Detailed information for compound 1792181

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 336.688 | Formula: C14H20Cl3N3
  • H donors: 1 H acceptors: 0 LogP: 3.45 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1N(CCc2c1cccc2Cl)CC1=NCCN1.Cl.Cl
  • InChi: 1S/C14H18ClN3.2ClH/c1-10-11-3-2-4-13(15)12(11)5-8-18(10)9-14-16-6-7-17-14;;/h2-4,10H,5-9H2,1H3,(H,16,17);2*1H
  • InChiKey: NQJCSOQANATJTO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Adrenergic receptor alpha-2 Starlite/ChEMBL References
Rattus norvegicus Adrenergic receptor alpha-1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis alpha 1A adrenergic receptor Adrenergic receptor alpha-2   450 aa 478 aa 20.7 %
Schistosoma mansoni amine GPCR Adrenergic receptor alpha-2   450 aa 439 aa 29.2 %
Schistosoma mansoni biogenic amine (5HT) receptor Adrenergic receptor alpha-2   450 aa 433 aa 27.9 %
Loa Loa (eye worm) TYRA-2 protein Adrenergic receptor alpha-2   450 aa 488 aa 23.8 %
Echinococcus multilocularis neuropeptides capa receptor Adrenergic receptor alpha-2   450 aa 486 aa 20.6 %
Echinococcus multilocularis fmrfamide receptor Adrenergic receptor alpha-2   450 aa 366 aa 19.9 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Adrenergic receptor alpha-2   450 aa 473 aa 24.1 %
Onchocerca volvulus Adrenergic receptor alpha-2   450 aa 420 aa 19.8 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Adrenergic receptor alpha-2   450 aa 378 aa 20.9 %
Echinococcus granulosus biogenic amine 5HT receptor Adrenergic receptor alpha-2   450 aa 423 aa 31.7 %
Onchocerca volvulus Adrenergic receptor alpha-2   450 aa 467 aa 25.1 %
Echinococcus granulosus alpha 1A adrenergic receptor Adrenergic receptor alpha-2   450 aa 476 aa 21.0 %
Echinococcus multilocularis serotonin receptor Adrenergic receptor alpha-2   450 aa 426 aa 31.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0242 0.0651
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0032 0.0158 0.0158
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0056 0.0519 0.0519
Brugia malayi G protein-coupled receptor F59B2.13 0.0317 0.4412 0.5684
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0475 0.1279
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0475 0.1279
Schistosoma mansoni histamine h1 receptor 0.0317 0.4412 0.4412
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Brugia malayi putative neuropeptide receptor 0.0317 0.4412 0.5684
Brugia malayi PHD-finger family protein 0.0032 0.0171 0.022
Loa Loa (eye worm) hypothetical protein 0.0037 0.0242 0.0242
Echinococcus multilocularis allatostatin A receptor 0.0317 0.4412 0.4412
Brugia malayi Cyclin, N-terminal domain containing protein 0.0086 0.0973 0.1253
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0475 0.1279
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Entamoeba histolytica cysteine protease, putative 0.0031 0.0153 0.157
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0242 0.0553
Echinococcus granulosus rhodopsin orphan GPCR 0.0317 0.4412 0.4412
Onchocerca volvulus 0.0317 0.4412 1
Trypanosoma cruzi cysteine protease, putative 0.0031 0.0153 0.0391
Toxoplasma gondii cathepsin CPL 0.0053 0.0475 0.4095
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0475 0.1218
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0242 0.0553
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0032 0.0158 0.136
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0317 0.4412 0.4412
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Loa Loa (eye worm) melatonin receptor type 1A 0.0317 0.4412 0.4412
Brugia malayi hypothetical protein 0.0317 0.4412 0.5684
Echinococcus granulosus cathepsin l1 0.0053 0.0475 0.0475
Brugia malayi Cathepsin L-like precursor 0.0053 0.0475 0.0612
Plasmodium vivax thioredoxin reductase, putative 0.0066 0.0672 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0317 0.4412 0.4412
Echinococcus granulosus tm gpcr rhodopsin 0.0317 0.4412 0.4412
Brugia malayi Serotonin receptor 0.0317 0.4412 0.5684
Echinococcus granulosus cyclins 0.0036 0.0223 0.0223
Echinococcus multilocularis cyclins 0.0036 0.0223 0.0223
Loa Loa (eye worm) serotonin transporter b 0.0186 0.2461 0.2461
Giardia lamblia Hypothetical protein 0.0036 0.0223 0.1922
Echinococcus multilocularis serotonin receptor 0.0692 1 1
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0242 0.3602
Echinococcus granulosus cyclin dependent kinase 0.005 0.0437 0.0437
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0028 0.0073
Brugia malayi Dopamine receptor protein 1 0.0317 0.4412 0.5684
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0153 0.0153
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0475 0.1218
Echinococcus granulosus tm gpcr rhodopsin 0.0317 0.4412 0.4412
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0475 0.4095
Brugia malayi AKH receptor 0.0317 0.4412 0.5684
Trypanosoma cruzi cysteine proteinase, putative 0.0031 0.0153 0.0391
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0056 0.0519 0.0519
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0475 0.4095
Trichomonas vaginalis cyclins, putative 0.0036 0.0223 0.06
Onchocerca volvulus 0.0053 0.0475 0.0865
Brugia malayi Cathepsin L-like precursor 0.0038 0.0255 0.0329
Loa Loa (eye worm) hypothetical protein 0.0086 0.0973 0.0973
Brugia malayi Cathepsin L-like precursor 0.0038 0.0255 0.0329
Brugia malayi neuropeptide F receptor 0.0317 0.4412 0.5684
Echinococcus multilocularis musashi 0.0028 0.0103 0.0103
Echinococcus multilocularis peregrin 0.0032 0.0171 0.0171
Echinococcus multilocularis dro:myosuppressin receptor 0.0317 0.4412 0.4412
Brugia malayi cathepsin L-like precursor 0.0038 0.0255 0.0329
Loa Loa (eye worm) thioredoxin reductase 0.0066 0.0672 0.0672
Entamoeba histolytica cell division protein kinase 2, putative 0.005 0.0437 0.4491
Echinococcus multilocularis rhodopsin orphan GPCR 0.0317 0.4412 0.4412
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0186 0.2461 0.2461
Brugia malayi Cathepsin L-like precursor 0.0053 0.0475 0.0612
Entamoeba histolytica cysteine protease, putative 0.0031 0.0153 0.157
Leishmania major cathepsin L-like protease 0.0053 0.0475 0.4095
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Brugia malayi putative neuropeptide receptor NPR1 0.0317 0.4412 0.5684
Echinococcus granulosus biogenic amine 5HT receptor 0.0317 0.4412 0.4412
Loa Loa (eye worm) hypothetical protein 0.0053 0.0475 0.0475
Leishmania major cathepsin L-like protease 0.0053 0.0475 0.4095
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Plasmodium falciparum phd finger protein, putative 0.0032 0.0171 0.254
Onchocerca volvulus 0.0037 0.0242 0.0323
Plasmodium falciparum cysteine proteinase falcipain 3 0.0053 0.0475 0.7075
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Schistosoma mansoni lamin 0.0028 0.0103 0.0103
