Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0025 | 0.0226 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0226 | 0.0226 |
Onchocerca volvulus | 0.0025 | 0.0226 | 1 | |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0025 | 0.0226 | 0.0226 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0025 | 0.0226 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0226 | 0.0226 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0619 | 0.2323 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.9308 | 0.9308 |
Schistosoma mansoni | nAChR subunit | 0.0025 | 0.0226 | 0.0803 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0025 | 0.0226 | 0.0848 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0025 | 0.0226 | 0.0226 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0025 | 0.0226 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0226 | 0.0226 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0025 | 0.0226 | 0.0848 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0025 | 0.0226 | 0.0848 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0025 | 0.0226 | 0.0226 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0025 | 0.0226 | 0.0848 |
Plasmodium vivax | replication factor C subunit 1, putative | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0619 | 0.2323 |
Onchocerca volvulus | 0.0025 | 0.0226 | 1 | |
Trypanosoma brucei | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.0021 | 0 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0619 | 0.0619 |
Plasmodium falciparum | replication factor C subunit 1, putative | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0619 | 0.2198 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2667 | 0.9465 |
Schistosoma mansoni | nAChR subunit | 0.0025 | 0.0226 | 0.0803 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | replication factor C large subunit, putative | 0.0021 | 0 | 0.5 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0025 | 0.0226 | 0.0226 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0025 | 0.0226 | 0.0848 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0226 | 0.0226 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0619 | 0.2323 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0226 | 0.0226 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0025 | 0.0226 | 0.0848 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0025 | 0.0226 | 0.0803 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0619 | 0.0619 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0025 | 0.0226 | 0.0226 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0025 | 0.0226 | 0.0803 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0226 | 0.0226 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0226 | 0.0226 |
Brugia malayi | Cation transporter family protein | 0.0025 | 0.0226 | 0.0226 |
Trypanosoma cruzi | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.0021 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.0025 | 0.0226 | 0.0803 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0025 | 0.0226 | 0.0803 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0619 | 0.2323 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0025 | 0.0226 | 0.0848 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.2818 | 0.2818 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0025 | 0.0226 | 0.0848 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0226 | 0.0226 |
Loa Loa (eye worm) | ACC-1 protein | 0.0025 | 0.0226 | 0.0226 |
Giardia lamblia | Replication factor C, subunit 1 | 0.0021 | 0 | 0.5 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0025 | 0.0226 | 0.0226 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0025 | 0.0226 | 0.0226 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0025 | 0.0226 | 0.0803 |
Schistosoma mansoni | nAChR subunit | 0.0025 | 0.0226 | 0.0803 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0025 | 0.0226 | 0.0226 |
Schistosoma mansoni | nAChR subunit | 0.0025 | 0.0226 | 0.0803 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0025 | 0.0226 | 0.0803 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0021 | 0 | 0.5 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0025 | 0.0226 | 0.0226 |
Mycobacterium leprae | PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0226 | 0.0226 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0025 | 0.0226 | 0.0848 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0025 | 0.0226 | 0.0848 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0226 | 0.0226 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0 | 0.5 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.0021 | 0 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0619 | 0.0619 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0025 | 0.0226 | 0.0848 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2667 | 0.9465 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0025 | 0.0226 | 0.0848 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2667 | 0.9465 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2667 | 0.9465 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0025 | 0.0226 | 0.0226 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0619 | 0.2198 |
Entamoeba histolytica | Activator 1 140 kDa subunit, putative | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.4712 | 0.4712 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0025 | 0.0226 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0226 | 0.0226 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0619 | 0.0619 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0025 | 0.0226 | 0.0848 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0025 | 0.0226 | 0.0848 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.2667 | 1 |
Toxoplasma gondii | ATPase, AAA family protein | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.2667 | 0.2667 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0025 | 0.0226 | 0.0848 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0025 | 0.0226 | 0.0848 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.2667 | 0.2667 |
Onchocerca volvulus | Putative nachr subunit | 0.0025 | 0.0226 | 1 |
Onchocerca volvulus | 0.0025 | 0.0226 | 1 | |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0025 | 0.0226 | 0.0226 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0099 | 0.4712 | 0.4712 |
Loa Loa (eye worm) | ACC-1 protein | 0.0025 | 0.0226 | 0.0226 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0025 | 0.0226 | 0.0848 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0226 | 0.0226 |
Loa Loa (eye worm) | LGC-31 protein | 0.0025 | 0.0226 | 0.0226 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0025 | 0.0226 | 0.0848 |
Schistosoma mansoni | nAChR subunit | 0.0025 | 0.0226 | 0.0803 |
Onchocerca volvulus | 0.0025 | 0.0226 | 1 | |
Mycobacterium ulcerans | NAD-dependent DNA ligase LigA | 0.0021 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.2667 | 0.2667 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0025 | 0.0226 | 0.0848 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0025 | 0.0226 | 0.0226 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0619 | 0.2323 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0619 | 0.2198 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0025 | 0.0226 | 0.0848 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0025 | 0.0226 | 0.0226 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.2667 | 0.2667 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0226 | 0.0226 |
Onchocerca volvulus | 0.0025 | 0.0226 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0226 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0226 | 0.0226 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0025 | 0.0226 | 0.0226 |
Brugia malayi | Cation transporter family protein | 0.0025 | 0.0226 | 0.0226 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0025 | 0.0226 | 0.0848 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0025 | 0.0226 | 0.0226 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.2667 | 0.2667 |
Treponema pallidum | DNA ligase (lig) | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0226 | 0.0226 |
Schistosoma mansoni | nAChR subunit | 0.0025 | 0.0226 | 0.0803 |
Echinococcus multilocularis | nAChR subunit | 0.0025 | 0.0226 | 0.0848 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.2818 | 0.2818 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0099 | 0.4712 | 0.4712 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0099 | 0.4712 | 0.4712 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.2818 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0025 | 0.0226 | 0.0803 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0226 | 0.0226 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0025 | 0.0226 | 0.0226 |
Brugia malayi | Cation transporter family protein | 0.0025 | 0.0226 | 0.0226 |
Brugia malayi | RNA binding protein | 0.0065 | 0.2667 | 0.2667 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0025 | 0.0226 | 0.0848 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0226 | 0.0226 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0025 | 0.0226 | 0.0226 |
Chlamydia trachomatis | DNA ligase | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0025 | 0.0226 | 0.0848 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0619 | 0.2198 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0619 | 0.2323 |
Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | nAChR subunit | 0.0025 | 0.0226 | 0.0848 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.2667 | 1 |
Onchocerca volvulus | 0.0025 | 0.0226 | 1 | |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0025 | 0.0226 | 0.0848 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2667 | 0.9465 |
Entamoeba histolytica | hypothetical protein | 0.0021 | 0 | 0.5 |
Trypanosoma cruzi | FHA domain containing protein, putative | 0.0021 | 0 | 0.5 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0025 | 0.0226 | 0.0226 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0025 | 0.0226 | 0.0848 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 5 mm | Antifungal activity against Candida albicans at 100 ug/ml after 48 hr by agar well diffusion method | ChEMBL. | No reference |
IZ (functional) | = 5 mm | Antibacterial activity against Escherichia coli ATCC 2343 at 100 ug/ml after 18 to 24 hr by agar well diffusion method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.