Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | ATP synthase subunit delta, mitochondrial homolog | 0.0062 | 0.0285 | 0.5284 |
Trypanosoma cruzi | vacuolar type h+ ATPase subunit, putative | 0.002 | 0.0005 | 0.005 |
Trypanosoma cruzi | ATPase subunit 9, putative | 0.0161 | 0.0965 | 1 |
Echinococcus granulosus | Vacuolar ATP synthase 16 kDa proteolipid | 0.002 | 0.0005 | 0.005 |
Leishmania major | ATPase subunit 9, putative | 0.0161 | 0.0965 | 1 |
Giardia lamblia | Vacuolar ATP synthase 16 kDa proteolipid subunit | 0.002 | 0.0005 | 1 |
Chlamydia trachomatis | V-type ATP synthase subunit K | 0.002 | 0.0005 | 0.0509 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit C | 0.0161 | 0.0965 | 0.4805 |
Mycobacterium tuberculosis | Probable ATP synthase a chain AtpB (protein 6) | 0.0174 | 0.105 | 0.0868 |
Trypanosoma cruzi | ATPase subunit 9, putative | 0.0161 | 0.0965 | 1 |
Trypanosoma cruzi | ATP synthase F1 subunit gamma protein, putative | 0.0049 | 0.02 | 0.2073 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE B CHAIN ATPF | 0.1475 | 0.9921 | 1 |
Schistosoma mansoni | vacuolar ATP synthase proteolipid subunit 1 2 3 | 0.002 | 0.0005 | 0.005 |
Toxoplasma gondii | ATP synthase F1 gamma subunit | 0.0049 | 0.02 | 0.2073 |
Plasmodium vivax | hypothetical protein, conserved | 0.0062 | 0.0285 | 0.2959 |
Plasmodium vivax | ATP synthase lipid-binding protein, mitochondrial precursor, putative | 0.0161 | 0.0965 | 1 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit delta | 0.0311 | 0.1984 | 0.1922 |
Brugia malayi | ATP synthase delta chain, mitochondrial precursor, putative | 0.0062 | 0.0285 | 0.2959 |
Loa Loa (eye worm) | vacuolar ATP synthase proteolipid subunit 1 | 0.002 | 0.0005 | 0.017 |
Onchocerca volvulus | ATP synthase subunit alpha, mitochondrial homolog | 0.0073 | 0.0362 | 1 |
Plasmodium vivax | ATP synthase alpha chain, putative | 0.0073 | 0.0362 | 0.375 |
Echinococcus multilocularis | ATP synthase subunit delta, mitochondrial | 0.0062 | 0.0285 | 0.2959 |
Trypanosoma brucei | mitochondrial ATP synthase delta chain | 0.0062 | 0.0285 | 0.2959 |
Leishmania major | vacuolar type h ATPase subunit, putative | 0.002 | 0.0005 | 0.005 |
Schistosoma mansoni | ATP synthase gamma subunit | 0.0049 | 0.02 | 0.2073 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0038 | 0.0121 | 0.1259 |
Echinococcus granulosus | ATP synthase subunit alpha mitochondrial | 0.0073 | 0.0362 | 0.375 |
Echinococcus granulosus | V type proton ATPase 21 kDa proteolipid subunit | 0.002 | 0.0005 | 0.005 |
Plasmodium falciparum | V-type proton ATPase 16 kDa proteolipid subunit | 0.002 | 0.0005 | 0.005 |
Brugia malayi | ATP synthase lipid-binding protein, mitochondrial precursor | 0.0161 | 0.0965 | 1 |
Schistosoma mansoni | ATP synthase delta chain mitochondrial | 0.0062 | 0.0285 | 0.2959 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE C CHAIN ATPE (LIPID-BINDING PROTEIN) (DICYCLOHEXYLCARBODIIMIDE-BINDING PROTEIN) | 0.0161 | 0.0965 | 0.0787 |
Echinococcus multilocularis | Vacuolar ATP synthase 16 kDa proteolipid | 0.002 | 0.0005 | 0.005 |
Plasmodium falciparum | ATP synthase subunit gamma, mitochondrial | 0.0049 | 0.02 | 0.2073 |
Schistosoma mansoni | ATP synthase lipid-binding protein-like protein | 0.0161 | 0.0965 | 1 |
Toxoplasma gondii | ATP synthase, putative | 0.0062 | 0.0285 | 0.2959 |
Echinococcus multilocularis | ATP synthase subunit alpha, mitochondrial | 0.0073 | 0.0362 | 0.375 |
Leishmania major | ATP synthase F1 subunit gamma protein, putative | 0.0049 | 0.02 | 0.2073 |
Trypanosoma cruzi | ATP synthase F1 subunit gamma protein, putative | 0.0049 | 0.02 | 0.2073 |
Trypanosoma brucei | ATP synthase F1 subunit gamma protein, putative | 0.0049 | 0.02 | 0.2073 |