Loa Loa (eye worm) fibroinase 0.0053 0.0475 0.0475
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0317 0.4412 0.4412
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0317 0.4412 1
Loa Loa (eye worm) glutamate receptor 2 0.0042 0.0319 0.0319
Echinococcus granulosus neuropeptide FF receptor 2 0.0317 0.4412 0.4412
Brugia malayi hypothetical protein 0.0317 0.4412 0.5684
Echinococcus multilocularis nmda type glutamate receptor 0.0093 0.1073 0.1073
Echinococcus multilocularis sodium and chloride dependent glycine 0.0032 0.0158 0.0158
Mycobacterium ulcerans lipase LipD 0.0037 0.0242 0.0553
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0032 0.0158 0.0158
Echinococcus granulosus somatostatin receptor 0.0317 0.4412 0.4412
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Brugia malayi jmjC domain containing protein 0.0039 0.0272 0.0351
Loa Loa (eye worm) hypothetical protein 0.0037 0.0242 0.0242
Echinococcus multilocularis glutamate receptor 2 0.0098 0.1141 0.1141
Brugia malayi G-protein coupled receptor 0.0317 0.4412 0.5684
Brugia malayi Glutamate receptor 1 precursor 0.0084 0.0942 0.1213
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0317 0.4412 0.4412
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0028 0.0073
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0106 0.1271 0.1271
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0317 0.4412 0.4412
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Echinococcus granulosus rhodopsin orphan GPCR 0.0317 0.4412 0.4412
Echinococcus granulosus hypothetical protein 0.0317 0.4412 0.4412
Schistosoma mansoni hypothetical protein 0.0317 0.4412 0.4412
Echinococcus multilocularis G protein coupled receptor 139 0.0317 0.4412 0.4412
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0032 0.0158 0.0203
Schistosoma mansoni jumonji domain containing protein 0.0085 0.0946 0.0946
Brugia malayi neuropeptide F receptor 0.0317 0.4412 0.5684
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Brugia malayi sulfakinin receptor protein 0.0317 0.4412 0.5684
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0028 0.0073
Echinococcus granulosus cathepsin L cysteine protease 0.0031 0.0153 0.0153
Schistosoma mansoni alpha-1 adrenergic receptor 0.0317 0.4412 0.4412
Onchocerca volvulus 0.0186 0.2461 0.5472
Brugia malayi Cathepsin L-like precursor 0.0053 0.0475 0.0612
Trichomonas vaginalis cyclins, putative 0.0086 0.0973 0.2617
Trichomonas vaginalis glutaminase, putative 0.0271 0.3718 1
Toxoplasma gondii cathepsin B 0.0099 0.1161 1
Brugia malayi Dopamine receptor protein 2 0.0317 0.4412 0.5684
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0098 0.1141 0.1141
Echinococcus granulosus neuropeptide receptor A26 0.0317 0.4412 0.4412
Echinococcus multilocularis fmrfamide receptor 0.0317 0.4412 0.4412
Brugia malayi beta-lactamase 0.0037 0.0242 0.0312
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0032 0.0158 0.0158
Onchocerca volvulus 0.0317 0.4412 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0475 0.1279
Schistosoma mansoni importin beta-1 0.0029 0.0112 0.0112
Echinococcus multilocularis cyclin dependent kinase 5 0.005 0.0437 0.0437
Trypanosoma cruzi cdc2-related kinase 3 0.005 0.0437 0.1119
Brugia malayi hypothetical protein 0.0317 0.4412 0.5684
Plasmodium vivax vivapain-2 0.0053 0.0475 0.7075
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0317 0.4412 0.4412
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0066 0.0672 0.1667
Trichomonas vaginalis cyclins, putative 0.0086 0.0973 0.2617
Echinococcus granulosus g protein coupled receptor 0.0317 0.4412 0.4412
Entamoeba histolytica cysteine protease, putative 0.0053 0.0475 0.4887
Brugia malayi Cathepsin L-like precursor 0.0053 0.0475 0.0612
Giardia lamblia Cathepsin B precursor 0.0099 0.1161 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0171 0.0171
Brugia malayi jmjC domain containing protein 0.0106 0.1271 0.1637
Schistosoma mansoni neuropeptide F-like receptor 0.0317 0.4412 0.4412
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0475 0.1279
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Onchocerca volvulus 0.0032 0.0158 0.0128
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Echinococcus granulosus glutamate receptor 2 0.0098 0.1141 0.1141
Echinococcus multilocularis neuropeptide FF receptor 2 0.0317 0.4412 0.4412
Echinococcus multilocularis neuropeptide receptor 0.0317 0.4412 0.4412
Mycobacterium tuberculosis Conserved protein 0.0037 0.0242 0.0553
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0317 0.4412 0.4412
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0032 0.0158 0.0158
Echinococcus multilocularis g protein coupled receptor 0.0317 0.4412 0.4412
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0067 0.0684 0.2696
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.005 0.0437 0.3764
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0317 0.4412 0.4412
Echinococcus granulosus glutamate receptor subunit protein glur 0.0068 0.0698 0.0698
Echinococcus multilocularis lamin dm0 0.0028 0.0103 0.0103
Loa Loa (eye worm) ctsf protein 0.0053 0.0475 0.0475
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0317 0.4412 0.4412
Brugia malayi cathepsin B-like cysteine proteinase 0.0283 0.3904 0.5029
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0272 0.0272
Entamoeba histolytica cysteine protease, putative 0.0031 0.0153 0.157
Onchocerca volvulus Alhambra homolog 0.0032 0.0171 0.0158
Mycobacterium tuberculosis Probable oxidoreductase 0.0282 0.389 1
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.0475 0.4879
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0475 0.4095
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0032 0.0158 0.1975
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0317 0.4412 0.4412
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0242 0.0312
Echinococcus multilocularis cyclin dependent kinase 9 0.0053 0.0475 0.0475
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.005 0.0437 0.0437
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0086 0.0973 0.8381
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0053 0.0475 0.0475
Echinococcus granulosus allatostatin A receptor 0.0317 0.4412 0.4412
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0317 0.4412 0.4412
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0023 0.0028 0.0244
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0032 0.0158 0.0158
Onchocerca volvulus 0.0317 0.4412 1
Echinococcus multilocularis snurportin 1 0.0305 0.4226 0.4226
Echinococcus granulosus sodium and chloride dependent glycine 0.0032 0.0158 0.0158
Echinococcus granulosus neuropeptide Y receptor 0.0317 0.4412 0.4412
