Detailed information for compound 179590

Basic information

Technical information
  • TDR Targets ID: 179590
  • Name: ethyl 6-cyclobutyl-4-ethyl-5-ethylsulfanylcar bonyl-2-phenylpyridine-3-carboxylate
  • MW: 397.53 | Formula: C23H27NO3S
  • H donors: 0 H acceptors: 3 LogP: 5.41 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1c(nc(c(c1CC)C(=O)SCC)C1CCC1)c1ccccc1
  • InChi: 1S/C23H27NO3S/c1-4-17-18(22(25)27-5-2)20(15-11-8-7-9-12-15)24-21(16-13-10-14-16)19(17)23(26)28-6-3/h7-9,11-12,16H,4-6,10,13-14H2,1-3H3
  • InChiKey: QZHIEJZCKKMBAV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 6-cyclobutyl-4-ethyl-5-ethylsulfanylcarbonyl-2-phenyl-pyridine-3-carboxylate
  • 6-cyclobutyl-4-ethyl-5-[(ethylthio)-oxomethyl]-2-phenyl-3-pyridinecarboxylic acid ethyl ester
  • 6-cyclobutyl-4-ethyl-5-(ethylthio)carbonyl-2-phenyl-nicotin ethyl ester
  • 6-cyclobutyl-4-ethyl-5-(ethylthio)carbonyl-2-phenyl-nicotinic acid ethyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei Silent information regulator 2 related protein 3 0.005 0.2654 0.4577
Echinococcus multilocularis cyclin t1 0.0022 0.1017 0.085
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0022 0.1017 0.1114
Entamoeba histolytica cyclin family protein 0.009 0.4996 1
Echinococcus multilocularis cyclins 0.009 0.4996 0.4903
Loa Loa (eye worm) hypothetical protein 0.0016 0.0677 0.0825
Schistosoma mansoni cpg binding protein 0.0032 0.1587 0.1587
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.2518 0.4743
Trichomonas vaginalis cyclin B3, putative 0.0022 0.1017 0.1798
Schistosoma mansoni Cyclin fold protein 0.0022 0.1017 0.1017
Echinococcus multilocularis cyclins 0.009 0.4996 0.4903
Brugia malayi hypothetical protein 0.0022 0.1017 0.1559
Giardia lamblia Cyclin B-like protein 0.0022 0.1017 0.0787
Echinococcus granulosus cyclins 0.009 0.4996 0.4903
Brugia malayi transcriptional regulator, Sir2 family protein 0.0016 0.0677 0.0838
Echinococcus multilocularis cyclin y 0.0022 0.1017 0.085
Trichomonas vaginalis cyclins, putative 0.0022 0.1017 0.1798
Brugia malayi Cyclin, N-terminal domain containing protein 0.0022 0.1017 0.1559
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.005 0.2654 0.4577
Loa Loa (eye worm) cyclin domain-containing protein 0.0022 0.1017 0.1547
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0677 0.0677
Plasmodium falciparum cyclin 1 0.0022 0.1017 0.0787
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0022 0.1017 0.1114
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.1017 0.1798
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0022 0.1017 0.0787
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.2518 0.2379
Brugia malayi Cyclin C 0.0022 0.1017 0.1559
Entamoeba histolytica cyclin family protein 0.009 0.4996 1
Toxoplasma gondii cyclin dependent kinase binding protein 0.0022 0.1017 0.1114
Schistosoma mansoni g1/s-specific cyclin C 0.0022 0.1017 0.1017
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0022 0.1017 0.085
Trichomonas vaginalis cyclins, putative 0.009 0.4996 1
Echinococcus multilocularis cpg binding protein 0.0032 0.1587 0.1431
Brugia malayi Cyclin, N-terminal domain containing protein 0.009 0.4996 1
Echinococcus multilocularis cyclins 0.009 0.4996 0.4903
Echinococcus multilocularis chromatin regulatory protein sir2 0.0016 0.0677 0.0503
Echinococcus granulosus cyclin y 0.0022 0.1017 0.085
Toxoplasma gondii cyclin 4, putative 0.0022 0.1017 0.1114
Echinococcus granulosus cyclin 0.0022 0.1017 0.085
Loa Loa (eye worm) transcriptional regulator 0.0016 0.0677 0.0825
