Detailed information for compound 1794401

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 508.238 | Formula: C22H21BrCl2N4O
  • H donors: 1 H acceptors: 2 LogP: 6.23 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: Brc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)NC(=O)N1CCCCC1
  • InChi: 1S/C22H21BrCl2N4O/c1-14-20(15-5-7-16(23)8-6-15)29(19-10-9-17(24)13-18(19)25)27-21(14)26-22(30)28-11-3-2-4-12-28/h5-10,13H,2-4,11-12H2,1H3,(H,26,27,30)
  • InChiKey: OKFVHQOOPINIEL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cannabinoid receptor 1 (brain) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.1239 0.1846
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0034 0.0357 0.1659
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0078 0.1323 0.1778
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.1239 0.1239
Schistosoma mansoni hypothetical protein 0.0359 0.744 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0078 0.1323 1
Toxoplasma gondii hypothetical protein 0.0054 0.0796 0.5448
Brugia malayi TAZ zinc finger family protein 0.0106 0.1924 0.423
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0078 0.1323 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.6711 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0325 0.6711 1
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.007 0.02
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0078 0.1323 0.1887
Echinococcus granulosus CREB binding protein 0.0106 0.1924 0.2585
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.1239 0.1239
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0344 0.0463
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.6711 1
Schistosoma mansoni tar DNA-binding protein 0.0205 0.4077 0.548
Brugia malayi beta-lactamase 0.0075 0.1239 0.2668
Schistosoma mansoni hypothetical protein 0.0034 0.0344 0.0463
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0307 0.0413
Echinococcus granulosus GPCR family 2 0.0034 0.0344 0.0463
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0181 0.0162
Loa Loa (eye worm) hypothetical protein 0.0075 0.1239 0.2668
Brugia malayi Pre-SET motif family protein 0.0032 0.0307 0.0542
Loa Loa (eye worm) hypothetical protein 0.0075 0.1239 0.2668
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0307 0.0413
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0078 0.1323 0.1778
Echinococcus granulosus geminin 0.0359 0.744 1
Brugia malayi exodeoxyribonuclease III family protein 0.0078 0.1323 0.286
Trichomonas vaginalis ap endonuclease, putative 0.0078 0.1323 0.1972
Onchocerca volvulus 0.0252 0.5121 1
Brugia malayi Cytochrome P450 family protein 0.0053 0.0763 0.1583
Leishmania major hypothetical protein, conserved 0.0075 0.1239 0.17
Mycobacterium ulcerans hypothetical protein 0.0075 0.1239 0.3564
Schistosoma mansoni CREB-binding protein 2 0.0106 0.1924 0.2585
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.1193 0.2563
Trichomonas vaginalis esterase, putative 0.0075 0.1239 0.1846
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0165 0.0139
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.6711 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0307 0.1226
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.007 0.02
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0282 0.0379
Brugia malayi ImpB/MucB/SamB family protein 0.0049 0.0672 0.1375
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0101 0.1809 0.397
Schistosoma mansoni hypothetical protein 0.0034 0.0344 0.0463
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.6711 1
Onchocerca volvulus 0.0075 0.1239 0.1936
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.1239 0.1846
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0644 0.0836
Loa Loa (eye worm) hypothetical protein 0.0072 0.1193 0.2563
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0181 0.0136
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.0181 0.027
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0093 0.1632 0.2194
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0147 0.2813 0.3781
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0336 0.6947 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0763 0.1583
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.1239 0.17
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0921 0.0921
Schistosoma mansoni hypothetical protein 0.0034 0.0344 0.0463
Toxoplasma gondii ABC1 family protein 0.0075 0.1239 0.9273
Schistosoma mansoni ap endonuclease 0.0078 0.1323 0.1778
Loa Loa (eye worm) RNA binding protein 0.0205 0.4077 0.9145
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0344 0.0627
Brugia malayi Cytochrome P450 family protein 0.0023 0.0117 0.0108
Loa Loa (eye worm) hypothetical protein 0.0075 0.1239 0.2668
Schistosoma mansoni DNA polymerase eta 0.0049 0.0672 0.0903
Loa Loa (eye worm) hypothetical protein 0.0025 0.0165 0.0218
Loa Loa (eye worm) hypothetical protein 0.0093 0.1632 0.3565
Plasmodium vivax SET domain protein, putative 0.0032 0.0307 0.1226
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0181 0.0136
Echinococcus multilocularis dna polymerase eta 0.0049 0.0672 0.0903
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0921 0.1238
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0117 0.0069
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0159 0.308 0.308
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0078 0.1323 0.1887
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0307 0.0413
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0307 0.0413
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.1239 0.1665
Onchocerca volvulus 0.0075 0.1239 0.1936
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.1239 0.1239
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0644 0.0836
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.1239 0.1239
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0921 0.1238
