Detailed information for compound 1794126

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 432.945 | Formula: C25H25ClN4O
  • H donors: 2 H acceptors: 1 LogP: 4.52 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C1C2=C(CCCC2)Nc2c1c(=O)[nH]c(n2)c1ccc(cc1)N(C)C
  • InChi: 1S/C25H25ClN4O/c1-30(2)18-13-9-16(10-14-18)23-28-24-22(25(31)29-23)21(15-7-11-17(26)12-8-15)19-5-3-4-6-20(19)27-24/h7-14,21H,3-6H2,1-2H3,(H2,27,28,29,31)
  • InChiKey: PIFNWPCJPIHZNX-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.013 0.013
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.013 0.013
Leishmania major proteasome alpha 1 subunit, putative 0.0189 0.1821 0.2134
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0182 0.1746 0.2046
Leishmania major proteasome alpha 2 subunit, putative 0.0195 0.188 0.2203
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.002 0.0006 0.0007
Schistosoma mansoni hypothetical protein 0.0194 0.1867 0.1867
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0196 0.0196
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0064 0.047 0.047
Leishmania major proteasome beta-1 subunit, putative 0.019 0.1831 0.2145
Toxoplasma gondii hypothetical protein 0.0027 0.0076 0.0089
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.013 0.013
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.019 0.1826 0.1826
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.013 0.013
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0157 0.1477 0.1731
Echinococcus multilocularis carbonic anhydrase II 0.0171 0.1624 0.1624
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.013 0.013
Schistosoma mansoni hypothetical protein 0.0194 0.1867 0.1867
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0029 0.01 0.0117
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0196 0.0196
Echinococcus granulosus death domain containing protein 0.0036 0.0177 0.0177
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0037 0.0181 0.0213
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.013 0.013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.013 0.0152
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.023 0.023
Onchocerca volvulus 0.0038 0.0196 0.1061
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.019 0.1826 0.1826
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0044 0.0256 0.03
Onchocerca volvulus 0.0032 0.013 0.0703
Schistosoma mansoni thyroid hormone receptor 0.0032 0.013 0.013
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.002 0.0006 0.0007
Echinococcus granulosus netrin receptor unc 5 0.0036 0.0177 0.0177
Loa Loa (eye worm) proteasome regulatory particle 0.0037 0.0181 0.0213
Echinococcus granulosus carbonic anhydrase II 0.0171 0.1624 0.1624
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0033 0.0144 0.0169
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0202 0.196 0.2296
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0171 0.1624 0.1903
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0189 0.1821 0.2134
Echinococcus granulosus transmembrane protease serine 3 0.0038 0.0196 0.0196
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0029 0.01 0.01
Loa Loa (eye worm) proteasome subunit beta type 3 0.0184 0.1764 0.2067
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.023 0.023
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0039 0.0205 0.024
Loa Loa (eye worm) hypothetical protein 0.0038 0.0196 0.0229
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0157 0.1477 0.1731
Giardia lamblia 20S proteasome alpha subunit 3 0.019 0.1826 0.214
Leishmania major proteasome alpha 7 subunit, putative 0.024 0.2358 0.2763
Loa Loa (eye worm) hypothetical protein 0.0064 0.047 0.0551
Toxoplasma gondii PCI domain-containing protein 0.003 0.0114 0.0134
Brugia malayi Trypsin family protein 0.0038 0.0196 0.0196
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0196 0.0196
Plasmodium vivax proteasome subunit alpha type-4, putative 0.019 0.1826 0.214
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.019 0.1831 0.2145
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0031 0.0116 0.0116
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0212 0.2061 0.2415
Giardia lamblia Proteasome subunit beta type 3 0.0184 0.1764 0.2067
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.0152
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0201 0.1949 0.2284
Brugia malayi Kringle domain containing protein 0.002 0.0005 0.0005
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0184 0.1764 0.2067
Echinococcus granulosus proteasome prosome macropain 0.0816 0.8535 0.8535
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.002 0.0006 0.0006
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0031 0.0116 0.0136
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.013 0.013
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0021 0.0019 0.0019
Brugia malayi Trypsin family protein 0.0038 0.0196 0.0196
Brugia malayi Trypsin family protein 0.0038 0.0196 0.0196
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0039 0.0211 0.0211
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0192 0.1844 0.2161
Giardia lamblia 20S proteasome alpha subunit 2 0.0195 0.188 0.2203
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.019 0.1831 0.2145
Brugia malayi proteasome subunit alpha type 6 0.0202 0.196 0.196
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.013 0.013
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0816 0.8535 1
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0201 0.1949 0.1949
Brugia malayi Proteasome/cyclosome repeat family protein 0.0032 0.0135 0.0135
Brugia malayi PCI domain containing protein 0.003 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.0152
Echinococcus multilocularis carbonic anhydrase 0.0064 0.047 0.047
