Detailed information for compound 1792428

Basic information

Technical information
  • TDR Targets ID: 1792428
  • Name: N-(piperidin-4-ylmethyl)-3,4-dihydro-2H-[1,3] oxazino[3,2-a]indole-10-carboxamide
  • MW: 313.394 | Formula: C18H23N3O2
  • H donors: 2 H acceptors: 1 LogP: 1.96 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1c2OCCCn2c2c1cccc2)NCC1CCNCC1
  • InChi: 1S/C18H23N3O2/c22-17(20-12-13-6-8-19-9-7-13)16-14-4-1-2-5-15(14)21-10-3-11-23-18(16)21/h1-2,4-5,13,19H,3,6-12H2,(H,20,22)
  • InChiKey: XCEAESKIYSJHOH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-piperidylmethyl)-3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxamide
  • N-(4-piperidinylmethyl)-3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Cavia porcellus Serotonin 4 (5-HT4) receptor Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Get druggable targets OG5_133042 All targets in OG5_133042
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Phospholipase d-related homolog Serotonin 4 (5-HT4) receptor   388 aa 404 aa 17.6 %
Echinococcus granulosus thyrotropin releasing hormone receptor Serotonin 4 (5-HT4) receptor   388 aa 346 aa 20.8 %
Echinococcus granulosus orexin receptor type 2 Serotonin 4 (5-HT4) receptor   388 aa 418 aa 22.5 %
Echinococcus granulosus dro:myosuppressin receptor Serotonin 4 (5-HT4) receptor   388 aa 360 aa 21.7 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Serotonin 4 (5-HT4) receptor   388 aa 352 aa 28.4 %
Schistosoma mansoni peptide (allatostatin)-like receptor Serotonin 4 (5-HT4) receptor   388 aa 332 aa 23.5 %
Onchocerca volvulus Serotonin 4 (5-HT4) receptor   388 aa 357 aa 22.1 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 4 (5-HT4) receptor   388 aa 363 aa 35.3 %
Echinococcus multilocularis orexin receptor type 2 Serotonin 4 (5-HT4) receptor   388 aa 418 aa 22.7 %
Echinococcus multilocularis allatostatin A receptor Serotonin 4 (5-HT4) receptor   388 aa 327 aa 26.3 %
Brugia malayi follicle stimulating hormone receptor 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 388 aa 314 aa 23.9 %
Brugia malayi follicle stimulating hormone receptor Serotonin 4 (5-HT4) receptor   388 aa 319 aa 24.5 %
Schistosoma mansoni biogenic amine (5HT) receptor Serotonin 4 (5-HT4) receptor   388 aa 385 aa 31.9 %
Echinococcus granulosus allatostatin A receptor Serotonin 4 (5-HT4) receptor   388 aa 359 aa 25.3 %
Loa Loa (eye worm) follicle stimulating hormone receptor Serotonin 4 (5-HT4) receptor   388 aa 345 aa 23.5 %
Onchocerca volvulus Serotonin 4 (5-HT4) receptor   388 aa 315 aa 19.7 %
Echinococcus granulosus somatostatin receptor Serotonin 4 (5-HT4) receptor   388 aa 375 aa 21.6 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Serotonin 4 (5-HT4) receptor   388 aa 326 aa 27.3 %
Onchocerca volvulus Serotonin 4 (5-HT4) receptor   388 aa 361 aa 24.1 %
Echinococcus multilocularis neuropeptide receptor Serotonin 4 (5-HT4) receptor   388 aa 325 aa 24.0 %
Echinococcus multilocularis dro:myosuppressin receptor Serotonin 4 (5-HT4) receptor   388 aa 360 aa 21.7 %
Onchocerca volvulus Serotonin 4 (5-HT4) receptor   388 aa 367 aa 30.8 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Serotonin 4 (5-HT4) receptor   388 aa 395 aa 29.6 %
Brugia malayi GnHR receptor homolog Serotonin 4 (5-HT4) receptor   388 aa 358 aa 20.7 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Serotonin 4 (5-HT4) receptor   388 aa 346 aa 21.1 %
Schistosoma japonicum FMRFamide receptor, putative Serotonin 4 (5-HT4) receptor   388 aa 351 aa 19.9 %
Brugia malayi Serotonin/octopamine receptor family protein 7 Serotonin 4 (5-HT4) receptor   388 aa 395 aa 29.4 %
Onchocerca volvulus Serotonin 4 (5-HT4) receptor   388 aa 321 aa 24.0 %
Schistosoma japonicum ko:K04255 opsin 4 (melanopsin), putative Serotonin 4 (5-HT4) receptor   388 aa 374 aa 18.7 %
Echinococcus granulosus neuropeptide receptor Serotonin 4 (5-HT4) receptor   388 aa 325 aa 24.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0175 0.0435
Loa Loa (eye worm) hypothetical protein 0.0027 0.015 0.0418
Loa Loa (eye worm) hypothetical protein 0.0025 0.0123 0.0344
Brugia malayi PHD-finger family protein 0.0029 0.0186 0.0518
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0101 0.1279 0.3778
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.014 0.1865 1
Echinococcus multilocularis Smad4 0.0017 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0233 0.3262 0.9088
Onchocerca volvulus 0.0047 0.0466 0.0992
Loa Loa (eye worm) hypothetical protein 0.0031 0.0224 0.0623
Trichomonas vaginalis heat shock protein, putative 0.0046 0.0439 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0035 0.0278 0.0774
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0457 0.1289
Schistosoma mansoni DNA polymerase eta 0.0041 0.0366 0.0366
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0256 0.0712
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0224 0.0623
Brugia malayi MH1 domain containing protein 0.0017 0.0011 0.0031
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.0233 0.3273 0.9817
