Detailed information for compound 1794000

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 584.75 | Formula: C29H36N4O5S2
  • H donors: 4 H acceptors: 4 LogP: 3.93 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCN(C(=O)COc1cccc2c1[nH]cc2C[C@H](NC[C@@H](c1cccc(c1)NS(=O)(=O)c1cccs1)O)C)CC
  • InChi: 1S/C29H36N4O5S2/c1-4-33(5-2)27(35)19-38-26-12-7-11-24-22(17-31-29(24)26)15-20(3)30-18-25(34)21-9-6-10-23(16-21)32-40(36,37)28-13-8-14-39-28/h6-14,16-17,20,25,30-32,34H,4-5,15,18-19H2,1-3H3/t20-,25+/m1/s1
  • InChiKey: ABZONQSYSVGCDW-NLFFAJNJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adrenoceptor beta 1 Starlite/ChEMBL References
Homo sapiens adrenoceptor beta 3 Starlite/ChEMBL References
Homo sapiens adrenoceptor beta 2, surface Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0022 0.0018 0.0022
Plasmodium vivax proteasome subunit beta type-7, putative 0.0264 0.2574 0.302
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0243 0.2358 0.2358
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0174 0.1625 0.1907
Schistosoma mansoni hypothetical protein 0.0039 0.0196 0.0196
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0039 0.0196 0.0196
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0204 0.1949 0.2287
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.013 0.013
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.013 0.013
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.013 0.013
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.0021 0.0006 0.0006
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0196 0.0196
Brugia malayi proteasome subunit beta type 2 0.0187 0.1763 0.1763
Loa Loa (eye worm) PCI domain-containing protein 0.0031 0.0114 0.0134
Echinococcus granulosus geminin 0.0197 0.1868 0.1868
Toxoplasma gondii proteasome subunit alpha type, putative 0.0193 0.1826 0.2142
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0187 0.1763 0.1763
Brugia malayi PCI domain containing protein 0.0034 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0029 0.01 0.0117
Mycobacterium ulcerans proteasome PrcB 0.0827 0.8523 1
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.0021 0.0006 0.0006
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0022 0.0019 0.0019
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0187 0.1763 0.1763
Loa Loa (eye worm) proteasome subunit beta type 3 0.0187 0.1763 0.2069
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.016 0.1477 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.013 0.013
Toxoplasma gondii proteasome subunit beta type, putative 0.0827 0.8523 1
Brugia malayi Probable 26S protease regulatory subunit 4 0.0021 0.0006 0.0006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.013 0.013
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0031 0.0116 0.0116
Loa Loa (eye worm) proteasome 26S subunit 0.002 0.0000017055 0.0000020011
Toxoplasma gondii SAC3/GANP family protein 0.0029 0.01 0.0117
Leishmania major proteasome beta 5 subunit, putative 0.0827 0.8523 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0196 0.0196
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0029 0.01 0.0117
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0192 0.1821 0.2136
Echinococcus granulosus proteasome subunit alpha type 2 0.0198 0.188 0.188
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.0152
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0243 0.2358 0.2358
Brugia malayi ecdysteroid receptor 0.0032 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0039 0.0196 0.023
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0215 0.2061 0.2418
Brugia malayi hypothetical protein 0.0039 0.0196 0.0196
Onchocerca volvulus 0.0039 0.0196 0.1062
Onchocerca volvulus 0.0021 0.0006 0.0033
Leishmania major proteasome alpha 1 subunit, putative 0.0205 0.1959 0.2299
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0193 0.1826 0.2142
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0089 0.0734 0.0733
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.013 0.013
Echinococcus granulosus nuclear factor of activated T cells 5 0.0359 0.3584 0.3584
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0022 0.0019 0.0023
Echinococcus multilocularis carbonic anhydrase 0.0065 0.0471 0.0471
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0031 0.0116 0.0136
Toxoplasma gondii proteasome subunit 0.0193 0.1831 0.2148
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0039 0.0196 0.0196
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0264 0.2574 0.302
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0827 0.8523 1
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0033 0.0135 0.0158
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0205 0.1959 0.2299
Brugia malayi small heat shock protein 0.0671 0.6876 0.6876
Toxoplasma gondii proteasome regulatory subunit 0.0031 0.0116 0.0136
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0827 0.8523 1
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0034 0.0145 0.017
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.004 0.0211 0.0211
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.013 0.013
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0039 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0006
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.004 0.0211 0.0248
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.013 0.013
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.013 0.013
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0033 0.0135 0.0158
Loa Loa (eye worm) proteasome Regulatory Particle 0.0034 0.0144 0.0169
Leishmania major proteasome alpha 7 subunit, putative 0.0243 0.2358 0.2767
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0029 0.01 0.0117
Giardia lamblia Proteasome subunit beta type 3 0.0187 0.1763 0.2069
Brugia malayi Protein kinase domain containing protein 0.0037 0.0177 0.0177