Trypanosoma brucei mitotic cyclin 6 0.009 0.4996 1
Giardia lamblia Transcriptional regulator, Sir2 family 0.005 0.2654 0.4577
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.1488 0.2548
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.2518 0.2379
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.005 0.2654 0.4577
Echinococcus multilocularis cyclin B 0.009 0.4996 0.4903
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0677 0.0677
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.3435 0.3435
Onchocerca volvulus 0.003 0.1488 0.1185
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0288 0.0108
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.2518 0.2518
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0016 0.0677 0.0503
Echinococcus granulosus cyclins 0.009 0.4996 0.4903
Trichomonas vaginalis cyclins, putative 0.009 0.4996 1
Giardia lamblia Cyclin A 0.009 0.4996 1
Trichomonas vaginalis cyclin B, putative 0.0022 0.1017 0.1798
Loa Loa (eye worm) hypothetical protein 0.009 0.4996 1
Loa Loa (eye worm) cyclin domain-containing protein 0.0022 0.1017 0.1547
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.2518 0.2379
Schistosoma mansoni cyclin G2 0.0022 0.1017 0.1017
Schistosoma mansoni cyclin l 0.0022 0.1017 0.1017
Trichomonas vaginalis conserved hypothetical protein 0.009 0.4996 1
Trichomonas vaginalis cyclins, putative 0.0022 0.1017 0.1798
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.005 0.2654 0.5172
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0016 0.0677 0.0503
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.009 0.4996 1
Entamoeba histolytica cyclin, putative 0.009 0.4996 1
Schistosoma mansoni chromatin regulatory protein sir2 0.005 0.2654 0.2654
Echinococcus multilocularis cyclins 0.009 0.4996 0.4903
Echinococcus granulosus cyclin A3 4 0.0022 0.1017 0.085
Trypanosoma brucei cyclin 3 0.0022 0.1017 0.0787
Echinococcus multilocularis cyclins 0.009 0.4996 0.4903
Schistosoma mansoni cyclins 0.009 0.4996 0.4996
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0016 0.0677 0.0503
Schistosoma mansoni hypothetical protein 0.0022 0.1017 0.1017
Brugia malayi transcriptional regulator, Sir2 family protein 0.0016 0.0677 0.0838
Trichomonas vaginalis cyclins, putative 0.009 0.4996 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0677 0.0677
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0016 0.0677 0.0503
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0677 0.1097
Echinococcus multilocularis cyclin y 0.0022 0.1017 0.085
Onchocerca volvulus 0.009 0.4996 1
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0022 0.1017 0.085
Toxoplasma gondii hypothetical protein 0.0022 0.1017 0.1114
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0677 0.1097
Giardia lamblia Hypothetical protein 0.009 0.4996 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.3042 0.7746
Brugia malayi Cyclin, N-terminal domain containing protein 0.0022 0.1017 0.1559
Giardia lamblia Cyclin fold protein 1, putative 0.0022 0.1017 0.0787
Schistosoma mansoni cpg binding protein 0.003 0.1488 0.1488
Brugia malayi Cyclin, N-terminal domain containing protein 0.009 0.4996 1
Echinococcus granulosus G1:S specific cyclin D1 0.0022 0.1017 0.085
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0677 0.1097
Echinococcus granulosus cyclins 0.009 0.4996 0.4903
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0022 0.1017 0.0787
Mycobacterium tuberculosis Transcriptional regulatory protein 0.005 0.2654 0.5
