Detailed information for compound 1796225

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 249.393 | Formula: C10H19NO2S2
  • H donors: 0 H acceptors: 2 LogP: 1.55 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CC(SC(=O)C)CCSC(=O)C)C
  • InChi: 1S/C10H19NO2S2/c1-8(12)14-6-5-10(7-11(3)4)15-9(2)13/h10H,5-7H2,1-4H3
  • InChiKey: PLMGSOICBGBPPB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0545 0.397
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0275 0.2137
Loa Loa (eye worm) beta-lactamase 0.0072 0.0898 0.0954
Brugia malayi beta-lactamase family protein 0.0072 0.0898 0.0937
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0041 0.043 0.0354
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0898 0.3266
Schistosoma mansoni ap endonuclease 0.0042 0.0448 0.0372
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0393 0.0408
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0042 0.0448 0.0426
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0898 0.0957
Schistosoma mansoni microtubule-associated protein tau 0.0688 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0043 0.0471 0.0493
Schistosoma mansoni ap endonuclease 0.0042 0.0448 0.0372
Echinococcus multilocularis musashi 0.0027 0.0232 0.0209
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0103 0.0077
Loa Loa (eye worm) TAR-binding protein 0.0284 0.403 0.434
Onchocerca volvulus 0.0029 0.0251 0.065
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0448 0.3168
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0898 0.6876
Mycobacterium ulcerans lipase LipD 0.0072 0.0898 0.0957
Loa Loa (eye worm) hypothetical protein 0.0072 0.0898 0.0954
Schistosoma mansoni alpha-glucosidase 0.0166 0.2281 0.222
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0393 0.0317
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0008
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0284 0.403 0.434
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0043 0.046 0.3272
Schistosoma mansoni smad1 5 8 and 0.0043 0.0471 0.0395
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0042 0.0456 0.4422
Echinococcus granulosus intermediate filament protein 0.0027 0.0232 0.0209
Schistosoma mansoni amine oxidase 0.0041 0.043 0.0354
Onchocerca volvulus 0.0072 0.0898 0.2887
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0042 0.0448 0.0467
Giardia lamblia PHD finger protein 15 0.003 0.0275 0.1445
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0568 0.0546
Loa Loa (eye worm) hypothetical protein 0.0072 0.0898 0.0954
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.0115 0.0108
Trypanosoma brucei polo-like protein kinase 0.0098 0.1277 1
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0393 0.0371
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.1277 0.4199
Loa Loa (eye worm) hypothetical protein 0.0016 0.0064 0.0052
Brugia malayi Bromodomain containing protein 0.003 0.0275 0.0263
Trypanosoma cruzi UDP-galactopyranose mutase 0.0041 0.043 0.3022
Brugia malayi MH2 domain containing protein 0.0043 0.0471 0.0475
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0568 0.0546
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0106 0.0349
Brugia malayi amine oxidase, flavin-containing family protein 0.0041 0.043 0.0431
Schistosoma mansoni hypothetical protein 0.005 0.0568 0.0492
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0193 0.2678 0.2878
Mycobacterium leprae Probable lipase LipE 0.0072 0.0898 0.3266
Loa Loa (eye worm) hypothetical protein 0.005 0.0568 0.0597
Brugia malayi Calcitonin receptor-like protein seb-1 0.0158 0.2165 0.231
Echinococcus multilocularis smad 0.0043 0.0471 0.0449
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0568 0.0546
Echinococcus granulosus lysine specific histone demethylase 1A 0.0041 0.043 0.0408
Plasmodium falciparum glutathione reductase 0.0054 0.063 1
Echinococcus multilocularis GPCR, family 2 0.005 0.0568 0.0546
Loa Loa (eye worm) hypothetical protein 0.0072 0.0898 0.0954
Loa Loa (eye worm) hypothetical protein 0.0052 0.0595 0.0626
Schistosoma mansoni smad 0.0019 0.0115 0.0036
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0568 0.0546
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1277 1
Echinococcus granulosus GPCR family 2 0.005 0.0568 0.0546
Loa Loa (eye worm) transcription factor SMAD2 0.0638 0.9266 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0898 0.0937
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0232 0.0234
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0158 0.2165 0.2324
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0898 0.6876
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0158 0.2165 0.231
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0042 0.0448 0.0413
Schistosoma mansoni Smad4 0.0043 0.0471 0.0395
Loa Loa (eye worm) hypothetical protein 0.0072 0.0898 0.0954
Loa Loa (eye worm) hypothetical protein 0.0027 0.0232 0.0234
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.1277 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0106 0.1682
Mycobacterium tuberculosis Possible oxidoreductase 0.0041 0.043 0.0423