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0827 0.8523 1
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0194 0.1844 0.2163
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.013 0.0152
Echinococcus multilocularis proteasome subunit beta type 6 0.0193 0.1831 0.1831
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0198 0.188 0.2206
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.0152
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0034 0.0144 0.0169
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0007
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.016 0.1477 0.1477
Echinococcus multilocularis proteasome (prosome, macropain) 0.0827 0.8523 0.8523
Brugia malayi hypothetical protein 0.0042 0.023 0.023
Echinococcus multilocularis netrin receptor unc 5 0.0037 0.0177 0.0177
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0193 0.1831 0.2148
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0196 0.0196
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0031 0.0116 0.0116
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.013 0.013
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0039 0.0196 0.0196
Onchocerca volvulus 0.0039 0.0196 0.1062
Echinococcus granulosus transmembrane protease serine 3 0.0039 0.0196 0.0196
Plasmodium vivax cysteine repeat modular protein 1, putative 0.002 0.0005 0.0006
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0031 0.0116 0.0136
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.013 0.013
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0205 0.1959 0.2299
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0029 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.0152
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0044 0.0256 0.03
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0192 0.1821 0.2136
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0022 0.0019 0.0023
Toxoplasma gondii hypothetical protein 0.0065 0.0471 0.0552
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0031 0.0114 0.0114
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0029 0.01 0.0117
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.013 0.013
Entamoeba histolytica proteasome regulatory subunit, putative 0.0034 0.0144 0.0169
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.013 0.0152
Leishmania major hypothetical protein, conserved 0.002 0.0005 0.0006
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0187 0.1763 0.2069
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0827 0.8523 1
Echinococcus granulosus netrin receptor unc 5 0.0037 0.0177 0.0177
Leishmania major proteasome beta 3 subunit, putative 0.0187 0.1763 0.2069
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0097 0.0809 0.0809
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0264 0.2574 0.302
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.004 0.0211 0.0211
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.0021 0.0006 0.0007
Giardia lamblia 20S proteasome alpha subunit 1 0.0205 0.1959 0.2299
Loa Loa (eye worm) hypothetical protein 0.0671 0.6876 0.8067
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0021 0.0006 0.0007
Loa Loa (eye worm) RPN-3 protein 0.004 0.0211 0.0248
Giardia lamblia 20S proteasome alpha subunit 3 0.0193 0.1826 0.2142
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0176 0.1652 0.1939
Trypanosoma brucei ATP-dependent protease subunit HslV 0.016 0.1477 0.1733
Loa Loa (eye worm) proteasome subunit beta type 2 0.0187 0.1763 0.2069
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.0152
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0215 0.2061 0.2418
Brugia malayi 26S proteasome subunit P45 family protein 0.0021 0.0006 0.0006
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0198 0.188 0.2206
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.013 0.013
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.013 0.013
Toxoplasma gondii hypothetical protein 0.0027 0.0076 0.0089
Schistosoma mansoni netrin receptor unc5 0.0037 0.0177 0.0177
Echinococcus multilocularis tissue type plasminogen activator 0.002 0.0005 0.0005
Entamoeba histolytica hypothetical protein 0.0039 0.0205 0.024
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.004 0.0211 0.0211
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.013 0.0152
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0044 0.0256 0.0256
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0204 0.1949 0.1949
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0031 0.0116 0.0116
Plasmodium vivax proteasome subunit beta type-5, putative 0.0827 0.8523 1
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0031 0.0116 0.0136
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0187 0.1763 0.1763
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0187 0.1763 0.2069
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0022 0.0019 0.0023
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0039 0.0205 0.024
Loa Loa (eye worm) hypothetical protein 0.0039 0.0196 0.023
Echinococcus granulosus carbonic anhydrase 0.0065 0.0471 0.0471
Schistosoma mansoni proteasome regulatory subunit-related 0.0034 0.0145 0.0145
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0029 0.01 0.01
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0204 0.1949 0.2287
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0029 0.01 0.0117
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0219 0.2108 0.2108
Brugia malayi proteasome subunit alpha type 6 0.0205 0.1959 0.1959
Plasmodium falciparum cysteine repeat modular protein 1 0.002 0.0005 0.0006
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0827 0.8523 1
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0827 0.8523 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0065 0.0471 0.0471
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0021 0.0013 0.0015