Mycobacterium leprae Probable NAD-dependent deacetylase NpdA (Regulatory protein SIR2 homolog) 0.0034 0.1728 0.5
Trypanosoma cruzi cyclin 6, putative 0.009 0.4996 1
Trichomonas vaginalis cyclins, putative 0.009 0.4996 1
Trichomonas vaginalis cyclin D, putative 0.009 0.4996 1
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0016 0.0677 0.0503
Trypanosoma cruzi cyclin, putative 0.009 0.4996 1
Loa Loa (eye worm) sirtuin 4 0.0016 0.0677 0.0825
Schistosoma mansoni hypothetical protein 0.0176 1 1
Trypanosoma brucei cyclin 9 0.0022 0.1017 0.0787
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0677 0.1097
Loa Loa (eye worm) hypothetical protein 0.009 0.4996 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.2518 0.2518
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0022 0.1017 0.172
Echinococcus multilocularis G1:S specific cyclin D1 0.0022 0.1017 0.085
Echinococcus multilocularis cyclin A3 4 0.0022 0.1017 0.085
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.1017 0.1798
Plasmodium falciparum cyclin 0.009 0.4996 1
Echinococcus granulosus Cyclin L1 0.0022 0.1017 0.085
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0016 0.0677 0.0503
Loa Loa (eye worm) cyclin C 0.0022 0.1017 0.1547
Plasmodium vivax cyclin 4, putative 0.0022 0.1017 0.172
Echinococcus multilocularis Cyclin L1 0.0022 0.1017 0.085
Schistosoma mansoni hypothetical protein 0.0176 1 1
Trichomonas vaginalis cyclin B, putative 0.0022 0.1017 0.1798
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0677 0.1097
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.009 0.4996 0.4903
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0016 0.0677 0.0503
Schistosoma mansoni cyclin B 0.009 0.4996 0.4996
Brugia malayi Cyclin, N-terminal domain containing protein 0.0022 0.1017 0.1559
Echinococcus granulosus cyclin b3 0.009 0.4996 0.4903
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0022 0.1017 0.1547
Echinococcus granulosus cyclin t1 0.0022 0.1017 0.085
Trichomonas vaginalis cyclin B3, putative 0.009 0.4996 1
Echinococcus multilocularis cyclin G2 0.0022 0.1017 0.085
Brugia malayi transcriptional regulator, Sir2 family protein 0.0016 0.0677 0.0838
Trichomonas vaginalis cyclin D, putative 0.0022 0.1017 0.1798
Trichomonas vaginalis cyclins, putative 0.009 0.4996 1
Giardia lamblia Hypothetical protein 0.0022 0.1017 0.0787
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0677 0.1097
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0677 0.1097
Loa Loa (eye worm) hypothetical protein 0.0022 0.1017 0.1547
Loa Loa (eye worm) cyclin domain-containing protein 0.0022 0.1017 0.1547
Brugia malayi Cyclin, N-terminal domain containing protein 0.0022 0.1017 0.1559
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0022 0.1017 0.0787
Echinococcus granulosus cyclin G2 0.0022 0.1017 0.085
Echinococcus multilocularis cyclin 0.0022 0.1017 0.085
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.1017 0.1798
Loa Loa (eye worm) cyclin domain-containing protein 0.0022 0.1017 0.1547
Entamoeba histolytica cyclin, putative 0.009 0.4996 1
Plasmodium vivax NAD-dependent deacetylase, putative 0.005 0.2654 1
Brugia malayi NAD-dependent deacetylase SIRT1 0.0016 0.0677 0.0838
Toxoplasma gondii hypothetical protein 0.0068 0.373 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.005 0.2654 0.5172
Loa Loa (eye worm) transcriptional regulator 0.0016 0.0677 0.0825
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.2518 0.2518
Schistosoma mansoni cyclin B3 0.009 0.4996 0.4996