Schistosoma mansoni hypothetical protein 0.0317 0.4412 0.4412
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0242 0.0651
Schistosoma mansoni sodium-dependent amino acid transporter 0.0032 0.0158 0.0158
Echinococcus granulosus neuropeptide s receptor 0.0317 0.4412 0.4412
Echinococcus granulosus cathepsin L 0.0031 0.0153 0.0153
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0475 0.1279
Trypanosoma brucei trypanothione reductase 0.0066 0.0672 0.5788
Schistosoma mansoni biogenic amine receptor 0.0317 0.4412 0.4412
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0317 0.4412 0.4412
Loa Loa (eye worm) glutaminase 0.0271 0.3718 0.3718
Echinococcus granulosus rhodopsin orphan GPCR 0.0317 0.4412 0.4412
Echinococcus granulosus thioredoxin glutathione reductase 0.0066 0.0672 0.0672
Echinococcus multilocularis rhodopsin orphan GPCR 0.0317 0.4412 0.4412
Brugia malayi hypothetical protein 0.0032 0.0158 0.0203
Trichomonas vaginalis cyclin B, putative 0.0086 0.0973 0.2617
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0255 0.2625
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0242 1
Schistosoma mansoni biogenic amine receptor 0.0317 0.4412 0.4412
Schistosoma mansoni myosin xvIII 0.0317 0.4412 0.4412
Echinococcus multilocularis rhodopsin orphan GPCR 0.0317 0.4412 0.4412
Giardia lamblia Cathepsin B precursor 0.0099 0.1161 1
Plasmodium vivax vivapain-3 0.0031 0.0153 0.2273
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0028 0.0244
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0317 0.4412 0.5684
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0475 0.1279
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0242 0.0553
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0437 0.0437
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0317 0.4412 0.4412
Giardia lamblia G2/mitotic-specific cyclin B 0.0086 0.0973 0.8381
Brugia malayi beta-lactamase family protein 0.0037 0.0242 0.0312
Leishmania major hypothetical protein, conserved 0.0037 0.0242 0.2085
Schistosoma mansoni cyclin B 0.0086 0.0973 0.0973
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0067 0.0684 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0031 0.0153 0.0391
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0023 0.0028 0.0244
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0475 0.4095
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0036 0.0223 0.0223
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0068 0.0698 0.0698
Brugia malayi Protein kinase domain containing protein 0.005 0.0437 0.0563
Trypanosoma cruzi cysteine proteinase, putative 0.0031 0.0153 0.0391
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0242 0.062
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0032 0.0158 0.0158
Giardia lamblia Kinase, CMGC CDK 0.005 0.0437 0.3764
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0317 0.4412 0.4412
Toxoplasma gondii thioredoxin reductase 0.0066 0.0672 0.5788
Loa Loa (eye worm) cysteine protease 0.0053 0.0475 0.0475
Echinococcus granulosus glutamate receptor 2 0.0072 0.0752 0.0752
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0158
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0026 0.0076 0.0076
Brugia malayi Cathepsin L-like cysteine proteinase 0.0038 0.0255 0.0329
Entamoeba histolytica cysteine proteinase 1, putative 0.0031 0.0153 0.157
Echinococcus granulosus peregrin 0.0032 0.0171 0.0171
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0242 0.0553
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Schistosoma mansoni sodium/chloride dependent transporter 0.0033 0.0171 0.0171
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0317 0.4412 0.4412
Trichomonas vaginalis mercuric reductase, putative 0.0023 0.0028 0.0076
Mycobacterium leprae Probable lipase LipE 0.0037 0.0242 1
Trichomonas vaginalis cyclin B3, putative 0.0036 0.0223 0.06
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0475 0.1279
Brugia malayi hypothetical protein 0.0317 0.4412 0.5684
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0028 0.0244
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0475 0.1218
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0317 0.4412 0.4412
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0023 0.0028 0.0422
Loa Loa (eye worm) hypothetical protein 0.0086 0.0973 0.0973
Brugia malayi Thioredoxin reductase 0.0066 0.0672 0.0866
Onchocerca volvulus Cathepsin F homolog 0.0053 0.0475 0.0865
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0038 0.0255 0.0654
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.005 0.0437 0.3764
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0242 0.0651
Echinococcus multilocularis cathepsin b 0.0283 0.3904 0.3904
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0023 0.0028 0.5
Schistosoma mansoni neuropeptide f receptor 76f 0.0317 0.4412 0.4412
Echinococcus multilocularis cyclin b3 0.0036 0.0223 0.0223
Schistosoma mansoni neuropeptide receptor 0.0317 0.4412 0.4412
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0032 0.0082
Loa Loa (eye worm) hypothetical protein 0.0692 1 1
Echinococcus multilocularis cathepsin L 0.0031 0.0153 0.0153
Trichomonas vaginalis cyclin B, putative 0.0086 0.0973 0.2617
Echinococcus multilocularis cyclins 0.0036 0.0223 0.0223
Toxoplasma gondii hypothetical protein 0.0032 0.0158 0.136
Plasmodium vivax vivapain-2 0.0053 0.0475 0.7075
Mycobacterium ulcerans short chain dehydrogenase 0.0282 0.389 1
Entamoeba histolytica cysteine protease, putative 0.0031 0.0153 0.157
Loa Loa (eye worm) hypothetical protein 0.0038 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Schistosoma mansoni biogenic amine (5HT) receptor 0.0692 1 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0317 0.4412 0.4412
Echinococcus granulosus lamin dm0 0.0028 0.0103 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0475 0.1279
Schistosoma mansoni hypothetical protein 0.0305 0.4226 0.4226
Echinococcus granulosus sodium and chloride dependent glycine 0.0032 0.0158 0.0158
Entamoeba histolytica cyclin family protein 0.0036 0.0223 0.2293
Onchocerca volvulus 0.0053 0.0475 0.0865
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0032 0.0158 0.0158
Schistosoma mansoni amine GPCR 0.0317 0.4412 0.4412
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0317 0.4412 0.4412
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0032 0.0086
Brugia malayi cell division control protein 2 homolog 0.005 0.0437 0.0563
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0242 0.0242
Echinococcus granulosus tachykinin peptides receptor 99D 0.0317 0.4412 0.4412
Echinococcus granulosus cysteine protease 0.0031 0.0153 0.0153
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0317 0.4412 0.4412
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0158
