Detailed information for compound 1792162

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 360.406 | Formula: C22H20N2O3
  • H donors: 1 H acceptors: 4 LogP: 3.46 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CCC(=O)/C=C/c1cn(nc1c1ccc(cc1)C)c1ccccc1
  • InChi: 1S/C22H20N2O3/c1-16-7-9-17(10-8-16)22-18(11-12-20(25)13-14-21(26)27)15-24(23-22)19-5-3-2-4-6-19/h2-12,15H,13-14H2,1H3,(H,26,27)/b12-11+
  • InChiKey: FJUCJYYVZLUQDX-VAWYXSNFSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.011 0.1212 0.1175
Loa Loa (eye worm) glutaminase 0.0274 0.3229 0.5979
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0062 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0077 0.0065
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.1372 0.3466
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0132 0.1481 0.6682
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0042 0.0109
Schistosoma mansoni ap endonuclease 0.0075 0.0782 0.1021
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0327 0.3879 1
Treponema pallidum NADH oxidase 0.0017 0.0062 0.018
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0152 0.0285
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0138 0.0156
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0062 0.0052
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0333 0.1349
Plasmodium falciparum glutathione reductase 0.0049 0.0453 0.1072
Schistosoma mansoni cpg binding protein 0.0058 0.0567 0.0724
Leishmania major pyruvate kinase 0.0039 0.0334 0.076
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0328 0.0287
Echinococcus granulosus pyruvate kinase 0.0039 0.0334 0.0476
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0062 0.0052
Echinococcus multilocularis histone acetyltransferase MYST2 0.011 0.1212 0.1175
Brugia malayi beta-lactamase family protein 0.0038 0.0328 0.0846
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0132 0.1481 0.1445
Echinococcus granulosus GPCR family 2 0.0079 0.0825 0.1276
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0334 0.076
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0062 0.0052
Schistosoma mansoni survival motor neuron protein 0.0047 0.0433 0.054
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.116 0.5189
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0015 0.0042 0.008
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0208 0.0431
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0152 0.0508
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0328 0.0745
Loa Loa (eye worm) glutathione reductase 0.0049 0.0453 0.0771
Schistosoma mansoni ap endonuclease 0.0075 0.0782 0.1021
Trypanosoma cruzi sterol C-24 reductase, putative 0.0046 0.0422 0.099
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.138 0.1845
Schistosoma mansoni hypothetical protein 0.0605 0.7291 1
Schistosoma mansoni hypothetical protein 0.0047 0.0433 0.054
Loa Loa (eye worm) hypothetical protein 0.0038 0.0328 0.0536
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0327 0.3879 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0486 0.1156
Mycobacterium ulcerans pyruvate kinase 0.0039 0.0334 0.0711
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0328 0.0846
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0007 0.0019
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0046 0.0004
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0046 0.0005
Schistosoma mansoni glutaminase 0.0274 0.3229 0.4397
Loa Loa (eye worm) hypothetical protein 0.0024 0.0152 0.0205
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.0825 0.1276
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0376 0.087
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0065 0.0058
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0825 0.2126
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0128 0.1426 0.4388
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.3086 0.9554
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0062 0.0033
Schistosoma mansoni hypothetical protein 0.0079 0.0825 0.1079
Echinococcus multilocularis lamin b receptor 0.0046 0.0422 0.0381
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0062 0.0052
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0128 0.1426 0.4388
Onchocerca volvulus 0.0097 0.1047 0.36
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0328 0.097
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0065 0.0058
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0062 0.0052
Schistosoma mansoni myelin transcription factor 1 myt1 0.011 0.1212 0.1614
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0152 0.0234
Brugia malayi RNA binding protein 0.0189 0.2185 0.5632
Brugia malayi Pyruvate kinase, muscle isozyme 0.0039 0.0334 0.0861
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0208 0.0431
Brugia malayi hypothetical protein 0.019 0.2196 0.5661
Leishmania major hypothetical protein, conserved 0.0051 0.0486 0.1156
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0132 0.1481 0.2347
Plasmodium vivax glutathione reductase, putative 0.0049 0.0453 0.1072
Toxoplasma gondii pyruvate kinase PyKII 0.002 0.0101 0.0153
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.3086 0.9554
Mycobacterium tuberculosis Probable reductase 0.0111 0.122 0.3069
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0263 0.3086 0.7956
Giardia lamblia Pyruvate kinase 0.0039 0.0334 0.394
Leishmania major hypothetical protein, conserved 0.0038 0.0328 0.0745
