Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Metabotropic glutamate receptor 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.3187 | 0.4041 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.4163 | 0.4395 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.3818 | 0.4014 |
Schistosoma mansoni | bromodomain containing protein | 0.0072 | 0.7886 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.3187 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0068 | 0.724 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0041 | 0.3003 | 0.4148 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0041 | 0.2951 | 0.4076 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.0535 | 0.0739 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.006 | 0.6072 | 0.8388 |
Loa Loa (eye worm) | glutamate receptor | 0.0049 | 0.427 | 0.4513 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.3187 | 0.4402 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0191 | 0.0242 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.3187 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.3187 | 0.4041 |
Brugia malayi | hypothetical protein | 0.0042 | 0.3187 | 0.2997 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.0535 | 0.0739 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.3187 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.5339 | 0.677 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0041 | 0.3003 | 0.3809 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0068 | 0.724 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.3391 | 0.3541 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.006 | 0.6072 | 0.8388 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.9228 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.3187 | 0.5 |
Brugia malayi | PHD-finger family protein | 0.0028 | 0.0963 | 0.0711 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.3187 | 0.4402 |
Brugia malayi | Bromodomain containing protein | 0.0043 | 0.3378 | 0.3194 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0049 | 0.427 | 0.411 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0535 | 0.0679 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0041 | 0.3003 | 0.4148 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0044 | 0.3536 | 0.3356 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0041 | 0.2951 | 0.4076 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.6072 | 0.6508 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0024 | 0.0271 | 0.0343 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
%max (binding) | = 0.8 % | Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium mobilization at 30 uM preincubated for 140 seconds prior to glutamate-stimulation measured after 60 seconds relative to glutamate | ChEMBL. | 24074843 |
IC50 (binding) | = 7.72 | Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium mobilization preincubated for 140 seconds prior to glutamate-stimulation measured after 60 seconds | ChEMBL. | 24074843 |
IC50 (binding) | = 19 nM | Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium mobilization preincubated for 140 seconds prior to glutamate-stimulation measured after 60 seconds | ChEMBL. | 24074843 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.