Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0034 | 0.0034 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0086 | 0.0169 | 0.6668 |
Loa Loa (eye worm) | glutamate receptor | 0.0045 | 0.0061 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.3749 | 0.983 | 0.983 |
Mycobacterium leprae | conserved hypothetical protein | 0.0064 | 0.0112 | 0.5 |
Brugia malayi | phosphoglycerate mutase family protein | 0.0064 | 0.0112 | 0.4392 |
Onchocerca volvulus | Protein UBASH3A homolog | 0.0064 | 0.0112 | 0.0112 |
Echinococcus granulosus | single minded 2 | 0.0044 | 0.0057 | 0.0057 |
Mycobacterium leprae | PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) | 0.0064 | 0.0112 | 0.5 |
Plasmodium falciparum | conserved protein, unknown function | 0.0118 | 0.0254 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0061 | 0.0061 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.0128 | 0.0278 | 0.0278 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.0254 | 0.0254 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0048 | 0.0068 | 0.0068 |
Onchocerca volvulus | Putative endochitinase | 0.0075 | 0.0138 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0018 | 0.0018 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0086 | 0.0169 | 0.0169 |
Mycobacterium ulcerans | phosphoglycerate mutase | 0.0064 | 0.0112 | 0.0094 |
Mycobacterium ulcerans | hypothetical protein | 0.0064 | 0.0112 | 0.0094 |
Mycobacterium ulcerans | acid phosphatase | 0.0064 | 0.0112 | 0.0094 |
Onchocerca volvulus | 0.0127 | 0.0277 | 0.0277 | |
Mycobacterium leprae | Possible phosphoglycerate mutase | 0.0064 | 0.0112 | 0.5 |
Mycobacterium ulcerans | lipoprotein LpqD | 0.0064 | 0.0112 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.2186 | 0.5708 | 0.5708 |
Brugia malayi | Endochitinase | 0.0084 | 0.0162 | 0.6384 |
Mycobacterium ulcerans | phosphohistidine phosphatase SixA | 0.0064 | 0.0112 | 0.0094 |
Brugia malayi | endochitinase | 0.0075 | 0.0138 | 0.545 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0118 | 0.0254 | 0.0254 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.3749 | 0.983 | 0.9828 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0064 | 0.0109 | 0.009 |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.0128 | 0.0278 | 0.0278 |
Chlamydia trachomatis | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase | 0.0064 | 0.0112 | 0.5 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.3814 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.3749 | 0.983 | 0.9828 |
Mycobacterium leprae | PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) | 0.0064 | 0.0112 | 0.5 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0064 | 0.0112 | 0.0112 |
Mycobacterium ulcerans | hypothetical protein | 0.2251 | 0.5878 | 1 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0072 | 0.013 | 0.013 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0064 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | phosphoglycerate mutase | 0.0064 | 0.0112 | 0.0112 |
Giardia lamblia | Hypothetical protein | 0.2251 | 0.5878 | 0.5 |
Onchocerca volvulus | Putative endochitinase | 0.0084 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0045 | 0.0061 | 0.0061 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0118 | 0.0254 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0084 | 0.0162 | 0.0162 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0086 | 0.0169 | 0.0169 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0064 | 0.0112 | 0.5 |
Onchocerca volvulus | 0.0118 | 0.0254 | 0.0254 | |
Onchocerca volvulus | 0.3814 | 1 | 1 | |
Mycobacterium tuberculosis | Glucosyl-3-phosphoglycerate phosphatase GpgP | 0.0064 | 0.0112 | 1 |
Onchocerca volvulus | 0.0048 | 0.0068 | 0.0068 | |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0109 | 0.0109 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.0277 | 0.0277 |
Brugia malayi | bHLH-PAS transcription factor | 0.0044 | 0.0057 | 0.2247 |
Echinococcus granulosus | tumor protein p63 | 0.0328 | 0.0808 | 0.0808 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0112 | 0.0112 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0034 | 0.1336 |
Loa Loa (eye worm) | glutamate receptor | 0.007 | 0.0125 | 0.0125 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1627 | 0.4234 | 0.4169 |
Onchocerca volvulus | 0.0118 | 0.0254 | 0.0254 | |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.0112 | 0.0112 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0064 | 0.0112 | 0.0133 |