Plasmodium falciparum | V-type proton ATPase 21 kDa proteolipid subunit, putative | 0.002 | 0.0005 | 0.005 |
Leishmania major | ATPase alpha subunit | 0.0062 | 0.0285 | 0.2953 |
Schistosoma mansoni | ATP synthase alpha subunit mitochondrial | 0.0073 | 0.0362 | 0.375 |
Toxoplasma gondii | ATP synthase F0 subunit 9, putative | 0.0161 | 0.0965 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0038 | 0.0121 | 0.1259 |
Brugia malayi | ATP synthase gamma chain, mitochondrial precursor, putative | 0.0049 | 0.02 | 0.2073 |
Leishmania major | ATPase beta subunit, putative | 0.0034 | 0.0095 | 0.0988 |
Schistosoma mansoni | ATP synthase gamma subunit | 0.0049 | 0.02 | 0.2073 |
Echinococcus multilocularis | ATP synthase gamma subunit | 0.0049 | 0.02 | 0.2073 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit C | 0.0161 | 0.0965 | 0.0885 |
Schistosoma mansoni | vacuolar ATP synthase proteolipid subunit 1 2 3 | 0.002 | 0.0005 | 0.005 |
Leishmania major | ATPase alpha subunit | 0.0062 | 0.0285 | 0.2953 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.0105 | 1 |
Plasmodium vivax | ATP synthase subunit gamma, mitochondrial, putative | 0.0049 | 0.02 | 0.2073 |
Giardia lamblia | Vacuolar ATP synthase 16 kDa proteolipid subunit | 0.002 | 0.0005 | 1 |
Loa Loa (eye worm) | ATP synthase subunit beta | 0.0022 | 0.0018 | 0.0644 |
Trypanosoma cruzi | ATPase subunit 9, putative | 0.0161 | 0.0965 | 1 |
Leishmania major | vacuolar ATP synthase, putative | 0.002 | 0.0005 | 0.005 |
Trypanosoma cruzi | vacuolar type h+ ATPase subunit, putative | 0.002 | 0.0005 | 0.005 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit A | 0.0174 | 0.105 | 0.0972 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit B | 0.0299 | 0.1904 | 1 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE DELTA CHAIN ATPH | 0.0311 | 0.1984 | 0.1835 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE A CHAIN ATPB (PROTEIN 6) | 0.0174 | 0.105 | 0.0875 |
Trypanosoma cruzi | ATP synthase, epsilon chain, putative | 0.0062 | 0.0285 | 0.2959 |
Trypanosoma brucei | Mitochondrial ATP synthase subunit c-2 | 0.0161 | 0.0965 | 1 |
Echinococcus granulosus | mitochondrial ATP synthase subunit 9 | 0.0161 | 0.0965 | 1 |
Trypanosoma brucei | V-type ATPase, C subunit, putative | 0.002 | 0.0005 | 0.005 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit gamma | 0.0049 | 0.02 | 0.0578 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0088 | 0.3069 |
Plasmodium vivax | V-type proton ATPase 16 kDa proteolipid subunit, putative | 0.002 | 0.0005 | 0.005 |
Trypanosoma brucei | Mitochondrial ATP synthase subunit c-1 | 0.0161 | 0.0965 | 1 |
Schistosoma mansoni | vacuolar ATP synthase proteolipid subunit | 0.002 | 0.0005 | 0.005 |
Brugia malayi | Vacuolar ATP synthase 21 kDa proteolipid subunit, putative | 0.002 | 0.0005 | 0.005 |
Trichomonas vaginalis | vacuolar ATP synthase proteolipid subunit, putative | 0.002 | 0.0005 | 0.0464 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit epsilon | 0.0062 | 0.0285 | 0.0193 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit alpha | 0.0073 | 0.0362 | 0.1473 |
Trypanosoma cruzi | ATPase subunit 9, putative | 0.0161 | 0.0965 | 1 |
Trichomonas vaginalis | vacuolar ATP synthase proteolipid subunit, putative | 0.002 | 0.0005 | 0.0464 |
Trichomonas vaginalis | vacuolar ATP synthase proteolipid subunit 1, 2, 3, putative | 0.002 | 0.0005 | 0.0464 |
Schistosoma mansoni | ATP synthase gamma subunit | 0.0049 | 0.02 | 0.2073 |
Schistosoma mansoni | ATP synthase gamma subunit | 0.0049 | 0.02 | 0.2073 |
Leishmania major | V-type ATPase, C subunit, putative | 0.002 | 0.0005 | 0.005 |
Mycobacterium tuberculosis | Probable ATP synthase C chain AtpE (lipid-binding protein) (dicyclohexylcarbodiimide-binding protein) | 0.0161 | 0.0965 | 0.078 |
