Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0069 | 0.1407 | 0.1407 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0594 | 0.0594 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0099 | 0.2148 | 0.3818 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0594 | 0.0594 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0099 | 0.2148 | 0.3818 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.0594 | 0.5575 |
Brugia malayi | Carboxylesterase family protein | 0.0069 | 0.1407 | 0.1407 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0013 | 0 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0039 | 0.0641 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0037 | 0.0594 | 0.1056 |
Brugia malayi | Carboxylesterase family protein | 0.0069 | 0.1407 | 0.1407 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0089 | 0.1898 | 0.3374 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0541 | 0.0541 |
Loa Loa (eye worm) | carboxylesterase | 0.0069 | 0.1407 | 0.0865 |
Echinococcus granulosus | carboxylesterase 5A | 0.041 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.041 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.041 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.041 | 1 | 1 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0056 | 0.1065 | 0.1893 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0037 | 0.0594 | 0.1056 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0594 | 0.9262 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0099 | 0.2148 | 0.3818 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0037 | 0.0594 | 0.1056 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0541 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0037 | 0.0594 | 0.422 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0056 | 0.1065 | 0.1065 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0056 | 0.1065 | 0.1065 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0037 | 0.0594 | 0.0594 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0069 | 0.1407 | 0.1407 |
Loa Loa (eye worm) | hypothetical protein | 0.041 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0039 | 0.0641 | 0.0641 |
Loa Loa (eye worm) | glutathione reductase | 0.0039 | 0.0641 | 0.005 |
Brugia malayi | hypothetical protein | 0.0069 | 0.1407 | 0.1407 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0089 | 0.1898 | 0.3374 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0069 | 0.1407 | 0.1407 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0069 | 0.1407 | 0.2501 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0099 | 0.2148 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0594 | 0.422 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0052 | 0.0971 | 0.0401 |
Mycobacterium tuberculosis | Probable reductase | 0.0089 | 0.1898 | 0.3374 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0056 | 0.1065 | 0.757 |
Plasmodium vivax | glutathione reductase, putative | 0.0039 | 0.0641 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0069 | 0.1407 | 0.0865 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0056 | 0.1065 | 0.1065 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1407 | 0.0865 |
Brugia malayi | glutathione reductase | 0.0039 | 0.0641 | 0.0641 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0069 | 0.1407 | 0.1407 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0541 | 0.5 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0056 | 0.1065 | 0.757 |
Brugia malayi | follicle stimulating hormone receptor | 0.0238 | 0.5667 | 0.5667 |
Onchocerca volvulus | 0.0069 | 0.1407 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1407 | 0.0865 |
Brugia malayi | Carboxylesterase family protein | 0.0069 | 0.1407 | 0.1407 |
Echinococcus multilocularis | acetylcholinesterase | 0.041 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0069 | 0.1407 | 0.1407 |
Echinococcus multilocularis | neuroligin | 0.0069 | 0.1407 | 0.1407 |
Trichomonas vaginalis | esterase, putative | 0.0037 | 0.0594 | 0.422 |
Toxoplasma gondii | thioredoxin reductase | 0.0039 | 0.0641 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0089 | 0.1898 | 0.3374 |
Loa Loa (eye worm) | carboxylesterase | 0.041 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.041 | 1 | 1 |
Onchocerca volvulus | 0.0069 | 0.1407 | 1 | |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0069 | 0.1407 | 0.1407 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0039 | 0.0654 | 0.0654 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.2703 | 0.2242 |
Mycobacterium ulcerans | lipase LipD | 0.0037 | 0.0594 | 0.422 |
Brugia malayi | Carboxylesterase family protein | 0.0069 | 0.1407 | 0.1407 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.0594 | 0.9262 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0594 | 0.422 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0238 | 0.5667 | 0.5394 |
Brugia malayi | Carboxylesterase family protein | 0.041 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.041 | 1 | 1 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0056 | 0.1065 | 0.1065 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0541 | 0.0541 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0039 | 0.0654 | 0.0654 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0069 | 0.1407 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0069 | 0.1407 | 0.1407 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0541 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.2703 | 0.2242 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0069 | 0.1407 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.2703 | 0.2703 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1407 | 0.0865 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0037 | 0.0594 | 0.1056 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0.0594 | 0.422 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0.0594 | 0.9262 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0039 | 0.0641 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0039 | 0.0641 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0594 | 0.9262 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0037 | 0.0594 | 0.422 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0037 | 0.0594 | 0.1056 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0594 | 0.422 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.041 | 1 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0037 | 0.0594 | 0.9262 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0069 | 0.1407 | 0.2501 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1407 | 0.0865 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0594 | 0.1056 |
Plasmodium falciparum | thioredoxin reductase | 0.0039 | 0.0641 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0013 | 0 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0069 | 0.1407 | 0.2501 |
Echinococcus granulosus | neuroligin | 0.0069 | 0.1407 | 0.1407 |
Mycobacterium ulcerans | beta-lactamase | 0.0037 | 0.0594 | 0.422 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0013 | 0 | 0.5 |
Leishmania major | trypanothione reductase | 0.0039 | 0.0641 | 0.6019 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0069 | 0.1407 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0037 | 0.0594 | 0.0594 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0013 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0237 | 0.5626 | 1 |
Onchocerca volvulus | 0.0069 | 0.1407 | 1 | |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0541 | 0.0541 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0039 | 0.0641 | 0.114 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0541 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0594 | 0.422 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0541 | 0.0541 |
Schistosoma mansoni | gliotactin | 0.0069 | 0.1407 | 0.1407 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0069 | 0.1407 | 0.1407 |
Onchocerca volvulus | 0.0069 | 0.1407 | 1 | |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0089 | 0.1898 | 0.3374 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0594 | 0.422 |
Brugia malayi | beta-lactamase | 0.0037 | 0.0594 | 0.0594 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.0594 | 0.0594 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0089 | 0.1898 | 0.8393 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1407 | 0.0865 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1407 | 0.0865 |
Treponema pallidum | NADH oxidase | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0069 | 0.1407 | 0.1407 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0037 | 0.0594 | 0.1056 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0594 | 0.0594 |
Onchocerca volvulus | 0.0069 | 0.1407 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1407 | 0.0865 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.041 | 1 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0594 | 0.0594 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0039 | 0.0641 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0069 | 0.1407 | 0.1407 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0594 | 0.1056 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0594 | 0.1056 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0069 | 0.1407 | 0.1407 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0037 | 0.0594 | 0.1056 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0069 | 0.1407 | 0.1407 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0039 | 0.0641 | 0.005 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0541 | 0.0541 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0056 | 0.1065 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0089 | 0.1898 | 0.3374 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kb (binding) | > 2 uM | Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay | ChEMBL. | 24080460 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.