Schistosoma mansoni tar DNA-binding protein 0.0189 0.2185 0.2956
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0328 0.0466
Echinococcus granulosus tar DNA binding protein 0.0189 0.2185 0.3494
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.2474 0.4563
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0334 0.0547
Brugia malayi TAR-binding protein 0.0189 0.2185 0.5632
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0334 0.1044
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0111 0.122 0.3069
Echinococcus granulosus histone acetyltransferase MYST2 0.011 0.1212 0.1909
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.1262 0.3178
Onchocerca volvulus 0.0038 0.0328 0.1024
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0328 0.0745
Mycobacterium ulcerans glutaminase 0.0274 0.3229 0.8299
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.0825 0.0786
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0152 0.0508
Schistosoma mansoni hypothetical protein 0.0079 0.0825 0.1079
Trypanosoma brucei pyruvate kinase 1 0.0039 0.0334 0.076
Schistosoma mansoni sex comb on midleg homolog 0.0097 0.1047 0.1387
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0825 0.1468
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0062 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.1975 0.6096
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0062 0.0052
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0152 0.0234
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0328 0.0745
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0042 0.0109
Schistosoma mansoni hypothetical protein 0.0514 0.6173 0.8458
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.011 0.1212 0.1909
Echinococcus multilocularis polycomb protein SCMH1 0.0097 0.1047 0.1009
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0015 0.0042 0.008
Entamoeba histolytica hypothetical protein 0.019 0.2196 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0825 0.1468
Brugia malayi mbt repeat family protein 0.0097 0.1047 0.2701
Brugia malayi CCR4 0.0015 0.0042 0.0109
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0208 0.0431
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0046 0.0006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0152 0.0285
Loa Loa (eye worm) hypothetical protein 0.0051 0.0486 0.0832
Brugia malayi phosphofructokinase 0.0106 0.116 0.299
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0327 0.3879 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0042 0.0109
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0086 0.0223
Trichomonas vaginalis glutaminase, putative 0.0274 0.3229 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0062 0.0052
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0397 0.4741 0.7664
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.116 0.2913
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0075 0.0782 0.1886
Schistosoma mansoni tar DNA-binding protein 0.0189 0.2185 0.2956
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0075 0.0782 0.1929
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0152 0.0285
Loa Loa (eye worm) hypothetical protein 0.0038 0.0328 0.0536
Loa Loa (eye worm) hypothetical protein 0.0038 0.0328 0.0536
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0327 0.3879 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0233 0.2723 0.2692
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0075 0.0782 0.1929
Loa Loa (eye worm) hypothetical protein 0.0449 0.5372 1
Brugia malayi hypothetical protein 0.0051 0.0486 0.1253
Loa Loa (eye worm) TAR-binding protein 0.0189 0.2185 0.4019
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0075 0.0782 0.1886
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.116 0.2876
Brugia malayi beta-lactamase family protein 0.0038 0.0328 0.0846
Brugia malayi latrophilin 2 splice variant baaae 0.017 0.195 0.5026
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.1975 0.6923
Brugia malayi Zinc finger, C2H2 type family protein 0.0128 0.1426 0.3677
Toxoplasma gondii pyruvate kinase PyK1 0.0039 0.0334 0.076
Loa Loa (eye worm) hypothetical protein 0.0018 0.0077 0.0065
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0077 0.009
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0062 0.0272
Schistosoma mansoni sex comb on midleg homolog 0.0097 0.1047 0.1387
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0062 0.0052
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.116 0.1542
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0376 0.112
Echinococcus multilocularis GPCR, family 2 0.0079 0.0825 0.0786
Schistosoma mansoni tar DNA-binding protein 0.0189 0.2185 0.2956
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0042 0.0109
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0208 0.0595
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.116 0.1542
Trypanosoma cruzi C-14 sterol reductase, putative 0.0046 0.0422 0.099
Entamoeba histolytica pyruvate kinase, putative 0.0027 0.0189 0.0681
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0334 0.0988
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0062 0.0052
Echinococcus granulosus polycomb protein SCMH1 0.0097 0.1047 0.164
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0062 0.0052
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0042 0.0109
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0062 0.0161
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0097 0.1047 0.36