Leishmania major cathepsin L-like protease 0.0053 0.0475 0.4095
Echinococcus multilocularis neuropeptide receptor A26 0.0317 0.4412 0.4412
Entamoeba histolytica cysteine protease, putative 0.0031 0.0153 0.157
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.036 0.036
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0475 0.1279
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0238 0.3233 0.8299
Trypanosoma cruzi cruzipain precursor, putative 0.0053 0.0475 0.1218
Brugia malayi Importin beta-1 subunit 0.0029 0.0112 0.0145
Brugia malayi intermediate filament protein 0.0028 0.0103 0.0132
Echinococcus granulosus cyclins 0.0036 0.0223 0.0223
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0153 0.0153
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0317 0.4412 0.5684
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0242 0.0242
Echinococcus granulosus neuropeptides capa receptor 0.0317 0.4412 0.4412
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0032 0.0086
Schistosoma mansoni kinase 0.0053 0.0475 0.0475
Echinococcus granulosus rhodopsin orphan GPCR 0.0317 0.4412 0.4412
Schistosoma mansoni glutaminase 0.0271 0.3718 0.3718
Entamoeba histolytica cysteine protease, putative 0.0031 0.0153 0.157
Brugia malayi Melatonin receptor type 1A 0.0317 0.4412 0.5684
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0053 0.0475 0.7075
Trichomonas vaginalis esterase, putative 0.0037 0.0242 0.0651
Brugia malayi hypothetical protein 0.0317 0.4412 0.5684
Onchocerca volvulus 0.0317 0.4412 1
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Echinococcus granulosus neuropeptide Y receptor 0.0317 0.4412 0.4412
Loa Loa (eye worm) hypothetical protein 0.0042 0.0309 0.0309
Onchocerca volvulus 0.0053 0.0475 0.0865
Trypanosoma brucei cysteine peptidase C (CPC) 0.0099 0.1161 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0023 0.0028 0.0028
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0153 0.157
Loa Loa (eye worm) hypothetical protein 0.0042 0.0309 0.0309
Echinococcus granulosus g protein coupled receptor 0.0317 0.4412 0.4412
Entamoeba histolytica cell division protein kinase 2, putative 0.0059 0.0573 0.5887
Entamoeba histolytica cysteine protease, putative 0.0031 0.0153 0.157
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0437 0.1175
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0317 0.4412 0.4412
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0283 0.3904 0.3904
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0028 0.0244
Echinococcus multilocularis serotonin receptor 0.0692 1 1
Loa Loa (eye worm) norepinephrine transporter 0.0186 0.2461 0.2461
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0283 0.3904 0.3904
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0153 0.1316
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0475 0.1279
Echinococcus multilocularis cathepsin L cysteine protease 0.0053 0.0475 0.0475
Trypanosoma cruzi cdc2-related kinase 3 0.005 0.0437 0.1119
Echinococcus multilocularis neuropeptide receptor 0.0317 0.4412 0.4412
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0317 0.4412 0.4412
Echinococcus multilocularis cathepsin L cysteine protease 0.0053 0.0475 0.0475
Brugia malayi G protein-coupled receptor 0.0317 0.4412 0.5684
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0028 0.0073
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0475 0.4095
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0475 0.0475
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0053 0.0475 0.0475
Echinococcus granulosus dro:myosuppressin receptor 0.0317 0.4412 0.4412
Echinococcus granulosus microtubule associated protein 2 0.0675 0.9739 0.9739
Entamoeba histolytica cysteine protease, putative 0.0031 0.0153 0.157
Onchocerca volvulus 0.0317 0.4412 1
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0067 0.0684 0.2696
Trypanosoma brucei cdc2-related kinase 3 0.005 0.0437 0.3764
Loa Loa (eye worm) hypothetical protein 0.0038 0.0255 0.0255
Giardia lamblia Kinase, CMGC CDK 0.005 0.0437 0.3764
Mycobacterium tuberculosis Conserved protein 0.0037 0.0242 0.0553
Echinococcus granulosus tm gpcr rhodopsin 0.0317 0.4412 0.4412
Onchocerca volvulus Neuropeptide F receptor homolog 0.0317 0.4412 1
Onchocerca volvulus 0.0317 0.4412 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0317 0.4412 0.4412
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0053 0.0475 0.0475
Echinococcus granulosus cathepsin l cysteine peptidase 0.0053 0.0475 0.0475
Onchocerca volvulus 0.0317 0.4412 1
Schistosoma mansoni cathepsin F (C01 family) 0.0053 0.0475 0.0475
Trichomonas vaginalis cyclins, putative 0.0059 0.0566 0.1523
Mycobacterium ulcerans glutaminase 0.0271 0.3718 0.9556
Loa Loa (eye worm) hypothetical protein 0.0186 0.2461 0.2461
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0272 0.0272
Entamoeba histolytica cysteine protease, putative 0.0031 0.0153 0.157
Leishmania major cathepsin L-like protease 0.0053 0.0475 0.4095
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0099 0.1161 0.2974
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0475 0.1279
Brugia malayi Serotonin receptor 0.0317 0.4412 0.5684
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0223 0.06
Echinococcus granulosus g-protein coupled receptor 0.0317 0.4412 0.4412
Entamoeba histolytica cysteine protease, putative 0.0031 0.0153 0.157
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0255 0.0687
Onchocerca volvulus Cathepsin L homolog 0.0053 0.0475 0.0865
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0103 0.0103
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0283 0.3904 0.3904
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0242 0.2085
Schistosoma mansoni lamin 0.0028 0.0103 0.0103
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0153 0.0153
Echinococcus granulosus cyclin dependent kinase 9 0.0053 0.0475 0.0475
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0158
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0317 0.4412 0.4412
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0023 0.0028 0.0037
Trypanosoma cruzi cysteine peptidase, putative 0.0031 0.0153 0.0391
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0242 0.0553
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0023 0.0028 0.0028
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0153 0.0197
Plasmodium falciparum transporter, putative 0.0032 0.0158 0.235
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.005 0.0437 0.0437
Brugia malayi RNA, U transporter 1 0.0081 0.0896 0.1155
Entamoeba histolytica cyclin, putative 0.0036 0.0223 0.2293
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0032 0.0158 0.0158
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0032 0.0158 0.0158