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.002 0.0006 0.0007
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0033 0.0144 0.0169
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0182 0.1746 0.2046
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.024 0.2358 0.2763
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0036 0.0177 0.0207
Plasmodium vivax cysteine repeat modular protein 1, putative 0.002 0.0005 0.0006
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0033 0.0144 0.0144
Echinococcus multilocularis proteasome subunit beta type 7 0.0952 1 1
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0044 0.0256 0.03
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0201 0.1949 0.2284
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0182 0.1746 0.2046
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0021 0.0019 0.0022
Entamoeba histolytica proteasome regulatory subunit, putative 0.003 0.0114 0.0134
Plasmodium falciparum carbonic anhydrase 0.0064 0.047 0.0551
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.003 0.0114 0.0134
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0192 0.1844 0.2161
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.013 0.013
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.024 0.2358 0.2763
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.013 0.013
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0095 0.0808 0.0808
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0033 0.0144 0.0144
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0031 0.0116 0.0136
Entamoeba histolytica proteasome regulatory subunit, putative 0.0021 0.0018 0.0022
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0044 0.0256 0.0256
Brugia malayi small heat shock protein 0.0661 0.6872 0.6872
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.013 0.0152
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0179 0.1705 0.1997
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0212 0.2061 0.2415
Leishmania major proteasome beta 2 subunit, putative 0.026 0.2575 0.3017
Leishmania major hypothetical protein, conserved 0.005 0.032 0.0375
Toxoplasma gondii proteasome subunit 0.019 0.1831 0.2145
Brugia malayi ecdysteroid receptor 0.0032 0.013 0.013
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.024 0.2358 0.2358
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0039 0.0211 0.0247
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.003 0.0114 0.0134
Schistosoma mansoni hypothetical protein 0.0059 0.0423 0.0423
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0021 0.0018 0.0018
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0816 0.8535 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.0152
Brugia malayi proteasome subunit alpha type 2 0.0195 0.188 0.188
Brugia malayi hypothetical protein 0.0041 0.023 0.023
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.003 0.0114 0.0114
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.024 0.2358 0.2763
Brugia malayi Trypsin-like protease protein 5 0.0038 0.0196 0.0196
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.013 0.013
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0095 0.0808 0.0808
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0201 0.1949 0.2284
Schistosoma mansoni 26S proteasome subunit S9 0.0037 0.0181 0.0181
Schistosoma mansoni carbonic anhydrase-related 0.0064 0.047 0.047
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0064 0.047 0.047
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0216 0.2107 0.2107
Loa Loa (eye worm) hypothetical protein 0.0064 0.047 0.0551
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0064 0.047 0.047
Plasmodium falciparum cysteine repeat modular protein 1 0.002 0.0005 0.0006
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.002 0.0006 0.0007
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0064 0.047 0.047
Toxoplasma gondii kringle domain-containing protein 0.002 0.0005 0.0006
Brugia malayi proteasome subunit alpha type 4 0.0174 0.1651 0.1651
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0212 0.2061 0.2415
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.003 0.0114 0.0114
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.002 0.0006 0.0007
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.003 0.0114 0.0134
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.002 0.0006 0.0007
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0182 0.1746 0.2046
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0044 0.0256 0.03
Toxoplasma gondii heat shock protein hslv, putative 0.0157 0.1477 0.1731
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0029 0.01 0.01
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0031 0.0116 0.0116
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.013 0.013
Schistosoma mansoni hypothetical protein 0.002 0.0005 0.0005
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.013 0.013
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.002 0.0006 0.0007
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0037 0.0181 0.0213
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0185 0.1774 0.1774
Brugia malayi PCI domain containing protein 0.0033 0.0145 0.0145
Leishmania major carbonic anhydrase-like protein 0.0171 0.1624 0.1903
Brugia malayi Trypsin family protein 0.0038 0.0196 0.0196
Onchocerca volvulus 0.002 0.0006 0.0033
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.002 0.0006 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.013 0.013
Echinococcus multilocularis enteropeptidase 0.0038 0.0196 0.0196
Toxoplasma gondii SAC3/GANP family protein 0.0029 0.01 0.0117
Onchocerca volvulus Netrin receptor homolog 0.0036 0.0177 0.0958
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0189 0.1821 0.2134
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0157 0.1477 0.1731