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0022 0.0018 0.0022
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0192 0.1821 0.1821
Giardia lamblia 26S protease regulatory subunit 6A 0.0022 0.0019 0.0023
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0196 0.0196
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0243 0.2358 0.2767
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0215 0.2061 0.2061
Loa Loa (eye worm) hypothetical protein 0.0027 0.0076 0.0089
Schistosoma mansoni hypothetical protein 0.0197 0.1868 0.1868
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0031 0.0114 0.0134
Trichomonas vaginalis 26S proteasome subunit, putative 0.0031 0.0114 0.0134
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0031 0.0116 0.0116
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0022 0.0019 0.0023
Leishmania major proteasome beta 7 subunit, putative 0.0185 0.1745 0.2048
Giardia lamblia 26S protease regulatory subunit 6B 0.0021 0.0006 0.0007
Onchocerca volvulus 0.0039 0.0196 0.1062
Brugia malayi proteasome subunit alpha type 4 0.0176 0.165 0.165
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.023 0.023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.013 0.0152
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0187 0.1763 0.2069
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.013 0.013
Echinococcus granulosus carbonic anhydrase 0.0065 0.0471 0.0471
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0205 0.1959 0.2299
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.0021 0.0006 0.0007
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.0021 0.0006 0.0007
Schistosoma mansoni thyroid hormone receptor 0.0032 0.013 0.013
Schistosoma mansoni hypothetical protein 0.0042 0.023 0.023
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0022 0.0019 0.0023
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0192 0.1821 0.2136
Loa Loa (eye worm) proteasome subunit beta type 1 0.0215 0.2061 0.2418
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0185 0.1745 0.1745
Brugia malayi Proteasome/cyclosome repeat family protein 0.0033 0.0135 0.0135
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.004 0.0211 0.0248
Brugia malayi nuclear hormone receptor 0.0032 0.013 0.013
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0034 0.0145 0.017
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0177 0.0177
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0097 0.0809 0.0949
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0031 0.0114 0.0134
Echinococcus granulosus proteasome subunit beta type 7 0.0966 1 1
Entamoeba histolytica proteasome regulatory subunit, putative 0.0029 0.01 0.0117
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0089 0.0734 0.0733
Brugia malayi Proteasome/cyclosome repeat family protein 0.0033 0.0135 0.0135
Brugia malayi Death domain containing protein 0.0037 0.0177 0.0177
Entamoeba histolytica proteasome regulatory subunit, putative 0.0034 0.0145 0.017
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0187 0.1763 0.1763
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0037 0.0182 0.0213
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0185 0.1745 0.2048
Brugia malayi Proteasome subunit alpha type 7-1 0.0243 0.2358 0.2358
Echinococcus granulosus Ankyrin 0.0037 0.0178 0.0178
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0065 0.0471 0.0471
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.004 0.0211 0.0248
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0193 0.1831 0.1831
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0022 0.0019 0.0022
Leishmania major carbonic anhydrase-like protein 0.0174 0.1625 0.1907
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0031 0.0116 0.0136
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0185 0.1745 0.2048
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.0152
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0174 0.1625 0.1907
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0065 0.0471 0.0471
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0029 0.01 0.01
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0022 0.0019 0.0019
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0022 0.0018 0.0018
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0031 0.0114 0.0134
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0029 0.01 0.01
Echinococcus multilocularis proteasome subunit alpha type 2 0.0198 0.188 0.188
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0065 0.0471 0.0552
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0196 0.0196
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0044 0.0256 0.03
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0194 0.1844 0.1844
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.013 0.013
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0022 0.0019 0.0019
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0034 0.0145 0.017
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0065 0.0471 0.0471
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0031 0.0116 0.0116
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.013 0.013
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0192 0.1821 0.2136
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0187 0.1763 0.2069
Loa Loa (eye worm) PCI domain-containing protein 0.0034 0.0145 0.017
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0021 0.0006 0.0007
Echinococcus multilocularis Mastin 0.0039 0.0196 0.0196
Loa Loa (eye worm) trypsin family protein 0.0039 0.0196 0.023
Toxoplasma gondii proteasome 26S regulatory subunit 0.0021 0.0013 0.0015
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.013 0.0152
Echinococcus granulosus Proteasome subunit alpha type 7 0.0243 0.2358 0.2358
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.013 0.013
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0034 0.0144 0.0169