Brugia malayi MH2 domain containing protein 0.0254 0.3589 1
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0047 0.0457 0.1272
Loa Loa (eye worm) hypothetical protein 0.0022 0.0077 0.0215
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0366 0.1015
Brugia malayi MH2 domain containing protein 0.0017 0.0011 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0366 0.1015
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0123 0.0279
Schistosoma mansoni 6-phosphofructokinase 0.0237 0.3333 0.3333
Entamoeba histolytica hypothetical protein 0.0148 0.198 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0366 0.1015
Schistosoma mansoni heat shock protein 0.0046 0.0439 0.0439
Brugia malayi Bromodomain containing protein 0.0029 0.0186 0.0518
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0101 0.1279 0.3778
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0366 0.1015
Trypanosoma brucei heat shock protein 90, putative 0.0046 0.0439 0.1237
Giardia lamblia Hypothetical protein 0.014 0.1865 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.049 0.1365
Echinococcus multilocularis musashi 0.0027 0.015 0.015
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0366 0.1015
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0278 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0224 0.0623
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0366 0.0366
Entamoeba histolytica heat shock protein 90, putative 0.0046 0.0439 0.2096
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0077 0.1132
Echinococcus granulosus expressed protein 0.0423 0.6134 0.6134
Echinococcus multilocularis phd:f box containing protein 0.0025 0.0123 0.0123
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0025 0.0123 0.0395
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0457 0.2321
Schistosoma mansoni smad1 5 8 and 0.0017 0.0011 0.0011
Echinococcus granulosus Smad4 0.0017 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0031 0.0224 0.0623
Entamoeba histolytica hypothetical protein 0.0148 0.198 1
Plasmodium vivax heat shock protein, putative 0.0173 0.2365 1
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0224 0.0224
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0366 0.1015
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0031 0.0031
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0077 0.0077
Toxoplasma gondii heat shock protein 90, putative 0.0046 0.0439 0.175
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0186 0.0664
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0224 0.0224
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0224 0.0623
Echinococcus multilocularis peregrin 0.0029 0.0186 0.0186
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0233 0.3273 0.9817
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0077 0.0077
Brugia malayi MH1 domain containing protein 0.0017 0.0011 0.0031
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.049 0.1365
Loa Loa (eye worm) hypothetical protein 0.0049 0.049 0.1365
Echinococcus granulosus intermediate filament protein 0.0027 0.015 0.015
Schistosoma mansoni microtubule-associated protein tau 0.0679 1 1
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0077 0.0077
Schistosoma mansoni survival motor neuron protein 0.0047 0.0466 0.0466
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0123 0.0344
Trypanosoma brucei unspecified product 0.0028 0.0175 0.0435
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0457 0.2321
Trypanosoma brucei heat shock protein, putative 0.0046 0.0439 0.1237
Echinococcus granulosus endoplasmin 0.0043 0.0397 0.0397
Entamoeba histolytica heat shock protein 90, putative 0.0046 0.0439 0.2096
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0224 0.0224
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.0123 0.0123
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0224 0.0224
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0224 0.0224
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0043 0.0397 0.8601
Loa Loa (eye worm) endoplasmin 0.0046 0.0439 0.1224
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0224 0.0224
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0457 0.2184
Schistosoma mansoni ap endonuclease 0.0019 0.0031 0.0031
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0366 0.7875
Leishmania major heat shock protein 83-1 0.0046 0.0439 0.1237
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0237 0.3333 1
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0077 0.0077
Trypanosoma brucei heat shock protein 84, putative 0.003 0.0208 0.0535
Trypanosoma brucei heat shock protein, putative 0.0046 0.0439 0.1237
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.0123 0.0123
Loa Loa (eye worm) heat shock protein 75 0.003 0.0208 0.0579
Schistosoma mansoni endoplasmin 0.0046 0.0439 0.0439
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0077 0.0077
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0077 0.0215
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0224 0.0224