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0201 0.1949 0.2284
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0157 0.1477 0.5
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0029 0.01 0.0117
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0021 0.0018 0.0022
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0184 0.1764 0.2067
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0031 0.0116 0.0116
Echinococcus multilocularis geminin 0.0194 0.1867 0.1867
Echinococcus granulosus geminin 0.0194 0.1867 0.1867
Echinococcus granulosus enteropeptidase 0.0038 0.0196 0.0196
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.013 0.0703
Brugia malayi Proteasome/cyclosome repeat family protein 0.0032 0.0135 0.0135
Entamoeba histolytica hypothetical protein 0.0041 0.023 0.027
Plasmodium vivax proteasome subunit beta type-6, putative 0.019 0.1831 0.2145
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0816 0.8535 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0177 0.0207
Entamoeba histolytica proteasome regulatory subunit, putative 0.0039 0.0211 0.0247
Onchocerca volvulus 0.002 0.0006 0.0033
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0202 0.196 0.2296
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.003 0.0114 0.0134
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0182 0.1746 0.1746
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0027 0.0076 0.0089
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0007
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0031 0.0116 0.0136
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.026 0.2575 0.3017
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0039 0.0205 0.0205
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0021 0.0019 0.0022
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0182 0.1746 0.2046
Plasmodium falciparum proteasome subunit beta type-4 0.0182 0.1746 0.2046
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.0152
Schistosoma mansoni multiubiquitin binding protein S5a 0.0021 0.0018 0.0018
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0088 0.0733 0.0733
Echinococcus granulosus tissue type plasminogen activator 0.002 0.0005 0.0005
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.024 0.2358 0.2763
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.013 0.013
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.013 0.013
Entamoeba histolytica proteasome regulatory subunit, putative 0.0029 0.01 0.0117
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.0152
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0192 0.1844 0.2161
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0182 0.1746 0.2046
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0044 0.0256 0.03
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0033 0.0145 0.0145
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0202 0.196 0.2296
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.019 0.1826 0.214
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0184 0.1764 0.2067
Plasmodium falciparum proteasome subunit beta type-5 0.0816 0.8535 1
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0201 0.1949 0.1949
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0033 0.0144 0.0144
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0033 0.0145 0.017
Loa Loa (eye worm) proteasome subunit beta type 1 0.0212 0.2061 0.2415
Toxoplasma gondii proteasome subunit alpha type, putative 0.019 0.1826 0.214
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.005 0.032 0.0375
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0021 0.0019 0.0022
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0195 0.188 0.2203
Brugia malayi proteasome subunit alpha type 1 0.0189 0.1821 0.1821
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0029 0.01 0.0117
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0196 0.0196
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0029 0.0105 0.0123
Plasmodium falciparum proteasome subunit beta type-6, putative 0.019 0.1831 0.2145
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0039 0.0211 0.0211
Onchocerca volvulus 0.0038 0.0196 0.1061
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.013 0.013
Brugia malayi Proteasome subunit alpha type 1 0.0173 0.1645 0.1645
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0031 0.0116 0.0116
Schistosoma mansoni hypothetical protein 0.0036 0.0177 0.0177
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0202 0.196 0.2296
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0044 0.0256 0.0256
Loa Loa (eye worm) PAS-3 protein 0.0174 0.1651 0.1934
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0044 0.0256 0.0256
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0044 0.0256 0.0256
Brugia malayi Proteasome A-type and B-type family protein 0.0182 0.1746 0.1746
Schistosoma mansoni carbonic anhydrase-related 0.0064 0.047 0.047
Toxoplasma gondii hypothetical protein 0.0064 0.047 0.0551
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.019 0.1831 0.1831
Echinococcus granulosus Mastin 0.0038 0.0196 0.0196
Schistosoma mansoni hypothetical protein 0.0038 0.0196 0.0196
Schistosoma mansoni 26S protease regulatory subunit 6b 0.002 0.0006 0.0006
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0202 0.196 0.2296
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.013 0.0703
Echinococcus multilocularis tissue type plasminogen activator 0.002 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0661 0.6872 0.8052
Brugia malayi Proteasome subunit alpha type 7-1 0.024 0.2358 0.2358
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0039 0.0211 0.0211
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0029 0.01 0.0117
Echinococcus granulosus nuclear factor of activated T cells 5 0.0354 0.3582 0.3582