Brugia malayi beta-lactamase 0.0038 0.0328 0.0846
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.019 0.2196 0.3513
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0215 0.0281
Brugia malayi 6-phosphofructokinase 0.0106 0.116 0.299
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0263 0.3086 0.571
Echinococcus granulosus lamin b receptor 0.0046 0.0422 0.062
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.3086 0.9554
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0486 0.1156
Echinococcus multilocularis pyruvate kinase 0.002 0.0101 0.0059
Plasmodium falciparum pyruvate kinase 0.0039 0.0334 0.076
Schistosoma mansoni hypothetical protein 0.017 0.195 0.2631
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0015 0.0042 0.008
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0328 0.0745
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0042 0.0109
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.2089 0.6451
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.1577 0.2504
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.116 0.3558
Echinococcus granulosus pyruvate kinase 0.002 0.0101 0.0095
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0042 0.0109
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0077 0.009
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0075 0.0782 0.1929
Leishmania major C-14 sterol reductase, putative 0.0046 0.0422 0.099
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0376 0.087
Loa Loa (eye worm) RNA binding protein 0.0189 0.2185 0.4019
Loa Loa (eye worm) hypothetical protein 0.0249 0.2919 0.5397
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0208 0.5348
Schistosoma mansoni hypothetical protein 0.019 0.2196 0.2971
Loa Loa (eye worm) hypothetical protein 0.017 0.195 0.3578
Echinococcus multilocularis pyruvate kinase 0.0039 0.0334 0.0293
Giardia lamblia Pyruvate kinase 0.002 0.0101 0.0791
Echinococcus multilocularis pyruvate kinase 0.002 0.0101 0.0059
Brugia malayi glutathione reductase 0.0049 0.0453 0.1169
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0328 0.0696
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0208 0.0431
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.1975 0.6096
Brugia malayi CXXC zinc finger family protein 0.0058 0.0567 0.1463
Schistosoma mansoni hypothetical protein 0.0514 0.6173 0.8458
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0111 0.122 0.3069
Loa Loa (eye worm) hypothetical protein 0.0024 0.0152 0.0205
Brugia malayi glutaminase DH11.1 0.0274 0.3229 0.8326
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0328 0.097
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0208 0.0431
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0062 0.0052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0233 0.2723 0.3699
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0328 0.0536
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0152 0.0234
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0334 0.076
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0062 0.0143
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0376 0.087
Echinococcus granulosus SAM and MBT domain containing protein 0.0097 0.1047 0.164
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0328 0.0394
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0327 0.3879 1
Mycobacterium leprae Probable pyruvate kinase PykA 0.0039 0.0334 0.0489
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0244 0.0329
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0244 0.0278
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0233 0.2723 0.3699
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0486 0.1156
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0075 0.0782 0.0743
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0062 0.0143
Onchocerca volvulus 0.0038 0.0328 0.1024
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0376 0.0545
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.1372 0.3275
Onchocerca volvulus 0.0242 0.2834 1
Mycobacterium tuberculosis Conserved protein 0.0038 0.0328 0.0745
Schistosoma mansoni Lamin B receptor (ERG24) 0.0046 0.0422 0.0524
Schistosoma mansoni tar DNA-binding protein 0.0189 0.2185 0.2956
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.116 0.2913
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0015 0.0042 0.008
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0152 0.0508
Echinococcus granulosus cpg binding protein 0.0061 0.0608 0.0923
Plasmodium vivax pyruvate kinase 2, putative 0.002 0.0101 0.0153
Brugia malayi hypothetical protein 0.0231 0.2691 0.6937
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0152 0.0234
Brugia malayi RNA recognition motif domain containing protein 0.0189 0.2185 0.5632
Echinococcus granulosus dnaJ subfamily B 0.0399 0.4765 0.7703
Schistosoma mansoni hypothetical protein 0.0079 0.0825 0.1079
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0233 0.2723 0.503
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0015 0.0042 0.008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0062 0.0052
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0334 0.0547
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0152 0.0391
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0327 0.3879 1
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.4765 0.4742
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0077 0.0037
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0046 0.0006