Echinococcus multilocularis expressed protein 0.0423 0.6134 0.6134
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0031 0.0086
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0077 0.0215
Schistosoma mansoni jumonji/arid domain-containing protein 0.0093 0.1151 0.1151
Trypanosoma brucei unspecified product 0.0028 0.0175 0.0435
Brugia malayi hypothetical protein 0.0022 0.0077 0.0215
Schistosoma mansoni lamin 0.0027 0.015 0.015
Brugia malayi Hsp90 protein 0.003 0.0208 0.0579
Brugia malayi Smad1 0.0017 0.0011 0.0031
Trichomonas vaginalis heat shock protein, putative 0.0033 0.025 0.5367
Schistosoma mansoni Smad4 0.0017 0.0011 0.0011
Brugia malayi PXA domain containing protein 0.0022 0.0077 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0224 0.0623
Loa Loa (eye worm) hypothetical protein 0.0029 0.0186 0.0518
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0077 0.0215
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0148 0.198 0.198
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0224 0.0224
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0077 0.0077
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0077 0.0215
Onchocerca volvulus Alhambra homolog 0.0029 0.0186 0.0113
Schistosoma mansoni ap endonuclease 0.0019 0.0031 0.0031
Echinococcus multilocularis geminin 0.0528 0.7717 0.7717
Leishmania major heat shock protein 83-1 0.0046 0.0439 0.1237
Giardia lamblia DINP protein human, muc B family 0.0041 0.0366 0.1828
Plasmodium falciparum heat shock protein 90, putative 0.0173 0.2365 1
Giardia lamblia PHD finger protein 15 0.0029 0.0186 0.0845
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0224 0.0224
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.0123 0.0123
Trichomonas vaginalis heat shock protein, putative 0.0039 0.034 0.7559
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0224 0.0232
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.3262 0.3262
Loa Loa (eye worm) hypothetical protein 0.0034 0.0256 0.0712
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0457 1
Schistosoma mansoni heat shock protein 0.003 0.0208 0.0208
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0237 0.3333 1
Toxoplasma gondii Hsp90 domain-containing protein 0.0173 0.2365 1
Onchocerca volvulus Huntingtin homolog 0.0121 0.1569 0.4458
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0011 0.0011
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0022 0.0077 0.1132
Echinococcus multilocularis endoplasmin 0.0043 0.0397 0.0397
Schistosoma mansoni hypothetical protein 0.0047 0.0466 0.0466
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.0123 0.0123
Leishmania major DNA polymerase eta, putative 0.0041 0.0366 0.1015
Leishmania major DNA polymerase kappa, putative 0.0041 0.0366 0.1015
Trypanosoma brucei unspecified product 0.0041 0.0366 0.1015
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0151 0.2926
Trypanosoma brucei DNA polymerase eta, putative 0.0041 0.0366 0.1015
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.0237 0.3333 0.3333
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0123 0.0279
Trypanosoma brucei Heat shock protein 83, putative 0.0046 0.0439 0.1237
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0457 1
Leishmania major heat shock protein 83-1 0.0046 0.0439 0.1237
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0077 0.1132
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0077 0.0077
Trypanosoma cruzi heat shock protein 85, putative 0.0046 0.0439 0.1237
Schistosoma mansoni endoplasmin 0.0046 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0022 0.0077 0.0215
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0224 0.0224
Trypanosoma brucei heat shock protein, putative 0.0046 0.0439 0.1237
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0031 0.0086
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.034 0.1684
Trypanosoma brucei heat shock protein, putative 0.0046 0.0439 0.1237
Echinococcus multilocularis dna polymerase eta 0.0041 0.0366 0.0366
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0224 0.0224
Echinococcus granulosus phd:f box containing protein 0.0025 0.0123 0.0123
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0366 0.1828
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0457 0.1272
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0224 0.0623
Toxoplasma gondii heat shock protein 75, putative 0.003 0.0208 0.0758
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0077 0.0077
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0151 0.0512
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0224 0.0623
Brugia malayi nuclear hormone receptor 0.0031 0.0224 0.0623
Echinococcus granulosus 6 phosphofructo 2 kinase:fructose 2 0.0237 0.3333 0.3333
Brugia malayi heat shock protein 90 0.0046 0.0439 0.1224
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0249 0.5121
Leishmania major heat shock protein 83-1 0.0046 0.0439 0.1237
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0366 0.1015
