Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0053 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0051 | 0.7156 | 0.7156 |
Echinococcus granulosus | peroxidasin | 0.0051 | 0.7156 | 0.7156 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0053 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0053 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0053 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0051 | 0.7156 | 0.7156 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.7156 | 0.7156 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.7156 | 0.7156 |
Brugia malayi | Animal haem peroxidase family protein | 0.0051 | 0.7156 | 0.7156 |
Schistosoma mansoni | peroxidasin | 0.0051 | 0.7156 | 0.7156 |
Echinococcus multilocularis | peroxidasin | 0.0051 | 0.7156 | 0.7156 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.7156 | 0.7156 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0051 | 0.7156 | 0.7156 |
Schistosoma mansoni | coup transcription factor | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0053 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0053 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.7156 | 0.7156 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0051 | 0.7156 | 0.7156 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0053 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0053 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0053 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0053 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0053 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0053 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0053 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0051 | 0.7156 | 0.7156 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.7156 | 0.7156 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.7156 | 0.7156 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.7156 | 0.7156 |
Schistosoma mansoni | peroxidasin | 0.0051 | 0.7156 | 0.7156 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0053 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0053 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.7156 | 0.7156 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0053 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0053 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0053 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0053 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0053 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0053 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.7156 | 0.7156 |
Schistosoma mansoni | nuclear hormone receptor | 0.0053 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0051 | 0.7156 | 0.7156 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0053 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.7156 | 0.7156 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.7156 | 0.7156 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0053 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0053 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0053 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0051 | 0.7156 | 0.7156 |
Brugia malayi | hypothetical protein | 0.0051 | 0.7156 | 0.7156 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0053 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.7156 | 0.7156 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0053 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0053 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0053 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0053 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.7156 | 0.7156 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.7156 | 0.7156 |
Schistosoma mansoni | thyroid hormone receptor | 0.0053 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0053 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0051 | 0.7156 | 0.7156 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0053 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0053 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0053 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0051 | 0.7156 | 0.7156 |
Onchocerca volvulus | 0.0053 | 1 | 1 | |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0053 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0053 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0053 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0051 | 0.7156 | 0.7156 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0053 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0053 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0051 | 0.7156 | 0.7156 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antifungal activity against Candida albicans at 200 ug/ml by broth dilution technique | ChEMBL. | 24120538 | |
MIC (functional) | = 30 ug ml-1 | Antibacterial activity against Escherichia coli by broth dilution technique | ChEMBL. | 24120538 |
MIC (functional) | = 50 ug ml-1 | Antifungal activity against Cryptococcus neoformans by broth dilution technique | ChEMBL. | 24120538 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.