D 0.011 0.2361 0.2337
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.011 0.2361 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.011 0.2361 1
Echinococcus multilocularis neuropeptide receptor 0.011 0.2361 0.2337
Onchocerca volvulus 0.011 0.2361 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.011 0.2361 0.2337
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Schistosoma mansoni hypothetical protein 0.011 0.2361 0.4914
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.011 0.2361 0.2337
Schistosoma mansoni neuropeptide receptor 0.011 0.2361 0.4914
Schistosoma mansoni amine GPCR 0.011 0.2361 0.4914
Trypanosoma cruzi adenosine kinase, putative 0.0105 0.2209 1
Schistosoma mansoni adenoreceptor 0.011 0.2361 0.4914
Schistosoma mansoni myosin xvIII 0.011 0.2361 0.4914
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.012 0.2631 0.8342
Echinococcus multilocularis neuropeptides capa receptor 0.011 0.2361 0.2337
Echinococcus multilocularis g protein coupled receptor 0.011 0.2361 0.2337
Echinococcus multilocularis rhodopsin orphan GPCR 0.011 0.2361 0.2337
Echinococcus granulosus allatostatin A receptor 0.011 0.2361 0.2337
Toxoplasma gondii kinase, pfkB family protein 0.0105 0.2209 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.011 0.2361 0.2337
Brugia malayi Tachykinin-like peptides receptor 99D 0.011 0.2361 1
Brugia malayi putative neuropeptide receptor NPR1 0.011 0.2361 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.014 0.3204 0.3182
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Schistosoma mansoni opsin-like receptor 0.011 0.2361 0.4914
Echinococcus granulosus alpha 1A adrenergic receptor 0.011 0.2361 0.2337
Echinococcus multilocularis biogenic amine (5HT) receptor 0.011 0.2361 0.2337
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Onchocerca volvulus 0.0093 0.1866 0.6866
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011 0.2361 0.4914
Brugia malayi Dopamine receptor protein 1 0.011 0.2361 1
Schistosoma mansoni neuropeptide receptor 0.011 0.2361 0.4914
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.011 0.2361 0.2337
Schistosoma mansoni hypothetical protein 0.011 0.2361 0.4914
Mycobacterium tuberculosis Probable oxidoreductase 0.0133 0.3013 1
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Echinococcus granulosus hypothetical protein 0.011 0.2361 0.2337
Brugia malayi hypothetical protein 0.011 0.2361 1
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011 0.2361 0.4914
Brugia malayi Serotonin receptor 0.011 0.2361 1
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.011 0.2361 0.2337
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.011 0.2361 0.4914
Brugia malayi GnHR receptor homolog 0.011 0.2361 1
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Brugia malayi sulfakinin receptor protein 0.011 0.2361 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0921 0.39
Schistosoma mansoni biogenic amine receptor 0.011 0.2361 0.4914
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.011 0.2361 1
Schistosoma mansoni histamine h1 receptor 0.011 0.2361 0.4914
Echinococcus granulosus tm gpcr rhodopsin 0.011 0.2361 0.2337
Echinococcus multilocularis lamin dm0 0.006 0.0921 0.0892
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Echinococcus multilocularis dro:myosuppressin receptor 0.011 0.2361 0.2337
Schistosoma mansoni biogenic amine receptor 0.011 0.2361 0.4914
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011 0.2361 0.4914
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Brugia malayi hypothetical protein 0.011 0.2361 1
Brugia malayi glutathione reductase 0.0053 0.0705 0.2601
Echinococcus granulosus somatostatin receptor 0.011 0.2361 0.2337
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.011 0.2361 0.2337
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.011 0.2361 0.4914
Loa Loa (eye worm) follicle stimulating hormone receptor 0.011 0.2361 1
Onchocerca volvulus 0.011 0.2361 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.011 0.2361 0.2337
Echinococcus granulosus tm gpcr rhodopsin 0.011 0.2361 0.2337
Echinococcus granulosus intermediate filament protein 0.006 0.0921 0.0892
Brugia malayi Melatonin receptor type 1A 0.011 0.2361 1
Onchocerca volvulus 0.011 0.2361 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0705 0.0676
Schistosoma mansoni lamin 0.006 0.0921 0.0431