Schistosoma mansoni | single-minded | 0.0059 | 0.0098 | 0.0098 |
Schistosoma mansoni | phosphoglycerate mutase | 0.0064 | 0.0112 | 0.0112 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0064 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0075 | 0.0138 | 0.0138 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1627 | 0.4234 | 0.4169 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3749 | 0.983 | 0.9828 |
Mycobacterium leprae | conserved hypothetical protein | 0.0064 | 0.0112 | 0.5 |
Loa Loa (eye worm) | chitinase I | 0.0075 | 0.0138 | 0.0138 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0064 | 0.0112 | 0.0112 |
Mycobacterium ulcerans | phosphoglyceromutase | 0.0064 | 0.0112 | 0.0094 |
Mycobacterium ulcerans | hydrolase MutT1 | 0.0064 | 0.0112 | 0.0094 |
Brugia malayi | UBASH3A protein homolog | 0.0064 | 0.0112 | 0.4392 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0029 | 0.0018 | 0.069 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0045 | 0.0061 | 0.2419 |
Onchocerca volvulus | Protein UBASH3A homolog | 0.0064 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.3814 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3814 | 1 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.3814 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.3749 | 0.983 | 0.9828 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0064 | 0.0109 | 0.009 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1627 | 0.4234 | 0.4169 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0064 | 0.0112 | 0.0112 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0064 | 0.0112 | 0.5 |
Onchocerca volvulus | Protein UBASH3A homolog | 0.0064 | 0.0112 | 0.0112 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0064 | 0.0112 | 0.0112 |
Mycobacterium leprae | POSSIBLE HYDROLASE MUTT1 | 0.0064 | 0.0112 | 0.5 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0064 | 0.0112 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.1627 | 0.4234 | 0.4169 |
Mycobacterium leprae | Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) | 0.0064 | 0.0112 | 0.5 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0045 | 0.0061 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.0254 | 0.0254 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.0112 | 0.0112 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0064 | 0.0112 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0118 | 0.0254 | 0.0254 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0034 | 0.0034 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0086 | 0.0169 | 0.0169 |
Echinococcus granulosus | serine:threonine protein phosphatase PGAM5 | 0.0064 | 0.0112 | 0.0112 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0064 | 0.0112 | 1 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0045 | 0.0061 | 0.2419 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0064 | 0.0112 | 0.5 |
Entamoeba histolytica | phosphoglycerate mutase family protein. putative | 0.0064 | 0.0112 | 0.0133 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.0112 | 0.0112 |
Leishmania major | chitinase | 0.0075 | 0.0138 | 0.0027 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.2251 | 0.5878 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqD | 0.0064 | 0.0112 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0064 | 0.0112 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0328 | 0.0808 | 0.0808 |
Onchocerca volvulus | Putative endochitinase | 0.0075 | 0.0138 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0169 | 0.0169 |
Plasmodium vivax | hypothetical protein, conserved | 0.0118 | 0.0254 | 1 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0118 | 0.0254 | 0.0254 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0236 | 0.0236 |
Mycobacterium tuberculosis | Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) | 0.0064 | 0.0112 | 1 |
Mycobacterium tuberculosis | Possible hydrolase MutT1 | 0.0064 | 0.0112 | 1 |
Mycobacterium ulcerans | phosphoglycerate mutase | 0.0064 | 0.0112 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0112 | 0.0112 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0171 | 0.0394 | 0.0394 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0112 | 0.0112 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3814 | 1 | 1 |
