Detailed information for compound 1795148

Basic information

Technical information
  • TDR Targets ID: 1795148
  • Name: N-(1,3-dioxoisoindol-5-yl)quinoline-8-sulfona mide
  • MW: 353.352 | Formula: C17H11N3O4S
  • H donors: 2 H acceptors: 5 LogP: 1.51 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC(=O)c2c1cc(cc2)NS(=O)(=O)c1cccc2c1nccc2
  • InChi: 1S/C17H11N3O4S/c21-16-12-7-6-11(9-13(12)17(22)19-16)20-25(23,24)14-5-1-3-10-4-2-8-18-15(10)14/h1-9,20H,(H,19,21,22)
  • InChiKey: OTTMKNNBOAZAAY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(1,3-dioxoisoindolin-5-yl)quinoline-8-sulfonamide
  • N-(1,3-dioxo-5-isoindolinyl)-8-quinolinesulfonamide
  • N-(1,3-diketoisoindolin-5-yl)quinoline-8-sulfonamide
  • ZINC01926388
  • STK238249

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni caspase-7 (C14 family) 0.009 0.4185 0.6354
Plasmodium falciparum metacaspase 1 0.0047 0.1046 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0064 0.2275 0.2275
Echinococcus granulosus caspase 2 0.009 0.4185 0.6354
Brugia malayi hypothetical protein 0.005 0.1309 0.2693
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.1046 0.1046
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.2275 1
Trichomonas vaginalis conserved hypothetical protein 0.0171 1 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.0755 0.0755
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.1046 0.1046
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.0755 0.0755
Loa Loa (eye worm) hypothetical protein 0.005 0.1309 0.2693
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.2275 1
Plasmodium falciparum metacaspase-like protein 0.0047 0.1046 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.2275 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.2275 1
Trichomonas vaginalis conserved hypothetical protein 0.0171 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0065 0.2341 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0064 0.2275 0.2275
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0043 0.0755 0.0755
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.2302 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0036 0.0249 0.0378
Schistosoma mansoni caspase-3 (C14 family) 0.0123 0.6586 1
Trypanosoma cruzi metacaspase 5, putative 0.0047 0.1046 0.3935
Brugia malayi polk-prov protein 0.0039 0.0501 0.0639
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.0043 0.0755 0.0755
Brugia malayi Cell death protein 3 precursor 0.009 0.4185 1
Trichomonas vaginalis conserved hypothetical protein 0.0171 1 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.0755 0.0755
Trypanosoma brucei metacaspase 0.0047 0.1046 0.3935
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.0755 0.0755
Echinococcus granulosus dna polymerase eta 0.0036 0.0249 0.0378
Trypanosoma cruzi arginine N-methyltransferase, putative 0.005 0.1309 0.5231
Echinococcus multilocularis caspase 0.0123 0.6586 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.1046 0.1046
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0755 0.0755
Trypanosoma brucei metacaspase MCA3 0.0047 0.1046 0.3935
Schistosoma mansoni hypothetical protein 0.0043 0.0815 0.1237
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.2275 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.2275 1
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0171 1 1
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0047 0.1046 0.1588
Echinococcus granulosus apoptotic protease activating factor 1 0.0043 0.0815 0.1237
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.005 0.1309 0.5231
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0501 0.1241
Echinococcus granulosus caspase 0.0123 0.6586 1
Echinococcus multilocularis caspase 2 0.009 0.4185 0.6354
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.2302 0.9835
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0054 0.1551 0.2355
Trichomonas vaginalis conserved hypothetical protein 0.0171 1 1
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0039 0.0464 0.1026
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0755 0.0755
Trichomonas vaginalis conserved hypothetical protein 0.0171 1 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.0755 0.0755
Echinococcus granulosus caspase 3 0.0077 0.3216 0.4883
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.2302 0.3495
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.1046 0.1046
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0065 0.2341 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0065 0.2341 1
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.0043 0.0755 0.4778
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0171 1 1
Giardia lamblia NADPH oxidoreductase, putative 0.0171 1 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.2302 0.3495
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.0755 0.0755
Giardia lamblia NADPH oxidoreductase, putative 0.0171 1 1
Trypanosoma cruzi metacaspase 5, putative 0.0047 0.1046 0.3935
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.2275 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.0755 0.0755
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.1046 0.1046
Trypanosoma brucei DNA polymerase IV, putative 0.0064 0.2275 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.0755 0.0755
Trichomonas vaginalis conserved hypothetical protein 0.0171 1 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.0755 0.0755
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0047 0.1046 0.4545
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.0755 0.0755
Trypanosoma cruzi metacaspase, putative 0.0047 0.1046 0.3935
Entamoeba histolytica modulator of drug activity B homolog, putative 0.0043 0.0755 0.4778
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0043 0.0755 0.0755
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0047 0.1046 0.4545
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0036 0.0249 0.0378
Trypanosoma cruzi metacaspase, putative 0.0047 0.1046 0.3935
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0755 0.0755
Entamoeba histolytica hypothetical protein 0.0043 0.0755 0.4778
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.2275 1
Trichomonas vaginalis conserved hypothetical protein 0.0171 1 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.1046 0.2025
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.1046 0.1046