Echinococcus granulosus cathepsin l1 0.0038 0.0255 0.0255
Trypanosoma cruzi trypanothione reductase, putative 0.0066 0.0672 0.1721
Onchocerca volvulus 0.0053 0.0475 0.0865
Echinococcus multilocularis cyclin dependent kinase 0.005 0.0437 0.0437
Schistosoma mansoni ATP-binding cassette transporter 0.0042 0.0319 0.0319
Echinococcus multilocularis cyclins 0.0036 0.0223 0.0223
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0171 0.147
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0026 0.0076 0.0076
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.005 0.0437 0.0437
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0475 0.4095
Loa Loa (eye worm) hypothetical protein 0.0038 0.0255 0.0255
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0317 0.4412 0.4412
Echinococcus granulosus importin subunit beta 1 0.0029 0.0112 0.0112
Echinococcus multilocularis neuropeptide Y receptor 0.0317 0.4412 0.4412
Toxoplasma gondii ABC1 family protein 0.0037 0.0242 0.2085
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0032 0.0158 0.0158
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0153 0.0411
Echinococcus multilocularis sex peptide receptor 0.0317 0.4412 0.4412
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0032 0.0158 0.0158
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0242 0.0553
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0093 0.1073 0.1073
Echinococcus multilocularis rhodopsin orphan GPCR 0.0317 0.4412 0.4412
Leishmania major cathepsin L-like protease 0.0053 0.0475 0.4095
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0106 0.1271 0.1271
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Echinococcus multilocularis glutamate receptor 4 0.0042 0.0309 0.0309
Echinococcus granulosus cyclin dependent kinase 1 0.005 0.0437 0.0437
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0023 0.0028 0.0244
Brugia malayi hypothetical protein 0.0317 0.4412 0.5684
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0255 0.0687
Echinococcus granulosus cyclin dependent kinase 9 0.0062 0.061 0.061
Schistosoma mansoni intermediate filament proteins 0.0028 0.0103 0.0103
Onchocerca volvulus 0.0038 0.0255 0.0354
Entamoeba histolytica cysteine protease, putative 0.0031 0.0153 0.157
Loa Loa (eye worm) glutaminase 2 0.0271 0.3718 0.3718
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0026 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0158
Trypanosoma cruzi cdc2-related kinase 1 0.005 0.0437 0.1119
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0112 0.0967
Loa Loa (eye worm) hypothetical protein 0.005 0.0437 0.0437
Echinococcus multilocularis cyclins 0.0036 0.0223 0.0223
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0053 0.0475 0.1279
Loa Loa (eye worm) hypothetical protein 0.0056 0.0516 0.0516
Echinococcus multilocularis fmrfamide receptor 0.0317 0.4412 0.4412
Onchocerca volvulus 0.0032 0.0158 0.0128
Echinococcus granulosus cyclin B3 1 0.0036 0.0223 0.0223
Brugia malayi cyclin-dependent kinase 9 0.0053 0.0475 0.0611
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0032 0.0158 0.0158
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0475 0.4095
Trichomonas vaginalis cyclin B, putative 0.0086 0.0973 0.2617
Brugia malayi hypothetical protein 0.0317 0.4412 0.5684
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Plasmodium falciparum thioredoxin reductase 0.0023 0.0028 0.0422
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0186 0.2461 0.317
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0026 0.0076 0.0076
Echinococcus granulosus cathepsin b 0.0283 0.3904 0.3904
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0283 0.3904 1
Entamoeba histolytica cysteine protease, putative 0.0031 0.0153 0.157
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0032 0.0158 0.0158
Brugia malayi G-protein coupled receptor 0.0317 0.4412 0.5684
Echinococcus granulosus rhodopsin orphan GPCR 0.0317 0.4412 0.4412
Echinococcus multilocularis cathepsin b 0.0283 0.3904 0.3904
Onchocerca volvulus Cathepsin L homolog 0.0053 0.0475 0.0865
Entamoeba histolytica cyclin, putative 0.0086 0.0973 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0317 0.4412 0.4412
Leishmania major cathepsin L-like protease 0.0053 0.0475 0.4095
Plasmodium falciparum protein kinase 5 0.005 0.0437 0.6503
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0028 0.0073
Trypanosoma cruzi cyclin, putative 0.0086 0.0973 0.2492
Schistosoma mansoni glutamate receptor kainate 0.0042 0.0319 0.0319
Loa Loa (eye worm) cyclin domain-containing protein 0.0036 0.0223 0.0223
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0475 0.1279
Trichomonas vaginalis cyclins, putative 0.0086 0.0973 0.2617
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0283 0.3904 0.3904
Schistosoma mansoni cyclin B3 0.0036 0.0223 0.0223
Brugia malayi beta-lactamase family protein 0.0037 0.0242 0.0312
Echinococcus multilocularis glutamate receptor 2 0.0084 0.0942 0.0942
Onchocerca volvulus 0.0317 0.4412 1
Schistosoma mansoni hypothetical protein 0.0317 0.4412 0.4412
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0099 0.1161 0.1161
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0305 0.4226 0.4226
Onchocerca volvulus 0.0317 0.4412 1
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0317 0.4412 0.4412
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Schistosoma mansoni glutamate receptor kainate 0.0042 0.0319 0.0319
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0317 0.4412 0.4412
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0171 0.254
Schistosoma mansoni neuropeptide F-like receptor 0.0317 0.4412 0.4412
Onchocerca volvulus 0.0053 0.0475 0.0865
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0032 0.0158 0.0158
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0475 0.1279
Schistosoma mansoni hypothetical protein 0.0032 0.0171 0.0171
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0032 0.0158 0.0203
Schistosoma mansoni biogenic amine receptor 0.0317 0.4412 0.4412
Echinococcus multilocularis neuropeptide Y receptor 0.0317 0.4412 0.4412
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Leishmania major cathepsin L-like protease 0.0053 0.0475 0.4095
Loa Loa (eye worm) neuropeptide F receptor 0.0317 0.4412 0.4412
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0032 0.0158 0.0158
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0475 0.1279
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Loa Loa (eye worm) hypothetical protein 0.0037 0.0242 0.0242
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0475 0.1218
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0028 0.0244
Brugia malayi glutaminase DH11.1 0.0271 0.3718 0.479
Mycobacterium ulcerans hypothetical protein 0.0037 0.0242 0.0553