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0184 0.1764 0.2067
Loa Loa (eye worm) PCI domain-containing protein 0.0033 0.0145 0.017
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.002 0.0006 0.0007
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0021 0.0012 0.0015
Mycobacterium ulcerans proteasome PrcA 0.0157 0.1477 0.1537
Schistosoma mansoni hypothetical protein 0.0088 0.0733 0.0733
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0952 1 1
Echinococcus granulosus Ankyrin 0.0036 0.0178 0.0178
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0212 0.2061 0.2061
Leishmania major proteasome beta 7 subunit, putative 0.0182 0.1746 0.2046
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.002 0.0006 0.0007
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0044 0.0256 0.03
Echinococcus multilocularis Proteasome subunit alpha type 7 0.024 0.2358 0.2358
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0182 0.1746 0.2046
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0038 0.0196 0.0196
Echinococcus multilocularis Ankyrin 0.0036 0.0178 0.0178
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0196 0.0196
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0189 0.1821 0.2134
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.006 0.0436 0.2366
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0182 0.1746 0.1746
Plasmodium vivax proteasome subunit alpha type-7, putative 0.024 0.2358 0.2763
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0021 0.0019 0.0019
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0033 0.0144 0.0169
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0031 0.0116 0.0136
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.024 0.2358 0.2763
Brugia malayi Proteasome A-type and B-type family protein 0.019 0.1831 0.1831
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0196 0.0196
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0184 0.1764 0.1764
Entamoeba histolytica hypothetical protein 0.0039 0.0205 0.024
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.019 0.1831 0.2145
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0036 0.0178 0.0178
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.019 0.1831 0.2145
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0037 0.0181 0.0213
Schistosoma mansoni coup transcription factor 0.0032 0.013 0.013
Loa Loa (eye worm) PCI domain-containing protein 0.003 0.0114 0.0134
Onchocerca volvulus Notchless protein homolog 0.0192 0.1844 1
Giardia lamblia 20S proteasome alpha subunit 7 0.0192 0.1844 0.2161
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0031 0.0116 0.0136
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0184 0.1764 0.2067
Echinococcus granulosus Proteasome subunit alpha beta 0.0192 0.1844 0.1844
Schistosoma mansoni hypothetical protein 0.0216 0.2107 0.2107
Onchocerca volvulus 0.002 0.0005 0.0027
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0033 0.0145 0.017
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.013 0.013
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0039 0.0211 0.0211
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.019 0.1826 0.214
Toxoplasma gondii proteasome regulatory subunit 0.0031 0.0116 0.0136
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0202 0.196 0.2296
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0031 0.0116 0.0136
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0064 0.047 0.0551
Entamoeba histolytica hypothetical protein 0.0041 0.023 0.027
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0033 0.0144 0.0144
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.013 0.0152
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0212 0.2061 0.2061
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.024 0.2358 0.2763
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0037 0.0181 0.0181
Loa Loa (eye worm) trypsin family protein 0.0038 0.0196 0.0229
Entamoeba histolytica hypothetical protein 0.0041 0.023 0.027
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0195 0.188 0.2203
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0039 0.0205 0.0205
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0031 0.0116 0.0136
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.0152
Loa Loa (eye worm) RPT-2 protein 0.002 0.0006 0.0007
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0182 0.1746 0.2046
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0021 0.0019 0.0022
Brugia malayi Protein kinase domain containing protein 0.002 0.0005 0.0005
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0177 0.0177
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0039 0.0205 0.024
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0201 0.1949 0.1949
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0037 0.0181 0.0213
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0184 0.1764 0.1764
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0033 0.0145 0.017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.013 0.0152
Giardia lamblia 26S protease regulatory subunit 6A 0.0021 0.0019 0.0022
Loa Loa (eye worm) hypothetical protein 0.0038 0.0196 0.0229
Leishmania major proteasome beta 5 subunit, putative 0.0816 0.8535 1
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0021 0.0018 0.0018
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.019 0.1826 0.214
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0039 0.0211 0.0247
Onchocerca volvulus 0.0038 0.0196 0.1061
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0184 0.1764 0.2067
Entamoeba histolytica hypothetical protein 0.0041 0.023 0.027
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0354 0.3582 0.3582
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0201 0.1949 0.2284