Plasmodium falciparum phd finger protein, putative 0.0029 0.0186 0.0664
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0077 0.0215
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0025 0.0123 0.0123
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein 0.0101 0.1279 0.3778
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0077 0.0077
Brugia malayi jmjC domain containing protein 0.0025 0.0123 0.0344
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0186 0.0664
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0366 0.1828
Echinococcus multilocularis smad 0.0017 0.0011 0.0011
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0077 0.0077
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0224 0.0224
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0366 0.1015
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0366 0.1015
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0237 0.3333 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0011 0.0031
Trypanosoma brucei heat shock protein, putative 0.0046 0.0439 0.1237
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0011 0.0011
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0077 0.0077
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.3262 0.3262
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0651 0.1813
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0077 0.0215
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0077 0.0077
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0457 0.2321
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0224 0.0623
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.0233 0.3273 0.9817
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0186 0.0186
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0224 0.0224
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0043 0.0397 1
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.0208 0.0182
Echinococcus granulosus lamin 0.0027 0.015 0.015
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0278 0.1058
Echinococcus multilocularis lysine specific demethylase 5A 0.0093 0.1151 0.1151
Echinococcus granulosus lamin dm0 0.0027 0.015 0.015
Schistosoma mansoni smad1 5 8 and 0.0017 0.0011 0.0011
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0366 0.1015
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0278 0.5799
Loa Loa (eye worm) hypothetical protein 0.0149 0.1994 0.5555
Loa Loa (eye worm) hypothetical protein 0.0035 0.0278 0.0774
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0077 0.0215
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0186 0.0664
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0043 0.0397 0.1108
Loa Loa (eye worm) hypothetical protein 0.0121 0.1569 0.4372
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0366 0.1015
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0366 0.0366
Entamoeba histolytica hypothetical protein 0.0022 0.0077 0.0237
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0011 0.0031
Plasmodium vivax heat shock protein 90, putative 0.003 0.0208 0.0758
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.0123 0.0123
Plasmodium falciparum endoplasmin, putative 0.0033 0.025 0.0939
Loa Loa (eye worm) hypothetical protein 0.0035 0.0278 0.0774
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0278 0.1058
Echinococcus multilocularis lamin 0.0027 0.015 0.015
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0457 0.2321
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.0233 0.3273 0.9817
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0224 0.0224
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0366 0.0366
Loa Loa (eye worm) intermediate filament protein 0.0027 0.015 0.0418
Echinococcus granulosus smad 0.0017 0.0011 0.0011
Schistosoma mansoni transcription factor LCR-F1 0.0148 0.198 0.198
Echinococcus granulosus lysine specific demethylase 5A 0.0093 0.1151 0.1151
Schistosoma mansoni jumonji domain containing protein 0.0025 0.0123 0.0123
Schistosoma mansoni phd/f-box containing protein 0.0025 0.0123 0.0123
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0366 0.1015
Leishmania major heat shock protein 83-1 0.0046 0.0439 0.1237
Brugia malayi hypothetical protein 0.0233 0.3262 0.9088
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0224 0.0224
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0186 0.0186
Trypanosoma brucei heat shock protein, putative 0.0046 0.0439 0.1237
Plasmodium vivax endoplasmin, putative 0.0046 0.0439 0.175
Loa Loa (eye worm) hypothetical protein 0.0121 0.1569 0.4372
Loa Loa (eye worm) Smad1 0.0017 0.0011 0.0031
Loa Loa (eye worm) hypothetical protein 0.0237 0.3333 0.9286
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0039 0.034 0.034
Echinococcus granulosus geminin 0.0528 0.7717 0.7717
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0224 0.0623
Brugia malayi jmjC domain containing protein 0.0025 0.0123 0.0344
Trichomonas vaginalis endoplasmin, putative 0.0033 0.025 0.5367