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.1772 0.7519
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0065 0.2341 0.3554
Echinococcus granulosus dna polymerase kappa 0.0064 0.2275 0.3454
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.1752 0.3819
Schistosoma mansoni DNA polymerase eta 0.0036 0.0249 0.0378
Brugia malayi hypothetical protein 0.0043 0.0815 0.1437
Onchocerca volvulus Cell death protein 3 homolog 0.009 0.4185 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.1046 0.1046
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.0755 0.0755
Echinococcus multilocularis apoptotic protease activating factor 1 0.0043 0.0815 0.1237
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.1046 0.1046
Schistosoma mansoni caspase-7 (C14 family) 0.0123 0.6586 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.2275 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.1046 0.1046
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.1046 0.1046
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0047 0.1046 0.4545
Entamoeba histolytica hypothetical protein 0.005 0.1309 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0501 0.0639
Trichomonas vaginalis conserved hypothetical protein 0.0171 1 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.2302 0.3495
Echinococcus multilocularis nmda type glutamate receptor 0.0054 0.1551 0.2355
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.2341 0.5315
Trichomonas vaginalis conserved hypothetical protein 0.0171 1 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.2302 0.9815
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.0755 0.0755
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.0755 0.0755
Trichomonas vaginalis conserved hypothetical protein 0.0128 0.6921 0.6921
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.2302 0.9794
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0043 0.0752 0.2403
Echinococcus multilocularis dna polymerase kappa 0.0064 0.2275 0.3454
Echinococcus multilocularis caspase 3 0.0077 0.3216 0.4883
Trypanosoma cruzi arginine N-methyltransferase, putative 0.005 0.1309 0.5231
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0755 0.0755
Leishmania major DNA polymerase eta, putative 0.0036 0.0249 0.1064
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.2302 0.9794
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.1046 0.1046
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.0755 0.0755
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.1046 0.1046
Mycobacterium ulcerans DNA polymerase IV 0.0064 0.2275 0.9649
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.1046 0.1046
Plasmodium vivax hypothetical protein, conserved 0.0047 0.1046 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.0755 0.0755
Plasmodium vivax metacaspase 1, putative 0.0047 0.1046 1
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0047 0.1046 0.2025
Leishmania major metacaspase, putative 0.0047 0.1046 0.447
Trypanosoma brucei Metacaspase-4 0.0047 0.1046 0.3935
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0171 1 1
Trypanosoma cruzi metacaspase, putative 0.0047 0.1046 0.3935
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.1046 0.1046
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0043 0.0752 0.3211
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.0755 0.0755
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0039 0.0464 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0171 1 1
Echinococcus multilocularis caspase 8 0.0047 0.1046 0.1588
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0036 0.0249 0.0378
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0755 0.0755
Trypanosoma brucei unspecified product 0.0057 0.1772 0.7519
Trypanosoma cruzi metacaspase, putative 0.0047 0.1046 0.3935
Echinococcus multilocularis dna polymerase eta 0.0036 0.0249 0.0378
Trichomonas vaginalis conserved hypothetical protein 0.0171 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0752 0.2481
Mycobacterium ulcerans DNA polymerase IV 0.0064 0.2275 0.9649
Trichomonas vaginalis conserved hypothetical protein 0.0171 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0755 0.0755
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.1046 0.1046
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.0755 0.0755
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0039 0.0464 0.5
Trypanosoma brucei metacaspase 5, putative 0.0047 0.1046 0.3935
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0065 0.2341 0.3554
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0039 0.0464 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.0815 0.1437
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0123 0.6586 1
Trypanosoma brucei DNA polymerase IV, putative 0.0064 0.2275 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0065 0.2341 1
Echinococcus granulosus nmda type glutamate receptor 0.0054 0.1551 0.2355
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.005 0.1309 1
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0123 0.6586 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.0755 0.0755
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.2302 0.3495
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.0755 0.0755
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0501 0.1241
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.0755 0.0755
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0755 0.0755
Loa Loa (eye worm) hypothetical protein 0.009 0.4185 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0036 0.0249 0.0378
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.2302 0.9794
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0065 0.2341 0.3554
Leishmania major DNA polymerase kappa, putative 0.0043 0.0752 0.3211
Trichomonas vaginalis conserved hypothetical protein 0.0171 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.2275 1
Trypanosoma brucei metacaspase MCA2 0.0047 0.1046 0.3935
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.2275 1
Chlamydia trachomatis glutamine binding protein 0.0039 0.0464 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.2275 1
Echinococcus granulosus caspase 8 0.0047 0.1046 0.1588
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0755 0.0755
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.2275 1
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0755 0.0755

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.