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0212 0.2061 0.2415
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0039 0.0211 0.0247
Brugia malayi Ubiquitin interaction motif family protein 0.0021 0.0018 0.0018
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0184 0.1764 0.2067
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0039 0.0211 0.0247
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.002 0.0006 0.0007
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.002 0.0006 0.0007
Leishmania major proteasome beta 2 subunit, putative 0.0184 0.1764 0.2067
Brugia malayi steroid hormone receptor 0.0032 0.013 0.013
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0192 0.1844 0.2161
Brugia malayi proteasome subunit beta type 3 0.0184 0.1764 0.1764
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0816 0.8535 1
Trypanosoma cruzi 20S proteasome subunit 0.0184 0.1764 0.2067
Giardia lamblia Proteasome subunit beta type 9 precursor 0.019 0.1831 0.2145
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0184 0.1764 0.2067
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0037 0.0181 0.0181
Schistosoma mansoni hypothetical protein 0.0038 0.0196 0.0196
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0201 0.1949 0.2284
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0033 0.0145 0.017
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0195 0.188 0.188
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0064 0.047 0.047
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0044 0.0256 0.0256
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0021 0.0019 0.0022
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0031 0.0116 0.0136
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0088 0.0733 0.0733
Onchocerca volvulus 0.0038 0.0196 0.1061
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.013 0.013
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0201 0.1949 0.2284
Loa Loa (eye worm) hypothetical protein 0.0036 0.0178 0.0209
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0192 0.1844 0.2161
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0044 0.0256 0.03
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.026 0.2575 0.3017
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.0152
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0033 0.0145 0.017
Schistosoma mansoni hypothetical protein 0.003 0.0114 0.0114
Echinococcus multilocularis netrin receptor unc 5 0.0036 0.0177 0.0177
Leishmania major proteasome alpha 1 subunit, putative 0.0202 0.196 0.2296
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.013 0.013
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0216 0.2107 0.2468
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.026 0.2575 0.3017
Loa Loa (eye worm) hypothetical protein 0.0029 0.01 0.0117
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0184 0.1764 0.2067
Brugia malayi Protein kinase domain containing protein 0.0036 0.0177 0.0177
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0816 0.8535 1
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0031 0.0116 0.0116
Echinococcus multilocularis transmembrane protease serine 3 0.0038 0.0196 0.0196
Leishmania major proteasome alpha 3 subunit, putative 0.019 0.1826 0.214
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.013 0.013
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0184 0.1764 0.1764
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.013 0.013
Brugia malayi proteasome subunit alpha type 3 0.0192 0.1844 0.1844
Trypanosoma brucei proteasome beta 7 subunit 0.0182 0.1746 0.2046
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0095 0.0808 0.0947
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0202 0.196 0.196
Loa Loa (eye worm) proteasome subunit beta type 2 0.0184 0.1764 0.2067
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0021 0.0019 0.0022
Plasmodium vivax proteasome subunit beta type-5, putative 0.0816 0.8535 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.019 0.1831 0.2145
Schistosoma mansoni ankyrin 23/unc44 0.0036 0.0177 0.0177
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0157 0.1477 0.1731
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0171 0.1624 0.1624
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0182 0.1746 0.2046
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.026 0.2575 0.3017
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.019 0.1826 0.214
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.013 0.013
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0021 0.0019 0.0022
Leishmania major hypothetical protein, conserved 0.002 0.0005 0.0006
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0196 0.0196
Plasmodium falciparum proteasome subunit beta type-7, putative 0.026 0.2575 0.3017
Giardia lamblia Proteasome subunit beta type 1 0.0212 0.2061 0.2415
Echinococcus multilocularis proteasome subunit beta type 6 0.019 0.1831 0.1831
Trichomonas vaginalis 26S proteasome regulatory subunit rpn1, putative 0.0023 0.0032 0.0038
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0192 0.1844 0.2161
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.002 0.0006 0.0006
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0189 0.1821 0.1821
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0029 0.01 0.0117
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0021 0.0019 0.0022
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0021 0.0018 0.0022
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0037 0.0181 0.0213
Trypanosoma brucei proteasome beta 6 subunit 0.0212 0.2061 0.2415
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0005 0.0006
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.002 0.0006 0.0007
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0033 0.0144 0.0169