Loa Loa (eye worm) MH2 domain-containing protein 0.0254 0.3589 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0224 0.0623
Leishmania major heat shock protein 83-1 0.0046 0.0439 0.1237
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0457 0.2321
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.049 0.1365
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0224 0.0623
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0224 0.0623
Loa Loa (eye worm) transcription factor SMAD2 0.0254 0.3589 1
Toxoplasma gondii heat shock protein HSP90 0.0046 0.0439 0.175
Echinococcus granulosus dna polymerase eta 0.0041 0.0366 0.0366
Leishmania major heat shock protein 83-1 0.0046 0.0439 0.1237
Trypanosoma brucei heat shock protein, putative 0.0046 0.0439 0.1237
Brugia malayi Endoplasmin precursor 0.0046 0.0439 0.1224
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0224 0.0224
Leishmania major heat shock protein 83-1 0.0046 0.0439 0.1237
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0175 0.0435
Echinococcus multilocularis heat shock protein 0.0046 0.0439 0.0439
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0224 0.0224
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0224 0.0224
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0011 0.0011
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.034 0.0935
Trichomonas vaginalis heat shock protein, putative 0.0043 0.0397 0.8962
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0025 0.0123 0.0279
Entamoeba histolytica hypothetical protein 0.0022 0.0077 0.0237
Brugia malayi ecdysteroid receptor 0.0031 0.0224 0.0623
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0249 0.5121
Brugia malayi jmjC domain containing protein 0.0153 0.2053 0.5719
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0224 0.0232
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0077 0.1132
Brugia malayi hypothetical protein 0.0022 0.0077 0.0215
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0366 0.1015
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0224 0.0224
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0077 0.0077
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0457 0.1272
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0077 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0077 0.1132
Loa Loa (eye worm) hypothetical protein 0.0031 0.0224 0.0623
Loa Loa (eye worm) hypothetical protein 0.0065 0.0731 0.2036
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0224 0.0623
Echinococcus multilocularis microtubule associated protein 2 0.0679 1 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0224 0.0224
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0186 0.0518
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0457 0.1289
Echinococcus multilocularis heat shock protein 90 0.0046 0.0439 0.0439
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0077 0.0077
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0224 0.0224
Echinococcus granulosus jumonji domain containing protein 0.004 0.0357 0.0357
Giardia lamblia Hypothetical protein 0.014 0.1865 1
Schistosoma mansoni protein phosphatase 2C 0.0025 0.0123 0.0123
Entamoeba histolytica hypothetical protein 0.0022 0.0077 0.0237
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0077 0.1132
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0077 0.0215
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0457 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0025 0.0123 0.0123
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0077 0.0077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0224 0.0623
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0224 0.0623
Onchocerca volvulus 0.0149 0.1994 0.5793
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0077 0.0077
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0148 0.198 0.198
Echinococcus granulosus heat shock protein 90 0.0046 0.0439 0.0439
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0366 0.102
Brugia malayi jmjC domain containing protein 0.0093 0.1151 0.3208
Loa Loa (eye worm) hypothetical protein 0.0035 0.0278 0.0774
Loa Loa (eye worm) hypothetical protein 0.0025 0.0123 0.0344
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0366 0.1015
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.0123 0.0123
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.015 0.0418
Schistosoma mansoni smad1 5 8 and 0.0017 0.0011 0.0011
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0457 0.2184
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0224 0.0623
Treponema pallidum heat shock protein 90 0.0043 0.0397 1
Leishmania major heat shock protein 83-1 0.0046 0.0439 0.1237
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0366 0.1015
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0077 0.0215
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0035 0.0278 0.0774
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0077 0.1132
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0077 0.0077
Leishmania major heat shock protein 83-1 0.0046 0.0439 0.1237