Leishmania major | ATPase beta subunit, putative | 0.0034 | 0.0095 | 0.0988 |
Brugia malayi | ATP synthase alpha chain, mitochondrial precursor, putative | 0.0073 | 0.0362 | 0.375 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE ALPHA CHAIN ATPA | 0.0073 | 0.0362 | 0.0166 |
Brugia malayi | ATP synthase beta chain, mitochondrial precursor, putative | 0.0034 | 0.0095 | 0.0988 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit epsilon | 0.0062 | 0.0285 | 0.1051 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.02 | 0.7005 |
Plasmodium falciparum | ATP synthase subunit beta, mitochondrial | 0.0034 | 0.0095 | 0.0988 |
Mycobacterium tuberculosis | Probable ATP synthase B chain AtpF | 0.1475 | 0.9921 | 0.9919 |
Chlamydia trachomatis | type III secretion system ATPase | 0.0034 | 0.0095 | 1 |
Trypanosoma cruzi | vacuolar type h+ ATPase subunit, putative | 0.002 | 0.0005 | 0.005 |
Echinococcus multilocularis | ATP synthase subunit beta, mitochondrial | 0.0034 | 0.0095 | 0.0988 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit alpha | 0.0073 | 0.0362 | 0.0271 |
Trypanosoma brucei | ATP synthase F1, alpha subunit | 0.0062 | 0.0285 | 0.2953 |
Plasmodium falciparum | ATP synthase subunit delta, mitochondrial, putative | 0.0062 | 0.0285 | 0.2959 |
Plasmodium falciparum | ATP synthase subunit C, putative | 0.0161 | 0.0965 | 1 |
Brugia malayi | Vacuolar ATP synthase 16 kDa proteolipid subunit, putative | 0.002 | 0.0005 | 0.005 |
Entamoeba histolytica | V-type ATPase, C subunit, putative | 0.002 | 0.0005 | 1 |
Trypanosoma brucei | hypothetical protein | 0.0141 | 0.0825 | 0.8555 |
Trypanosoma cruzi | vacuolar ATP synthase, putative | 0.002 | 0.0005 | 0.005 |
Treponema pallidum | V-type ATP synthase subunit K | 0.002 | 0.0005 | 0.0509 |
Trypanosoma brucei | Mitochondrial ATP synthase subunit c-3 | 0.0161 | 0.0965 | 1 |
Mycobacterium tuberculosis | Probable ATP synthase epsilon chain AtpC | 0.0062 | 0.0285 | 0.0087 |
Echinococcus granulosus | 5'partial|ATP synthase subunit delta mitochondrial | 0.0062 | 0.0285 | 0.2959 |
Schistosoma mansoni | ATP synthase F0 subunit 6 | 0.0105 | 0.058 | 0.6015 |
Loa Loa (eye worm) | vacuolar ATP synthase proteolipid subunit | 0.002 | 0.0005 | 0.017 |
Schistosoma mansoni | ATP synthase lipid-binding protein-like protein | 0.0161 | 0.0965 | 1 |
Echinococcus granulosus | ATP synthase subunit beta mitochondrial | 0.0034 | 0.0095 | 0.0988 |
Leishmania major | ATPase subunit 9, putative | 0.0161 | 0.0965 | 1 |
Leishmania major | vacuolar type h ATPase subunit, putative | 0.002 | 0.0005 | 0.005 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0038 | 0.0121 | 0.1259 |
Trichomonas vaginalis | vacuolar ATP synthase proteolipid subunit 1, 2, 3, putative | 0.002 | 0.0005 | 0.0464 |
Trypanosoma brucei | vacuolar type h+ ATPase subunit, putative | 0.002 | 0.0005 | 0.005 |
Brugia malayi | Vacuolar ATP synthase 16 kDa proteolipid subunit 1, putative | 0.002 | 0.0005 | 0.005 |
Trypanosoma brucei | vacuolar ATP synthase 16 kDa proteolipid subunit, putative | 0.002 | 0.0005 | 0.005 |
Loa Loa (eye worm) | ATP synthase subunit delta | 0.0062 | 0.0285 | 1 |
Plasmodium vivax | ATP synthase subunit beta, mitochondrial, putative | 0.0034 | 0.0095 | 0.0988 |
Trypanosoma brucei | vacuolar ATP synthase, putative | 0.002 | 0.0005 | 0.005 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0038 | 0.0121 | 0.4254 |
Trichomonas vaginalis | vacuolar ATP synthase proteolipid subunit, putative | 0.002 | 0.0005 | 0.0464 |
Trypanosoma cruzi | vacuolar ATP synthase, putative | 0.002 | 0.0005 | 0.005 |
Echinococcus multilocularis | mitochondrial ATP synthase subunit 9 | 0.0161 | 0.0965 | 1 |