Loa Loa (eye worm) neuropeptide F receptor 0.011 0.2361 1
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Echinococcus granulosus biogenic amine 5HT receptor 0.011 0.2361 0.2337
Onchocerca volvulus 0.011 0.2361 1
Echinococcus granulosus tm gpcr rhodopsin 0.011 0.2361 0.2337
Brugia malayi follicle stimulating hormone receptor 0.011 0.2361 1
Echinococcus multilocularis tumor protein p63 0.0377 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.011 0.2361 0.2337
Schistosoma mansoni intermediate filament proteins 0.006 0.0921 0.0431
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.011 0.2361 1
Loa Loa (eye worm) neuropeptide F receptor 0.011 0.2361 1
Onchocerca volvulus 0.011 0.2361 1
Echinococcus multilocularis neuropeptide Y receptor 0.011 0.2361 0.2337
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Echinococcus multilocularis fmrfamide receptor 0.011 0.2361 0.2337
Schistosoma mansoni adenosine kinase 0.0105 0.2209 0.444
Brugia malayi larval opioid receptor 0.011 0.2361 1
Echinococcus granulosus rhodopsin orphan GPCR 0.011 0.2361 0.2337
Schistosoma mansoni adenosine kinase 0.0105 0.2209 0.444
Onchocerca volvulus 0.011 0.2361 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.011 0.2361 0.2337
Echinococcus multilocularis g-protein coupled receptor 0.011 0.2361 0.2337
Schistosoma mansoni opsin-like receptor 0.011 0.2361 0.4914
Echinococcus multilocularis g protein coupled receptor 0.011 0.2361 0.2337
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011 0.2361 0.4914
Brugia malayi hypothetical protein 0.011 0.2361 1
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Schistosoma mansoni opsin-like receptor 0.011 0.2361 0.4914
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0133 0.3013 1
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Loa Loa (eye worm) G-protein coupled receptor 0.011 0.2361 1
Schistosoma mansoni growth hormone secretagogue receptor 0.011 0.2361 0.4914
Echinococcus granulosus 7TM GPCR rhodopsin 0.011 0.2361 0.2337
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.011 0.2361 0.2337
Brugia malayi hypothetical protein 0.011 0.2361 1
Schistosoma mansoni hypothetical protein 0.014 0.3204 0.7536
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Echinococcus granulosus rhodopsin orphan GPCR 0.011 0.2361 0.2337
Brugia malayi hypothetical protein 0.011 0.2361 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.011 0.2361 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.012 0.2631 0.8342
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0123 0.052
Plasmodium falciparum glutathione reductase 0.0053 0.0705 0.5
Brugia malayi RE15519p 0.011 0.2361 1
Onchocerca volvulus 0.006 0.0921 0.0878
Brugia malayi Serotonin receptor 0.011 0.2361 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.011 0.2361 0.4914
Schistosoma mansoni neuropeptide F-like receptor 0.011 0.2361 0.4914
Brugia malayi hypothetical protein 0.011 0.2361 1
Schistosoma mansoni amine GPCR 0.011 0.2361 0.4914
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Schistosoma mansoni biogenic amine receptor 0.011 0.2361 0.4914
Schistosoma mansoni neuropeptide receptor 0.011 0.2361 0.4914
Echinococcus multilocularis rhodopsin orphan GPCR 0.011 0.2361 0.2337
Schistosoma mansoni thyroid hormone receptor 0.0151 0.3525 0.8536
Echinococcus multilocularis rhodopsin orphan GPCR 0.011 0.2361 0.2337
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Trypanosoma brucei adenosine kinase, putative 0.0105 0.2209 1
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.011 0.2361 0.2337
Loa Loa (eye worm) G-protein coupled receptor 0.011 0.2361 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.011 0.2361 0.2337
Echinococcus granulosus neuropeptide receptor 0.011 0.2361 0.2337
Onchocerca volvulus 0.011 0.2361 1
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Brugia malayi intermediate filament protein 0.006 0.0921 0.3566
Echinococcus multilocularis alpha 1A adrenergic receptor 0.011 0.2361 0.2337
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.011 0.2361 0.2337
Trypanosoma brucei adenosine kinase, putative 0.0105 0.2209 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.011 0.2361 0.2337
Echinococcus granulosus neuropeptides capa receptor 0.011 0.2361 0.2337
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.011 0.2361 1