Loa Loa (eye worm) jmjC domain-containing protein 0.0093 0.1151 0.3208
Giardia lamblia Grp94/Hsp90 0.0043 0.0397 0.1996
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.0123 0.0123
Schistosoma mansoni hypothetical protein 0.0528 0.7717 0.7717
Giardia lamblia Heat shock protein HSP 90-alpha 0.0046 0.0439 0.2228
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0278 0.1346
Loa Loa (eye worm) hypothetical protein 0.0136 0.1804 0.5026
Plasmodium falciparum JmjC domain-containing protein, putative 0.0025 0.0123 0.0395
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0224 0.0623
Loa Loa (eye worm) hypothetical protein 0.0022 0.0077 0.0215
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0175 0.0435
Schistosoma mansoni hypothetical protein 0.0528 0.7717 0.7717
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.015 0.0418
Loa Loa (eye worm) hypothetical protein 0.0022 0.0077 0.0215
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0186 0.0186
Brugia malayi MH2 domain containing protein 0.0017 0.0011 0.0031
Trichomonas vaginalis heat shock protein, putative 0.0043 0.0397 0.8962
Loa Loa (eye worm) hypothetical protein 0.0031 0.0224 0.0623
Loa Loa (eye worm) hypothetical protein 0.0031 0.0224 0.0623
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0031 0.0031
Brugia malayi hypothetical protein 0.0149 0.1994 0.5555
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0224 0.0623
Brugia malayi hypothetical protein 0.0148 0.198 0.5516
Loa Loa (eye worm) hypothetical protein 0.0047 0.0457 0.1272
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0366 0.8206
Trypanosoma cruzi Heat shock protein 83, putative 0.0046 0.0439 0.1237
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0224 0.0623
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0224 0.0623
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0077 0.0215
Brugia malayi intermediate filament protein 0.0027 0.015 0.0418
Echinococcus granulosus dna polymerase kappa 0.0041 0.0366 0.0366
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0357 0.0357
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0366 0.8206
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0011 0.0011
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0077 0.0077
Leishmania major hypothetical protein, conserved 0.0025 0.0123 0.0279
Leishmania major heat shock protein 83-1 0.0046 0.0439 0.1237
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0077 0.0077
Trypanosoma brucei heat shock protein 90, putative 0.0046 0.0439 0.1237
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0038 0.0022
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0224 0.0224
Brugia malayi nuclear receptor NHR-88 0.0031 0.0224 0.0623
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0047 0.0457 0.1272
Onchocerca volvulus 0.0031 0.0224 0.0232
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0031 0.0224 0.0623
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0077 0.0077
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0077 0.0077
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0077 0.0077
Schistosoma mansoni heat shock protein 0.0046 0.0439 0.0439
Plasmodium falciparum heat shock protein 90 0.0046 0.0439 0.175
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0466 0.1298
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0366 0.172
Loa Loa (eye worm) hypothetical protein 0.0022 0.0077 0.0215
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0366 0.0366
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.014 0.1865 0.9409
Onchocerca volvulus Huntingtin homolog 0.0121 0.1569 0.4458
Schistosoma mansoni hypothetical protein 0.0034 0.0256 0.0256
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0224 0.0224
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0153 0.2053 0.2053
Leishmania major heat shock protein 83-1 0.0046 0.0439 0.1237
Mycobacterium ulcerans hypothetical protein 0.0047 0.0457 0.2321
Schistosoma mansoni hypothetical protein 0.0029 0.0186 0.0186
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.0208 0.0907
Schistosoma mansoni intermediate filament proteins 0.0027 0.015 0.015
Mycobacterium ulcerans hypothetical protein 0.014 0.1865 1
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.0123 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0224 0.0623
Schistosoma mansoni jumonji domain containing protein 0.0133 0.1759 0.1759
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0011 0.0011
Leishmania major heat shock protein 83-1 0.0046 0.0439 0.1237
Brugia malayi steroid hormone receptor 0.0031 0.0224 0.0623
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0031 0.0224 0.0623
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0153 0.2053 0.2053
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0224 0.0224
Trypanosoma cruzi heat shock protein, putative 0.003 0.0208 0.0535
Onchocerca volvulus 0.0237 0.3333 1
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0208 0.0208
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0249 0.5121
