Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0154 | 0.2796 | 1 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0244 | 0.4963 | 0.4963 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0056 | 0.0428 | 0.0428 |
Schistosoma mansoni | tyrosine kinase | 0.0145 | 0.2593 | 0.2593 |
Schistosoma mansoni | tyrosine kinase | 0.024 | 0.4876 | 0.4876 |
Echinococcus granulosus | insulin receptor | 0.0145 | 0.2593 | 0.2593 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0045 | 0.0176 | 0.0103 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0145 | 0.2593 | 0.246 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0154 | 0.2796 | 0.2796 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0154 | 0.2796 | 1 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0145 | 0.2593 | 0.2593 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0154 | 0.2796 | 0.2796 |
Brugia malayi | Protein kinase domain containing protein | 0.0236 | 0.4772 | 0.4733 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0154 | 0.2796 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0056 | 0.0428 | 0.0428 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0051 | 0.0325 | 0.0325 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0453 | 1 | 1 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0154 | 0.2796 | 0.2796 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0428 | 0.0256 |
Schistosoma mansoni | tyrosine kinase | 0.0244 | 0.4963 | 0.4963 |
Schistosoma mansoni | tyrosine kinase | 0.0453 | 1 | 1 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0154 | 0.2796 | 0.2742 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0154 | 0.2796 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0154 | 0.2796 | 0.2667 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0244 | 0.4963 | 0.4963 |
Echinococcus multilocularis | insulin receptor | 0.0145 | 0.2593 | 0.2593 |
Schistosoma mansoni | tyrosine kinase | 0.024 | 0.4876 | 0.4876 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0145 | 0.2593 | 0.2593 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.0236 | 0.477 | 0.4676 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0453 | 1 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0244 | 0.4963 | 0.4963 |
Schistosoma mansoni | tyrosine kinase | 0.024 | 0.4876 | 0.4876 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0453 | 1 | 1 |
Echinococcus multilocularis | 0.014 | 0.2459 | 0.2459 | |
Schistosoma mansoni | tyrosine kinase | 0.0244 | 0.4963 | 0.4963 |
Brugia malayi | Protein kinase domain containing protein | 0.0145 | 0.2593 | 0.2538 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.4013 | 0.3906 |
Leishmania major | 0.0154 | 0.2796 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.0145 | 0.2593 | 0.2593 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 6.3 uM | Cytotoxicity against human MOLT4 cells overexpressing TdT assessed as growth inhibition after 24 to 48 hrs by MTT assay | ChEMBL. | 23968551 |
IC50 (binding) | > 40 uM | Inhibition of human recombinant DNA polymerase beta | ChEMBL. | 23968551 |
IC50 (ADMET) | > 40 uM | Cytotoxicity against TdT-deficient human HeLa cells assessed as growth inhibition after 24 to 48 hrs by MTT assay | ChEMBL. | 23968551 |
ID50 (binding) | = 4.1 uM | Inhibition of human recombinant TdT using [3H]dNTP as substrate after 10 mins by scintillation counting analysis | ChEMBL. | 23968551 |
ID50 (binding) | = 11 uM | Inhibition of human recombinant full length DNA polymerase lambda using [3H]dTTP as substrate and 10 poly(dA)/oligo(dT) as template-primer after 15 mins by scintillation counting analysis | ChEMBL. | 23968551 |
ID50 (binding) | > 40 uM | Inhibition of human recombinant full length DNA polymerase lambda TdT-like activity using [3H]dNTP as substrate after 10 mins by scintillation counting analysis | ChEMBL. | 23968551 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23968551 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.