Echinococcus granulosus g protein coupled receptor 0.011 0.2361 0.2337
Schistosoma mansoni biogenic amine (5HT) receptor 0.011 0.2361 0.4914
Brugia malayi G protein-coupled receptor F59B2.13 0.011 0.2361 1
Brugia malayi Thioredoxin reductase 0.0053 0.0705 0.2601
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0133 0.3013 1
Echinococcus multilocularis sex peptide receptor 0.011 0.2361 0.2337
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011 0.2361 0.4914
Schistosoma mansoni peptide (allatostatin)-like receptor 0.011 0.2361 0.4914
Brugia malayi putative neuropeptide receptor 0.011 0.2361 1
Echinococcus multilocularis adenosine kinase 0.0105 0.2209 0.2184
Echinococcus multilocularis G protein coupled receptor 139 0.011 0.2361 0.2337
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0705 0.5
Schistosoma mansoni alpha-1 adrenergic receptor 0.011 0.2361 0.4914
Loa Loa (eye worm) intermediate filament protein 0.006 0.0921 0.39
Echinococcus granulosus orexin receptor type 2 0.011 0.2361 0.2337
Echinococcus granulosus 7tm_1 domain containing protein 0.011 0.2361 0.2337
Loa Loa (eye worm) melatonin receptor type 1A 0.011 0.2361 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.011 0.2361 0.2337
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Echinococcus granulosus neuropeptide receptor 0.011 0.2361 0.2337
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0133 0.3013 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011 0.2361 0.4914
Trypanosoma cruzi adenosine kinase, putative 0.0105 0.2209 1
Echinococcus multilocularis serotonin receptor 0.011 0.2361 0.2337
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Echinococcus multilocularis musashi 0.006 0.0921 0.0892
Echinococcus granulosus rhodopsin orphan GPCR 0.011 0.2361 0.2337
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.011 0.2361 0.4914
Echinococcus granulosus neuropeptide Y receptor 0.011 0.2361 0.2337
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.011 0.2361 0.2337
Schistosoma mansoni neuropeptide f receptor 76f 0.011 0.2361 0.4914
Onchocerca volvulus 0.011 0.2361 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.011 0.2361 0.2337
Onchocerca volvulus 0.011 0.2361 1
Brugia malayi neuropeptide F receptor 0.011 0.2361 1
Leishmania major adenosine kinase, putative 0.0105 0.2209 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.011 0.2361 0.2337
Onchocerca volvulus 0.011 0.2361 1
Echinococcus granulosus serotonin receptor 0.011 0.2361 0.2337
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.011 0.2361 0.2337
Brugia malayi Serotonin/octopamine receptor family protein 7 0.011 0.2361 1
Brugia malayi AKH receptor 0.011 0.2361 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0782 0.3313
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Echinococcus granulosus neuropeptide FF receptor 2 0.011 0.2361 0.2337
Mycobacterium tuberculosis Putative ferredoxin reductase 0.012 0.2631 0.8342
Brugia malayi G protein-coupled receptor 0.011 0.2361 1
Echinococcus multilocularis orexin receptor type 2 0.011 0.2361 0.2337
Echinococcus granulosus g protein coupled receptor 0.011 0.2361 0.2337
Schistosoma mansoni thyroid hormone receptor 0.0151 0.3525 0.8536
Echinococcus granulosus neuropeptide receptor A26 0.011 0.2361 0.2337
Echinococcus multilocularis neuropeptide receptor 0.011 0.2361 0.2337
Mycobacterium tuberculosis Probable reductase 0.012 0.2631 0.8342
Brugia malayi G-protein coupled receptor 0.011 0.2361 1
Echinococcus granulosus lamin 0.006 0.0921 0.0892
Echinococcus multilocularis somatostatin receptor 0.011 0.2361 0.2337
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Onchocerca volvulus 0.011 0.2361 1
Echinococcus multilocularis lamin 0.006 0.0921 0.0892
Onchocerca volvulus 0.006 0.0921 0.0878
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Echinococcus granulosus g-protein coupled receptor 0.011 0.2361 0.2337
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.011 0.2361 1
Brugia malayi Dopamine receptor protein 2 0.011 0.2361 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0705 0.0676
Echinococcus granulosus g protein coupled receptor 0.011 0.2361 0.2337
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.011 0.2361 0.4914
Schistosoma mansoni biogenic amine (5HT) receptor 0.011 0.2361 0.4914
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.011 0.2361 0.4914