Loa Loa (eye worm) hypothetical protein 0.0037 0.0177 0.0207
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0031 0.0114 0.0134
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0215 0.2061 0.2418
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.003 0.0105 0.0123
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0022 0.0019 0.0023
Echinococcus multilocularis enteropeptidase 0.0039 0.0196 0.0196
Mycobacterium ulcerans proteasome PrcA 0.016 0.1477 0.1538
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0034 0.0145 0.017
Echinococcus granulosus Mastin 0.0039 0.0196 0.0196
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.013 0.013
Brugia malayi Ubiquitin interaction motif family protein 0.0022 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0039 0.0196 0.023
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0185 0.1745 0.2048
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0037 0.0182 0.0213
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0243 0.2358 0.2358
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0188 0.1773 0.1773
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0187 0.1763 0.2069
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0044 0.0256 0.0256
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0192 0.1821 0.1821
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0204 0.1949 0.1949
Schistosoma mansoni 26S protease regulatory subunit 6b 0.0021 0.0006 0.0006
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0192 0.1821 0.2136
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.0021 0.0006 0.0007
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.013 0.0704
Schistosoma mansoni hypothetical protein 0.006 0.0423 0.0423
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0022 0.0019 0.0019
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.0021 0.0006 0.0007
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0021 0.0006 0.0007
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0193 0.1826 0.1826
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0037 0.0177 0.0207
Entamoeba histolytica hypothetical protein 0.0042 0.023 0.027
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.013 0.013
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0097 0.0809 0.0809
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.013 0.013
Giardia lamblia 20S proteasome alpha subunit 7 0.0194 0.1844 0.2163
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0243 0.2358 0.2767
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0219 0.2108 0.2473
Leishmania major hypothetical protein, conserved 0.005 0.032 0.0376
Loa Loa (eye worm) hypothetical protein 0.0039 0.0196 0.023
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0205 0.1959 0.1959
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0243 0.2358 0.2767
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0181 0.1704 0.1999
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.004 0.0211 0.0211
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0264 0.2574 0.302
Trypanosoma brucei carbonic anhydrase-like protein 0.0174 0.1625 0.1907
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0827 0.8523 0.8523
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.023 0.023
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0243 0.2358 0.2767
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0031 0.0116 0.0136
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0187 0.1763 0.2069
Echinococcus granulosus subfamily T1A non peptidase ue 0.0204 0.1949 0.1949
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0187 0.1763 0.2069
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0034 0.0145 0.017
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0193 0.1826 0.2142
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0205 0.1959 0.2299
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.013 0.013
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0264 0.2574 0.302
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0215 0.2061 0.2418
Trypanosoma brucei proteasome beta 7 subunit 0.0185 0.1745 0.2048
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0022 0.0018 0.0018
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0034 0.0144 0.0144
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0031 0.0114 0.0134
Schistosoma mansoni 26S proteasome subunit S9 0.0037 0.0182 0.0182
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0174 0.1625 0.1625
Entamoeba histolytica hypothetical protein 0.0042 0.023 0.027
Loa Loa (eye worm) hypothetical protein 0.0039 0.0196 0.023
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0193 0.1826 0.1826
Brugia malayi Proteasome A-type and B-type family protein 0.0185 0.1745 0.1745
Plasmodium vivax proteasome subunit beta type-2, putative 0.0187 0.1763 0.2069
Entamoeba histolytica proteasome regulatory subunit, putative 0.0022 0.0018 0.0022
Brugia malayi Trypsin family protein 0.0039 0.0196 0.0196
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0187 0.1763 0.1763
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.013 0.013
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0022 0.0019 0.0023
Echinococcus granulosus proteasome subunit beta t family 0.0187 0.1763 0.1763
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0031 0.0116 0.0116
Brugia malayi Proteasome subunit alpha type 1 0.0176 0.1645 0.1645
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.0021 0.0006 0.0007
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0205 0.1959 0.2299
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0192 0.1821 0.2136
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0037 0.0182 0.0213
Leishmania major proteasome alpha 1 subunit, putative 0.0192 0.1821 0.2136
Plasmodium vivax proteasome subunit beta type-6, putative 0.0193 0.1831 0.2148