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0075 0.0782 0.1929
Mycobacterium tuberculosis Conserved protein 0.0038 0.0328 0.0745
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0097 0.1047 0.1387
Brugia malayi Pyruvate kinase, M2 isozyme 0.0039 0.0334 0.0861
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0233 0.2723 0.2692
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.116 0.2913
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0453 0.1072
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0208 0.0431
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0208 0.0595
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.116 0.5189
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0042 0.0109
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.116 0.3558
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0327 0.3879 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0062 0.0052
Loa Loa (eye worm) acetyltransferase 0.0144 0.1627 0.2973
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0825 0.2126
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0152 0.0234
Schistosoma mansoni cpg binding protein 0.0061 0.0608 0.078
Loa Loa (eye worm) hypothetical protein 0.0097 0.1047 0.1886
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.1975 0.6096
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0138 0.0096
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0062 0.0052
Echinococcus multilocularis pyruvate kinase 0.0039 0.0334 0.0293
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.116 0.1823
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.3086 0.9554
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0825 0.1276
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0486 0.1156
Mycobacterium leprae Probable lipase LipE 0.0038 0.0328 0.0473
Loa Loa (eye worm) hypothetical protein 0.0038 0.0328 0.0536
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0334 0.1044
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0042 0.0109
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0062 0.0052
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.1372 0.3466
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0233 0.2723 0.4373
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0453 0.0671
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0128 0.1426 0.4388
Onchocerca volvulus 0.0024 0.0152 0.0392
Echinococcus multilocularis pyruvate kinase 0.002 0.0101 0.0059
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0328 0.0745
Mycobacterium ulcerans lipase LipD 0.0038 0.0328 0.0696
Mycobacterium tuberculosis Probable dehydrogenase 0.0111 0.122 0.3069
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.3086 0.9554
Leishmania major trypanothione reductase 0.0049 0.0453 0.1072
Brugia malayi Pre-SET motif family protein 0.0032 0.0244 0.063
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0208 0.0595
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0015 0.0042 0.008
Loa Loa (eye worm) hypothetical protein 0.0038 0.0328 0.0536
Schistosoma mansoni transcription factor LCR-F1 0.019 0.2196 0.2971
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.1975 0.6096
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0328 0.0745
Echinococcus granulosus pyruvate kinase 0.0039 0.0334 0.0476
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.1627 0.1592
Trypanosoma brucei trypanothione reductase 0.0049 0.0453 0.1072
Mycobacterium tuberculosis Conserved protein 0.0038 0.0328 0.0745
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0244 0.0203
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0062 0.0052
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0328 0.0394
Plasmodium vivax SET domain protein, putative 0.0032 0.0244 0.0526
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0453 0.1072
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0208 0.2234
Loa Loa (eye worm) beta-lactamase 0.0038 0.0328 0.0536
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0128 0.1426 0.4388
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.116 0.2913
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0075 0.0782 0.1207
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0062 0.0052
Loa Loa (eye worm) hypothetical protein 0.011 0.1212 0.2195
Plasmodium falciparum thioredoxin reductase 0.0017 0.0062 0.0052
Loa Loa (eye worm) MBCTL1 0.011 0.1212 0.2195
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0208 0.0595
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0453 0.1072
Brugia malayi Pre-SET motif family protein 0.0213 0.2474 0.6379
Brugia malayi exodeoxyribonuclease III family protein 0.0075 0.0782 0.2017
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0075 0.0782 1
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0327 0.3879 1
Echinococcus granulosus geminin 0.0514 0.6173 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0075 0.0782 0.6622
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0327 0.3879 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0249 0.2919 0.7526
Loa Loa (eye worm) phosphofructokinase 0.0106 0.116 0.2097
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0152 0.0234
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0077 0.009
Onchocerca volvulus 0.0058 0.0567 0.1881
Mycobacterium ulcerans beta-lactamase 0.0038 0.0328 0.0696
Brugia malayi hypothetical protein 0.0033 0.0262 0.0676
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.2691 0.432