Brugia malayi cyclin fold protein 1 variant b 0.0022 0.1017 0.1559
Loa Loa (eye worm) CYL-1 protein 0.0022 0.1017 0.1547
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0022 0.1017 0.085
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0677 0.0677
Giardia lamblia Hypothetical protein 0.0022 0.1017 0.0787
Echinococcus multilocularis cyclin B3 1 0.009 0.4996 0.4903
Brugia malayi Cyclin, N-terminal domain containing protein 0.0022 0.1017 0.1559
Giardia lamblia G2/mitotic-specific cyclin B 0.009 0.4996 1
Echinococcus granulosus cyclin y 0.0022 0.1017 0.085
Trichomonas vaginalis cyclin B, putative 0.009 0.4996 1
Trypanosoma cruzi cyclin 9, putative 0.0022 0.1017 0.0787
Schistosoma mansoni cyclin d 0.0022 0.1017 0.1017
Trypanosoma brucei mitotic cyclin 0.0022 0.1017 0.0787
Echinococcus granulosus cyclin k 0.0022 0.1017 0.085
Loa Loa (eye worm) cyclin domain-containing protein 0.0022 0.1017 0.1547
Echinococcus granulosus cpg binding protein 0.0032 0.1587 0.1431
Trypanosoma cruzi CYC2-like cyclin, putative 0.009 0.4996 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.005 0.2654 0.5172
Brugia malayi Cyclin, N-terminal domain containing protein 0.0022 0.1017 0.1559
Echinococcus multilocularis geminin 0.0176 1 1
Echinococcus multilocularis cyclin k 0.0022 0.1017 0.085
Plasmodium vivax hypothetical protein, conserved 0.0022 0.1017 0.172
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.005 0.2654 0.4577
Trypanosoma cruzi mitotic cyclin, putative 0.0022 0.1017 0.0787
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.1017 0.0787
Trichomonas vaginalis cyclins, putative 0.0022 0.1017 0.1798
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0677 0.0677
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0016 0.0677 0.0503
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0182 0.0182
Echinococcus granulosus cyclins 0.009 0.4996 0.4903
Leishmania major cyclin 0.009 0.4996 1
Trichomonas vaginalis cyclin B, putative 0.009 0.4996 1
Leishmania major mitotic cyclin, putative 0.0022 0.1017 0.0787
Echinococcus granulosus cyclin B3 1 0.009 0.4996 0.4903
Echinococcus granulosus G2:mitotic specific cyclin B3 0.009 0.4996 0.4903
Trichomonas vaginalis cyclin A, putative 0.0022 0.1017 0.1798
Echinococcus multilocularis cyclins 0.009 0.4996 0.4903
Entamoeba histolytica cyclin, domain containing protein 0.0022 0.1017 0.0787
Loa Loa (eye worm) transcriptional regulator 0.0016 0.0677 0.0825
Plasmodium falciparum transcriptional regulatory protein sir2a 0.005 0.2654 0.4577
Toxoplasma gondii histone deacetylase SIR2 0.005 0.2654 0.6475
Trypanosoma cruzi cyclin, putative 0.009 0.4996 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.2518 0.4735
Trichomonas vaginalis cyclin B3, putative 0.0022 0.1017 0.1798
Trichomonas vaginalis cyclin B, putative 0.009 0.4996 1
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0022 0.1017 0.085
Brugia malayi hypothetical protein 0.0022 0.1017 0.1559
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.1017 0.1798
Echinococcus multilocularis cyclin G2 0.0022 0.1017 0.085
Trichomonas vaginalis cyclin D, putative 0.009 0.4996 1
Brugia malayi CXXC zinc finger family protein 0.003 0.1488 0.2559
Schistosoma mansoni cpg binding protein 0.0032 0.1587 0.1587
Loa Loa (eye worm) cyclin domain-containing protein 0.0022 0.1017 0.1547
Trypanosoma cruzi mitotic cyclin, putative 0.0022 0.1017 0.0787
Entamoeba histolytica hypothetical protein 0.0022 0.1017 0.0787
Leishmania major mitotic cyclin, putative 0.0022 0.1017 0.0787