Onchocerca volvulus 0.0032 0.0158 0.0128
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0032 0.0158 0.136
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0437 0.1175
Trichomonas vaginalis cyclin B, putative 0.0036 0.0223 0.06
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0317 0.4412 0.4412
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0242 0.062
Schistosoma mansoni microtubule-associated protein tau 0.0675 0.9739 0.9739
Brugia malayi glutathione reductase 0.0066 0.0672 0.0866
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0053 0.0475 0.0475
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0242 0.0242
Schistosoma mansoni amine GPCR 0.0317 0.4412 0.4412
Schistosoma mansoni neuropeptide receptor 0.0317 0.4412 0.4412
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0042 0.0319 0.0319
Echinococcus multilocularis lamin 0.0028 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0692 1 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0171 0.0171
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0317 0.4412 0.5684
Echinococcus granulosus cyclin dependent kinase 5 0.005 0.0437 0.0437
Toxoplasma gondii hypothetical protein 0.0027 0.0094 0.0807
Echinococcus granulosus neuropeptide receptor 0.0317 0.4412 0.4412
Echinococcus granulosus orexin receptor type 2 0.0317 0.4412 0.4412
Trypanosoma cruzi cyclin 6, putative 0.0086 0.0973 0.2492
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Plasmodium vivax importin-beta 2, putative 0.0029 0.0112 0.1671
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0317 0.4412 0.4412
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0475 0.1279
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Echinococcus multilocularis thioredoxin glutathione reductase 0.0066 0.0672 0.0672
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0056 0.0519 0.0519
Leishmania major cyclin 0.0086 0.0973 0.8381
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0317 0.4412 0.4412
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0475 0.4887
Echinococcus multilocularis neuropeptides capa receptor 0.0317 0.4412 0.4412
Echinococcus granulosus cyclins 0.0036 0.0223 0.0223
Schistosoma mansoni glutamate receptor NMDA 0.0056 0.0519 0.0519
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0171 0.0171
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0317 0.4412 0.4412
Plasmodium vivax amine transporter, putative 0.0032 0.0158 0.235
Trichomonas vaginalis cyclin A, putative 0.0086 0.0973 0.2617
Echinococcus multilocularis cysteine protease 0.0053 0.0475 0.0475
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0475 0.4095
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0032 0.0086
Echinococcus granulosus neuropeptides capa receptor 0.0317 0.4412 0.4412
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0242 0.0553
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0475 0.1279
Loa Loa (eye worm) cathepsin B 0.0099 0.1161 0.1161
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0317 0.4412 0.4412
Schistosoma mansoni amine GPCR 0.0317 0.4412 0.4412
Loa Loa (eye worm) hypothetical protein 0.0186 0.2461 0.2461
Schistosoma mansoni neuropeptide receptor 0.0317 0.4412 0.4412
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Brugia malayi hypothetical protein 0.0317 0.4412 0.5684
Trypanosoma cruzi cyclin, putative 0.0086 0.0973 0.2492
Echinococcus granulosus sex peptide receptor 0.0317 0.4412 0.4412
Leishmania major cathepsin L-like protease 0.0053 0.0475 0.4095
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0272 0.0272
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0542 0.7763 0.7763
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0475 0.1279
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0053 0.0475 0.1279
Schistosoma mansoni cathepsin F (C01 family) 0.0038 0.0255 0.0255
Echinococcus granulosus serotonin receptor 0.0317 0.4412 0.4412
Schistosoma mansoni glutamate receptor NMDA 0.0042 0.0319 0.0319
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0317 0.4412 0.4412
Echinococcus multilocularis G-protein coupled receptor, putative 0.0317 0.4412 0.4412
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0053 0.0475 0.0475
Echinococcus granulosus cyclins 0.0036 0.0223 0.0223
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0103 0.0103
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0686 0.0686
Echinococcus multilocularis microtubule associated protein 2 0.0675 0.9739 0.9739
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0153 0.157
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0317 0.4412 0.4412
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0028 0.0073
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0317 0.4412 0.4412
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0067 0.0684 0.1698
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0032 0.0158 0.0158
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0153 0.157
Loa Loa (eye worm) TYRA-2 protein 0.0317 0.4412 0.4412
Echinococcus multilocularis cyclins 0.0036 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Echinococcus granulosus neuropeptide receptor 0.0317 0.4412 0.4412
Brugia malayi Tachykinin-like peptides receptor 99D 0.0317 0.4412 0.5684
Brugia malayi larval opioid receptor 0.0317 0.4412 0.5684
Trypanosoma brucei mitotic cyclin 6 0.0086 0.0973 0.8381
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Trichomonas vaginalis cyclin D, putative 0.0036 0.0223 0.06
Loa Loa (eye worm) glutamate receptor 1 0.0084 0.0942 0.0942
Onchocerca volvulus 0.0317 0.4412 1
Echinococcus multilocularis cyclin B 0.0086 0.0973 0.0973
Echinococcus multilocularis g protein coupled receptor 0.0317 0.4412 0.4412
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0171 0.0171
Giardia lamblia Cathepsin B precursor 0.0099 0.1161 1
Echinococcus multilocularis cyclin dependent kinase 9 0.0062 0.061 0.061
Echinococcus multilocularis cyclins 0.0036 0.0223 0.0223
Echinococcus multilocularis serotonin transporter 0.0186 0.2461 0.2461
Onchocerca volvulus 0.0317 0.4412 1
Schistosoma mansoni glutamate receptor AMPA 0.0042 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0153 0.1316
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0026 0.0076 0.0076
Leishmania major importin beta-1 subunit, putative 0.0023 0.0032 0.0274
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0023 0.0028 0.0028
Schistosoma mansoni glutamate receptor kainate 0.0042 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0049 0.0424 0.0424
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Brugia malayi Dopamine receptor 0.0317 0.4412 0.5684
Entamoeba histolytica cysteine proteinase 2 0.0031 0.0153 0.157
Loa Loa (eye worm) beta-lactamase 0.0037 0.0242 0.0242
Onchocerca volvulus 0.0037 0.0242 0.0323
