Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0049 | 0.027 | 0.1087 | |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0.0138 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.1346 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0227 | 0.1607 | 0.1516 |
Onchocerca volvulus | 0.0227 | 0.1607 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0227 | 0.1607 | 0.1516 |
Echinococcus multilocularis | neuroligin | 0.0227 | 0.1607 | 0.1607 |
Echinococcus multilocularis | musashi | 0.0028 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | hypothetical protein | 0.1346 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0227 | 0.1607 | 0.1598 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0414 | 0.0414 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0227 | 0.1607 | 0.1607 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.0138 | 0.0127 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.027 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.1713 | 0.1713 |
Loa Loa (eye worm) | carboxylesterase | 0.1346 | 1 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0242 | 0.1713 | 0.1713 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.1607 | 0.1607 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0239 | 0.0228 |
Brugia malayi | Carboxylesterase family protein | 0.1346 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0028 | 0.0107 | 0.0107 |
Echinococcus granulosus | acetylcholinesterase | 0.1346 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0227 | 0.1607 | 0.1598 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0138 | 0.0138 |
Brugia malayi | hypothetical protein | 0.0227 | 0.1607 | 0.1598 |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0.0138 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.1607 | 0.1607 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0103 | 0.0103 |
Onchocerca volvulus | 0.0227 | 0.1607 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0651 | 0.0651 |
Loa Loa (eye worm) | carboxylesterase | 0.0227 | 0.1607 | 0.1607 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.01 | 0.0651 | 0.0641 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0227 | 0.1607 | 0.1607 |
Onchocerca volvulus | 0.0227 | 0.1607 | 1 | |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.0138 | 0.0138 |
Schistosoma mansoni | acetylcholinesterase | 0.0227 | 0.1607 | 0.1516 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.01 | 0.0651 | 0.0641 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0239 | 0.0239 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0227 | 0.1607 | 0.1516 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0138 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.1607 | 0.1607 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0239 | 0.0133 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.0107 | 0.0107 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0049 | 0.027 | 0.0259 |
Brugia malayi | hypothetical protein | 0.0242 | 0.1713 | 0.1704 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0138 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.1607 | 0.1607 |
Brugia malayi | Carboxylesterase family protein | 0.0227 | 0.1607 | 0.1598 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.01 | 0.0651 | 0.0651 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0239 | 0.0239 |
Onchocerca volvulus | 0.0227 | 0.1607 | 1 | |
Brugia malayi | intermediate filament protein | 0.0028 | 0.0107 | 0.0096 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0227 | 0.1607 | 0.1516 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0227 | 0.1607 | 0.1607 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.1607 | 0.1607 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0242 | 0.1713 | 0.1713 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0227 | 0.1607 | 0.1607 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0227 | 0.1607 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0107 | 0.0107 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0239 | 0.0239 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0227 | 0.1607 | 0.1516 |
Echinococcus granulosus | neuroligin | 0.0227 | 0.1607 | 0.1607 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1346 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1346 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1346 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.1346 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1346 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.0227 | 0.1607 | 0.1516 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.1607 | 0.1607 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.0107 | 0.0096 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0138 | 0.0138 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0138 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0107 | 0.0107 |
Echinococcus multilocularis | lamin | 0.0028 | 0.0107 | 0.0107 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0138 | 0.0138 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0138 | 0.0031 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0239 | 0.0133 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0227 | 0.1607 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1346 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0414 | 0.031 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0227 | 0.1607 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0049 | 0.027 | 0.0165 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0227 | 0.1607 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0227 | 0.1607 | 0.1607 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0239 | 0.0239 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.0414 | 0.0403 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.1607 | 0.1607 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.0138 | 0.0127 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0239 | 0.0133 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1346 | 1 | 1 |
Onchocerca volvulus | 0.0227 | 0.1607 | 1 | |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0227 | 0.1607 | 0.1607 |
Brugia malayi | Carboxylesterase family protein | 0.0227 | 0.1607 | 0.1598 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0227 | 0.1607 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0239 | 0.0239 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0227 | 0.1607 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0227 | 0.1607 | 0.1607 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0011 | 0.0011 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0138 | 0.0031 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.0107 | 0.0107 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.0107 | 0.0107 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0138 | 0.0138 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 1.5 mAU ml-1 | Amount of proteinase K required to release folin positive amino acids at a substrate concentration of 304 microM | ChEMBL. | 12951094 |
Activity (functional) | = 1.5 mAU ml-1 | Amount of proteinase K required to release folin positive amino acids at a substrate concentration of 304 microM | ChEMBL. | 12951094 |
K obs (ADMET) | = 1.11 hr-1 | Rate constant for the compound at a substrate concentration of 218 microM was determined | ChEMBL. | 12951094 |
Krel (ADMET) | = 0.59 | Relativity constant of the compound was determined at a substrate concentration of 218 microM | ChEMBL. | 12951094 |
T1/2 (ADMET) | = 37.5 min | Half-life period of the compound at a substrate concentration of 218 microM was determined | ChEMBL. | 12951094 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.