Schistosoma mansoni cyclin G 0.0022 0.1017 0.1017
Echinococcus granulosus cyclins 0.0022 0.1017 0.085
Trichomonas vaginalis cyclin A, putative 0.009 0.4996 1
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0022 0.1017 0.1017
Trichomonas vaginalis cyclin B, putative 0.009 0.4996 1
Loa Loa (eye worm) cyclin domain-containing protein 0.009 0.4996 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0677 0.0677
Brugia malayi Cyclin, N-terminal domain containing protein 0.0022 0.1017 0.1559
Trichomonas vaginalis cyclin B, putative 0.009 0.4996 1
Echinococcus multilocularis cyclin b3 0.009 0.4996 0.4903
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0288 0.0108
Leishmania major cyclin 9, putative 0.0022 0.1017 0.0787
Loa Loa (eye worm) hypothetical protein 0.0022 0.1017 0.1547
Entamoeba histolytica cyclin, domain containing protein 0.0022 0.1017 0.0787
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.005 0.2654 0.4577
Echinococcus granulosus cyclin G2 0.0022 0.1017 0.085
Schistosoma mansoni hypothetical protein 0.0022 0.1017 0.1017
Echinococcus granulosus cyclins 0.009 0.4996 0.4903
Echinococcus granulosus chromatin regulatory protein sir2 0.0016 0.0677 0.0503
Echinococcus granulosus cyclin B 0.009 0.4996 0.4903
Brugia malayi Cyclin, N-terminal domain containing protein 0.009 0.4996 1
Schistosoma mansoni cyclin k 0.0022 0.1017 0.1017
Mycobacterium ulcerans NAD-dependent deacetylase 0.005 0.2654 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.2518 0.2379
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0677 0.1097
Echinococcus multilocularis cyclins 0.009 0.4996 0.4903
Plasmodium vivax cyclin homologue, putative 0.0022 0.1017 0.172
Entamoeba histolytica cyclin C, putative 0.0022 0.1017 0.0787

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 0.145 % Binding affinity towards adenosine A3 receptor by measuring its ability to displace [125I]-AB-MECA binding to membranes prepared from HEK-293 cells ChEMBL. 9703464
Inhibition (binding) = 0.145 % Binding affinity towards adenosine A3 receptor by measuring its ability to displace [125I]-AB-MECA binding to membranes prepared from HEK-293 cells ChEMBL. 9703464
Inhibition (binding) = 22 % Binding affinity towards adenosine A2A receptor by measuring its ability to displace [3H]-CGS- 21680 in rat striatal membranes at a concentration of 10e-4 M ChEMBL. 9703464
Inhibition (binding) = 22 % Binding affinity towards adenosine A2A receptor by measuring its ability to displace [3H]-CGS- 21680 in rat striatal membranes at a concentration of 10e-4 M ChEMBL. 9703464
Inhibition (binding) = 30 % Binding affinity towards adenosine A1 receptor by measuring its ability to displace [3H]-R-PIA in rat brain membranes at a concentration of 10e-4 M ChEMBL. 9703464
Inhibition (binding) = 30 % Binding affinity towards adenosine A1 receptor by measuring its ability to displace [3H]-R-PIA in rat brain membranes at a concentration of 10e-4 M ChEMBL. 9703464
Log Ki (binding) = 6.84 uM Displacement of specific [125 I]AB-MECA binding at human Adenosine A3 receptor expressed in HEK cells ChEMBL. 10052977
Log Ki (binding) = 6.84 uM Displacement of specific [125 I]AB-MECA binding at human Adenosine A3 receptor expressed in HEK cells ChEMBL. 10052977
Ratio (binding) > 500 Selectivity for binding affinity towards A1 adenosine receptor in rat brain membrane and human A3 receptor expressed in HEK cells ChEMBL. 9703464

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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