Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | neuropeptide Y receptor Y2 | Starlite/ChEMBL | References |
Homo sapiens | neuropeptide Y receptor Y5 | Starlite/ChEMBL | References |
Homo sapiens | neuropeptide Y receptor type 4-like | Starlite/ChEMBL | References |
Homo sapiens | neuropeptide Y receptor Y1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | neuropeptide receptor | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Schistosoma mansoni | neuropeptide receptor | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Echinococcus multilocularis | G protein coupled receptor 139 | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Echinococcus granulosus | neuropeptide receptor | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | neuropeptide Y receptor Y1 | 384 aa | 345 aa | 22.0 % |
Brugia malayi | follicle stimulating hormone receptor | neuropeptide Y receptor type 4-like | 375 aa | 346 aa | 23.1 % |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | neuropeptide Y receptor Y2 | 381 aa | 388 aa | 20.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0201 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0034 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0201 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0201 | 1 | 1 |
Echinococcus multilocularis | neuropeptide receptor | 0.0199 | 0.9893 | 0.9893 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0199 | 0.9893 | 0.9893 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0034 | 0 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0034 | 0 | 0.5 |
Schistosoma mansoni | neuropeptide receptor | 0.0199 | 0.9893 | 0.9893 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 1 | 1 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0201 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0201 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0201 | 1 | 1 |
Echinococcus granulosus | neuropeptide receptor | 0.0199 | 0.9893 | 0.9893 |
Echinococcus multilocularis | acetylcholinesterase | 0.0201 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0201 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0201 | 1 | 1 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0034 | 0 | 0.5 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0201 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0034 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0034 | 0 | 0.5 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kb (functional) | = 0.25 nM | Antagonist activity at neuropeptide Y receptor type 1 in HEL assessed as inhibition of pNPY-induced calcium mobilization by Fura-2 calcium assay | ChEMBL. | 24074877 |
Kb (functional) | = 20 nM | Antagonist activity at human neuropeptide Y receptor type 4 expressed in CHO cells co-expressing Gqi5-mtAEQ assessed as inhibition of hPP-induced calcium mobilization by Aequorin assay | ChEMBL. | 24074877 |
Ki (binding) | = 24 nM | Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells | ChEMBL. | 24074877 |
Ki (binding) | = 48 nM | Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human MCF7 cells | ChEMBL. | 24074877 |
Ki (binding) | = 130 nM | Binding affinity to human neuropeptide Y receptor type 4 receptor expressed in CHO cells using Cy5-[K4]-hPP by flow cytometric analysis | ChEMBL. | 24074877 |
Ki (binding) | = 920 nM | Binding affinity to human neuropeptide Y receptor type 2 receptor expressed in CHO cells using Cy5-pNPY by flow cytometric analysis | ChEMBL. | 24074877 |
Ki (binding) | > 5000 nM | Binding affinity to human neuropeptide Y receptor type 5 receptor expressed in HEC-1B cells using Cy5-pNPY by flow cytometric analysis | ChEMBL. | 24074877 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.