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0041 0.043 0.683
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0898 0.0877
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.1277 0.1257
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.1292 0.1272
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0041 0.043 0.0392
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.1277 1
Schistosoma mansoni cpg binding protein 0.003 0.0276 0.0198
Echinococcus granulosus lysosomal alpha glucosidase 0.0193 0.2678 0.2661
Loa Loa (eye worm) hypothetical protein 0.0024 0.0184 0.0182
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0898 0.0957
Loa Loa (eye worm) hypothetical protein 0.0072 0.0898 0.0954
Entamoeba histolytica hypothetical protein 0.0075 0.0943 0.7249
Loa Loa (eye worm) hypothetical protein 0.0072 0.0898 0.0954
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0898 0.6876
Schistosoma mansoni cpg binding protein 0.0029 0.0251 0.0173
Plasmodium vivax hypothetical protein, conserved 0.0041 0.043 0.4793
Mycobacterium ulcerans monoamine oxidase 0.0041 0.043 0.0392
Loa Loa (eye worm) glutathione reductase 0.0054 0.063 0.0664
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0879 0.0806
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0211 0.2953 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.063 0.6619
Echinococcus granulosus Smad4 0.0043 0.0471 0.0449
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.1277 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0043 0.046 0.3272
Toxoplasma gondii thioredoxin reductase 0.0054 0.063 0.6618
Brugia malayi RNA recognition motif domain containing protein 0.0284 0.403 0.4329
Echinococcus multilocularis lysosomal alpha glucosidase 0.0193 0.2678 0.2661
Onchocerca volvulus Alhambra homolog 0.003 0.0275 0.0732
Schistosoma mansoni tar DNA-binding protein 0.0284 0.403 0.3982
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0275 0.0281
Echinococcus multilocularis mothers against decapentaplegic 5 0.0043 0.0471 0.0449
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0898 0.1032
Trichomonas vaginalis maltase-glucoamylase, putative 0.0043 0.046 0.3272
Brugia malayi MH1 domain containing protein 0.0043 0.0471 0.0475
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.1277 0.1257
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0578 0.8379 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0043 0.046 0.0481
Mycobacterium tuberculosis Probable dehydrogenase 0.0124 0.1657 0.2022
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0879 0.0858
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0152 0.208 0.2232
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0042 0.0448 0.0426
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0106 0.008
Brugia malayi jmjC domain containing protein 0.0038 0.0393 0.0391
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0898 0.6876
Brugia malayi MH2 domain containing protein 0.0043 0.0471 0.0475
Loa Loa (eye worm) hypothetical protein 0.0158 0.2165 0.2324
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0751 0.0795
Entamoeba histolytica hypothetical protein 0.0075 0.0943 0.7249
Trichomonas vaginalis esterase, putative 0.0072 0.0898 0.6876
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0232 0.0234
Treponema pallidum exodeoxyribonuclease (exoA) 0.0042 0.0448 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.046 0.3272
Brugia malayi Latrophilin receptor protein 2 0.005 0.0568 0.058
Schistosoma mansoni Smad4 0.0019 0.0115 0.0036
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0879 0.0858
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.1277 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0106 0.0349
Schistosoma mansoni amine oxidase 0.0041 0.043 0.0354
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.063 0.7017
Loa Loa (eye worm) hypothetical protein 0.0041 0.043 0.0448
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.1292 0.1272
Brugia malayi intermediate filament protein 0.0027 0.0232 0.0216
Schistosoma mansoni hypothetical protein 0.005 0.0568 0.0492
Onchocerca volvulus 0.0027 0.0232 0.0582
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0106 0.0349
Brugia malayi Glycosyl hydrolases family 31 protein 0.0193 0.2678 0.2865
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0898 0.0877
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.0041 0.043 0.0448
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0124 0.1657 0.8574
Brugia malayi CXXC zinc finger family protein 0.0029 0.0251 0.0237
Loa Loa (eye worm) hypothetical protein 0.0041 0.043 0.0448
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0943 0.087
Brugia malayi hypothetical protein 0.0041 0.043 0.0431
Onchocerca volvulus 0.0041 0.043 0.1269
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0898 0.0825
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.1277 0.1348
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0106 0.0349
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0152 0.208 0.2218
