Detailed information for compound 1792629

Basic information

Technical information
  • TDR Targets ID: 1792629
  • Name: 4-[(4-phenylphenyl)methyl]morpholine
  • MW: 253.339 | Formula: C17H19NO
  • H donors: 0 H acceptors: 0 LogP: 3.01 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O1CCN(CC1)Cc1ccc(cc1)c1ccccc1
  • InChi: 1S/C17H19NO/c1-2-4-16(5-3-1)17-8-6-15(7-9-17)14-18-10-12-19-13-11-18/h1-9H,10-14H2
  • InChiKey: MDGALBAMJOZMMH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(4-phenylbenzyl)morpholine
  • Oprea1_679205

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0045 0 0.5
Mycobacterium leprae Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) 0.0045 0 0.5
Chlamydia trachomatis 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 0.0045 0 0.5
Plasmodium vivax phosphoglucomutase-2, putative 0.0045 0 0.5
Mycobacterium ulcerans hypothetical protein 0.1564 0.5831 1
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.265 1 1
Mycobacterium leprae Possible phosphoglycerate mutase 0.0045 0 0.5
Toxoplasma gondii phosphoglycerate mutase family protein 0.0045 0 0.5
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.2605 0.9828 0.9828
Mycobacterium leprae conserved hypothetical protein 0.0045 0 0.5
Loa Loa (eye worm) hypothetical protein 0.2605 0.9828 0.9828
Mycobacterium tuberculosis Glucosyl-3-phosphoglycerate phosphatase GpgP 0.0045 0 0.5
Plasmodium vivax phosphoglycerate mutase, putative 0.0045 0 0.5
Plasmodium falciparum phosphoglucomutase-2 0.0045 0 0.5
Loa Loa (eye worm) hypothetical protein 0.1519 0.566 0.566
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0045 0 0.5
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.265 1 1
Onchocerca volvulus 0.265 1 1
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1131 0.4169 0.4169
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.265 1 1
Mycobacterium leprae conserved hypothetical protein 0.0045 0 0.5
Toxoplasma gondii phosphoglycerate mutase family protein 0.0045 0 0.5
Mycobacterium tuberculosis Conserved protein 0.0045 0 0.5
Mycobacterium tuberculosis Possible hydrolase MutT1 0.0045 0 0.5
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.2605 0.9828 0.9828
Mycobacterium leprae PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) 0.0045 0 0.5
Brugia malayi GnHR receptor homolog 0.2415 0.9098 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0045 0 0.5
Schistosoma mansoni 6-phosphofructokinase 0.265 1 1
Mycobacterium tuberculosis Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) 0.0045 0 0.5
Mycobacterium tuberculosis Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) 0.0045 0 0.5
Giardia lamblia Hypothetical protein 0.1564 0.5831 0.5
Toxoplasma gondii phosphoglycerate mutase PGMII 0.0045 0 0.5
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0045 0 0.5
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0045 0 0.5
Mycobacterium leprae probable isochorismate synthase EntC 0.0045 0 0.5
Plasmodium falciparum phosphoglycerate mutase, putative 0.0045 0 0.5
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.265 1 1
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1131 0.4169 0.4169
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.1564 0.5831 1
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0045 0 0.5
Mycobacterium leprae conserved hypothetical protein 0.0045 0 0.5
Toxoplasma gondii phosphoglycerate mutase 0.0045 0 0.5
Mycobacterium tuberculosis Probable conserved lipoprotein LpqD 0.0045 0 0.5
Mycobacterium leprae PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) 0.0045 0 0.5
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.2605 0.9828 0.9828
Mycobacterium leprae POSSIBLE HYDROLASE MUTT1 0.0045 0 0.5
Treponema pallidum phosphoglyceromutase 0.0045 0 0.5
Toxoplasma gondii phosphoglycerate mutase family protein 0.0045 0 0.5
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.2605 0.9828 0.9828
Trichomonas vaginalis conserved hypothetical protein 0.0045 0 0.5
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein 0.1131 0.4169 0.4169
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1131 0.4169 0.4169
Mycobacterium tuberculosis Conserved protein 0.0045 0 0.5
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.265 1 1
Mycobacterium tuberculosis PE-PGRS family protein PE_PGRS11 0.0045 0 0.5
Loa Loa (eye worm) hypothetical protein 0.265 1 1
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.1564 0.5831 1
Toxoplasma gondii phosphoglycerate mutase family protein 0.0045 0 0.5
Giardia lamblia Hypothetical protein 0.1564 0.5831 0.5
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0045 0 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 3 Inhibition of Homo sapiens (human) recombinant fatty acid amide hydrolase assessed as inhibition of [3H]-AEA hydrolysis after 10 min by liquid scintillation counting ChEMBL. No reference
IC50 (binding) > 3 Inhibition of Homo sapiens (human) recombinant monoacylglycerol lipase assessed as inhibition of [3H]-2-oleolylglycerol hydrolysis after 10 min by liquid scintillation counting ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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