Schistosoma mansoni | ATP synthase beta subunit | 0.0034 | 0.0095 | 0.0988 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0041 | 0.0145 | 0.1502 |
Plasmodium falciparum | ATP synthase F1, alpha subunit | 0.0073 | 0.0362 | 0.375 |
Giardia lamblia | Vacuolar ATP synthase 16 kDa proteolipid subunit | 0.002 | 0.0005 | 1 |
Trypanosoma brucei | ATP synthase F1, alpha subunit | 0.0062 | 0.0285 | 0.2953 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE BETA CHAIN ATPD | 0.0078 | 0.0395 | 0.0201 |
Plasmodium vivax | V-type proton ATPase 21 kDa proteolipid subunit, putative | 0.002 | 0.0005 | 0.005 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit A | 0.0174 | 0.105 | 0.528 |
Echinococcus multilocularis | V type proton ATPase 21 kDa proteolipid subunit | 0.002 | 0.0005 | 0.005 |
Trypanosoma cruzi | V-type ATPase, C subunit, putative | 0.002 | 0.0005 | 0.005 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE EPSILON CHAIN ATPC | 0.0062 | 0.0285 | 0.0088 |
Entamoeba histolytica | Vacuolar ATP synthase proteolipid subunit, putative | 0.002 | 0.0005 | 1 |
Toxoplasma gondii | V-ATPase subunit c' proteolipid, putative | 0.002 | 0.0005 | 0.005 |
Trypanosoma brucei | ATP synthase subunit beta, mitochondrial | 0.0034 | 0.0095 | 0.0988 |
Trypanosoma cruzi | ATP synthase subunit beta, mitochondrial, putative | 0.0034 | 0.0095 | 0.0988 |
Toxoplasma gondii | ATP synthase beta subunit ATP-B | 0.0034 | 0.0095 | 0.0988 |
Loa Loa (eye worm) | vacuolar ATP synthase proteolipid subunit | 0.002 | 0.0005 | 0.017 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0041 | 0.0145 | 0.1502 |
Echinococcus multilocularis | Vacuolar ATP synthase 16 kDa proteolipid | 0.002 | 0.0005 | 0.005 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.0105 | 1 |
Treponema pallidum | flagellum-specific ATP synthase (fliI) | 0.0034 | 0.0095 | 1 |
Leishmania major | ATP synthase, epsilon chain, putative | 0.0062 | 0.0285 | 0.2959 |
Trypanosoma cruzi | ATPase subunit 9, putative | 0.0161 | 0.0965 | 1 |
Schistosoma mansoni | ATP synthase gamma subunit | 0.0049 | 0.02 | 0.2073 |
Leishmania major | ATPase subunit 9, putative | 0.0161 | 0.0965 | 1 |
Trypanosoma cruzi | vacuolar type h+ ATPase subunit, putative | 0.002 | 0.0005 | 0.005 |
Echinococcus granulosus | ATP synthase gamma subunit | 0.0049 | 0.02 | 0.2073 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit gamma | 0.0049 | 0.02 | 0.0106 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit B | 0.1475 | 0.9921 | 1 |
Mycobacterium tuberculosis | Probable ATP synthase alpha chain AtpA | 0.0073 | 0.0362 | 0.0165 |
Leishmania major | vacuolar ATP synthase, putative | 0.002 | 0.0005 | 0.005 |
Echinococcus granulosus | Vacuolar ATP synthase 16 kDa proteolipid | 0.002 | 0.0005 | 0.005 |
Mycobacterium tuberculosis | Probable ATP synthase beta chain AtpD | 0.0078 | 0.0395 | 0.0199 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 40 uM | Inhibition of human recombinant DNA polymerase beta | ChEMBL. | 23968551 |
IC50 (ADMET) | > 40 uM | Cytotoxicity against TdT-deficient human HeLa cells assessed as growth inhibition after 24 to 48 hrs by MTT assay | ChEMBL. | 23968551 |
ID50 (binding) | = 5 uM | Inhibition of human recombinant full length DNA polymerase lambda TdT-like activity using [3H]dNTP as substrate after 10 mins by scintillation counting analysis | ChEMBL. | 23968551 |
ID50 (binding) | = 7.3 uM | Inhibition of human recombinant TdT using [3H]dNTP as substrate after 10 mins by scintillation counting analysis | ChEMBL. | 23968551 |
ID50 (binding) | > 40 uM | Inhibition of human recombinant full length DNA polymerase lambda using [3H]dTTP as substrate and 10 poly(dA)/oligo(dT) as template-primer after 15 mins by scintillation counting analysis | ChEMBL. | 23968551 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.