Brugia malayi MH2 domain containing protein 0.0638 0.9266 1
Brugia malayi Smad1 0.0043 0.0471 0.0475
Echinococcus multilocularis peregrin 0.003 0.0275 0.0253
Plasmodium falciparum thioredoxin reductase 0.0019 0.0106 0.1682
Entamoeba histolytica hypothetical protein 0.0075 0.0943 0.7249
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0042 0.0448 0.0446
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0991 0.0919
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0042 0.0448 0.3168
Schistosoma mansoni lamin 0.0027 0.0232 0.0154
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.063 0.0608
Loa Loa (eye worm) hypothetical protein 0.0108 0.1426 0.1524
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0064 0.0034
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0043 0.0471 0.0395
Schistosoma mansoni hypothetical protein 0.005 0.0568 0.0492
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0462 0.6662 0.8547
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1277 1
Loa Loa (eye worm) nuclear factor I 0.0024 0.0184 0.0182
Trypanosoma brucei trypanothione reductase 0.0054 0.063 0.4669
Echinococcus granulosus mothers against decapentaplegic 2 0.0019 0.0115 0.0093
Echinococcus multilocularis lysosomal alpha glucosidase 0.0193 0.2678 0.2661
Mycobacterium ulcerans dehydrogenase 0.0041 0.043 0.0392
Mycobacterium tuberculosis Probable reductase 0.0124 0.1657 0.2022
Schistosoma mansoni smad1 5 8 and 0.0043 0.0471 0.0395
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0106 0.0349
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0898 0.1032
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0137 0.1861 1
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0041 0.043 0.4793
Brugia malayi MH1 domain containing protein 0.0024 0.0184 0.0164
Echinococcus granulosus smad 0.0043 0.0471 0.0449
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0879 0.0934
Loa Loa (eye worm) hypothetical protein 0.0019 0.0115 0.0108
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0448 0.7111
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0106 0.118
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0898 0.6876
Schistosoma mansoni hypothetical protein 0.005 0.0568 0.0492
Schistosoma mansoni tar DNA-binding protein 0.0284 0.403 0.3982
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0898 0.1032
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.046 0.3272
Plasmodium falciparum thioredoxin reductase 0.0054 0.063 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0044 0.0031
Mycobacterium ulcerans oxidoreductase 0.0041 0.043 0.0392
Brugia malayi hypothetical protein 0.0075 0.0943 0.0986
Echinococcus multilocularis 0.0041 0.043 0.0408
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0124 0.1657 0.2022
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0578 0.8379 1
Schistosoma mansoni tar DNA-binding protein 0.0284 0.403 0.3982
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0106 0.0349
Echinococcus granulosus lamin dm0 0.0027 0.0232 0.0209
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0043 0.046 0.3272
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0879 0.1008
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0137 0.1861 0.2288
Echinococcus granulosus lysine specific histone demethylase 1A 0.0041 0.043 0.0408
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.063 0.0664
Echinococcus granulosus neutral alpha glucosidase AB 0.0043 0.046 0.0439
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0137 0.1861 0.2288
Brugia malayi beta-lactamase family protein 0.0072 0.0898 0.0937
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0232 0.0216
Onchocerca volvulus 0.0072 0.0898 0.2887
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0106 0.0083
Mycobacterium ulcerans hypothetical protein 0.0072 0.0898 0.0957
Schistosoma mansoni cpg binding protein 0.003 0.0276 0.0198
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0106 0.0349
Schistosoma mansoni Smad4 0.0019 0.0115 0.0036
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0042 0.0448 0.3168
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0152 0.208 0.2062
Echinococcus granulosus cpg binding protein 0.003 0.0276 0.0253
Trypanosoma brucei glucosidase, putative 0.0043 0.046 0.3272
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0152 0.208 0.2017
Schistosoma mansoni kinase 0.005 0.0564 0.0489
Brugia malayi glutathione reductase 0.0054 0.063 0.0647
Brugia malayi PHD-finger family protein 0.003 0.0275 0.0263
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.043 0.0423
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0275 0.0197
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0106 0.0349
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0042 0.0448 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0106 0.0349
Loa Loa (eye worm) MH1 domain-containing protein 0.0043 0.0471 0.0493
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0879 0.0806
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0898 0.0954
Onchocerca volvulus 0.0072 0.0898 0.2887