Giardia lamblia 26S proteasome regulatory subunit, putative 0.0023 0.0032 0.0038
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0194 0.1844 0.2163
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0044 0.0256 0.03
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0196 0.0196
Brugia malayi Trypsin family protein 0.0039 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.0152
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0187 0.1763 0.2069
Onchocerca volvulus 0.002 0.0005 0.0027
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0039 0.0205 0.0205
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0031 0.0116 0.0136
Brugia malayi proteasome subunit beta type 1 0.0215 0.2061 0.2061
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0196 0.0196
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0198 0.188 0.2206
Toxoplasma gondii PCI domain-containing protein 0.0037 0.0182 0.0213
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0174 0.1625 0.1625
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0193 0.1831 0.2148
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0196 0.0196
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.0021 0.0006 0.0007
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0264 0.2574 0.302
Loa Loa (eye worm) hypothetical protein 0.0029 0.01 0.0117
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0065 0.0471 0.0471
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0194 0.1844 0.2163
Onchocerca volvulus Notchless protein homolog 0.0194 0.1844 1
Echinococcus multilocularis transmembrane protease serine 3 0.0039 0.0196 0.0196
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0029 0.01 0.0117
Schistosoma mansoni hypothetical protein 0.0039 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0065 0.0471 0.0552
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.013 0.013
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0187 0.1763 0.2069
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0021 0.0013 0.0015
Schistosoma mansoni thyroid hormone receptor 0.0032 0.013 0.013
Leishmania major proteasome beta 2 subunit, putative 0.0264 0.2574 0.302
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0034 0.0145 0.017
Loa Loa (eye worm) hypothetical protein 0.0097 0.0809 0.0949
Brugia malayi Protein kinase domain containing protein 0.002 0.0005 0.0005
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.016 0.1477 0.1733
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.004 0.0211 0.0248
Loa Loa (eye worm) TK/ROR protein kinase 0.002 0.0005 0.0006
Schistosoma mansoni hypothetical protein 0.0197 0.1868 0.1868
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.013 0.013
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0037 0.0182 0.0213
Echinococcus multilocularis proteasome subunit alpha type 6 0.0205 0.1959 0.1959
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0039 0.0205 0.024
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0243 0.2358 0.2767
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.004 0.0211 0.0211
Giardia lamblia 20S proteasome alpha subunit 4 0.0243 0.2358 0.2767
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0215 0.2061 0.2418
Echinococcus granulosus Proteasome subunit alpha beta 0.0194 0.1844 0.1844
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.0152
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0185 0.1745 0.2048
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0264 0.2574 0.302
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0034 0.0144 0.0169
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0044 0.0256 0.03
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0185 0.1745 0.2048
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0034 0.0144 0.0169
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0187 0.1763 0.2069
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.013 0.013
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0031 0.0116 0.0136
Toxoplasma gondii PCI domain-containing protein 0.0031 0.0114 0.0134
Onchocerca volvulus 0.0039 0.0196 0.1062
Echinococcus granulosus carbonic anhydrase 0.0065 0.0471 0.0471
Plasmodium vivax proteasome subunit beta type-3, putative 0.0187 0.1763 0.2069
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0185 0.1745 0.2048
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0204 0.1949 0.2287
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.013 0.013
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.0021 0.0006 0.0007
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0039 0.0205 0.0205
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0185 0.1745 0.2048
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0174 0.1625 0.1625
Leishmania major proteasome beta 2 subunit, putative 0.0187 0.1763 0.2069
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.013 0.013
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0193 0.1831 0.2148
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0037 0.0178 0.0178
Echinococcus granulosus FTZ F1 alpha 0.0032 0.013 0.013
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0181 0.1704 0.1999
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0215 0.2061 0.2418
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0264 0.2574 0.302
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0205 0.1959 0.2299
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.023 0.023
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0044 0.0256 0.0256
Echinococcus granulosus carbonic anhydrase II 0.0174 0.1625 0.1625
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.013 0.0704
Echinococcus granulosus death domain containing protein 0.0037 0.0177 0.0177
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0196 0.0196
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.013 0.0152
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0021 0.0006 0.0007