Onchocerca volvulus | Protein UBASH3A homolog | 0.0064 | 0.0112 | 0.0112 |
Echinococcus granulosus | serine:threonine protein phosphatase PGAM5 | 0.0064 | 0.0112 | 0.0112 |
Echinococcus multilocularis | serine:threonine protein phosphatase PGAM5 | 0.0064 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0238 | 0.0238 |
Entamoeba histolytica | chitinase, putative | 0.0075 | 0.0138 | 0.0179 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0029 | 0.0018 | 0.069 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0029 | 0.0018 | 0.0018 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0064 | 0.0112 | 0.0112 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0072 | 0.013 | 0.013 |
Brugia malayi | phosphoglycerate mutase family protein | 0.0064 | 0.0112 | 0.4392 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.0112 | 0.0112 |
Onchocerca volvulus | 0.0064 | 0.0112 | 0.0112 | |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0064 | 0.0112 | 0.0112 |
Onchocerca volvulus | 0.0064 | 0.0112 | 0.0112 | |
Mycobacterium tuberculosis | PE-PGRS family protein PE_PGRS11 | 0.0064 | 0.0112 | 1 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0029 | 0.0018 | 0.0018 |
Mycobacterium tuberculosis | Conserved protein | 0.0064 | 0.0112 | 1 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0064 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0068 | 0.0068 |
Echinococcus multilocularis | serine:threonine protein phosphatase PGAM5 | 0.0064 | 0.0112 | 0.0112 |
Brugia malayi | aryl hydrocarbon receptor AHR-1 | 0.0112 | 0.0236 | 0.9311 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0064 | 0.0112 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.0112 | 0.0112 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0118 | 0.0253 | 0.0253 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0064 | 0.0112 | 0.0112 |
Mycobacterium ulcerans | hypothetical protein | 0.0064 | 0.0112 | 0.0094 |
Mycobacterium ulcerans | bifunctional RNase H/acid phosphatase | 0.0064 | 0.0112 | 0.0094 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3814 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.007 | 0.0125 | 0.0125 |
Onchocerca volvulus | 0.0044 | 0.0058 | 0.0058 | |
Giardia lamblia | Hypothetical protein | 0.2251 | 0.5878 | 0.5 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0029 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0073 | 0.0133 | 0.0133 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.2251 | 0.5878 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0106 | 0.0222 | 0.0222 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.0112 | 0.0112 |
Onchocerca volvulus | Putative endochitinase | 0.0084 | 0.0162 | 0.0162 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0064 | 0.0112 | 0.0112 |
Onchocerca volvulus | 0.0064 | 0.0112 | 0.0112 | |
Mycobacterium tuberculosis | Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) | 0.0064 | 0.0112 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0034 | 0.0034 |
Schistosoma mansoni | phosphoglycerate mutase | 0.0064 | 0.0112 | 0.0112 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0064 | 0.0112 | 0.0133 |
Mycobacterium tuberculosis | Conserved protein | 0.0064 | 0.0112 | 1 |
Treponema pallidum | phosphoglyceromutase | 0.0064 | 0.0112 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0118 | 0.0253 | 0.0253 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0034 | 0.0034 |
Brugia malayi | endochitinase | 0.0084 | 0.0162 | 0.6384 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0044 | 0.0057 | 0.0057 |
Mycobacterium leprae | probable isochorismate synthase EntC | 0.0064 | 0.0112 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3814 | 1 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0064 | 0.0112 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0118 | 0.0254 | 1 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0029 | 0.0018 | 0.0018 |
Brugia malayi | PAS domain containing protein | 0.0059 | 0.0098 | 0.3842 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 25 ug ml-1 | Antibacterial activity against Escherichia coli MTCC 443 assessed as growth inhibition after 24 to 48 hr by NCCLS broth microdilution method | ChEMBL. | No reference |
MIC (functional) | > 1000 ug ml-1 | Antifungal activity against Candida albicans MTCC 227 assessed as growth inhibition after 24 to 48 hr by NCCLS broth microdilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.