Trypanosoma brucei pyruvate kinase 1, putative 0.0039 0.0334 0.076
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.116 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0111 0.122 0.3069
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0015 0.0042 0.008
Plasmodium falciparum glutathione reductase 0.0017 0.0062 0.0052
Brugia malayi Calcitonin receptor-like protein seb-1 0.0249 0.2919 0.7526
Mycobacterium ulcerans hypothetical protein 0.0024 0.0152 0.0234
Leishmania major dihydroorotate dehydrogenase 0.0327 0.3879 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0334 0.0547
Loa Loa (eye worm) mbt repeat family protein 0.0097 0.1047 0.1886
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0334 0.0547
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0132 0.1481 0.4559
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0233 0.2723 0.4373
Echinococcus multilocularis pyruvate kinase 0.0031 0.0233 0.0191
Echinococcus granulosus pyruvate kinase 0.002 0.0101 0.0095
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0007 0.0019
Entamoeba histolytica hypothetical protein 0.019 0.2196 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.116 0.2097
Schistosoma mansoni pyruvate kinase 0.0039 0.0334 0.0402
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0433 0.1118
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0075 0.0782 0.1929
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0327 0.3879 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0077 0.0065
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0244 0.0278
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0132 0.1481 0.2347
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0453 0.0771
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0328 0.0745
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0328 0.0745
Onchocerca volvulus 0.0032 0.0244 0.0723
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.116 0.1122
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0567 0.0985
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0233 0.2723 0.7021
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.2089 0.6451
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0244 0.0203
Loa Loa (eye worm) hypothetical protein 0.0024 0.0152 0.0205
Trypanosoma brucei C-14 sterol reductase, putative 0.0046 0.0422 0.099
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0328 0.0696
Leishmania major sterol C-24 reductase, putative 0.0046 0.0422 0.099
Chlamydia trachomatis pyruvate kinase 0.0039 0.0334 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0376 0.112
Echinococcus multilocularis SAM and MBT domain containing protein 0.0097 0.1047 0.1009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0062 0.0052
Trichomonas vaginalis ap endonuclease, putative 0.0075 0.0782 0.2384
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0244 0.0278
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0075 0.0782 0.1929
Loa Loa (eye worm) glutaminase 2 0.0274 0.3229 0.5979
Schistosoma mansoni cpg binding protein 0.0061 0.0608 0.078
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0208 0.0595
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0132 0.1481 0.1445
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0111 0.122 0.3069
Loa Loa (eye worm) hypothetical protein 0.0038 0.0328 0.0536
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.1627 0.4195
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0486 0.1156
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.116 0.2705
Trypanosoma cruzi C-14 sterol reductase, putative 0.0046 0.0422 0.099
Loa Loa (eye worm) hypothetical protein 0.0018 0.0077 0.0065
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0128 0.1426 0.3607
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.1975 0.6096
Loa Loa (eye worm) hypothetical protein 0.0032 0.0244 0.0379
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0077 0.0527
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0334 0.1044
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0333 0.0757
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0189 0.2185 0.4019
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0062 0.0052
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0111 0.122 0.2866
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0089 0.0077
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0016 0.0054 0.0032
Loa Loa (eye worm) hypothetical protein 0.0231 0.2691 0.4968
Brugia malayi mbt repeat family protein 0.0097 0.1047 0.2701
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0089 0.0088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0233 0.2723 0.3699
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.019 0.2196 0.2163
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0486 0.1156
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0249 0.2919 0.5397
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0208 0.0768
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0208 0.0431
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.1627 0.2187
Schistosoma mansoni tar DNA-binding protein 0.0189 0.2185 0.2956
Plasmodium falciparum thioredoxin reductase 0.0049 0.0453 0.1072
Loa Loa (eye worm) hypothetical protein 0.0027 0.0189 0.0275
Onchocerca volvulus 0.0047 0.0433 0.1401
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0039 0.0334 0.076
Schistosoma mansoni hypothetical protein 0.0023 0.0138 0.0132
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0334 0.0988