Echinococcus multilocularis mothers against decapentaplegic 2 0.0019 0.0115 0.0093
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0042 0.0448 0.3168
Brugia malayi beta-lactamase 0.0072 0.0898 0.0937
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0043 0.046 0.4478
Brugia malayi jmjC domain containing protein 0.0099 0.1292 0.1365
Onchocerca volvulus 0.0027 0.0232 0.0582
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0943 0.0922
Plasmodium falciparum phd finger protein, putative 0.003 0.0275 0.4368
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.1277 0.1363
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0448 0.499
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0898 0.6876
Plasmodium vivax hypothetical protein, conserved 0.0041 0.043 0.4793
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0275 0.0253
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0106 0.0349
Schistosoma mansoni lamin 0.0027 0.0232 0.0154
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0152 0.208 0.2062
Toxoplasma gondii histone lysine-specific demethylase 0.0041 0.043 0.4096
Leishmania major trypanothione reductase 0.0054 0.063 0.4669
Loa Loa (eye worm) hypothetical protein 0.0041 0.043 0.0448
Echinococcus multilocularis tar DNA binding protein 0.0284 0.403 0.4016
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0124 0.1657 0.2022
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0106 0.0349
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0898 0.1032
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.045 0.0428
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0393 0.0317
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.063 0.4669
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1277 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0152 0.208 0.2017
Schistosoma mansoni tar DNA-binding protein 0.0284 0.403 0.3982
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0043 0.046 0.3272
Brugia malayi Thioredoxin reductase 0.0054 0.063 0.0647
Loa Loa (eye worm) MH2 domain-containing protein 0.0638 0.9266 1
Brugia malayi TAR-binding protein 0.0284 0.403 0.4329
Echinococcus multilocularis neutral alpha glucosidase AB 0.0043 0.046 0.0439
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.0115 0.0108
Loa Loa (eye worm) hypothetical protein 0.003 0.0275 0.0281
Brugia malayi MH1 domain containing protein 0.0043 0.0471 0.0475
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0106 0.0349
Plasmodium falciparum protoporphyrinogen oxidase 0.0041 0.043 0.683
Brugia malayi latrophilin 2 splice variant baaae 0.0108 0.1426 0.1509
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0879 0.0934
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0898 0.1032
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0042 0.0448 0.2921
Brugia malayi MH1 domain containing protein 0.0024 0.0184 0.0164
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0054 0.063 0.0683
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0041 0.043 0.683
Echinococcus multilocularis protoporphyrinogen oxidase 0.0041 0.043 0.0408
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0106 0.0083
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.046 0.3272
Echinococcus multilocularis Smad4 0.0043 0.0471 0.0449
Schistosoma mansoni alpha-glucosidase 0.0166 0.2281 0.222
Loa Loa (eye worm) hypothetical protein 0.0211 0.2953 0.3175
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.046 0.3272
Schistosoma mansoni intermediate filament proteins 0.0027 0.0232 0.0154
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0898 0.1032
Brugia malayi exodeoxyribonuclease III family protein 0.0042 0.0448 0.045
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0019 0.0115 0.018
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0879 0.9764
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0106 0.0349
Echinococcus granulosus peregrin 0.003 0.0275 0.0253
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0106 0.0349
Echinococcus granulosus jumonji domain containing protein 0.0042 0.045 0.0428
Entamoeba histolytica hypothetical protein 0.0075 0.0943 0.7249
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0124 0.1657 0.2022
Brugia malayi Glycosyl hydrolases family 31 protein 0.0043 0.046 0.0464
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0898 0.6876
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1277 1
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0041 0.043 0.4793
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0124 0.1657 0.2022
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0568 0.058
Onchocerca volvulus 0.0111 0.1476 0.489
Mycobacterium ulcerans beta-lactamase 0.0072 0.0898 0.0957
Echinococcus multilocularis mothers against decapentaplegic 6 0.0019 0.0115 0.0093
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0898 0.1032
Schistosoma mansoni smad 0.0043 0.0471 0.0395
Mycobacterium tuberculosis Conserved protein 0.0072 0.0898 0.1032
Schistosoma mansoni smad1 5 8 and 0.0043 0.0471 0.0395
Toxoplasma gondii ABC1 family protein 0.0072 0.0898 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0251 0.0255