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0034 0.0145 0.0145
Schistosoma mansoni carbonic anhydrase-related 0.0065 0.0471 0.0471
Toxoplasma gondii PCI domain-containing protein 0.004 0.0211 0.0248
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0031 0.0114 0.0134
Entamoeba histolytica hypothetical protein 0.0042 0.023 0.027
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0198 0.188 0.2206
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0204 0.1949 0.1949
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.016 0.1477 0.1733
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0031 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0037 0.0178 0.0209
Plasmodium vivax proteasome subunit beta type-1, putative 0.0215 0.2061 0.2418
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0031 0.0116 0.0136
Loa Loa (eye worm) 26S protease regulatory subunit 8 0.002 0.0000017055 0.0000020011
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0204 0.1949 0.2287
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0029 0.01 0.01
Brugia malayi 20S proteasome alpha5 subunit 0.0204 0.1949 0.1949
Brugia malayi Uncoordinated protein 44 0.0037 0.0177 0.0177
Echinococcus multilocularis proteasome subunit beta type 7 0.0966 1 1
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0205 0.1959 0.2299
Echinococcus multilocularis adhesion regulating molecule 1 0.0097 0.0809 0.0809
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0196 0.0196
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0193 0.1826 0.2142
Brugia malayi proteasome subunit alpha type 2 0.0198 0.188 0.188
Giardia lamblia 20S proteasome alpha subunit 2 0.0198 0.188 0.2206
Echinococcus granulosus tissue type plasminogen activator 0.002 0.0005 0.0005
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0044 0.0256 0.0256
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.005 0.032 0.0376
Echinococcus multilocularis Ankyrin 0.0037 0.0178 0.0178
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0196 0.0196
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0204 0.1949 0.2287
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0187 0.1763 0.2069
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0022 0.0019 0.0023
Onchocerca volvulus 0.0032 0.013 0.0704
Entamoeba histolytica proteasome regulatory subunit, putative 0.0031 0.0114 0.0134
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0194 0.1844 0.1844
Plasmodium falciparum proteasome subunit beta type-5 0.0827 0.8523 1
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0044 0.0256 0.0256
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0196 0.0196
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0022 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0039 0.0196 0.023
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0037 0.0182 0.0182
Giardia lamblia Hypothetical protein 0.0037 0.0182 0.0213
Echinococcus granulosus enteropeptidase 0.0039 0.0196 0.0196
Loa Loa (eye worm) RPT-2 protein 0.0021 0.0006 0.0007
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0029 0.01 0.0117
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0185 0.1745 0.1745
Plasmodium falciparum carbonic anhydrase 0.0065 0.0471 0.0552
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0187 0.1763 0.1763
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0196 0.0196
Brugia malayi proteasome subunit beta type 3 0.0187 0.1763 0.1763
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0196 0.0196
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0022 0.0019 0.0023
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0198 0.188 0.2206
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.013 0.013
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0192 0.1821 0.2136
Schistosoma mansoni multiubiquitin binding protein S5a 0.0022 0.0018 0.0018
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0187 0.1763 0.2069
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0034 0.0145 0.0145
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0198 0.188 0.188
Leishmania major proteasome beta-1 subunit, putative 0.0193 0.1831 0.2148
Entamoeba histolytica proteasome regulatory subunit, putative 0.0037 0.0182 0.0213
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0198 0.188 0.2206
Echinococcus multilocularis geminin 0.0197 0.1868 0.1868
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0196 0.0196
Schistosoma mansoni carbonic anhydrase 0.0065 0.0471 0.0471
Brugia malayi Proteasome A-type and B-type family protein 0.0827 0.8523 0.8523
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0185 0.1745 0.2048
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.0152
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0827 0.8523 1
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0204 0.1949 0.2287
Echinococcus granulosus proteasome subunit beta type 6 0.0193 0.1831 0.1831
Loa Loa (eye worm) hypothetical protein 0.0065 0.0471 0.0552
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.0021 0.0006 0.0006
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0031 0.0116 0.0136
Loa Loa (eye worm) PAS-3 protein 0.0176 0.165 0.1936
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0031 0.0116 0.0136
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0194 0.1844 0.2163
Onchocerca volvulus 0.0039 0.0196 0.1062
Brugia malayi proteasome subunit alpha type 3 0.0194 0.1844 0.1844
Brugia malayi Trypsin family protein 0.0039 0.0196 0.0196
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0185 0.1745 0.2048
Echinococcus granulosus glycoprotein Antigen 5 0.0039 0.0196 0.0196
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0037 0.0182 0.0213
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.013 0.013
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0039 0.0196 0.0196
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0021 0.0006 0.0007