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0397 0.4741 0.4719
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0246 0.2878 0.739
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.116 0.3558
Brugia malayi 6-phosphofructokinase 0.0106 0.116 0.299
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0328 0.0745
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.1975 0.6096
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0328 0.097
Schistosoma mansoni hypothetical protein 0.0399 0.4765 0.6515
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0328 0.0473
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0065 0.0058
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0062 0.0028
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0075 0.0782 0.1388
Leishmania major pyruvate kinase 0.0039 0.0334 0.076
Toxoplasma gondii ABC1 family protein 0.0038 0.0328 0.0745
Schistosoma mansoni hypothetical protein 0.0079 0.0825 0.1079
Schistosoma mansoni pyruvate kinase 0.002 0.0101 0.0081
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0062 0.0052
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.116 0.2097
Schistosoma mansoni pyruvate kinase 0.0039 0.0334 0.0402
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0075 0.0782 0.1929
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0328 0.097
Loa Loa (eye worm) pyruvate kinase-PB 0.0027 0.0189 0.0275
Schistosoma mansoni dihydroorotate dehydrogenase 0.0327 0.3879 0.5293
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0152 0.0234
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0015 0.0042 0.008
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0244 0.0526
Brugia malayi Thioredoxin reductase 0.0049 0.0453 0.1169
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0152 0.0391
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0333 0.3926
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0152 0.0285
Trypanosoma cruzi sterol C-24 reductase, putative 0.0046 0.0422 0.099
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.116 0.3558
Toxoplasma gondii thioredoxin reductase 0.0049 0.0453 0.1072
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0328 0.0745
Onchocerca volvulus 0.0038 0.0328 0.1024
Echinococcus multilocularis cpg binding protein 0.0061 0.0608 0.0568
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0132 0.1481 0.4559
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0065 0.0058
Plasmodium falciparum dihydroorotate dehydrogenase 0.0327 0.3879 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0046 0.0004
Plasmodium vivax pyruvate kinase, putative 0.0039 0.0334 0.076
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.1372 0.3466
Toxoplasma gondii exonuclease III APE 0.0075 0.0782 0.1929
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0327 0.3879 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.011 0.1212 0.3126
Echinococcus granulosus pyruvate kinase 0.002 0.0101 0.0095
Entamoeba histolytica hypothetical protein 0.019 0.2196 1
Trichomonas vaginalis esterase, putative 0.0038 0.0328 0.097
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.3086 0.9554
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0062 0.0052
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0328 0.097
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0328 0.0745
Plasmodium falciparum pyruvate kinase 2 0.002 0.0101 0.0153
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0208 0.1479
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0152 0.0391
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0208 0.0595
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0062 0.0052
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0062 0.0052
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0089 0.0047
Loa Loa (eye worm) hypothetical protein 0.0018 0.0077 0.0065
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.2691 0.266
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0486 0.1156
Echinococcus multilocularis geminin 0.0514 0.6173 0.6157
Trichomonas vaginalis ap endonuclease, putative 0.0075 0.0782 0.2384
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.1975 0.6096
Leishmania major pantothenate kinase subunit, putative 0.0016 0.0054 0.0032
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0825 0.0786
Trichomonas vaginalis Phospholipase C precursor, putative 0.0015 0.0042 0.008
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.116 0.5189
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0075 0.0782 0.3437
Trichomonas vaginalis set domain proteins, putative 0.0242 0.2834 0.877
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0152 0.0285
Entamoeba histolytica hypothetical protein 0.019 0.2196 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0208 0.5348
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0208 0.0595
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0327 0.3879 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0453 0.0413
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0244 0.0278
Echinococcus multilocularis tar DNA binding protein 0.0189 0.2185 0.2151
Mycobacterium ulcerans hypothetical protein 0.0038 0.0328 0.0696

Activities

Activity type Activity value Assay description Source Reference
Time (functional) = 6.47 s Analgesic activity in Mus musculus (mouse) assessed as paw withdrawal latency time at 50 mg/kg, ip after 30 min ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.