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0898 0.6876
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0042 0.0448 0.3168
Leishmania major UDP-galactopyranose mutase 0.0041 0.043 0.3022
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0106 0.1682
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0943 0.0922
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0537 0.7777 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0106 0.0349
Mycobacterium tuberculosis Conserved protein 0.0072 0.0898 0.1032
Echinococcus multilocularis lamin dm0 0.0027 0.0232 0.0209
Plasmodium vivax glutathione reductase, putative 0.0054 0.063 0.7017
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0726 0.0652
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0043 0.046 0.3272
Plasmodium vivax hypothetical protein, conserved 0.003 0.0275 0.3065
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0568 0.0597
Schistosoma mansoni hypothetical protein 0.003 0.0275 0.0197
Loa Loa (eye worm) hypothetical protein 0.0041 0.043 0.0448
Chlamydia trachomatis protoporphyrinogen oxidase 0.0041 0.043 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0043 0.0471 0.0449
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0879 0.0934
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1277 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0898 0.0825
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0106 0.0349
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0106 0.0349
Giardia lamblia Kinase, PLK 0.0098 0.1277 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0152 0.208 0.2017
Echinococcus granulosus TGF beta signal transducer SmadC 0.0043 0.0471 0.0449
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0042 0.0448 0.3168
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0106 0.118
Leishmania major alpha glucosidase II subunit, putative 0.0043 0.046 0.3272
Trypanosoma cruzi UDP-galactopyranose mutase 0.0041 0.043 0.3022
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0041 0.043 0.0408
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0152 0.208 0.2062
Echinococcus granulosus tar DNA binding protein 0.0284 0.403 0.4016
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0041 0.043 0.0354
Leishmania major hypothetical protein, conserved 0.0072 0.0898 0.6876
Loa Loa (eye worm) RNA binding protein 0.0284 0.403 0.434
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0898 1
Mycobacterium tuberculosis Conserved protein 0.0072 0.0898 0.1032
Brugia malayi RNA binding protein 0.0284 0.403 0.4329
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.046 0.3272
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0152 0.208 0.2062
Echinococcus multilocularis lamin 0.0027 0.0232 0.0209
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1277 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0369 0.0347
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0275 0.2137
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0106 0.0027
Echinococcus granulosus lamin 0.0027 0.0232 0.0209
Toxoplasma gondii exonuclease III APE 0.0042 0.0448 0.4319
Echinococcus granulosus mothers against decapentaplegic 6 0.0019 0.0115 0.0093
Brugia malayi N-terminal motif family protein 0.0211 0.2953 0.3163
Echinococcus granulosus mothers against decapentaplegic 5 0.0043 0.0471 0.0449
Loa Loa (eye worm) hypothetical protein 0.0027 0.0224 0.0226
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.063 0.0608
Brugia malayi SWIRM domain containing protein 0.0041 0.043 0.0431
Loa Loa (eye worm) hypothetical protein 0.0041 0.043 0.0448
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.046 0.3272
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0275 0.0253
Plasmodium falciparum glutathione reductase 0.0019 0.0106 0.1682
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.1277 0.1207
Mycobacterium tuberculosis Probable oxidoreductase 0.0137 0.1861 0.2288
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0879 0.6722
Loa Loa (eye worm) Smad1 0.0043 0.0471 0.0493
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0545 0.397
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0448 0.3168
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0106 0.0349
Schistosoma mansoni tar DNA-binding protein 0.0284 0.403 0.3982
Echinococcus multilocularis cpg binding protein 0.003 0.0276 0.0253
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1277 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0106 0.0349
Brugia malayi mothers against decapentaplegic homolog 3 0.0019 0.0115 0.009
Brugia malayi MH2 domain containing protein 0.0019 0.0115 0.009
Echinococcus multilocularis microtubule associated protein 2 0.0688 1 1
Schistosoma mansoni alpha glucosidase 0.0043 0.046 0.0384
Schistosoma mansoni hypothetical protein 0.0108 0.1426 0.1357
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.046 0.3272
Schistosoma mansoni hypothetical protein 0.0075 0.0943 0.087

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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