Toxoplasma gondii NADPH-glutathione reductase 0.0023 0.0028 0.0244
Echinococcus multilocularis orexin receptor type 2 0.0317 0.4412 0.4412
Schistosoma mansoni opsin-like receptor 0.0317 0.4412 0.4412
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0475 0.1279
Onchocerca volvulus 0.0086 0.0973 0.2019
Entamoeba histolytica cyclin family protein 0.0036 0.0223 0.2293
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Echinococcus granulosus g protein coupled receptor 0.0317 0.4412 0.4412
Chlamydia trachomatis glutamine binding protein 0.0067 0.0684 1
Leishmania major trypanothione reductase 0.0066 0.0672 0.5788
Echinococcus granulosus snurportin 1 0.0305 0.4226 0.4226
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Trypanosoma brucei cdc2-related kinase 1 0.005 0.0437 0.3764
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0317 0.4412 0.4412
Echinococcus granulosus cyclin b3 0.0036 0.0223 0.0223
Echinococcus multilocularis sodium and chloride dependent glycine 0.0032 0.0158 0.0158
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0317 0.4412 0.4412
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0098 0.1141 0.1141
Brugia malayi GnHR receptor homolog 0.0317 0.4412 0.5684
Echinococcus multilocularis cysteine protease 0.0053 0.0475 0.0475
Trichomonas vaginalis glutathione reductase, putative 0.0023 0.0028 0.0076
Giardia lamblia Cyclin A 0.0036 0.0223 0.1922
Schistosoma mansoni opsin-like receptor 0.0317 0.4412 0.4412
Toxoplasma gondii hypothetical protein 0.0032 0.0158 0.136
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0317 0.4412 0.5684
Brugia malayi Cyclin, N-terminal domain containing protein 0.0086 0.0973 0.1253
Echinococcus granulosus rhodopsin orphan GPCR 0.0317 0.4412 0.4412
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0317 0.4412 0.4412
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Echinococcus granulosus intermediate filament protein 0.0028 0.0103 0.0103
Onchocerca volvulus 0.0317 0.4412 1
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0317 0.4412 0.4412
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0475 0.1279
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0317 0.4412 0.4412
Loa Loa (eye worm) hypothetical protein 0.0028 0.0103 0.0103
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0112 0.0112
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0053 0.0475 0.7075
Echinococcus granulosus glutamate receptor 4 0.0042 0.0309 0.0309
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0067 0.0684 0.1698
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0317 0.4412 0.4412
Loa Loa (eye worm) hypothetical protein 0.0037 0.0242 0.0242
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0056 0.0519 0.0519
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0242 0.0242
Giardia lamblia NADH oxidase lateral transfer candidate 0.0023 0.0028 0.0244
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Trypanosoma cruzi trypanothione reductase, putative 0.0023 0.0028 0.0073
Plasmodium vivax glutathione reductase, putative 0.0066 0.0672 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0317 0.4412 0.4412
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0099 0.1161 0.3122
Echinococcus granulosus cyclins 0.0036 0.0223 0.0223
Plasmodium vivax protein kinase Crk2 0.005 0.0437 0.6503
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0317 0.4412 0.4412
Echinococcus granulosus serotonin transporter 0.0186 0.2461 0.2461
Schistosoma mansoni neuropeptide receptor 0.0317 0.4412 0.4412
Brugia malayi hypothetical protein 0.0317 0.4412 0.5684
Schistosoma mansoni hypothetical protein 0.0317 0.4412 0.4412
Schistosoma mansoni amine GPCR 0.0317 0.4412 0.4412
Schistosoma mansoni glutamate receptor AMPA 0.0042 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Echinococcus granulosus glutamate NMDA receptor subunit 0.0042 0.0319 0.0319
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0317 0.4412 0.5684
Trichomonas vaginalis cyclin B, putative 0.0086 0.0973 0.2617
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0028 0.0073
Plasmodium falciparum thioredoxin reductase 0.0066 0.0672 1
Schistosoma mansoni amine GPCR 0.0317 0.4412 0.4412
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0023 0.0028 0.0422
Schistosoma mansoni growth hormone secretagogue receptor 0.0317 0.4412 0.4412
Echinococcus granulosus 7tm_1 domain containing protein 0.0317 0.4412 0.4412
Schistosoma mansoni opsin-like receptor 0.0317 0.4412 0.4412
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0475 0.1279
Loa Loa (eye worm) neuropeptide F receptor 0.0317 0.4412 0.4412
Brugia malayi Cyclin, N-terminal domain containing protein 0.0036 0.0223 0.0287
Trichomonas vaginalis cyclin D, putative 0.0036 0.0223 0.06
Loa Loa (eye worm) hypothetical protein 0.0037 0.0242 0.0242
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0023 0.0028 0.0422
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0158 0.235
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0103 0.0132
Echinococcus multilocularis neuropeptides capa receptor 0.0317 0.4412 0.4412
Plasmodium falciparum glutathione reductase 0.0023 0.0028 0.0422
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0317 0.4412 0.4412
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0032 0.0158 0.0203
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0242 0.0553
Brugia malayi Bromodomain containing protein 0.0032 0.0171 0.022
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0272 0.0272
Plasmodium falciparum cysteine proteinase falcipain 1 0.0031 0.0153 0.2273
Trichomonas vaginalis cyclins, putative 0.0086 0.0973 0.2617
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0475 0.4095
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Echinococcus multilocularis rhodopsin orphan GPCR 0.0317 0.4412 0.4412
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0023 0.0028 0.0244
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Brugia malayi Papain family cysteine protease containing protein 0.0053 0.0475 0.0612
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.005 0.0437 0.3764
Echinococcus multilocularis glutamate receptor 2 0.0072 0.0752 0.0752
Echinococcus granulosus jumonji domain containing protein 0.0045 0.036 0.036
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0112 0.0967
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0437 0.1175
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0158
Onchocerca volvulus 0.0037 0.0242 0.0323
Schistosoma mansoni cyclins 0.0036 0.0223 0.0223
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0242 0.0651
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0023 0.0028 0.0244
Brugia malayi Cathepsin L-like precursor 0.0053 0.0475 0.0612