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0075 0.1239 0.2668
Toxoplasma gondii exonuclease III APE 0.0078 0.1323 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.6711 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.1239 0.1665
Entamoeba histolytica serine/threonine protein kinase, putative 0.0101 0.1809 0.262
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.007 0.0093
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.007 0.0093
Echinococcus granulosus tar DNA binding protein 0.0205 0.4077 0.548
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.1809 0.253
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0921 0.1942
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.1239 0.1239
Schistosoma mansoni tar DNA-binding protein 0.0205 0.4077 0.548
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0147 0.2813 0.6259
Mycobacterium tuberculosis Conserved protein 0.0075 0.1239 0.1239
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0159 0.3084 0.4383
Echinococcus multilocularis tar DNA binding protein 0.0205 0.4077 0.548
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.1239 0.1239
Schistosoma mansoni hypothetical protein 0.0359 0.744 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0101 0.1809 0.253
Echinococcus multilocularis CREB binding protein 0.0073 0.1198 0.161
Loa Loa (eye worm) hypothetical protein 0.0049 0.0672 0.1375
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.0644 0.0836
Brugia malayi beta-lactamase family protein 0.0075 0.1239 0.2668
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.0181 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0147 0.2813 0.3781
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0344 0.0463
Onchocerca volvulus Serine\/threonine kinase homolog 0.0101 0.1809 0.3121
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0921 0.1238
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.1239 0.17
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0205 0.4077 0.9145
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.6711 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0344 0.0627
Plasmodium vivax hypothetical protein, conserved 0.0075 0.1239 0.9273
Onchocerca volvulus 0.0075 0.1239 0.1936
Trypanosoma brucei polo-like protein kinase 0.0101 0.1809 0.253
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.4452 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0147 0.2813 0.3781
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0159 0.3084 0.4383
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.1239 0.1846
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0147 0.2813 0.3781
Onchocerca volvulus 0.0093 0.1632 0.2753
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.1239 0.1846
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0078 0.1323 0.1823
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.007 0.0093
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0117 0.0336
Loa Loa (eye worm) hypothetical protein 0.0034 0.0344 0.0627
Brugia malayi beta-lactamase family protein 0.0075 0.1239 0.2668
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.1239 0.2668
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0181 0.0136
Loa Loa (eye worm) hypothetical protein 0.0106 0.1924 0.4231
Mycobacterium tuberculosis Conserved protein 0.0075 0.1239 0.1239
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0181 0.0521
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.007 0.0104
Echinococcus multilocularis geminin 0.0359 0.744 1
Leishmania major cytochrome p450-like protein 0.0023 0.0117 0.0069
Mycobacterium leprae conserved hypothetical protein 0.0075 0.1239 0.4022
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.0357 0.0418
Mycobacterium tuberculosis Conserved protein 0.0075 0.1239 0.1239
Schistosoma mansoni hypothetical protein 0.0034 0.0344 0.0463
Giardia lamblia Fructose-bisphosphate aldolase 0.0325 0.6711 1
Mycobacterium ulcerans hypothetical protein 0.0177 0.3476 1
Schistosoma mansoni hypothetical protein 0.0072 0.1193 0.1603
Echinococcus granulosus L aminoadipate semialdehyde 0.0093 0.1632 0.2194
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0181 0.0136
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0344 0.0463
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0344 0.0463
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0078 0.1323 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0159 0.308 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.1239 0.3564
Trypanosoma brucei DNA polymerase eta, putative 0.0049 0.0672 0.0876
Schistosoma mansoni tar DNA-binding protein 0.0205 0.4077 0.548
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.1924 0.4231
Loa Loa (eye worm) hypothetical protein 0.0032 0.0307 0.0542
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0921 0.2649
Mycobacterium leprae conserved hypothetical protein 0.0026 0.0181 0.0587
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0078 0.1323 0.1823
Trichomonas vaginalis set domain proteins, putative 0.0252 0.5121 0.7631
Echinococcus granulosus CREB binding protein 0.0065 0.1038 0.1395
Brugia malayi hypothetical protein 0.0025 0.0165 0.0218
Trichomonas vaginalis CAMK family protein kinase 0.005 0.07 0.1044
Brugia malayi Cytochrome P450 family protein 0.0023 0.0117 0.0108
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0106 0.1924 0.2585
Echinococcus multilocularis GPCR, family 2 0.0034 0.0344 0.0463
Mycobacterium leprae Probable lipase LipE 0.0075 0.1239 0.4022
Echinococcus multilocularis L aminoadipate semialdehyde 0.0093 0.1632 0.2194
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1809 0.2696
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.1809 0.253
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1809 0.2696
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.6711 1
Leishmania major DNA polymerase eta, putative 0.0049 0.0672 0.0876
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.1239 0.2668