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.011 0.2361 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.011 0.2361 0.2337
Onchocerca volvulus 0.011 0.2361 1
Echinococcus granulosus neuropeptides capa receptor 0.011 0.2361 0.2337
Brugia malayi Dopamine receptor 0.011 0.2361 1
Echinococcus granulosus rhodopsin orphan GPCR 0.011 0.2361 0.2337
Echinococcus granulosus neuropeptide Y receptor 0.011 0.2361 0.2337
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.011 0.2361 0.2337
Schistosoma mansoni biogenic amine (dopamine) receptor 0.011 0.2361 0.4914
Onchocerca volvulus 0.011 0.2361 1
Echinococcus granulosus lamin dm0 0.006 0.0921 0.0892
Echinococcus multilocularis rhodopsin orphan GPCR 0.011 0.2361 0.2337
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0705 0.2986
Schistosoma mansoni lamin 0.006 0.0921 0.0431
Onchocerca volvulus 0.011 0.2361 1
Echinococcus granulosus sex peptide receptor 0.011 0.2361 0.2337
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Echinococcus multilocularis serotonin receptor 0.011 0.2361 0.2337
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.011 0.2361 0.2337
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.011 0.2361 0.2337
Loa Loa (eye worm) glutathione reductase 0.0053 0.0705 0.2986
Echinococcus granulosus neuropeptide s receptor 0.011 0.2361 0.2337
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011 0.2361 0.4914
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011 0.2361 0.4914
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.011 0.2361 0.4914
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0133
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.011 0.2361 0.4914
Schistosoma mansoni amine GPCR 0.011 0.2361 0.4914
Schistosoma mansoni hypothetical protein 0.011 0.2361 0.4914
Schistosoma mansoni amine GPCR 0.011 0.2361 0.4914
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Brugia malayi hypothetical protein 0.011 0.2361 1
Brugia malayi neuropeptide F receptor 0.011 0.2361 1
Echinococcus granulosus fmrfamide receptor 0.011 0.2361 0.2337
Onchocerca volvulus 0.011 0.2361 1
Brugia malayi G-protein coupled receptor 0.011 0.2361 1
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Echinococcus granulosus rhodopsin orphan GPCR 0.011 0.2361 0.2337
Echinococcus multilocularis neuropeptide receptor A26 0.011 0.2361 0.2337
Echinococcus granulosus G protein coupled receptor 139 0.011 0.2361 0.2337
Brugia malayi hypothetical protein 0.011 0.2361 1
Echinococcus multilocularis neuropeptides capa receptor 0.011 0.2361 0.2337
Plasmodium falciparum thioredoxin reductase 0.0053 0.0705 0.5
Brugia malayi Adenosine kinase-like 0.0105 0.2209 0.932
Loa Loa (eye worm) hypothetical protein 0.0105 0.2209 0.9355
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.011 0.2361 0.4914
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.012 0.2631 0.8342
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.006 0.0921 0.39
Echinococcus granulosus dro:myosuppressin receptor 0.011 0.2361 0.2337
Schistosoma mansoni biogenic amine (dopamine) receptor 0.011 0.2361 0.4914
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Echinococcus granulosus rhodopsin orphan GPCR 0.011 0.2361 0.2337
Onchocerca volvulus 0.011 0.2361 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0889 0.3767
Brugia malayi gonadotropin-releasing hormone receptor 2 0.011 0.2361 1
Mycobacterium tuberculosis Probable dehydrogenase 0.012 0.2631 0.8342
Brugia malayi ORL1-like opioid receptor 0.011 0.2361 1
Loa Loa (eye worm) TYRA-2 protein 0.011 0.2361 1
Schistosoma mansoni neuropeptide F-like receptor 0.011 0.2361 0.4914
Loa Loa (eye worm) hypothetical protein 0.011 0.2361 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.014 0.3204 0.3182
Brugia malayi hypothetical protein 0.011 0.2361 1
Echinococcus multilocularis allatostatin A receptor 0.011 0.2361 0.2337
Echinococcus multilocularis g protein coupled receptor 0.011 0.2361 0.2337
Schistosoma mansoni neuropeptide receptor 0.011 0.2361 0.4914
Echinococcus granulosus thyrotropin releasing hormone receptor 0.011 0.2361 0.2337

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.081 Inhibition of Toxoplasma gondii adenosine kinase ChEMBL. No reference
IC50 (binding) = 8.3 uM Inhibition of Toxoplasma gondii adenosine kinase ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.