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0158
Schistosoma mansoni sodium/chloride dependent transporter 0.0032 0.0158 0.0158
Echinococcus granulosus cathepsin L cysteine proteinase 0.0053 0.0475 0.0475
Loa Loa (eye worm) hypothetical protein 0.0037 0.0242 0.0242
Echinococcus multilocularis rhodopsin orphan GPCR 0.0317 0.4412 0.4412
Echinococcus granulosus fmrfamide receptor 0.0317 0.4412 0.4412
Echinococcus multilocularis rhodopsin orphan GPCR 0.0317 0.4412 0.4412
Echinococcus multilocularis neuropeptide s receptor 0.0317 0.4412 0.4412
Loa Loa (eye worm) hypothetical protein 0.0042 0.0309 0.0309
Schistosoma mansoni adenoreceptor 0.0317 0.4412 0.4412
Loa Loa (eye worm) G-protein coupled receptor 0.0317 0.4412 0.4412
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0032 0.0158 0.0158
Onchocerca volvulus 0.0317 0.4412 1
Mycobacterium ulcerans beta-lactamase 0.0037 0.0242 0.0553
Onchocerca volvulus 0.0317 0.4412 1
Brugia malayi follicle stimulating hormone receptor 0.0542 0.7763 1
Echinococcus granulosus cathepsin b 0.0283 0.3904 0.3904
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0028 0.0073
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0317 0.4412 0.4412
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0099 0.1161 1
Trypanosoma cruzi cdc2-related kinase 1 0.005 0.0437 0.1119
Echinococcus multilocularis NMDA receptor 0.0026 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0029 0.0112 0.0112
Schistosoma mansoni hypothetical protein 0.0026 0.0076 0.0076
Echinococcus granulosus G protein coupled receptor 139 0.0317 0.4412 0.4412
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0242 0.0553
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0437 0.0437
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0475 0.4095
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0158
Onchocerca volvulus 0.0317 0.4412 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0153 0.0411
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0056 0.0519 0.0519
Brugia malayi Glutamate receptor 2 precursor 0.0084 0.0942 0.1213
Schistosoma mansoni sodium/chloride dependent transporter 0.0186 0.2461 0.2461
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0317 0.4412 0.4412
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0032 0.0158 0.0203
Mycobacterium tuberculosis Conserved protein 0.0037 0.0242 0.0553
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0272 0.0272
Echinococcus multilocularis g protein coupled receptor 0.0317 0.4412 0.4412
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0317 0.4412 0.4412
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0475 0.1279
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0056 0.0519 0.0519
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0475 0.4095
Onchocerca volvulus 0.0053 0.0475 0.0865
Echinococcus multilocularis rhodopsin orphan GPCR 0.0317 0.4412 0.4412
Brugia malayi hypothetical protein 0.0317 0.4412 0.5684
Echinococcus granulosus cyclin B 0.0086 0.0973 0.0973
Schistosoma mansoni biogenic amine (5HT) receptor 0.0317 0.4412 0.4412
Plasmodium falciparum cyclin 0.0036 0.0223 0.332
Echinococcus granulosus lamin 0.0028 0.0103 0.0103
Loa Loa (eye worm) G-protein coupled receptor 0.0317 0.4412 0.4412
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0153 0.157
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0023 0.0028 0.0422
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0171 0.147
Echinococcus multilocularis g-protein coupled receptor 0.0317 0.4412 0.4412
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0153 0.0197
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0032 0.0158 0.136
Plasmodium vivax vivapain-1 0.0031 0.0153 0.2273
Loa Loa (eye worm) hypothetical protein 0.0283 0.3904 0.3904
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0036 0.0223 0.0223
Brugia malayi Cathepsin L-like precursor 0.0053 0.0475 0.0612
Echinococcus multilocularis cyclin dependent kinase 1 0.005 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Schistosoma mansoni cathepsin F (C01 family) 0.0053 0.0475 0.0475
Echinococcus granulosus peptide allatostatin:somatostatin 0.0317 0.4412 0.4412
Onchocerca volvulus 0.0317 0.4412 1
Loa Loa (eye worm) glutathione reductase 0.0066 0.0672 0.0672
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0475 0.4887
Brugia malayi ORL1-like opioid receptor 0.0317 0.4412 0.5684
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0023 0.0028 0.5
Brugia malayi RE15519p 0.0317 0.4412 0.5684
Echinococcus granulosus glutamate receptor 1 0.0042 0.0309 0.0309
Entamoeba histolytica hypothetical protein 0.0023 0.0032 0.0327
Plasmodium falciparum amino acid transporter, putative 0.0032 0.0158 0.235
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.005 0.0437 0.0437
Plasmodium falciparum glutathione reductase 0.0066 0.0672 1
Entamoeba histolytica cysteine protease, putative 0.0031 0.0153 0.157
Giardia lamblia PHD finger protein 15 0.0032 0.0171 0.147
Onchocerca volvulus 0.0053 0.0475 0.0865
Plasmodium falciparum importin beta, putative 0.0029 0.0112 0.1671
Echinococcus multilocularis cyclin B3 1 0.0036 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0186 0.2461 0.2461
Loa Loa (eye worm) hypothetical protein 0.0317 0.4412 0.4412
Echinococcus granulosus nmda type glutamate receptor 0.0093 0.1073 0.1073
Echinococcus multilocularis cyclins 0.0036 0.0223 0.0223
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0112 0.0967
Echinococcus multilocularis cyclin dependent kinase 1 0.005 0.0437 0.0437
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0317 0.4412 0.4412
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0475 0.1279
Echinococcus multilocularis somatostatin receptor 0.0317 0.4412 0.4412
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0242 0.0651
Plasmodium vivax unspecified product 0.0031 0.0153 0.2273
Trypanosoma cruzi CYC2-like cyclin, putative 0.0086 0.0973 0.2492
Onchocerca volvulus 0.0317 0.4412 1
Loa Loa (eye worm) solute carrier family 6 member 4 0.0186 0.2461 0.2461
Echinococcus granulosus 7TM GPCR rhodopsin 0.0317 0.4412 0.4412
Leishmania major cysteine peptidase A (CPA) 0.0053 0.0475 0.4095
Treponema pallidum sodium- and chloride- dependent transporter 0.0186 0.2461 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = -7.62 Binding affinity to the alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]-idazoxan as radioligand ChEMBL. 2153820
Ki (binding) = -6.74 Binding affinity to alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]-yohimbine as radioligand ChEMBL. 2153820
Ki (binding) = -5.2 Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]-prazosin as radioligand ChEMBL. 2153820

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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