Brugia malayi nuclear hormone receptor 0.0032 0.013 0.013
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.013 0.013
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.002 0.0006 0.0006
Brugia malayi Probable 26S protease regulatory subunit 4 0.002 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.013 0.013
Echinococcus granulosus proteasome subunit alpha type 2 0.0195 0.188 0.188
Brugia malayi proteasome subunit beta type 2 0.0184 0.1764 0.1764
Toxoplasma gondii proteasome subunit beta type, putative 0.0816 0.8535 1
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0029 0.01 0.01
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0033 0.0145 0.0145
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0201 0.1949 0.2284
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.013 0.013
Brugia malayi hypothetical protein 0.0038 0.0196 0.0196
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0021 0.0019 0.0019
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0816 0.8535 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0174 0.1653 0.1937
Schistosoma mansoni proteasome regulatory subunit-related 0.0033 0.0145 0.0145
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.013 0.013
Schistosoma mansoni hypothetical protein 0.0064 0.047 0.047
Trypanosoma brucei proteasome beta-1 subunit, putative 0.019 0.1831 0.2145
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0037 0.0181 0.0181
Toxoplasma gondii PCI domain-containing protein 0.0037 0.0181 0.0213
Echinococcus multilocularis Proteasome subunit alpha type 7 0.024 0.2358 0.2358
Echinococcus multilocularis Proteasome subunit alpha type 7 0.024 0.2358 0.2358
Toxoplasma gondii PCI domain-containing protein 0.0039 0.0211 0.0247
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0031 0.0116 0.0116
Echinococcus multilocularis proteasome (prosome, macropain) 0.0816 0.8535 0.8535
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0196 0.0196
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.013 0.013
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.013 0.013
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0816 0.8535 1
Echinococcus multilocularis glycoprotein Antigen 5 0.0038 0.0196 0.0196
Plasmodium vivax proteasome subunit beta type-2, putative 0.0184 0.1764 0.2067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.013 0.0152
Toxoplasma gondii proteasome subunit alpha type, putative 0.0082 0.067 0.0785
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0031 0.0116 0.0136
Echinococcus granulosus glycoprotein Antigen 5 0.0038 0.0196 0.0196
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0157 0.1477 0.1731
Trypanosoma brucei proteasome beta 2 subunit, putative 0.026 0.2575 0.3017
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0039 0.0205 0.024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.013 0.0152
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0816 0.8535 1
Entamoeba histolytica proteasome regulatory subunit, putative 0.0037 0.0181 0.0213
Leishmania major proteasome beta 3 subunit, putative 0.0184 0.1764 0.2067
Echinococcus granulosus carbonic anhydrase 0.0064 0.047 0.047
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0031 0.0116 0.0136
Loa Loa (eye worm) hypothetical protein 0.0038 0.0196 0.0229
Echinococcus multilocularis adhesion regulating molecule 1 0.0095 0.0808 0.0808
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0182 0.1746 0.2046
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0021 0.0019 0.0019
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0189 0.1821 0.1821
Brugia malayi 26S proteasome subunit P45 family protein 0.002 0.0006 0.0006
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0192 0.1844 0.2161
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0182 0.1746 0.1746
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0037 0.0181 0.0213
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0044 0.0256 0.03
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0039 0.0211 0.0211
Brugia malayi 26S protease regulatory subunit 6A 0.0021 0.0019 0.0019
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0033 0.0144 0.0169
Schistosoma mansoni 26S protease regulatory subunit 0.002 0.0006 0.0006
Loa Loa (eye worm) TK/ROR protein kinase 0.002 0.0005 0.0006
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.013 0.013
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0179 0.1705 0.1997
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0033 0.0145 0.017
Echinococcus granulosus adhesion regulating molecule 1 0.0095 0.0808 0.0808
Giardia lamblia 20S proteasome alpha subunit 1 0.0202 0.196 0.2296
Brugia malayi nuclear receptor NHR-88 0.0032 0.013 0.013
Echinococcus granulosus proteasome subunit beta type 7 0.0952 1 1
Entamoeba histolytica 26S protease regulatory subunit, putative 0.002 0.0006 0.0007
Schistosoma mansoni carbonic anhydrase-related 0.0064 0.047 0.047
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0189 0.1821 0.2134
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.019 0.1826 0.214
Toxoplasma gondii proteasome beta subunit 0.0184 0.1764 0.2067
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0157 0.1477 0.1477
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0184 0.1764 0.1764
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0031 0.0116 0.0136
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0184 0.1764 0.1764
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0031 0.0116 0.0136
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0202 0.196 0.2296
Loa Loa (eye worm) hypothetical protein 0.0038 0.0196 0.0229
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0038 0.0196 0.0196
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0029 0.01 0.01
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0196 0.0196