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0344 0.0627
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0117 0.0069
Schistosoma mansoni tar DNA-binding protein 0.0205 0.4077 0.548
Schistosoma mansoni ap endonuclease 0.0078 0.1323 0.1778
Giardia lamblia Kinase, PLK 0.0101 0.1809 0.262
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1809 0.2696
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0147 0.2813 0.6259
Treponema pallidum fructose-bisphosphate aldolase 0.0325 0.6711 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0147 0.2813 0.3781
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0181 0.1368
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.1239 0.1239
Mycobacterium ulcerans beta-lactamase 0.0075 0.1239 0.3564
Leishmania major hypothetical protein, conserved 0.0025 0.0165 0.0139
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0181 0.0521
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.007 0.0093
Trichomonas vaginalis CAMK family protein kinase 0.005 0.07 0.1044
Entamoeba histolytica hypothetical protein 0.0026 0.0181 0.0168
Schistosoma mansoni tar DNA-binding protein 0.0205 0.4077 0.548
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.1924 0.4231
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.1239 0.3564
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1809 0.2696
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0921 0.2649
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0117 0.0108
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0117 0.0108
Loa Loa (eye worm) CBP-B 0.0074 0.1218 0.262
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0336 0.6947 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.1239 0.2668
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0307 0.0413
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.007 0.007
Echinococcus granulosus dna polymerase kappa 0.0021 0.007 0.0093
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.1239 0.1846
Mycobacterium tuberculosis Conserved hypothetical protein 0.0177 0.3476 0.3476
Leishmania major DNA polymerase eta, putative 0.0034 0.0357 0.0418
Treponema pallidum exodeoxyribonuclease (exoA) 0.0078 0.1323 0.1972
Loa Loa (eye worm) beta-lactamase 0.0075 0.1239 0.2668
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0159 0.3084 0.4383
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.6711 1
Loa Loa (eye worm) TAR-binding protein 0.0205 0.4077 0.9145
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0165 0.0139
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0093 0.1632 0.3565
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0058 0.087 0.1164
Schistosoma mansoni kinase 0.0051 0.0729 0.098
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0147 0.2813 0.3781
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0117 0.0069
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1809 0.2696
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0078 0.1323 0.1823
Brugia malayi RNA binding protein 0.0205 0.4077 0.9145
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0307 0.0413
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0336 0.6947 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0078 0.1323 0.286
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0165 0.0139
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0101 0.1809 0.2432
Echinococcus granulosus dna polymerase eta 0.0049 0.0672 0.0903
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1809 0.2696
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0833 0.1741
Brugia malayi RNA recognition motif domain containing protein 0.0205 0.4077 0.9145
Brugia malayi Pre-SET motif family protein 0.0222 0.4452 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0101 0.1809 0.2432
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0644 0.0836
Leishmania major mitochondrial DNA polymerase beta 0.0336 0.6947 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.1239 0.1665
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0159 0.308 0.8861
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0117 0.0108
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0078 0.1323 0.1823
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0921 0.1238
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0181 0.0162
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.1924 0.4231
Echinococcus multilocularis dna polymerase kappa 0.0021 0.007 0.0093
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0078 0.1323 0.3806
Trypanosoma cruzi DNA polymerase eta, putative 0.0049 0.0672 0.0876
Loa Loa (eye worm) hypothetical protein 0.005 0.0698 0.1433
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0078 0.1323 0.1323
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.1809 0.2432
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0181 0.0181
Mycobacterium ulcerans lipase LipD 0.0075 0.1239 0.3564
Trichomonas vaginalis ap endonuclease, putative 0.0078 0.1323 0.1972
Brugia malayi TAR-binding protein 0.0205 0.4077 0.9145
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1809 0.2696
Brugia malayi serine/threonine-protein kinase plk-2 0.0101 0.1809 0.397
Loa Loa (eye worm) hypothetical protein 0.0075 0.1239 0.2668
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0325 0.6711 1
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.1239 0.17
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.007 0.0104
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0147 0.2813 0.3781
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.1239 0.1665
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0307 0.0413

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 7.328 Antagonist activity at CB1 receptor (unknown origin) ChEMBL. No reference
Ki (binding) = 47 nM Antagonist activity at CB1 receptor (unknown origin) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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