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0359 0.3584 0.3584
Brugia malayi Trypsin-like protease protein 5 0.0039 0.0196 0.0196
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0192 0.1821 0.1821
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0185 0.1745 0.2048
Trypanosoma brucei proteasome beta 6 subunit 0.0215 0.2061 0.2418
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0039 0.0205 0.024
Plasmodium vivax proteasome subunit beta type-4, putative 0.0185 0.1745 0.2048
Giardia lamblia 20S proteasome alpha subunit 6 0.0192 0.1821 0.2136
Toxoplasma gondii proteasome beta subunit 0.0187 0.1763 0.2069
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0029 0.01 0.0117
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0193 0.1831 0.2148
Brugia malayi 26S protease regulatory subunit 6A 0.0022 0.0019 0.0019
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0243 0.2358 0.2767
Echinococcus granulosus proteasome subunit alpha type 6 0.0205 0.1959 0.1959
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0034 0.0144 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.013 0.013
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0196 0.0196
Schistosoma mansoni nuclear hormone receptor 0.0032 0.013 0.013
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0044 0.0256 0.03
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0034 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0039 0.0196 0.023
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0215 0.2061 0.2061
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0044 0.0256 0.03
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0205 0.1959 0.2299
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0034 0.0144 0.0144
Echinococcus multilocularis carbonic anhydrase 0.0065 0.0471 0.0471
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0264 0.2574 0.302
Schistosoma mansoni 26S protease regulatory subunit 0.0021 0.0006 0.0006
Echinococcus multilocularis carbonic anhydrase II 0.0174 0.1625 0.1625
Brugia malayi Kringle domain containing protein 0.002 0.0005 0.0005
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0204 0.1949 0.2287
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0193 0.1826 0.2142
Loa Loa (eye worm) carbonic anhydrase 3 0.0174 0.1625 0.1907
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0044 0.0256 0.03
Brugia malayi Trypsin family protein 0.0039 0.0196 0.0196
Onchocerca volvulus Netrin receptor homolog 0.0037 0.0177 0.0959
Giardia lamblia Proteasome subunit beta type 2 0.0187 0.1763 0.2069
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0065 0.0471 0.0552
Echinococcus granulosus proteasome prosome macropain 0.0827 0.8523 0.8523
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0194 0.1844 0.2163
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0193 0.1826 0.2142
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0194 0.1844 0.2163
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0193 0.1831 0.2148
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0044 0.0256 0.0256
Schistosoma mansoni hypothetical protein 0.0031 0.0114 0.0114
Brugia malayi proteasome subunit alpha type 1 0.0192 0.1821 0.1821
Leishmania major proteasome alpha 3 subunit, putative 0.0193 0.1826 0.2142
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.0021 0.0006 0.0007
Trypanosoma cruzi 20S proteasome subunit 0.0187 0.1763 0.2069
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0193 0.1826 0.2142
Toxoplasma gondii kringle domain-containing protein 0.002 0.0005 0.0006
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.013 0.013
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0031 0.0116 0.0136
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0034 0.0144 0.0169
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0204 0.1949 0.2287
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0243 0.2358 0.2767
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.016 0.1477 0.1733
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.016 0.1477 0.1733
Schistosoma mansoni coup transcription factor 0.0032 0.013 0.013
Toxoplasma gondii heat shock protein hslv, putative 0.016 0.1477 0.1733
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0193 0.1826 0.2142
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0185 0.1745 0.2048
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0034 0.0144 0.0144
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0827 0.8523 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0196 0.0196
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0005 0.0006
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0198 0.188 0.2206
Schistosoma mansoni hypothetical protein 0.0219 0.2108 0.2108
Plasmodium falciparum proteasome subunit beta type-4 0.0185 0.1745 0.2048
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0193 0.1831 0.2148
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0966 1 1
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.0021 0.0006 0.0007
Trichomonas vaginalis 26S proteasome regulatory subunit rpn1, putative 0.0023 0.0032 0.0038
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0022 0.0019 0.0019
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0215 0.2061 0.2061
Brugia malayi PCI domain containing protein 0.0031 0.0114 0.0114
Onchocerca volvulus 0.0039 0.0196 0.1062
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0031 0.0114 0.0114
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0243 0.2358 0.2358
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.013 0.0152
Leishmania major proteasome alpha 7 subunit, putative 0.0194 0.1844 0.2163
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0037 0.0182 0.0182
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0193 0.1831 0.2148
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0039 0.0205 0.0205
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0031 0.0116 0.0136