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0021 0.0019 0.0019
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0171 0.1624 0.1624
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0029 0.01 0.0117
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0184 0.1764 0.2067
Entamoeba histolytica proteasome regulatory subunit, putative 0.0033 0.0145 0.017
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0029 0.01 0.0117
Giardia lamblia 20S proteasome alpha subunit 5 0.0201 0.1949 0.2284
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0184 0.1764 0.2067
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0021 0.0018 0.0018
Toxoplasma gondii peptidase, T1 family protein 0.0192 0.1844 0.2161
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0033 0.0144 0.0169
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0157 0.1477 0.1731
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0195 0.188 0.2203
Trypanosoma brucei carbonic anhydrase-like protein 0.0171 0.1624 0.1903
Brugia malayi proteasome subunit beta type 1 0.0212 0.2061 0.2061
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0039 0.0205 0.024
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0029 0.01 0.0117
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0032 0.0135 0.0158
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0212 0.2061 0.2415
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0031 0.0116 0.0116
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.003 0.0114 0.0134
Schistosoma mansoni hypothetical protein 0.0041 0.023 0.023
Schistosoma mansoni netrin receptor unc5 0.0036 0.0177 0.0177
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.013 0.0703
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0192 0.1844 0.2161
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0196 0.0196
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0196 0.0196
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0182 0.1746 0.2046
Echinococcus multilocularis proteasome subunit alpha type 2 0.0195 0.188 0.188
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0189 0.1821 0.2134
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0021 0.0018 0.0022
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0212 0.2061 0.2061
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0195 0.188 0.2203
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0044 0.0256 0.0256
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0171 0.1624 0.1903
Loa Loa (eye worm) hypothetical protein 0.0029 0.01 0.0117
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.013 0.013
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0195 0.188 0.2203
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.024 0.2358 0.2763
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0021 0.0019 0.0022
Loa Loa (eye worm) hypothetical protein 0.0038 0.0196 0.0229
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0006
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0202 0.196 0.2296
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.002 0.0006 0.0007
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0021 0.0012 0.0015
Schistosoma mansoni carbonic anhydrase 0.0064 0.047 0.047
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0195 0.188 0.2203
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.019 0.1826 0.214
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0196 0.0196
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0201 0.1949 0.2284
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.026 0.2575 0.3017
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0033 0.0144 0.0169
Plasmodium vivax proteasome subunit beta type-1, putative 0.0212 0.2061 0.2415
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0171 0.1624 0.1903
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.002 0.0006 0.0007
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0171 0.1624 0.1624
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0189 0.1821 0.2134
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0033 0.0145 0.017
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0196 0.0196
Mycobacterium ulcerans proteasome PrcB 0.0816 0.8535 1
Entamoeba histolytica proteasome regulatory subunit, putative 0.0033 0.0144 0.0169
Onchocerca volvulus 0.0038 0.0196 0.1061
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0196 0.0196
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0031 0.0116 0.0136
Echinococcus multilocularis Mastin 0.0038 0.0196 0.0196
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0192 0.1844 0.1844
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0182 0.1746 0.2046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.013 0.0152
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.013 0.013
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0038 0.0196 0.0196
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0192 0.1844 0.1844
Trichomonas vaginalis 26S proteasome subunit, putative 0.003 0.0114 0.0134
Echinococcus multilocularis carbonic anhydrase 0.0064 0.047 0.047
Echinococcus granulosus subfamily T1A non peptidase ue 0.0201 0.1949 0.1949
Loa Loa (eye worm) carbonic anhydrase 3 0.0171 0.1624 0.1903
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.013 0.013
Toxoplasma gondii proteasome subunit alpha1, putative 0.0202 0.196 0.2296
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.013 0.013
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0036 0.0177 0.0177
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.002 0.0006 0.0006
Giardia lamblia Hypothetical protein 0.0037 0.0181 0.0213
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0036 0.0177 0.0177
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0031 0.0116 0.0116
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0195 0.188 0.2203