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.034 0.0935
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0457 0.2184
Entamoeba histolytica hypothetical protein 0.0148 0.198 1
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0077 0.0215
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0366 0.1015
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0366 0.0366
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0457 0.2321
Schistosoma mansoni coup transcription factor 0.0031 0.0224 0.0224
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0208 0.0208
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0077 0.0077
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0457 0.1289
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0457 0.2321
Trypanosoma cruzi heat shock protein 85, putative 0.0046 0.0439 0.1237
Loa Loa (eye worm) heat shock protein 90 0.0046 0.0439 0.1224
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0457 0.1272
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0077 0.0077
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0077 0.0077
Trypanosoma cruzi heat shock protein 90, putative 0.0046 0.0439 0.1237
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0224 0.0232
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0123 0.0344
Brugia malayi PXA domain containing protein 0.0022 0.0077 0.0215
Echinococcus multilocularis heat shock protein 90 0.0039 0.034 0.034
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0101 0.1279 0.3778
Brugia malayi hypothetical protein 0.0121 0.1569 0.4372
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0025 0.0123 0.0395
Trypanosoma brucei heat shock protein, putative 0.0046 0.0439 0.1237
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0077 0.0077
Echinococcus multilocularis lamin dm0 0.0027 0.015 0.015
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0366 0.1015
Plasmodium vivax heat shock protein 86, putative 0.0046 0.0439 0.175
Schistosoma mansoni jumonji/arid domain-containing protein 0.0093 0.1151 0.1151
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0237 0.3333 1
Trypanosoma cruzi heat shock protein 85, putative 0.0046 0.0439 0.1237
Schistosoma mansoni lamin 0.0027 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0233 0.3273 0.9118
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0224 0.0623
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0224 0.0224
Leishmania major heat shock protein 83-1 0.0046 0.0439 0.1237
Brugia malayi jmjC domain containing protein 0.0025 0.0123 0.0344
Echinococcus granulosus peregrin 0.0029 0.0186 0.0186
Entamoeba histolytica hypothetical protein 0.0148 0.198 1
Mycobacterium ulcerans heat shock protein 90 0.0043 0.0397 0.1996
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0224 0.0623
Leishmania major heat shock protein 83-1 0.0046 0.0439 0.1237
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0366 0.1015
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0026 0.0143 0.0397
Loa Loa (eye worm) hypothetical protein 0.0041 0.0366 0.102
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0077 0.0077
Plasmodium vivax JmjC domain containing protein 0.0025 0.0123 0.0395
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0077 0.0077
Onchocerca volvulus 0.0047 0.0457 0.0963
Schistosoma mansoni hypothetical protein 0.0148 0.198 0.198
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.0366 0.7875
Loa Loa (eye worm) hypothetical protein 0.0031 0.0224 0.0623
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0249 0.5121
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0224 0.0623
Schistosoma mansoni smad 0.0017 0.0011 0.0011
Leishmania major heat shock protein 83-1 0.0046 0.0439 0.1237
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0077 0.0077
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0366 0.1015
Echinococcus granulosus heat shock protein 0.0046 0.0439 0.0439
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0224 0.0224
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0224 0.0623
Leishmania major heat shock protein 83-1 0.0046 0.0439 0.1237
Brugia malayi jmjC domain containing protein 0.0025 0.0123 0.0344
Leishmania major heat shock protein, putative 0.003 0.0208 0.0535
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0457 1
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0366 0.102
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0123 0.0344
Loa Loa (eye worm) hypothetical protein 0.0022 0.0077 0.0215
Echinococcus granulosus heat shock protein 90 0.0039 0.034 0.034
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0366 0.102

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 7.2 Displacement of [125I]SB207710 from 5-HT4 receptor in guinea pig brain membranes ChEMBL. 24113240
Ki (binding) = 7.2 Displacement of [125I]SB207710 from human recombinant 5-HT4 receptor ChEMBL. 24113240

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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