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0039 0.0205 0.024
Toxoplasma gondii proteasome subunit alpha1, putative 0.0205 0.1959 0.2299
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0031 0.0116 0.0136
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0187 0.1763 0.2069
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0192 0.1821 0.2136
Trypanosoma brucei proteasome alpha 7 subunit 0.0194 0.1844 0.2163
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0204 0.1949 0.2287
Schistosoma mansoni hypothetical protein 0.0037 0.0177 0.0177
Giardia lamblia 20S proteasome alpha subunit 5 0.0204 0.1949 0.2287
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0204 0.1949 0.2287
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.013 0.0704
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.013 0.0152
Schistosoma mansoni hypothetical protein 0.0065 0.0471 0.0471
Entamoeba histolytica hypothetical protein 0.0042 0.023 0.027
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0029 0.01 0.0117
Schistosoma mansoni ankyrin 23/unc44 0.0037 0.0177 0.0177
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.013 0.013
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0185 0.1745 0.2048
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.016 0.1477 0.1733
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0193 0.1831 0.2148
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0037 0.0182 0.0213
Toxoplasma gondii peptidase, T1 family protein 0.0194 0.1844 0.2163
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0022 0.0019 0.0023
Entamoeba histolytica proteasome regulatory subunit, putative 0.004 0.0211 0.0248
Schistosoma mansoni carbonic anhydrase-related 0.0065 0.0471 0.0471
Onchocerca volvulus 0.0021 0.0006 0.0033
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0204 0.1949 0.2287
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0174 0.1625 0.1625
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0174 0.1625 0.1907
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0044 0.0256 0.03
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0034 0.0145 0.017
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.013 0.013
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0193 0.1826 0.2142
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0196 0.0196
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0193 0.1826 0.1826
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.0021 0.0006 0.0006
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.013 0.013
Schistosoma mansoni hypothetical protein 0.0089 0.0734 0.0733
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0022 0.0018 0.0022
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0061 0.0436 0.2367
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0194 0.1844 0.2163
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.0021 0.0006 0.0007
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0021 0.0006 0.0007
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.016 0.1477 0.1733
Toxoplasma gondii proteasome subunit alpha type, putative 0.0083 0.067 0.0787
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0034 0.0144 0.0169
Leishmania major proteasome alpha 2 subunit, putative 0.0198 0.188 0.2206
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0021 0.0006 0.0007
Schistosoma mansoni hypothetical protein 0.002 0.0005 0.0005
Echinococcus granulosus adhesion regulating molecule 1 0.0097 0.0809 0.0809
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0243 0.2358 0.2767
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0034 0.0144 0.0169
Brugia malayi Proteasome A-type and B-type family protein 0.0193 0.1831 0.1831
Echinococcus multilocularis carbonic anhydrase 0.0065 0.0471 0.0471
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.013 0.013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.013 0.013
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0037 0.0177 0.0177
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0243 0.2358 0.2767
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0194 0.1844 0.2163
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0031 0.0116 0.0116
Schistosoma mansoni carbonic anhydrase-related 0.0065 0.0471 0.0471
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.013 0.013
Echinococcus multilocularis glycoprotein Antigen 5 0.0039 0.0196 0.0196
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0037 0.0177 0.0177
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.013 0.013
Brugia malayi steroid hormone receptor 0.0032 0.013 0.013
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0031 0.0116 0.0136
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0031 0.0116 0.0136
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.0021 0.0006 0.0007
Brugia malayi nuclear receptor NHR-88 0.0032 0.013 0.013
Giardia lamblia Proteasome subunit beta type 1 0.0215 0.2061 0.2418
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0185 0.1745 0.1745
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0037 0.0182 0.0182
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0021 0.0006 0.0007
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0827 0.8523 1
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0215 0.2061 0.2418
Loa Loa (eye worm) proteasome regulatory particle 0.0037 0.0182 0.0213
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0187 0.1763 0.1763

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 1.3 nM Agonist activity at Homo sapiens (human) beta3 adrenoreceptor ChEMBL. 21170122
EC50 (binding) = 6.8 nM Agonist activity at Homo sapiens (human) beta1 adrenoreceptor ChEMBL. 21170122
EC50 (functional) = 19 nM Agonist activity at Homo sapiens (human) beta2 adrenoreceptor ChEMBL. 21170122

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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