Brugia malayi Uncoordinated protein 44 0.0036 0.0177 0.0177
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0021 0.0019 0.0022
Echinococcus granulosus FTZ F1 alpha 0.0032 0.013 0.013
Brugia malayi Death domain containing protein 0.0036 0.0177 0.0177
Plasmodium vivax proteasome subunit beta type-4, putative 0.0182 0.1746 0.2046
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0184 0.1764 0.1764
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.002 0.0006 0.0007
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0021 0.0019 0.0022
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0044 0.0256 0.03
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0184 0.1764 0.2067
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.002 0.0006 0.0007
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0189 0.1821 0.2134
Loa Loa (eye worm) hypothetical protein 0.0038 0.0196 0.0229
Loa Loa (eye worm) hypothetical protein 0.0038 0.0196 0.0229
Toxoplasma gondii proteasome 26S regulatory subunit 0.0021 0.0012 0.0015
Echinococcus granulosus proteasome subunit beta type 6 0.019 0.1831 0.1831
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.013 0.013
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0816 0.8535 0.8535
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0816 0.8535 1
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0184 0.1764 0.2067
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0201 0.1949 0.2284
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0157 0.1477 0.1731
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0184 0.1764 0.1764
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0196 0.0196
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0032 0.0135 0.0158
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.019 0.1826 0.214
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0038 0.0196 0.0196
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.013 0.013
Echinococcus multilocularis carbonic anhydrase 0.0064 0.047 0.047
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0212 0.2061 0.2415
Entamoeba histolytica 26S protease regulatory subunit, putative 0.002 0.0006 0.0007
Giardia lamblia 20S proteasome alpha subunit 6 0.0189 0.1821 0.2134
Plasmodium vivax proteasome subunit beta type-3, putative 0.0184 0.1764 0.2067
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0212 0.2061 0.2415
Loa Loa (eye worm) proteasome Regulatory Particle 0.0033 0.0144 0.0169
Schistosoma mansoni thyroid hormone receptor 0.0032 0.013 0.013
Giardia lamblia 26S proteasome regulatory subunit, putative 0.0023 0.0032 0.0038
Echinococcus multilocularis proteasome subunit alpha type 6 0.0202 0.196 0.196
Giardia lamblia 20S proteasome alpha subunit 4 0.024 0.2358 0.2763
Loa Loa (eye worm) hypothetical protein 0.0095 0.0808 0.0947
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0201 0.1949 0.2284
Loa Loa (eye worm) RPN-3 protein 0.0039 0.0211 0.0247
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0031 0.0116 0.0136
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0064 0.047 0.0551
Echinococcus granulosus carbonic anhydrase 0.0064 0.047 0.047
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.0152
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0038 0.0196 0.0196
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.019 0.1826 0.1826
Echinococcus granulosus carbonic anhydrase 0.0064 0.047 0.047
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0039 0.0205 0.0205
Leishmania major proteasome alpha 7 subunit, putative 0.0192 0.1844 0.2161
Echinococcus granulosus Proteasome subunit alpha type 7 0.024 0.2358 0.2358
Giardia lamblia Proteasome subunit beta type 7 precursor 0.026 0.2575 0.3017
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.003 0.0114 0.0134
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.013 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.013 0.013
Plasmodium vivax proteasome subunit beta type-7, putative 0.026 0.2575 0.3017
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.002 0.0006 0.0007
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0171 0.1624 0.1624
Trypanosoma brucei proteasome alpha 7 subunit 0.0192 0.1844 0.2161
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.024 0.2358 0.2763
Brugia malayi Proteasome A-type and B-type family protein 0.0816 0.8535 0.8535
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0029 0.01 0.01
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0196 0.0196
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0189 0.1821 0.1821
Schistosoma mansoni nuclear hormone receptor 0.0032 0.013 0.013
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.013 0.013
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.013 0.013
Brugia malayi 20S proteasome alpha5 subunit 0.0201 0.1949 0.1949
Giardia lamblia 26S protease regulatory subunit 6B 0.002 0.0006 0.0007
Giardia lamblia Proteasome subunit beta type 2 0.0184 0.1764 0.2067
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0031 0.0116 0.0136
Onchocerca volvulus 0.0038 0.0196 0.1061
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0189 0.1821 0.2134
Echinococcus granulosus proteasome subunit alpha type 6 0.0202 0.196 0.196
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.013 0.013
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0196 0.0196
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0033 0.0144 0.0169
Echinococcus granulosus proteasome subunit beta t family 0.0184 0.1764 0.1764

Activities

Activity type Activity value Assay description Source Reference
GI (functional) < 10 % Cytotoxicity against Homo sapiens (human) MDA-MB-468 cells assessed as growth inhibition at 10 uM after 48 hr by coulter counter analysis ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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